References

NEWS

Exploiting the Zonulin Mouse Model to Establish the Role of Primary Impaired Gut Barrier Function on Microbiota Composition and Immune Profiles. Miranda-Ribera A, Ennamorati M, Serena G, et al. Front Immunol. 2019;10:2233. doi:10.3389/fimmu.2019.02233. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761304/#B24.

Inequalities in Exposure to Nitrogen Dioxide in Parks and Playgrounds in Greater London, Charlotte Sheridan et al. International Journal of Environmental Research and Public Health. DOI: 10.3390/ijerph16173194. https://www.mdpi.com/1660-4601/16/17/3194. Also see interactive map online at https://storymaps.arcgis.com/stories/963af101f5f044cb8e998d624cef1325.

El-Salhy M, Haltebakk JG, Gilja OH, et al. Effects of faecal microbiota transplantation in patients with irritable bowel syndrome (IBS): a randomised, double-blind placebo-controlled study. Presented at UEG Week October 21, 2019.

New releases

Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells. Zeevalk GD et al.
Neurochem Res 2010 ,Oct;35(10):1575-87. doi: 10.1007/s11064-010-0217-0. Epub 2010 Jun 10.

Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study. Memophenol-Bensalem, J et al.  J Gerontol A Biol Sci Med Sci. 2019, Jun 18;74(7):996-1007. doi: 10.1093/gerona/gly166.
Memophenol – Activ’Inside (2019). CTS-0162-A1_Clinical study 2_one shot_what are clinical results on students_V04.
Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. Silveri, M et al. NMR in Biomedicine 2008, 21(10), pp.1066-1075.

Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. McGlade E et al. Food and Nutrition Sciences 2012, 03(06), pp.769-77.

 BEN BROWN – Arsenic

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15. Frediani JK, Naioti EA, Vos MB, Figueroa J, Marsit CJ, Welsh JA. Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environ Health. 2018 Jan 15;17(1):6.
16. Molin M, Ulven SM, Dahl L, Lundebye AK, Holck M, Alexander J, Meltzer HM, Ydersbond TA. Arsenic in seafood is associated with increased thyroid-stimulating hormone (TSH) in healthy volunteers – A randomized controlled trial. J Trace Elem Med Biol. 2017 Dec;44:1-7.
17. Naujokas MF, Anderson B, Ahsan H, Aposhian HV, Graziano JH, Thompson C, Suk WA. The broad scope of health effects from chronic arsenic exposure: update on a worldwide public health problem. Environ Health Perspect. 2013 Mar;121(3):295-302.
18. Crinnion W. Arsenic: The Underrecognized Common Disease-inducing Toxin. Integr Med (Encinitas). 2017 Apr;16(2):8-13.
19. Cubadda F, Jackson BP, Cottingham KL, Van Horne YO, Kurzius-Spencer M. Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties. Sci Total Environ. 2017 Feb 1;579:1228-1239.
20. Hasanato RM, Almomen AM. Unusual presentation of arsenic poisoning in a case of celiac disease. Ann Saudi Med. 2015 Mar-Apr;35(2):165-7.
21. Nigra AE, Nachman KE, Love DC, Grau-Perez M, Navas-Acien A. Poultry Consumption and Arsenic Exposure in the U.S. Population. Environ Health Perspect. 2017 Mar;125(3):370-377.
22. Lundebye AK, Lock EJ, Rasinger JD, Nøstbakken OJ, Hannisdal R, Karlsbakk E, Wennevik V, Madhun AS, Madsen L, Graff IE, Ørnsrud R. Lower levels of Persistent  Organic Pollutants, metals and the marine omega 3-fatty acid DHA in farmed compared to wild Atlantic salmon (Salmo salar). Environ Res. 2017 May;155:49-59.
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29. Gamble MV, Liu X, Slavkovich V, Pilsner JR, Ilievski V, et al. Folic acid supplementation lowers blood arsenic. Am J Clin Nutr 2007;86:1202–9.
30. Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, et al. Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am J Clin Nutr 2006;84:1093–101.
31. Bozack AK, Hall MN, Liu X, Ilievski V, Lomax-Luu AM, Parvez F, Siddique AB, Shahriar H, Uddin MN, Islam T, Graziano JH, Gamble MV. Folic acid supplementation enhances arsenic methylation: results from a folic acid and creatine supplementation randomized controlled trial in Bangladesh. Am J Clin Nutr. 2019 Feb 1;109(2):380-391.
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36. Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Burton JP, Gloor GB, Reid G. Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children. MBio. 2014 Oct 7;5(5):e01580-14.

PCOS and NUTRIGENOMICS – GEORGIA MARRION

1. Boyle J, Teede HJ. Polycystic ovary syndrome – an update. Aust Fam Physician 2012;41(10):752-756. [Abstract]
2. Ha L, Shi Y, Zhao J, et al. Association between polycystic ovarian syndrome and the susceptibility genes polymorphisms in Hui Chinese women. PLoS One 2015;10(5):e0126505. [Full Text]
3. El-Shal AS, Zidan HE, Rashad NM, et al. Association between genes encoding components of the luteinizing hormone – choriogonadotrophin receptor pathway and polycystic ovary syndrome in Egyptian women. Int Union Biochem Mol Biol 2015;68(1):23-36. [Abstract]
4. Livadas S, Diamanti-Kandarakis E. Polycystic ovary syndrome: definitions, phenoytypes and diagnostic approach. Front Horm Res 2013;40:1-21. [Abstract]
5. Sanchez de Melo AS, Dias SV, Cavalli RDC, et al. Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause. Soc Repr Fertil 2015;150:R11-R24.[Abstract]
6. Pau CT, Mosbruger T, Saxena R, et al. Phenotype and tissue expression as a function of genetic risk of polycystic ovary syndrome. PLoS One 2017;12(1):e0168870.[Abstract]
7. Casarini L, Riccetti L, de Pascali F, et al. Estrogen modulates specific life and death signals induced by LH and hCG in human primary granulosa cells in vitro. Int J Mol Sci 2017;18(5).[Abstract]
8. Jones RE, Lopez KH. Human reproductive biology, 3rd edn. Elsevier, Sydney. 2006.[Source]
9. Mehrabian F, Afghahi M. Can sex-hormone binding globulin be considered as a predictor of response to pharmacological treatment in women with polycystic ovary syndrome? Int J Prev Med 2013;4(10):1169-1174.[Full Text]
10. McAllister JM, Legro RS, Modi BP, et al. Functional genomics of PCOS: from GWAS to molecular mechanisms. Trends Endocrinol Metab 2015;26(3):118-124.[Full Text]
11. Briden L. Period repair manual. Lara Briden, 2015.[Abstract]
12. Macut D, Pfeifer M, Yildiz BO, et al. Polycystic ovary syndrome: novel insights into causes and therapy. Front Horm Res. Basel, Karger 2013;40:1-21.[Abstract]
13. Allahbadia GN, Merchant R. Polycystic ovary syndrome and impact on health. Middle East Fertil Society J 2011;16(1):19-37.[Abstract]
14. Welt CK, Duran JM. The genetics of polycystic ovary syndrome. Semin Reprod Med 2014;32(3):177-182.[Abstract]
15. Almawi WY, Hubail B, Arekat D, et al. Luteinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome. J Assist Reprod Genet 2015;32:607-614.[Abstract]
16. Clark NM, Podolski AJ, Brooks ED, et al. Prevalence of polycystic ovary syndrome phenotypes using updated criteria for polycystic ovarian morphology. Reprod Sci 2014;21(8):1034-1043.[Abstract]
17. Barbieri RL, Makris A, Randall RW, et al. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986;62:904-910.[Abstract]
18. Nestler JE, Jakubowicz DJ, de Vargas AF, et al. Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab 1998;83:2001-2005.[Abstract]
19. Kumar A, Woods KS, Bartolucci AA, et al. Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf) 2005;62:644-649.[Abstract]
20. Franks S, Stark J, Hardy K. Follicle dynamics and anovulation in polycystic ovary syndrome. Hum Reprod Update 2008;14:367-378.[Abstract]
21. Papalou O, Diamanti-Kandarakis E. The role of stress in PCOS. Expert review of endocrinology and metabolism 2017;12(1):87-95.  [Abstract]
22. Kahsar-Miller MD, Nixon C, Boots LR, et al. Prevalence of polycystic ovary syndrome (PCOS) in first degree relatives of patients with PCOS. Fertil Steril 2001;75:53-58.[Abstract]
23. Colilla S, Cox NJ, Ehrmann DA. Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives. J Clin Endocrinol Metab 2001;86:2027- 2031.  [Abstract]
24. Legro RS, Bentley-Lewis R, Driscoll D, et al. Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity. J Clin Endocrinol Metab 2002;87:2128-2133.[Full Text]
25. Legro RS, Driscoll D, Strauss JF, et al. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci U S A. 1998;95:14956-14960.[Full Text]
26. Yildiz BO, Goodarzi MO, Guo X, et al. Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters. Fertil Steril 2006;86:1688-1693.[Abstract]
27. Vink JM, Sadrzadeh S, Lambalk CB, et al. Heritability of polycystic ovary syndrome in a Dutch twinfamily study. J Clin Endocrinol Metab 2006;91:2100-2104.[Abstract]
28. Jones MR, Brower MA, Xu N, et al. Systems genetics reveals the functional context of PCOS loci and identifies genetic and molecular mechanisms of disease heterogeneity. PLoS Genet 2015;11(8):e1005455.[Abstract]
29. Kumar TJ. ‘Been hit twice’: a novel bi-allelic heterozygous mutation in LHCGR. J Assist Reprod Genet 2014;31:783-786. [Abstract]
30. Arnhold IJ, Lofrano-Porto A, Latronico AC. Inactivating mutations of luteinizing hormone beta-subunit or luteinizing hormone receptor cause oligo-amenorrhea and infertility in women. Horm Res 2009;71:75-82.[Abstract]
31. Thathapudi S, Kodati V, Erukkambattu J, et al. Association of luteinizing hormone chorionic gonadotropin receptor gene polymorphism with polycystic ovarian syndrome. Genet Test Mol Bio 2015;19(3):128-132.[Abstract]
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33. Thangavelu M, Godla UR, Paul SFD, et al. Single nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 genes in the pathogenesis of polycystic ovary syndrome. J Genetics 2017;96(1):87-96.[Abstract]
34. Dunaif A. Perspectives in polycystic ovary syndrome: from hair to eternity. J Clin Endocrinol Metab 2016;101(3):759-768.[Abstract]

Thymus
Fahy, GM, Brooke, RT, Watson, JP, et al. Reversal of epigenetic aging and immunosenescent trends in humans. Aging Cell. 2019; 00:e13028. https://doi.org/10.1111/acel.13028.
DNA methylation age of human tissues and cell types. Horvath S. Genome Biol. 2013;14(10):R115.

Breast cancer
Vitamin D pathway related polymorphisms and vitamin D receptor expression in breast cancer. Francis I. Int J Vitam Nutr Res. 2019 Oct 18:1-9. doi: 10.1024/0300-9831/a000615.
Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis. Williams JD et al. Endocrinology. 2016 Apr;157(4):1341-7. doi: 10.1210/en.2015-2036. Epub 2016 Mar 2.

ANTIOXIDANTS

A randomized placebo-controlled trial to investigate the effect of lactolycopene on semen quality in healthy males. Elizabeth A. Williams, Madeleine Parker, Aisling Robinson, Sophie Pitt, Allan A. Pacey. European Journal of Nutrition, 2019,  DOI: 10.1007/s00394-019-02091-5.

Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Halicka HD, Zhao H, Li J, Traganos F, Studzinski GP, Darzynkiewicz Z. Aging (Albany NY). 2012 Apr 11. [Epub ahead of print]

Rate of Change of Circulating 25-Hydroxyvitamin D Following Sublingual and Capsular Vitamin D Preparations. Williams, Claire E., Elizabeth A. Williams, and Bernard M. Corfe. European Journal of Clinical Nutrition, September 23, 2019. https://doi.org/10.1038/s41430-019-0503-0.

Antioxidants: Scientific Literature Landscape Analysis. Oxid Med Cell Longev. 2019 Jan 8;2019:8278454. doi: 10.1155/2019/8278454. eCollection 2019. Yeung AWK et al.
Evaluation of antioxidant treatments for the modulation of macrophage function in the context of retinal degeneration. Elbaz-Hayoun S et al. Mol Vis. 2019 Sep 5;25:479-488. eCollection 2019.

Protective effect of carnosic acid, a pro-electrophilic compound, in models of oxidative stress and light-induced retinal degeneration T. Rezaie et al.

Investigative Ophthalmology & Visual Science, 2012; DOI: 10.1167/iovs.12-10793.

RESEARCH
Creatine uptake regulates CD8 T cell antitumour immunity. Stefano Di Biase, Xiaoya Ma, Xi Wang, Jiaji Yu, Yu-Chen Wang, Drake J. Smith, Yang Zhou, Zhe Li, Yu Jeong Kim, Nicole Clarke, Angela To, Lili Yang. The Journal of Experimental Medicine 2019; jem.20182044 DOI: 10.1084/jem.20182044.

Phenolic compounds from coffee by-products modulate adipogenesis-related inflammation, mitochondrial dysfunction, and insulin resistance in adipocytes, via insulin/PI3K/AKT signaling pathways. Miguel Rebollo-Hernanz, Qiaozhi Zhang, Yolanda Aguilera, Maria A. Martín-Cabrejas, Elvira Gonzalez de Mejia.  Food and Chemical Toxicology, 2019; 132: 110672 DOI: 10.1016/j.fct.2019.110672

Intra-articular Corticosteroid Injections in the Hip and Knee: Perhaps Not as Safe as We Thought? Andrew J. Kompel, Frank W. Roemer, Akira M. Murakami, Luis E. Diaz, Michel D. Crema, Ali Guermazi. Radiology, 2019; 190341 DOI: 10.1148/radiol.2019190341.

Ming-Feng Hsueh, Patrik Önnerfjord, Michael P. Bolognesi, Mark E. Easley, Virginia B. Kraus. Analysis of “old” proteins unmasks dynamic gradient of cartilage turnover in human limbs. Science Advances, 2019; 5 (10): eaax3203 DOI: 10.1126/sciadv.aax3203.

Cartilage regeneration – SIMON MARTIN

Prof Keith Baar: personal communication, and quotes from a Just Fly Sports podcast, July 3 2019, complete transcript at https://www.just-fly-sports.com/podcast-156-keith-barr-transcripts. Recommend following him on Twitter: @MuscleScience. All his papers are listed on his UC Davis website at http://fmblab.com – except the seminal first one on tendon repair! That is:
Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study. Gregory Shaw, Ben Serpell & Keith Baar. Journal of Sports Sciences 2019, 37:15, 1794-1803, DOI: 10.1080/02640414.2019.1594571.
Also worth listening to is the Institute of Performance Nutrition’s podcast with Dr Laurent Bannock interviewing Prof Baar: http://wedoscience.com/episode-110-collagen-peptides-with-prof-keith-baar

Dr Kaayla Daniel: http://drkaayladaniel.com. She reports on Dr Prudden’s research here: http://drkaayladaniel.com/wise-words-from-dr-john-f-prudden.
She has fully explained the history and science behind bone broth in contributions to Nourishing Broth: An Old-Fashioned Remedy for the Modern World (the follow-up book to Nourishing Traditions), co-authored with Sally Fallon Morell of the Weston A. Price Foundation.

Advertorial – page 16:

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Chauvel et al. (2012) A versatile overexpression strategy in the pathogenic yeast Candida albicans: identification of regulators of morphogenesis and fitness. PloS one, 7(9), e45912.

Cheng et al. (2006) Cellular and Molecular Biology of Candida albicans Estrogen Response. Eukaryotic Cell, 5 (1) 180-191.

Edman et al. (1986) Zinc status in women with recurrent vulvovaginal candidiasis. American Journal of Obstetrics & Gynecology, 155(5), 1082 – 1085

Finkel and Mitchell (2011) Genetic control of Candida albicans biofilm development. Nature reviews. Microbiology, 9(2), 109–118.

Ghannoum et al. (2015) The Role of Echinocandins in Candida Biofilm–Related Vascular Catheter Infections: In Vitro and In Vivo Model Systems. Clinical Infectious Diseases, 61(6), S618–S621.

Gunsalus et al. (2015) Manipulation of host diet to reduce gastrointestinal colonization by the opportunistic pathogen Candida albicans. mSphere 1(1):e00020-15.

Hall et al. (2010) CO2 Acts as a Signalling Molecule in Populations of the Fungal Pathogen Candida

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Kim et al. (2016) Oral manifestations in vitamin B12 deficiency patients with or without history of gastrectomy. BMC oral health, 16(1), 60.

Krasowska et al. (2009) The antagonistic effect of Saccharomyces boulardii on Candida albicans filamentation, adhesion and biofilm formation. FEMS Yeast Research, 9(8), 1312–1321.

Manohar et al. (2001) Anti-fungal activities of Origanum oil against Candida albicans. Molecular and Cellular Biochemistry, 228,111-117.

Marangoni et al. (2017) In vitro activity of Spirulina platensis water extract against different Candida species isolated from vulvo-vaginal candidiasis cases. PLoS ONE, 12(11): e0188567.

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Mathé and Van Dijck, (2013) Recent insights into Candida albicans biofilm resistance mechanisms. Current genetics, 59(4), 251–264.

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Williams et al. (2013) Interactions of Candida albicans with host epithelial surfaces. Journal of oral microbiology, 5, 10.3402/jom.v5i0.22434.

WELCOME -Simon Martin

1. Ashkan Afshin, Patrick John Sur, Kairsten A. Fay, Leslie Cornaby, Giannina Ferrara, Joseph S Salama, Erin C Mullany, Kalkidan Hassen Abate, Cristiana Abbafati, Zegeye Abebe, Mohsen Afarideh, Anju Aggarwal, Sutapa Agrawal, Tomi Akinyemiju, Fares Alahdab, Umar Bacha, Victoria F Bachman, Hamid Badali, Alaa Badawi, Isabela M Bensenor, Eduardo Bernabe, Sibhatu Kassa K Biadgilign, Stan H Biryukov, Leah E Cahill, Juan J Carrero, Kelly M. Cercy, Lalit Dandona, Rakhi Dandona, Anh Kim Dang, Meaza Girma Degefa, Maysaa El Sayed Zaki, Alireza Esteghamati, Sadaf Esteghamati, Jessica Fanzo, Carla Sofia e Sá Farinha, Maryam S Farvid, Farshad Farzadfar, Valery L. Feigin, Joao C Fernandes, Luisa Sorio Flor, Nataliya A. Foigt, Mohammad H Forouzanfar, Morsaleh Ganji, Johanna M. Geleijnse, Richard F Gillum, Alessandra C Goulart, Giuseppe Grosso, Idris Guessous, Samer Hamidi, Graeme J. Hankey, Sivadasanpillai Harikrishnan, Hamid Yimam Hassen, Simon I. Hay, Chi Linh Hoang, Masako Horino, Farhad Islami, Maria D. Jackson, Spencer L. James, Lars Johansson, Jost B. Jonas, Amir Kasaeian, Yousef Saleh Khader, Ibrahim A. Khalil, Young-Ho Khang, Ruth W Kimokoti, Yoshihiro Kokubo, G Anil Kumar, Tea Lallukka, Alan D Lopez, Stefan Lorkowski, Paulo A. Lotufo, Rafael Lozano, Reza Malekzadeh, Winfried März, Toni Meier, Yohannes A Melaku, Walter Mendoza, Gert B.M. Mensink, Renata Micha, Ted R Miller, Mojde Mirarefin, Viswanathan Mohan, Ali H Mokdad, Dariush Mozaffarian, Gabriele Nagel, Mohsen Naghavi, Cuong Tat Nguyen, Molly R Nixon, Kanyin L Ong, David M. Pereira, Hossein Poustchi, Mostafa Qorbani, Rajesh Kumar Rai, Christian Razo-García, Colin D Rehm, Juan A Rivera, Sonia Rodríguez-Ramírez, Gholamreza Roshandel, Gregory A Roth, Juan Sanabria, Tania G Sánchez-Pimienta, Benn Sartorius, Josef Schmidhuber, Aletta Elisabeth Schutte, Sadaf G. Sepanlou, Min-Jeong Shin, Reed J.D. Sorensen, Marco Springmann, Lucjan Szponar, Andrew L Thorne-Lyman, Amanda G Thrift, Mathilde Touvier, Bach Xuan Tran, Stefanos Tyrovolas, Kingsley Nnanna Ukwaja, Irfan Ullah, Olalekan A Uthman, Masoud Vaezghasemi, Tommi Juhani Vasankari, Stein Emil Vollset, Theo Vos, Giang Thu Vu, Linh Gia Vu, Elisabete Weiderpass, Andrea Werdecker, Tissa Wijeratne, Walter C Willett, Jason H Wu, Gelin Xu, Naohiro Yonemoto, Chuanhua Yu, Christopher J L Murray. Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 2019; 393 (10184): 1958 DOI: 10.1016/S0140-6736(19)30041-8

NEWS

Probiotics Reduce Health Care Cost and Societal Impact of Flu-Like Respiratory Tract Infections in the USA: An Economic Modeling Study. Irene Lenoir-Wijnkoop et al. Frontiers in Pharmacology, 2019; 10 DOI: 10.3389/fphar.2019.00980.

Circulating Micronutrient Biomarkers Are Associated With 3 Measures of Frailty: Evidence From the Irish Longitudinal Study on Ageing. Aisling M. O’Halloran, et al. JAMDA 2019, Sept: in press. DOI: https://doi.org/10.1016/j.jamda.2019.06.011

Prolonging healthy aging: Longevity vitamins and proteins. Bruce N. Ames.

Proceedings of the National Academy of Sciences Oct 2018, 115 (43) 10836-10844; DOI: 10.1073/pnas.1809045115.

Emma Derbyshire. Could we be overlooking a potential choline crisis in the United Kingdom? BMJ Nutrition, Prevention & Health, 2019; bmjnph-2019-000037 DOI: 10.1136/bmjnph-2019-000037

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans. Slaven Stekovic et al. Cell Metabolism 2019; DOI: 10.1016/j.cmet.2019.07.016

BEN BROWN – glutathione

1. Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12.
2. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92.
3. Deponte M. The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures? Antioxid Redox Signal. 2017 Nov 20;27(15):1130-1161
4. Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med. 1999 Nov;27(9-10):916-21.
5. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92.
6. Teskey G, Abrahem R, Cao R, Gyurjian K, Islamoglu H, Lucero M, Martinez A, Paredes E, Salaiz O, Robinson B, Venketaraman V. Glutathione as a Marker for Human Disease. Adv Clin Chem. 2018;87:141-159.
7. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. N-Acetylcysteine—a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9.
8. Paschalis V, Theodorou AA, Margaritelis NV, Kyparos A, Nikolaidis MG. N-acetylcysteine supplementation increases exercise performance and reduces oxidative stress only in individuals with low levels of glutathione. Free Radic Biol Med 2018;115:288–97.
9. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther. 2014 Feb;141(2):150-9.
10. Lang CA, Mills BJ, Mastropaolo W, Liu MC. Blood glutathione decreases in chronic diseases. J Lab Clin Med. 2000 May;135(5):402-5.
11. van ‘t Erve TJ, Wagner BA, Ryckman KK, Raife TJ, Buettner GR. The concentration of glutathione in human erythrocytes is a heritable trait. Free Radic Biol Med. 2013 Dec;65:742-749.
12. Richie JP Jr, Abraham P, Leutzinger Y. Long-term stability of blood glutathione and cysteine in humans. Clin Chem. 1996 Jul;42(7):1100-5.
13. Sedda V, De Chiara B, Parolini M, et al. Plasma glutathione levels are independently associated with γ-glutamyltransferase activity in subjects with cardiovascular risk factors. Free. Radic. Res. 2008;42(2):135–141.
14. Koenig G, Seneff S. Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular Antioxidant Inadequacy and Disease Risk. Dis Markers. 2015;2015:818570.
15. Lee DH, Jacobs DR Jr. Is serum gamma-glutamyltransferase a marker of exposure to various environmental pollutants? Free Radic Res. 2009 Jun;43(6):533-7.
16. Bulusu S, Sharma M. What does serum γ-glutamyltransferase tell us as a cardiometabolic risk marker? Ann Clin Biochem. 2016 May;53(Pt 3):312-32.
17. Bradley R, Fitzpatrick AL, Jenny NS, Lee DH, Jacobs DR Jr. Associations between total serum GGT activity and metabolic risk: MESA. Biomark Med. 2013 Oct;7(5):709-21.
18. Bulusu S, Sharma M. What does serum γ-glutamyltransferase tell us as a cardiometabolic risk marker? Ann Clin Biochem. 2016 May;53(Pt 3):312-32.
19. Lee DH, Steffes MW, Jacobs DR Jr. Can persistent organic pollutants explain the association between serum gamma-glutamyltransferase and type 2 diabetes? Diabetologia. 2008 Mar;51(3):402-7.
20. Minich DM, Brown BI. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019 Sep 3;11(9).

 

IBS

Colonic spirochetosis is associated with colonic eosinophilia and irritable bowel syndrome in a general population in Sweden. Walker MM et al. Hum Pathol. 2015 Feb;46(2):277-83. doi: 10.1016/j.humpath.2014.10.026. Epub 2014 Nov 15.

 

Hazel A Everitt, Sabine Landau, Gilly O’Reilly, Alice Sibelli, Stephanie Hughes, Sula Windgassen, Rachel Holland, Paul Little, Paul McCrone, Felicity L Bishop, Kim Goldsmith, Nicholas Coleman, Robert Logan, Trudie Chalder, Rona Moss-Morris. Cognitive behavioural therapy for irritable bowel syndrome: 24-month follow-up of participants in the ACTIB randomised trial. The Lancet Gastroenterology & Hepatology, 2019; DOI: 10.1016/S2468-1253(19)30243-2

Congenital sucrase-isomaltase deficiency: https://ghr.nlm.nih.gov/condition/congenital-sucrase-isomaltase-deficiency.

Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome.

Kim, S.B., Calmet, F.H., Garrido, J. et al. Dig Dis Sci (2019). https://doi.org/10.1007/s10620-019-05780-7.

Functional variants in the sucrase–isomaltase gene associate with increased risk of irritable bowel syndrome. Henström M, Diekmann L, Bonfiglio F, et al. Gut 2018, 67: 263-270. http://dx.doi.org/10.1136/gutjnl-2016-312456.

Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids. Shuai Wang et al. Microbiome 2019; 7 (1) DOI: 10.1186/s40168-019-0740-4

CBD – Dr Elisabeth Philipps

1. https://www.bbc.co.uk/programmes/p054ghbk.
2. https://www.rugbyworld.com/news/blogs/playing-pain-investigation-painkiller-use-rugby-77805.
3. https://www.bbc.co.uk/sport/39349956.
4. Jay L Goldstein (2015) Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies

Drug Healthc Patient Saf 7: 31–41. 

5. https://www.irishtimes.com/sport/rugby/brian-o-driscoll-s-painkiller-comments-open-up-a-can-of-worms-for-rugby-1.3723037.
6. https://www.bbc.co.uk/sport/39333763.
7. https://www.bbc.co.uk/news/health-26070749.
8. https://www.independent.co.uk/sport/football/premier-league/fletcher-can-take-heart-from-moody-recovery-6276542.html.
   9. https://www.independent.ie/life/health-wellbeing/health-features/champion-kickboxer-caradh-odonovan-on-her-painful-battle-with-crohns-disease-35508854.html
9. Pharmaceuticals (Basel). 2010 Apr; 3(4): 1084–1092. 

Non Steroidal Anti-Inflammatory Drugs and Inflammatory Bowel Disease

Amir Klein and  Rami Eliakin.
11. Elisabeth Philipps (2019). Pain Management nutrihub webinar https://nutrihub.org/cpd-webinars.

12. Perry G. Fine (2013) The Endocannabinoid System, Cannabinoids, and Pain Rambam Maimonides Med J 4(4): e0022.
13. Pertwee RG. Cannabinoid receptors and pain. Prog Neurobiol. 2001 Apr; 63(5):569-611.
14. Kozono S, Matsuyama T, Biwasa KK, et al. Involvement of the endocannabinoid system in periodontal healing. Biochem Biophys Res Commun 2010;394: 928–33.
15. Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review. Campbell FA, Tramèr MR, Carroll D, Reynolds DJ, Moore RA, McQuay HJ. BMJ. 2001 Jul 7; 323(7303):13-6.
16. Cannabinoids in pancreatic cancer: correlation with survival and pain.

Michalski CW, Oti FE, Erkan M, Sauliunaite D, Bergmann F, Pacher P, Batkai S, Müller MW, Giese NA, Friess H, Kleeff J. Int J Cancer. 2008 Feb 15; 122(4):742-50.

17. Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain. Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. J Pain Symptom Manage. 2010 Feb; 39(2):167-79.
18. Perry G. Fine, The Endocannabinoid System, Cannabinoids, and Pain Rambam Maimonides Med J 2013, 4(4): e0022. 
19. Klein K, et al. Pharmacogenomics of cytochrome P450 3A4: recent progress toward the “missing heritability” problem. Frontiers in Genetics. 2013; 4:12.
20. Zanger U, et al. Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Analytical and Bioanalytical Chemistry. 2008; 392(6):1093-108.
21. Yamaori S, et al. Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety. Life Sciences. 2011; 88(15-16):730-6.
22. Yamaori S, et al. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metabolism and Disposition. 2011; 39(11):2049-56.
23. Geffrey AL, et al. Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy. Epilepsia. 2015; 56(8):1246-51.
24. Grayson L, et al. An interaction between warfarin and cannabidiol, a case report. Epilepsy & Behavior Case Reports. 2018; 9:10-11.
25. Project CBD Releases Educational Primer on Cannabinoid-Drug Interactions. | Project CBD, 14 Jan. 2019, www.projectcbd.org/how-to/cbd-drug-interactions.
26. Gertsch J, Pertwee RG, Di Marzo V. Phytocannabinoids beyond the Cannabis plant – do they exist? Br J Pharmacol. 2010 Jun; 160(3):523-9.

For example, the terpene beta-caryophyllene, commonly found in plants including hemp, black pepper, cinnamon, clove, and other spices, selectively binds to the CB2 receptor at nanomolar concentrations and acts as a full agonist, effectively reducing neuropathic pain in a CB2 receptor-dependent manner.

27. Zimmer A, Racz I, Klauke AL, Markert A, Gertsch J. Betacaryophyllene, a phytocannabinoid acting on CB2 receptors. IACM 5th Conference on cannabinoids in medicine; Cologne, Germany. 2009: http://tinyurl.com/nlfozjg.
28. Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in anxiety and sleep: A large case series. Perm J, 2019;23:18-041. DOI: https://doi.org/10.7812/TPP/18-041.
29. J Clinical Pharmacy and Therapeutics 2014, 39, 564–566 doi: 10.1111/jcpt.12179. Case Report.
30. Vaughn LK, Denning G, Stuhr KL, de Wit H, Hill MN, Hillard CJ. Endocannabinoid signalling: has it got rhythm? Br J Pharmacol. 2010;160(3):530–43.
31. 31^. Roth T. Effects of excessive daytime sleepiness and fatigue on overall health and cognitive function. J Clin Psychiatry 2015;76(9):e1145.
32. Murillo-Rodriguez E, Sarro-Ramirez A, Sanchez D, Mijangos- Moreno S, Tejeda-Padron A, Poot-Ake A, et al. Potential effects of cannabidiol as a wake-promoting agent. Curr Neuropharmacol. 2014;12(3):269–72
33. Russo EB, Guy GW, Robson PJ. Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine. Chem Biodivers. 2007;4(8):1729–43
34. Nicholson AN, Turner C, Stone BM, Robson PJ. Effect of Delta-9- tetrahydrocannabinol and cannabidiol on nocturnal sleep and early- morning behavior in young adults. J Clin Psychopharmacol. 2004;24(3):305–13.
35. https://www.wada-ama.org/en/content/what-is-prohibited/prohibited-in-competition/cannabinoids.
    36. https://www.ukad.org.uk/athlete-advisory-note-cannabidiol-cbd.

 

RESEARCH

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment. Ravinder Nagpal, Bryan J. Neth, Shaohua Wang, Suzanne Craft, Hariom Yadav. EBioMedicine 2019, DOI: 10.1016/j.ebiom.2019.08.032

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy. Pryor R et al. Cell. 2019 Sep 5;178(6):1299-1312.e29. doi: 10.1016/j.cell.2019.08.003. Epub 2019 Aug 29.

Lima, YC et al. Whey protein sweetened with Stevia rebaudiana Bertoni (Bert.) increases mitochondrial biogenesis markers in the skeletal muscle of resistance-trained rats. Nutrition & Metabolism 2019, 16, 65. Open Access: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-019-0391-2#Sec19.

Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal. Danielle G Lemay et al. The Journal of Nutritional Biochemistry, 2019; 72: 108209 DOI: 10.1016/j.jnutbio.2019.06.007.

Blindness Caused by a Junk Food Diet. Rhys Harrison, Vicki Warburton, Andrew Lux, Denize Atan. Annals of Internal Medicine, 2019; DOI: 10.7326/L19-0361.

IN PRACTICE – Andy Jancewicz

1. Dayna M. Yorks, DO, et al, November 2017, Effects of Group Fitness Classes on Stress and Quality of Life of Medical Students. J American Osteopathic Association: Vol 117, No. 11.
2. Brown B, Brain on Fire: dietary patterns for Alzheimer’s and cognitive decline.

IHCAN, October 2017, p12-15.

3. Jancewicz A, 2001, Tai Chi Chuan’s role in maintaining independence in ageing people with chronic disease- literature review. J Bodywork and Movement Therapies, January 2001, p70-77.
4. Blair SN, Garcia ME, 1996 Get up and move: A call to action for older men and women. J American Geriatrics Society 44: 599-600.
5. Bland J, Personalised Lifestyle Medicine: the future – as Jeff Bland sees it.

IHCAN, May 2019, p18-19.

6. Ashish Sharma MD et al, Letters to the Editor. Exercise for Mental Health

Prim Care Companion, J Clin Psychiatry 2006;8(2).

The economic case for prevention of population vitamin D deficiency: a modelling study using data from England and Wales. Aguiar et’ al.  European Journal of Clinical Nutrition 2019, Aug 20. https://doi.org/10.1038/s41430-019-0486-x

Aguiar, M., Andronis, L., Pallan, M., Högler, W., and Frew, E. (2019). The economic case

Birnbaum, AK, Karanam, A, Marino, SE, et al. Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy. Epilepsia. 2019; 60: 1586– 1592. https://doi.org/10.1111/epi.16093.

Characteristics and patient pathways of Lyme disease patients: a retrospective analysis of hospital episode data in England and Wales (1998-2015) 
Tulloch et al. BMC Public Health 2019 
DOI: 10.1186/s12889-019-7245-8

https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-019-7245-8

Green R, Lanphear B, Hornung R, et al. Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada. JAMA Pediatr. Published online August 19, 2019. doi:10.1001/jamapediatrics.2019.1729

Ashley J. Malin, Corina Lesseur, Stefanie A. Busgang, Paul Curtin, Robert O. Wright, Alison P. Sanders. Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016. Environment International, 2019; 105012 DOI: 10.1016/j.envint.2019.105012

Mariosa D, Carreras-Torres R, Martin RM, Johansson M, Brennan P
What can Mendelian randomization tell us about causes of cancer?
Int J Epidemiol, 48(3):816–21. Published 25 July 2019;
https://doi.org/10.1093/ije/dyz151.

Omega-3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory From the American Heart Association. Ann C. Skulas-Ray et al. Ciculation 2019, 19 Aug. https://doi.org/10.1161/CIR.0000000000000709.

Prevalence and Severity of Sesame Allergy in the United States. Warren CM, Chadha AS, Sicherer SH, Jiang J, Gupta RS. JAMA Netw Open. Published online August 02, 20192(8):e199144. doi:10.1001/jamanetworkopen.2019.9144.

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes. Dequina A. Nicholas et al. Cell Metabolism,

2019, online Aug 1. https://doi.org/10.1016/j.cmet.2019.07.004.

Amir Minerbi, Emmanuel Gonzalez, Nicholas J.B. Brereton, Abraham Anjarkouchian, Ken Dewar, Mary-Ann Fitzcharles, Stéphanie Chevalier, Yoram Shir. Altered microbiome composition in individuals with fibromyalgia. PAIN, 2019; 1 DOI: 10.1097/j.pain.0000000000001640.

NEWS extra

Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.

Rory Cave et al. Scientific Reports 2019, vol 9, Article number: 9637. https://www.nature.com/articles/s41598-019-45886-6#Sec12.

Maija P T Ylilauri, Sari Voutilainen, Eija Lönnroos, Heli E K Virtanen, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen, Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study, The American Journal of Clinical Nutrition, , nqz148, https://doi.org/10.1093/ajcn/nqz148.

Effect of Montmorency tart cherry juice on cognitive performance in older adults: a randomized controlled trial. Chai SC et al.  Food Funct. 2019 Jul 17;10(7):4423-4431. doi: 10.1039/c9fo00913b.

NEW RELEASES – vitamin D

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912737/

Worm N. Heilkraft D: How the sun vitamin protects against heart attack, cancer and other lifestyle diseases. systemed Verlag, Lünen. 2010, p12.

LansdowAnaglin, Rebecca ES, et al. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. The British journal of psychiatry, 2013, 202. Jg., Nr. 2, S. 100-107.

Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl). 1998 Feb;135(4):319-23.

In a study, substitution with vitamin D three times significantly shortened sputum conversion in patients with open lung tuberculosis. Lancet (2011; doi: 10.1016/S0140-6736(10)61889-2)

Reins RV and McDermott  AM: Vitamin D: Implications for Ocular Disease and Therapeutic Potential. Exp Eye Res. 2015 May; 134: 101–110.

BEN BROWN – Fibromyalgia

1. Borchers AT, Gershwin ME. Fibromyalgia: A Critical and Comprehensive Review. Clin Rev Allergy Immunol. 2015 Oct;49(2):100-51.
2. Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013 Aug;17(8):356.
3. Wolfe F, Walitt B, Perrot S, Rasker JJ, Häuser W. Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias. PLoS One. 2018 Sep 13;13(9):e0203755.
4. Wang SM, Han C, Lee SJ, Patkar AA, Masand PS, Pae CU. Fibromyalgia diagnosis:  a review of the past, present and future. Expert Rev Neurother. 2015 Jun;15(6):667-79.
5. Choy E, Perrot S, Leon T, Kaplan J, Petersel D, Ginovker A, Kramer E. A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv Res. 2010 Apr 26;10:102.
6. Higgs JB. Fibromyalgia in Primary Care. Prim Care. 2018 Jun;45(2):325-341.
7. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016 Dec;46(3):319-329.
8. Zachrisson O, Regland B, Jahreskog M, Kron M, Gottfries CG. A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale). J Psychosom Res. 2002 Jun;52(6):501-9.
9. Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. Fibromyalgia syndrome in need of effective treatments. J Pharmacol Exp Ther. 2015 Nov;355(2):255-63.
10. Coskun Benlidayi I. Role of inflammation in the pathogenesis and treatment of  fibromyalgia. Rheumatol Int. 2019 May;39(5):781-791.
11. Meeus M, Nijs J, Hermans L, Goubert D, Calders P. The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets? Expert Opin Ther Targets. 2013 Sep;17(9):1081-9.
12. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55.
13. Clauw DJ, Arnold LM, McCarberg BH; FibroCollaborative. The science of fibromyalgia. Mayo Clin Proc. 2011 Sep;86(9):907-11.
14. Schmidt-Wilcke T, Clauw DJ. Fibromyalgia: from pathophysiology to therapy. Nat Rev Rheumatol. 2011 Jul 19;7(9):518-27.
15. Häuser W, Ablin J, Fitzcharles MA, Littlejohn G, Luciano JV, Usui C, Walitt B. Fibromyalgia. Nat Rev Dis Primers. 2015 Aug 13;1:15022.
16. Rahman A, Underwood M, Carnes D. Fibromyalgia. BMJ. 2014 Feb 24;348:g1224.
17. Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience. 2016 Dec 3;338:114-129.
18. Theoharides TC, Tsilioni I, Arbetman L, Panagiotidou S, Stewart JM, Gleason RM, Russell IJ. Fibromyalgia syndrome in need of effective treatments. J Pharmacol Exp Ther. 2015 Nov;355(2):255-63.
19. Macfarlane GJ, Kronisch C, Dean LE, Atzeni F, Häuser W, Fluß E, Choy E, Kosek  E, Amris K, Branco J, Dincer F, Leino-Arjas P, Longley K, McCarthy GM, Makri S, Perrot S, Sarzi-Puttini P, Taylor A, Jones GT. EULAR revised recommendations for the management of fibromyalgia. Ann Rheum Dis. 2017 Feb;76(2):318-328.
20. Logan, AC. Dietary Modifications and Fibromyalgia. Complementary Health Practice Review, vol. 8, no. 3, Oct. 2003, pp. 234–245
21. Bjørklund G, Dadar M, Chirumbolo S, Aaseth J. Fibromyalgia and nutrition: Therapeutic possibilities? Biomed Pharmacother. 2018 Jul;103:531-538.
22. Totsch SK, Waite ME, Sorge RE. Dietary influence on pain via the immune system. Prog Mol Biol Transl Sci. 2015;131:435-69.
23. Bell RF, Borzan J, Kalso E, Simonnet G. Food, pain, and drugs: does it matter what pain patients eat? Pain. 2012 Oct;153(10):1993-6.
24. Silva AR, Bernardo A, Costa J, Cardoso A, Santos P, de Mesquita MF, Vaz Patto  J, Moreira P, Silva ML, Padrão P. Dietary interventions in fibromyalgia: a systematic review. Ann Med. 2019;51(sup1):2-14.
25. Høstmark AT, Lystad E, Vellar OD, Hovi K, Berg JE. Reduced plasma fibrinogen, serum peroxides, lipids, and apolipoproteins after a 3-week vegetarian diet. Plant Foods Hum Nutr. 1993 Jan;43(1):55-61.
26. Kaartinen K, Lammi K, Hypen M, Nenonen M, Hanninen O, Rauma AL. Vegan diet alleviates fibromyalgia symptoms. Scand J Rheumatol. 2000;29(5):308-13.
27. Hänninen, Kaartinen K, Rauma AL, Nenonen M, Törrönen R, Häkkinen AS, Adlercreutz H, Laakso J. Antioxidants in vegan diet and rheumatic disorders. Toxicology. 2000 Nov 30;155(1-3):45-53.
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29. Donaldson MS, Speight N, Loomis S. Fibromyalgia syndrome improved using a mostly raw vegetarian diet: an observational study. BMC Complement Altern Med. 2001;1:7.
30. Michalsen A, Riegert M, Lüdtke R, Bäcker M, Langhorst J, Schwickert M, Dobos GJ. Mediterranean diet or extended fasting’s influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: an observational study. BMC Complement Altern Med. 2005 Dec 22;5:22.
31. Correa-Rodríguez M, Mansouri-Yachou JE, Tapia-Haro RM, Molina F, Rus A, Rueda-Medina B, Aguilar-Ferrandiz ME. Mediterranean Diet, Body Composition, and Activity Associated with Bone Health in Women with Fibromyalgia Syndrome. Nurs Res. 2019 Apr 1. doi: 10.1097/NNR.0000000000000361. [Epub ahead of print]
32. Costa de Miranda R, Paiva ES, Suter Correia Cadena SM, Brandt AP, Vilela RM. Polyphenol-Rich Foods Alleviate Pain and Ameliorate Quality of Life in Fibromyalgic Women. Int J Vitam Nutr Res. 2017 Mar;87(1-2):66-74.
33. Rus A, Molina F, Ramos MM, Martínez-Ramírez MJ, Del Moral ML. Extra Virgin Olive Oil Improves Oxidative Stress, Functional Capacity, and Health-Related Psychological Status in Patients With Fibromyalgia: A Preliminary Study. Biol Res Nurs. 2017 Jan;19(1):106-115.
34. Arranz LI, Rafecas M, Alegre C. Effects of obesity on function and quality of  life in chronic pain conditions. Curr Rheumatol Rep. 2014 Jan;16(1):390.
35. Timmerman GM, Calfa NA, Stuifbergen AK. Correlates of body mass index in women with fibromyalgia. Orthop Nurs. 2013 Mar-Apr;32(2):113-9.
36. Aparicio VA, Ortega FB, Carbonell-Baeza A, Camiletti D, Ruiz JR, Delgado-Fernández M. Relationship of weight status with mental and physical health in female fibromyalgia patients. Obes Facts. 2011;4(6):443-8.
37. Shapiro JR, Anderson DA, Danoff-Burg S. A pilot study of the effects of behavioral weight loss treatment on fibromyalgia symptoms. Journal of psychosomatic research. 2005;59(5):275-82.
38. Senna MK, Sallam RA, Ashour HS, Elarman M. Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: a randomized controlled trial. Clinical rheumatology. 2012;31(11):1591-7.
39. Rodrigo L, Blanco I, Bobes J, de Serres FJ. Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study. Arthritis Res Ther. 2013;15(6):R201.
40. Rodrigo L, Blanco I, Bobes J, de Serres FJ. Clinical impact of a gluten-free diet on health-related quality of life in seven fibromyalgia syndrome patients with associated celiac disease. BMC Gastroenterol. 2013 Nov 9;13:157.
41. Leone JE, Gray KA, Massie JE, Rossi JM. Celiac disease symptoms in a female collegiate tennis player: a case report. J Athl Train. 2005 Oct-Dec;40(4):365-9.
42. Taubman B, Mamula P, Sherry DD. Prevalence of asymptomatic celiac disease in children with fibromyalgia: a pilot study. Pediatr Rheumatol Online J. 2011 Jun 13;9:11.
43. Prada A, Isasi C, Campos J, Otón T, Polo J, García B, Mulero J. Coeliac disease and chronic pain: report of three cases diagnosed in a rheumatology unit, with remission of pain after gluten-free diet [Abstract 115] Rheumatology. 2010;15:i75–i76.
44. Tovoli F, Giampaolo L, Caio G, Monti M, Piscaglia M, Frisoni M, Bolondi L, Volta U. Fibromyalgia and coeliac disease: a media hype or an emerging clinical problem? Clin Exp Rheumatol. 2013 Nov-Dec;31(6 Suppl 79):S50-2.
45. Isasi C, Colmenero I, Casco F, Tejerina E, Fernandez N, Serrano-Vela JI, Castro MJ, Villa LF. Fibromyalgia and non-celiac gluten sensitivity: a description with remission of fibromyalgia. Rheumatol Int. 2014 Nov;34(11):1607-12.
46. Rodrigo L, Blanco I, Bobes J, de Serres FJ. Effect of one year of a gluten-free diet on the clinical evolution of irritable bowel syndrome plus fibromyalgia in patients with associated lymphocytic enteritis: a case-control study. Arthritis Res Ther. 2014 Aug 27;16(4):421.
47. Slim M, Calandre EP, Garcia-Leiva JM, Rico-Villademoros F, Molina-Barea R, Rodriguez-Lopez CM, Morillas-Arques P. The Effects of a Gluten-free Diet Versus a Hypocaloric Diet Among Patients With Fibromyalgia Experiencing Gluten Sensitivity-like Symptoms: A Pilot, Open-Label Randomized Clinical Trial. J Clin  Gastroenterol. 2017 Jul;51(6):500-507.
48. Marum AP, Moreira C, Saraiva F, Tomas-Carus P, Sousa-Guerreiro C. A low fermentable oligo-di-mono saccharides and polyols (FODMAP) diet reduced pain and  improved daily life in fibromyalgia patients. Scand J Pain. 2016 Oct;13:166-172
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53. Holton KF, Taren DL, Thomson CA, Bennett RM, Jones KD. The effect of dietary glutamate on fibromyalgia and irritable bowel symptoms. Clin Exp Rheumatol. 2012 Nov-Dec;30(6 Suppl 74):10-7.
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INFLAMMATION and AUTOPHAGY

Tusco R, Jacomin A-C, Jain A, Penman BS, Larsen KB, Johansen T, et al. Kenny mediates selective autophagic degradation of the IKK complex to control innate immune responses. Nature Communications 2017, Nov 2;8(1):1264. https://doi.org/10.1038/s41467-017-01287-9.

Santos RL, Raffatellu M, Bevins CL, et al. Life in the inflamed intestine, Salmonella style. Trends Microbiol. 2009;17(11):498–506. doi:10.1016/j.tim.2009.08.008.

Zha L, Garrett S, Sun J. Salmonella Infection in Chronic Inflammation and Gastrointestinal Cancer. Diseases. 2019;7(1):28. Published 2019 Mar 10. doi:10.3390/diseases7010028.

Padhmanand Sudhakar, Anne-Claire Jacomin, Isabelle Hautefort, Siva Samavedam, Koorosh Fatemian, Eszter Ari, Leila Gul, Amanda Demeter, Emily Jones, Tamas Korcsmaros & Ioannis P. Nezis (2019) Targeted interplay between bacterial pathogens and host autophagy, Autophagy, 15:9, 1620-1633, DOI: 10.1080/15548627.2019.1590519.

SUPERFOODS
Mortreux M et al. A moderate daily dose of resveratrol mitigates muscle deconditioning in a Martian gravity analog. Frontiers in Physiology 2019, 10(899). https://doi.org/10.3389/fphys.2019.00899.

Carla Di Mattia, Natalia Battista, Giampiero Sacchetti, Mauro Serafini. Antioxidant Activities in vitro of Water and Liposoluble Extracts Obtained by Different Species of Edible Insects and Invertebrates. Frontiers in Nutrition, 2019; 6 DOI: 10.3389/fnut.2019.00106

ANNE PEMBERTON: Sulphate
Ackerman Z. Oron-Herman M. Pappo O. et al (2010) Hepatic effects of rosiglitazone in rats with the metabolic syndrome. Basic Clin. 
Pharmacol. Toxicol,107, 663–668.

Bennett JM, Reeves G, Billman GE, et al (2018)Inflammation–Nature’s Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases  [Internet]. Vol. 5, Frontiers in Medicine  p. 316. Available from: https://www.frontiersin.org/article/10.3389/fmed.2018.00316

Davidson RM, Seneff S. (2012)The initial common pathway of inflammation, disease, and sudden death. Entropy 14, 1399–1442. 


Dufault.R. Lukiw WJ. Crider R. et al (2012). A macroepigenetic approach to identify factors responsible for the autism epidemic in the United States. Clin. 
Epigenet. 4, 6.

Fujita Y, Fujino Y, Onodera M, et al. (2011)A fatal case of acute hydrogen sulfide poisoning caused by hydrogen sulfide: hydroxocobalamin therapy for acute hydrogen sulfide poisoning. J Anal Toxicol;35(2):119-123.


Geier DA, Kern JK, Garver CR, et al (2009) A prospective study of transsulphuration biomarkers in autistic disorders. Neurochem. Res.34, 386–393. 


Hartzell S & Seneff S (2012) Impaired Sulphate Metabolism and Epigenetics: Is there a link in Autism? Entropy 14, 1953-1977; doi:10.3390/e14101953.

Nair, R. & Maseeh, A. (2012). Vitamin D: The “sunshine” vitamin. Journal of pharmacology & pharmacotherapeutics, 3(2), 118–126. doi:10.4103/0976-500X.95506

Jain R. Singh A. Mittal M. & Talukdar,B. (2015). Vitamin B12 Deficiency in Children: A Treatable Cause of Neurodevelopmental Delay. Journal of Child Neurology, 30(5), 641–643. https://doi.org/10.1177/0883073813516194

James S. Melnyk S. (2010) A functional polymorphism in the reduced folate carrier gene and DNA hypomethylation in mothers of children with autism. Am. J. Med. Genet. B Neuropsychiatr. Genet.153B, 1209–1220. 


James S. Melnyk S. Jernigan S. (2006) Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am. J. Med. Genet. B 141B, 947–956. 


Kane E (2017) Life on the membrane. Conference presentation at the Neurolipid conference 18.11.2017 Las Vegas.

Lauritano EC, Gabrielli M, Scarpellini E, et al.(2008)Small intestinal bacterial overgrowth recurrence 
after antibiotic therapy. Am J Gastroenterol. 103(8):2031-2035.
Lee S, Park JM, Jeong M, et al.(2016) Korean red ginseng ameliorated experimental pancreatitis through the inhibition of hydrogen sulfide in mice. Pancreatology;16(3):326-336.

Ben Lynch (2017): Pathway planner v5. www.drbenlynch.com

Mahboubi M. (2015). Rosa damascena as holy ancient herb with novel applications. Journal of traditional and complementary medicine, 6(1), 10–16. doi:10.1016/j.jtcme.2015.09.005.

Nair R, & Maseeh A. (2012). Vitamin D: The “sunshine” vitamin. Journal of pharmacology & pharmacotherapeutics, 3(2), 118–126. doi:10.4103/0976-500X.95506

Neumann M, Leimkühler S. (2008) Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli. FEBS J.

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Sabol, Jenny & Wei, Wei & Lopez-Hoyos, Marcos & Seo, Youjin & Andaya, Armann & A. Leary, Julie. (2014). Heparan Sulphate Differences in Rheumatoid Arthritis versus Healthy Sera. Matrix Biology. 40. 10.1016/j.matbio.2014.08.016.

Said JM. (2011) “The Role of Proteoglycans in Contributing to Placental Thrombosis and Fetal Growth Restriction,” Journal of Pregnancy, vol. 2011, Article ID 928381, 4 pages,. https://doi.org/10.1155/2011/928381.

Schultz, S.T.; Klonoff-Cohen, H.S.; Wingard, et al (2008) Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: The results of a parent survey. Autism 12, 293–307. 


Samsel & Seneff (2013) Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases†

Samsel A, Seneff S. Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdiscip Toxicol. 2013;6(4):159-184.

Seneff, S., Davidson, R. M., Lauritzen, A., Samsel, A., & Wainwright, G. (2015). A novel hypothesis for atherosclerosis as a cholesterol sulphate deficiency syndrome. Theoretical biology & medical modelling, 12, 9. doi:10.1186/s12976-015-0006-1

Seneff S, Lauritzen A, Davidson R, Lentz-Marino L. (2012) Is endothelial nitric oxide synthase a moonlighting protein whose day job is cholesterol sulphate synthesis? Implications for cholesterol transport, diabetes and cardiovascular disease. Entropy 14(12):2492-2530.

Seneff S, Mascitelli L. Davidson, R. (2012) Might cholesterol sulphate deficiency contribute to the 
development of autistic spectrum disorder? Med. Hypotheses 8, 213–217. 


Seneff S, Causton NJ, Nigh GL, et al. (2017) Can glyphosate’s disruption of the gut microbiome and induction of sulphate deficiency explain the epidemic in gout and associated diseases in the industrialized world? J Biol Phys Chem. 17(2):53-76.

Sturgeon C. & Fasano A. (2016). Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue barriers, 4(4), e1251384. doi:10.1080/21688370.2016.1251384

Theoharides TC, Zhang B (2011) Neuroinflammation, blood-brain barrier, seizures and autism. J. Neuroinflam. 8, 168. 


Waring RH. (2010) Report on Absorption of magnesium  sulphate (Epsom salts) across the skin. Epsom Salt Council Web site. http://www.epsomsaltcouncil.org/wp- content/uploads/2015/10/report_on_absorption_of_magnesium_sulphate.pdf. Accessed September 2, 2018. 


Greg Nigh
SIBO as an adaptation: a proposed role for hydrogen sulfide: https://ndnr.com/gastrointestinal/sibo-as-an-adaptation-a-proposed-role-for-hydrogen-sulfide.  Posted January 8, 2019.

RESEARCH 

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes.

Erick Riquelme et al. Cell 2019, August 8, Volume 178, Issue 4.
DOI: https://doi.org/10.1016/j.cell.2019.07.008.

Fellows Maxwell K, Wahls T, Browne RW, Rubenstein L, Bisht B, Chenard CA, et al. (2019) Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study. PLoS ONE 14(6): e0218075. https://doi.org/10.1371/journal.pone.0218075

WELCOME 

Van Ende, Wijnants, and Van Dijck, “Sugar Sensing and Signaling in Candida Albicans and Candida Glabrata.” Front. Microbiol 2019., 30 January. https://doi.org/10.3389/fmicb.2019.00099.

NEWS

 Millstone E and Dawson E. EFSA’s toxicological assessment of aspartame: was it even-handedly trying to identify possible unreliable positives and unreliable negatives?

Archives of Public Health 2019, 77:34. https://doi.org/10.1186/s13690-019-0355-z. Open Access.

Arturo Casadevall, Dimitrios P. Kontoyiannis, Vincent Robert. On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds. mBio, 2019; 10 (4) DOI: 10.1128/mBio.01397-19

Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack.

Chad J. Johnson et al. mBio 2018, August. DOI: 10.1128/mBio.01403-18.

Panagioti Maria et al. Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. BMJ 2019; 366 :l4185.

New drugs: where did we go wrong and what can we do better? The BMJ, DOI: 10.1136/bmj.l4340.

Angela Genoni et al. Long-term Paleolithic diet is associated with lower resistant starch intake, different gut microbiota composition and increased serum TMAO concentrations. European Journal of Nutrition, 2019; DOI: 10.1007/s00394-019-02036-y.

Charline Quiclet et al. Pancreatic adipocytes mediate hypersecretion of insulin in diabetes-susceptible mice. Metabolism, 2019; 97: 9 DOI: 10.1016/j.metabol.2019.05.005.

BEN BROWN – SIBO

Does Irritable Bowel Syndrome Exist? Identifiable and Treatable Causes of Associated Symptoms Suggest It May Not”. Gastrointest. Disord. 2019, 1(3), 314-340; https://doi.org/10.3390/gidisord1030027.

Abstract: https://www.mdpi.com/2624-5647/1/3/27

HTML Version: https://www.mdpi.com/2624-5647/1/3/27/htm

PDF Version: https://www.mdpi.com/2624-5647/1/3/27/pdf.

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 KEELEY BERRY – JOINTS AND BONES

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17. Roles of B cells in rheumatoid arthritis. Silverman, Gregg J and Carson, Dennis A. 4, s.l. : Biomed Central, 2003, Vol. 5.
18. Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ritterhouse, Lauren L, et al. 9, s.l. : Annals of the Rheumatic Diseases., 2011, Vol. 70, pp. 1569-1574.
19. University of Rochester Medical Centre Rochester, NY. New bone chewing role for B cells in rheumatoid arthritis. [Online] April 14, 2016. [Cited: July 12, 2019.] https://www.urmc.rochester.edu/news/story/4549/new-bone-chewing-role-for-b-cells-in-rheumatoid-arthritis.aspx.

Extra stories:

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nature Genetics, 5: 230–6 (2019). https://www.nature.com/articles/s41588-018-0327-1.

Ma Hao, Li Xiang, Sun Dianjianyi, Zhou Tao, LeySylvia H, Gustat Jeanette et al. Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank BMJ 2019; 365 :l1628. https://www.bmj.com/content/365/bmj.l1628.

DIGESTIVE HEALTH

Eran Blacher et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature, 2019 DOI: 10.1038/s41586-019-1443-5.

 de la Rubia JE et al. Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study. Amyotroph Lateral Scler Frontotemporal Degener. 2019 Feb;20(1-2):115-122. Epub 2019 Jan 22.  

Diana Matheoud et al. Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice. Nature 2019, July 17. DOI: 10.1038/s41586-019-1405-y.

J Psychiatry Neurosci 2019, Jul 1;44(4):269-276. Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study. Kelly DL et al.

Veronika L Tchesnokova et al. Pandemic uropathogenic fluoroquinolone-resistant Escherichia coli have enhanced ability to persist in the gut and cause bacteriuria in healthy women, Clinical Infectious Diseases 2019, July 4, ciz547, https://doi.org/10.1093/cid/ciz547.

Claire Buchta Rosean et al. Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumour cell dissemination in hormone receptor-positive breast cancer. Cancer Research 2019, July, canres.3464.2018 DOI: 10.1158/0008-5472.CAN-18-3464.

Nat Med. 2019 Jul;25(7):1164-1174. doi: 10.1038/s41591-019-0461-z. Epub 2019 Jun 24. Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. Abdel-Gadir A et al.

(Also see Curr Opin Immunol. 2019 Jul 11;60:141-147. doi: 10.1016/j.coi.2019.06.001. Regulation of oral immune tolerance by the microbiome in food allergy. Stephen-Victor E, Chatila TA.)

RESEARCH

Karin Müller et al. ‘Poly(ADP ribose) links the DNA damage response and biomineralization.’ Cell Reports (2019). DOI: 10.1016/j.celrep.2019.05.038.

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms. Kunio Kawanishi, Chirag Dhar, Raymond Do, Nissi Varki, Philip L. S. M.Gordts, Ajit Varki

Proceedings of the National Academy of Sciences Jul 2019, 201902902, DOI:10.1073/pnas.1902902116.

Santosh Dhakal et al. Amish (Rural) vs. non-Amish (Urban) Infant Faecal Microbiotas Are Highly Diverse and Their Transplantation Lead to Differences in Mucosal Immune Maturation in a Humanized Germfree Piglet Model. Frontiers in Immunology, 2019; 10 DOI: 10.3389/fimmu.2019.01509.

Clara Depommier et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine, 2019; DOI: 10.1038/s41591-019-0495-2.

Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. Kequan Zhou.  J Funct Foods 2017, Jun; 33: 194–201. Published online 2017 Mar 29. doi: 10.1016/j.jff.2017.03.045.

Neuron, Kim and Kwon et al.: “Transneuronal Propagation of Pathologic a-Synuclein from the Gut to the Brain Models Parkinson’s Disease” https://www.cell.com/neuron/fulltext/S0896-6273(19)30488-X.

Rían W. Manville, Geoffrey W. Abbott. Cilantro leaf harbors a potent potassium channel–activating anticonvulsant. The FASEB Journal, 2019; fj.201900485R DOI: 10.1096/fj.201900485R.

Obón-Santacana, Romaguera et al. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients, 2019; 11 (6): 1406 DOI: 10.3390/nu11061406

NEWS

Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Brandon L. Jutras et al. PNAS 2019,  first published June 17: https://doi.org/10.1073/pnas.1904170116.

Pre-existing commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor-positive breast cancer

Claire Buchta Rosean, Raegan R Bostic, Joshua C. M. Ferey, Tzu-Yu Feng, Francesca NAzar, Kenneth S Tung, Mikhail G Dozmorov, Ekaterina Smirnova, Paula D. Bos and Melanie R Rutkowski

Cancer Res, May 7, 2019 DOI: 10.1158/0008-5472.CAN-18-3464.

Schwabl P et al (2018), Assessment of microplastic concentrations in human stool – Preliminary results of a prospective study, Presented at UEG Week 2018 Vienna, October 24, 2018. 
Liang Lu, Zhiqin Wan, Ting Luo, Zhengwei Fu, Yuanxiang Jin. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice,

Science of The Total Environment, Volumes 631–632, 2018, Pages 449-458, https://doi.org/10.1016/j.scitotenv.2018.03.051.

Role of vitamin D supplementation for primary prevention of cancer: Meta-analysis of randomized controlled trials. Varun Samji, Tarek Haykal, Yazan Zayed, Inderdeep Gakhal, Vijay Veerapaneni, Michelle Obeid, Babikir Kheiri, Sunil Badami, Ghassan Bachuwa, and Rizwan Danish. Journal of Clinical Oncology 2019 37:15_suppl, 1534-1534.

M Kyla Shea, Stephen B Kritchevsky, Richard F Loeser, Sarah L Booth. Vitamin K Status and Mobility Limitation and Disability in Older Adults: The Health, Aging, and Body Composition Study. The Journals of Gerontology: Series A, 2019; DOI: 10.1093/gerona/glz108.

Perceptions of Constipation Among the General Public and People With Constipation Differ Strikingly From Those of General and Specialist Doctors and the Rome IV Criteria. Dimidi, Eirini PhD¹; Cox, Camilla MSc¹; Grant, Robert MSc²; Scott, S. Mark PhD³; Whelan, Kevin PhD. American Journal of Gastroenterology, June 4, 2019,

doi: 10.14309/ajg.0000000000000267.

Heini Natri, Angela R. Garcia, Kenneth H. Buetow, Benjamin C. Trumble, Melissa A. Wilson. The Pregnancy Pickle: Evolved Immune Compensation Due to Pregnancy Underlies Sex Differences in Human Diseases. Trends in Genetics, 2019; 35 (7): 478 DOI: 10.1016/j.tig.2019.04.008.

BEN BROWN

Terry Wahls quote: The Seventy Percent Solution, Terry L. Wahls, MD. J Gen Intern Med 26(10):1215–6. DOI: 10.1007/s11606-010-1631-3.

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Pietro KJ, Jensen AM, Schumacher JR, Anderson JW. Vitamin B12 intake correlated to physical and mental improvements in multiple sclerosis specific quality of life. Int J Adv Nutr Health Sci. 2014;2:98-108.

LEARNING ZONE

Developing the evidence for kinesiology-style manual muscle testing: A series of diagnostic test accuracy studies. Anne M. Jensen, Richard Stevens , Amanda Burls. Australasian Integrative Medicine Association Conference Abstracts, Sydney, Australia/ Advances in Integrative Medicine 2014, 1 (3): 158. https://doi.org/10.1016/j.aimed.2015.01.010.  

A double-blind, randomized study to assess the validity of applied kinesiology (AK) as a diagnostic tool and as a nonlocal proximity effect. Schwartz SA et al. Explore (NY). 2014 Mar-Apr;10(2):99-108. doi: 10.1016/j.explore.2013.12.002. Epub 2013 Dec 18.

Quality and reporting of diagnostic accuracy studies in TB, HIV and malaria: evaluation using QUADAS and STARD standards. Fontela PS et al. PLoS One. 2009 Nov 13;4(11):e7753. doi: 10.1371/journal.pone.0007753.

On the reliability and validity of manual muscle testing: a literature review

Scott Cuthbert and George J Goodheart, Jr. Chiropr Osteopat. 2007; 15: 4.

Published online 2007 Mar 6. doi: 10.1186/1746-1340-15-4.

RESEARCH

Daily Sampling Reveals Personalized Diet-Microbiome Associations in Humans

Author links open overlay panel. Abigail J.Johnson et al.  Cell Host and Microbe 2019, Volume 25, Issue 6, 12 June, 789-802.e5. https://doi.org/10.1016/j.chom.2019.05.005.

Daniel J Blum, Emmanuel During, Fiona Barwick, Polina Davidenko, Jamie M Zeitzer. 0009 Restless Leg Syndrome: Does It Start With A Gut Feeling? Sleep, 2019; 42 (Supplement_1): A4 DOI: 10.1093/sleep/zsz067.008.

High sensitivity and interindividual variability in the response of the human circadian system to evening light. Andrew J. K. Phillips, Parisa Vidafar, Angus C. Burns, Elise M. McGlashan, Clare Anderson, Shantha M. W. Rajaratnam, Steven W. Lockley, Sean W.Cain. Proceedings of the National Academy of Sciences Jun 2019, 116 (24) 12019-12024; DOI:10.1073/pnas.1901824116.

Kelsey E. McLimans, Bridget E Clark, Alexandra Plagman, Colleen Pappas, Brandon Klinedinst, Vellareddy Anantharam, Anumantha Kanthasamy, Auriel A Willette. Is CSF SOD1 a Biomarker of Tau but not Amyloid Induced Neurodegeneration in Alzheimer’s Disease? Antioxidants & Redox Signaling, 2019; DOI: 10.1089/ars.2019.7762.

Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults.

Lin Shi et al. The Journal of Nutrition, nxz068, https://doi.org/10.1093/jn/nxz068

18 June 2019.

JEFF BLAND

 Lim SH, Fast L et al. Sickle cell vaso-occlusive crisis: It’s a gut feeling. J Transl Med 2016; 14: 334-39.

Zhang D, Chen G et al. Neutrophil ageing is regulated by the microbiome. Nature 2015 Sep 24; 525: 528-38.

Lim SH, Methe BA et al. Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased permeability the missing link? J Transl Med 2018; 16: 239-46.

NEWS

Butyrate, a metabolite of intestinal bacteria, enhances sleep. Éva Szentirmai et al.

Scientific Reports 2019, 9: 7035, Published May 7.

BEN BROWN – CFS 

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Multivitamin mineral supplementation in patients with chronic fatigue syndrome. Med Sci Monit. 2014 Jan 14;20:47-53.

Blood test

A nanoelectronics-blood-based diagnostic biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

1. Esfandyarpour, A. Kashi, M. Nemat-Gorgani, J. Wilhelmy, and R. W. Davis

PNAS first published April 29, 2019 https://doi.org/10.1073/pnas.1901274116.

MUSHROOM NUTRITION

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24. Trovato A, Siracusa R, Di Paola R, Scuto M,Fronte V, Koverech C, Luca M, Serra A, Toscano M.A., Petralia A, Cuzzocrea S, Calabrese V. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer´s disease pathogenesis. Neurotoxicology. 53:350-8. doi: 10.1016/j.neuro.2015.09.012. 2016.
25. Trovato A, Siracusa R, Di Paola R, Scuto M, Ontario ML, Bua O, Di Mauro P, Toscano MA, Petralia CC, Maiolino L, Serra A, Cuzzocrea S, Calabrese V. Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis. Immun Ageing. 13:23. doi: 10.1186/s12979-016-0078-8. Jul 9 2016.

And theoretical background from:
Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer´s disease pathogenesis.    Trovato A, Siracusa R, Di Paola R, Scuto M,Fronte V, Koverech C, Luca M, Serra A, Toscano M.A., Petralia A, Cuzzocrea S, Calabrese V. Neurotoxicology. 53:350-8. doi: 10.1016/j.neuro.2015.09.012. 2016.

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis        Trovato A, Siracusa R, Di Paola R, Scuto M, Ontario ML, Bua O, Di Mauro P, Toscano MA, Petralia CC, Maiolino L, Serra A, Cuzzocrea S, Calabrese V.. Immun Ageing. 13:23. doi: 10.1186/s12979-016-0078-8. Jul 9 2016.

MENOPAUSE
Neurology, April 23, 2019; 92 (17). Reproductive period and risk of dementia in a diverse cohort of health care members. Paola Gilsanz et al. DOI: https://doi.org/10.1212/WNL.0000000000007326.

Dietary intake and age at natural menopause: results from the UK Women’s Cohort Study. Yashvee Dunneram, Darren C Greenwood, Victoria J Burley and Janet E Cade.

Journal of Epidemiology and Community Health, 30 April 2018, doi: 10.1136/jech-2017-209887.

Gail A. Greendale, et al. Changes in body composition and weight during the menopause transition. JCI Insight, 2019; 4 (5) DOI: 10.1172/jci.insight.124865.

Muhleisen, A. L., & Herbst-Kralovetz, M. (2016). Menopause and the vaginal microbiome. Maturitas, 91, 42-50. https://doi.org/10.1016/j.maturitas.2016.05.015.

Mitchell CM et al. 2017. Associations between improvement in genitourinary symptoms of menopause and changes in the vaginal ecosystem. Menopause.

Front. Microbiol., 14 February 2019 | https://doi.org/10.3389/fmicb.2019.00193

Comparison of the Vaginal Microbiomes of Premenopausal and Postmenopausal Women. Karol Gliniewicz et al.

Microb Ecol. 2013 Apr;65(3):773-80. doi: 10.1007/s00248-012-0154-3. Epub 2012 Dec 19. The restoration of the vaginal microbiota after treatment for bacterial vaginosis with metronidazole or probiotics.

Ling Z et al.

Gregor Reid. “Has knowledge of the vaginal microbiome altered approaches to health and disease?” F1000Res. 2018; 7: 460. Published online 2018 Apr 13. doi: 10.12688/f1000research.13706.1.

FEMS Microbiol Lett. 2019 Feb 1;366(4). doi: 10.1093/femsle/fnz025.

Vaginal microbiota transplantation for the treatment of bacterial vaginosis: a conceptual analysis. Ma D et al.

RESEARCH

Beibei Yang, Jinbao Wei, Peijun Ju, Jinghong Chen. Effects of regulating intestinal microbiota on anxiety symptoms: A systematic review. General Psychiatry, 2019; 32: e100056 DOI: 10. 1136/gpsych-2019-100056.

Anna M. Wang, Subechhya Pradhan, Jennifer M. Coughlin, Aditi Trivedi, Samantha L. DuBois, Jeffrey L. Crawford, Thomas W. Sedlak, Fredrick C. Nucifora, Gerald Nestadt, Leslie G. Nucifora, David J. Schretlen, Akira Sawa, Peter B. Barker. Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis. JAMA Psychiatry, 2019; 76 (3): 314 DOI: 10.1001/jamapsychiatry.2018.3637

Thomas W. Sedlak, Bindu D. Paul, Gregory M. Parker, Lynda D. Hester, Adele M. Snowman, Yu Taniguchi, Atsushi Kamiya, Solomon H. Snyder, Akira Sawa. The glutathione cycle shapes synaptic glutamate activity. Proceedings of the National Academy of Sciences, 2019; 116 (7): 2701 DOI: 10.1073/pnas.1817885116

Thomas W. Sedlak, Leslie G. Nucifora, Minori Koga, Lindsay S. Shaffer, Cecilia Higgs, Teppei Tanaka, Anna M. Wang, Jennifer M. Coughlin, Peter B. Barker, Jed W. Fahey, Akira Sawa. Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study. Molecular Neuropsychiatry, 2017; 3 (4): 214 DOI: 10.1159/000487639

Changwei Li, Jiang He, Shengxu Li, Wei Chen, Lydia Bazzano, Xiao Sun, Luqi Shen, Lirong Liang, Ye Shen, Xiaoying Gu, Tanika N Kelly. Novel Metabolites Are Associated With Augmentation Index and Pulse Wave Velocity: Findings From the Bogalusa Heart Study. American Journal of Hypertension, 2019; DOI: 10.1093/ajh/hpz046

‘Training for a first-time marathon reverses vascular ageing’ presented during the Young Investigator Award session on Friday 3 May at EuroCMR 2019.

Fuehrer D, Fennessy C, Reese RJ. 2014. Runners With More Training Miles Finish Marathons Faster. Runners World. Available online at: https://www.runnersworld.com/run-the-numbers/runners-with-more-training-miles-finish-marathons-faster.

Jones S, D’Silva A, Bhuva A, et al. Improved Exercise-Related Skeletal Muscle Oxygen Consumption Following Uptake of Endurance Training Measured Using Near-Infrared Spectroscopy. Front Physiol. 2017;8:1018. doi: 10.3389/fphys.2017.01018.

Epigenomics. 2019 Feb;11(3):349-362. doi: 10.2217/epi-2018-0081. Epub 2019 Jan 23.

Role of histone acetylation in gastric cancer: implications of dietetic compounds and clinical perspectives.

Calcagno DQ et al.

Cynthia Larbey, Susan M. Mentzer, Bertrand Ligouis, Sarah Wurz, Martin K. Jones. Cooked starchy food in hearths ca. 120 kya and 65 kya (MIS 5e and MIS 4) from Klasies River Cave, South Africa. Journal of Human Evolution, 2019; 131: 210 DOI: 10.1016/j.jhevol.2019.03.015.

Ziad Al Nabhani, Sophie Dulauroy, Rute Marques, Clara Cousu, Shahed Al Bounny, François Déjardin, Tim Sparwasser, Marion Bérard, Nadine Cerf-Bensussan, Gérard Eberl. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity, 2019; DOI: 10.1016/j.immuni.2019.02.014

Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart. Sangeetha Vadakke-Madathil, Gina LaRocca, Koen Raedschelders, JesseYoon, Sarah J. Parker, Joseph Tripodi, Vesna Najfeld, Jennifer E. Van Eyk, Hina W. Chaudhry

Proceedings of the National Academy of Sciences, May 2019, 201811827; DOI:10.1073/pnas.1811827116.

Tamia A. Harris, Sureka Gattu, Daniel C. Propheter, Zheng Kuang, Shai Bel, Kelly A. Ruhn, Andrew L. Chara, Marshall Edwards, Chenlu Zhang, Jay-Hyun Jo, Prithvi Raj, Christos C. Zouboulis, Heidi H. Kong, Julia A. Segre, Lora V. Hooper. Resistin-like Molecule α Provides Vitamin-A-Dependent Antimicrobial Protection in the Skin. Cell Host & Microbe, 2019; DOI: 10.1016/j.chom.2019.04.004.

Desai T, Roberts M, Bottom L. Effects of Montmorency tart cherry supplementation on cardio-metabolic markers in metabolic syndrome participants: a pilot study. Journal of Functional Foods. 2019; 57: 286-298.

IN PRACTICE – Thalia Pellegrini

Cowling P, Ebringer R, Cawdell D, Ishii M, Ebringer A. C-reactive protein, ESR, and klebsiella in ankylosing spondylitis Ann Rheum Dis. 1980 Feb;39(1):45-9.

Ebringer A, Wilson C The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis Clinical Rheumatology 1996 Jan;15 Suppl 1:62-66.

Ebringer A, Rashid T, Wilson C,  The Link between Ankylosing Spondylitis, Crohn’s Disease, Klebsiella, and Starch Consumption Clin Dev Immunol. 2013; 2013: 872632.

 Zhang L, Zhang YJ, Chen J, Huang XL, Fang GS, Yang LJ, Duan Y, Wang J. The association of HLA-B27 and Klebsiella pneumoniae in ankylosing spondylitis: A systematic review .Microb Pathog. 2018 Apr;117:49-54

The relationship between Klebsiella infection and ankylosing spondylitis Baillière’s Clinical Rheumatology Volume 3, Issue 2, August 1989, Pages 321-338

WELCOME

“Nutritional epidemiology is a scandal. It should just go to the waste bin”:

https://www.cbc.ca/news/health/second-opinion-alcohol180505-1.4648331.

John Ioannidis second quote is here: https://newfoodeconomy.org/world-health-organization-drops-its-high-profile-endorsement-of-the-eat-lancet-diet. Report by Sam Bloch.

Why Most Published Research Findings Are False. John P. A. Ioannidis. PLoS Med. 2005 Aug; 2(8): e124. doi: 10.1371/journal.pmed.0020124.

Ng K et al. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019 Apr 9;321(14):1370-1379. doi: 10.1001/jama.2019.2402.

NEWS

1. https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance
2. https://www.gov.uk/government/news/antimicrobial-resistance-uk-launches-5-year-action-plan-and-20-year-vision.

Hu XY et al. Andrographis paniculata (Chuān Xīn Lián) for symptomatic relief of acute respiratory tract infections in adults and children: A systematic review and meta-analysis. PLoS One. 2017 Aug 4;12(8):e0181780. doi: 10.1371/journal.pone.0181780.

Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome. Journal of Molecular Diagnostics 2019, in press.

Emily B. Hollister et al. doi: https://doi.org/10.1016/j.jmoldx.2019.01.006

Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D. M. Campbell, Daniel Y. Soong, Nadine Kamenjarin, Richard J. Mellanby. 1,25-Dihydroxyvitamin D3 Restrains CD4 T Cell Priming Ability of CD11c Dendritic Cells by Upregulating Expression of CD31. Frontiers in Immunology, 2019; 10 DOI: 10.3389/fimmu.2019.00600

BEN BROWN

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41. Maes M, Mihaylova I, Leunis JC. Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement  of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability. J Affect Disord. 2007 Apr;99(1-3):237-40.
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68. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Coenzyme  Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is  related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett. 2009;30(4):470-6.
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70. Cordero MD, Moreno-Fernández AM, deMiguel M, Bonal P, Campa F, Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez Alcázar JA, Salviati L, Navas P.  Coenzyme Q10 distribution in blood is altered in patients with fibromyalgia. Clin Biochem. 2009 May;42(7-8):732-5.
71. Cordero MD, De Miguel M, Moreno Fernández AM, Carmona López IM, Garrido Maraver J, Cotán D, Gómez Izquierdo L, Bonal P, Campa F, Bullon P, Navas P, Sánchez Alcázar JA. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther. 2010;12(1):R17.
72. Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA.  Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀  effect on clinical improvement. PLoS One. 2012;7(4):e35677.
73. Cordero MD, Alcocer-Gómez E, de Miguel M, Cano-García FJ, Luque CM, Fernández-Riejo P, Fernández AM, Sánchez-Alcazar JA. Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients. Mitochondrion. 2011 Jul;11(4):623-5.
74. Cordero MD, Santos-García R, Bermejo-Jover D, Sánchez-Domínguez B, Jaramillo-Santos MR, Bullón P. Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment. Clin Biochem. 2012 Apr;45(6):509-1
75. Castro-Marrero J, Cordero MD, Segundo MJ, Sáez-Francàs N, Calvo N, Román-Malo  L, Aliste L, Fernández de Sevilla T, Alegre J. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome? Antioxid Redox Signal. 2015 Mar 10;22(8):679-85.
76. Castro-Marrero J, Sáez-Francàs N, Segundo MJ, Calvo N, Faro M, Aliste L, Fernández de Sevilla T, Alegre J. Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial. Clin  Nutr. 2016 Aug;35(4):826-34.
77. Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, Kuratsune H, Watanabe  Y. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016 Jul 8;42(4):431-40.
78. Belcaro G, Saggino A, Cornelli U, Luzzi R, Dugall M, Hosoi M, Feragalli B, Cesarone MR. Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®. J Neurosurg Sci. 2018 Aug;62(4):423-427.
79. Ippolito E, Belcaro G, Luzzi R, Hosoi M, Dugall M, Rohdewald P, Feragalli B, Cotellese R, Peterzan P. Robuvit®: improvement of fatigue in medical convalescence. J Sports Med Phys Fitness. 2018 May;58(5):678-683.
80. Belcaro G, Cornelli U, Luzzi R, Cesarone MR, Dugall M, Feragalli B, Hu S, Pellegrini L, Ippolito E. Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation. Panminerva Med. 2014 Mar;56(1):63-72.
81. Belcaro G, Cornelli U, Luzzi R, Ledda A, Cacchio M, Saggino A, Cesarone MR, Dugall M, Feragalli B, Hu S, Pellegrini L, Ippolito E. Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased  oxidative stress. A pilot registry study. J Neurosurg Sci. 2015 Jun;59(2):105-17.
82. Galland L. Diet and inflammation. Nutr Clin Pract. 2010 Dec;25(6):634-40.
83. Calder PC. Omega-3 fatty acids and inflammatory processes. Nutrients. 2010 Mar;2(3):355-74.
84. Almoznino-Sarafian D, Berman S, Mor A, Shteinshnaider M, Gorelik O, Tzur I, Alon I, Modai D, Cohen N. Magnesium and C-reactive protein in heart failure: an anti-inflammatory effect of magnesium administration? Eur J Nutr. 2007 Jun;46(4):230-7.
85. Pieczenik SR, Neustadt J. Mitochondrial dysfunction and molecular pathways of  disease. Exp Mol Pathol. 2007 Aug;83(1):84-92.
86. Bains W. Treating Chronic Fatigue states as a disease of the regulation of energy metabolism. Med Hypotheses. 2008 Oct;71(4):481-8.
87. Myhill S, Booth NE, McLaren-Howard J. Chronic fatigue syndrome and mitochondrial dysfunction. Int J Clin Exp Med. 2009;2(1):1-16.
88. Maes M. An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):784-94.
89. Booth NE, Myhill S, McLaren-Howard J. Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Int J Clin Exp Med. 2012;5(3):208-20.
90. Behan WM, More IA, Behan PO. Mitochondrial abnormalities in the postviral fatigue syndrome. Acta Neuropathol. 1991;83(1):61-5.
91. Lane RJ, Barrett MC, Woodrow D, Moss J, Fletcher R, Archard LC. Muscle fibre characteristics and lactate responses to exercise in chronic fatigue syndrome. J  Neurol Neurosurg Psychiatry. 1998 Mar;64(3):362-7.
92. Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise  study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010 Oct 11;8:93.
93. Smits B, van den Heuvel L, Knoop H, Küsters B, Janssen A, Borm G, Bleijenberg  G, Rodenburg R, van Engelen B. Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome. Mitochondrion. 2011 Sep;11(5):735-8.
94. Liu J, Ames BN. Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer’s disease, and Parkinson’s disease. Nutr Neurosci. 2005 Apr;8(2):67-89.
95. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology. 1997;35(1):16-23.
96. Vermeulen RC, Scholte HR. Exploratory open label, randomized study of acetyl-  and propionylcarnitine in chronic fatigue syndrome. Psychosom Med. 2004 Mar-Apr;66(2):276-82.
97. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med. 2006 Nov;12(9):857-62.
98. Teitelbaum J, Jandrain J, McGrew R. Treatment of Chronic Fatigue Syndrome and Fybromyalgia with D-Ribose – An Open-label Multicenter Study. Open Pain J. 2012;5:32–37.
99. Ostojic SM. Advanced physiological roles of guanidinoacetic acid. Eur J Nutr. 2015 Dec;54(8):1211-5.
100. Ostojic SM, Stojanovic M, Drid P, Hoffman JR, Sekulic D, Zenic N. Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome. Nutrients. 2016 Jan 29;8(2):72.
101. Nicolson GL, Ellithorpe R. Lipid Replacement and Antioxidant Nutritional Therapy for  Restoring Mitochondrial Function and Reducing Fatigue in  Chronic Fatigue Syndrome and other Fatiguing Illnesses. Journal of Chronic Fatigue Syndrome. 2006; 13(1).
102. Myhill S, Booth NE, McLaren-Howard J. Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – a  clinical audit. Int J Clin Exp Med. 2013;6(1):1-15.
103. Comhaire F. Treating patients suffering from myalgic encephalopathy/chronic fatigue syndrome (ME/CFS) with sodium dichloroacetate: An open-label, proof-of-principle pilot trial. Med Hypotheses. 2018 May;114:45-48.

 JEFF BLAND

(1) G. J. Egger, A. F. Binns, and S. R. Rossner, “The emergence of “lifestyle medicine” as a structured approach for management of chronic disease,” Medical Journal of Australia, vol. 190, no. 3, pp. 143–145, 2009.

(2) W. S. Dysinger, “Lifestyle medicine competencies for primary care physicians,” Virtual Mentor, vol. 15, no. 4, pp. 306–310, 2013.

(3) L. Lianov and M. Johnson, “Physician competencies for prescribing lifestyle medicine,” Journal of the American Medical Association, vol. 304, no. 2, pp. 202–203, 2010.

(4) G. Egger, A. Binns, and S. Rossner, Lifestyle Medicine, McGraw- Hill, Sydney, Australia, 2008.

(5) W. H. Herman, T. J. Hoerger, M. Brandle et al., “The cost effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance,” Annals of Internal Medicine, vol. 142, no. 5, pp. 323–332, 2005.

(6) G. Xie, X. Li, H. Li, andW. Jia, “Toward personalized nutrition: comprehensive phytoprofiling and metabotyping,” Journal of Proteomic Research, vol. 12, no. 4, pp. 1547–1559, 2013.

(7) D. R. Jacobs and L. C. Tapsell, “Food synergy: the key to a healthy diet,” Proceedings of the Nutrition Society, vol. 72, no. 2, pp. 200–206, 2013.

(8) D. M. Minich and J. S. Bland, “Dietary management of the metabolic syndrome beyond macronutrients,” Nutrition Reviews, vol. 66, no. 8, pp. 429–444, 2008.

(9) P. C. Santos, J. E. Krieger, and A. C. Pereira, “Molecular diagnostic and pathogenesis of hereditary hemochromatosis,” International Journal of Molecular Sciences, vol. 13, no. 2, pp. 1497–1511, 2012.

(10) E.Mocchegiani, R.Giacconi, L.Costarelli et al., “Zinc deficiency and IL-6 -174G/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study,” Experimental Gerontology, vol. 43, no. 5, pp. 433–444, 2008.

(11) T. R. Neyestani, A. Djazayery, S. Shab- Bidar et al., “Vitamin D receptor Fok-I polymorphism modulates diabetic host response to vitamin D intake: need for a nutrigenetic approach,” Diabetes Care, vol. 36, no. 3, pp. 550–556, 2013.

(12) A. Fischer, C. Schmelzer, G. Rimbach, P. Niklowitz, T. Menke, and F. D¨oring, “Association between genetic variants in the Coenzyme Q10metabolism and Coenzyme Q10 status in humans,” BMC Research Notes, vol. 4, article 245, 2011.

(13) R. Horvath, B. Czermin, S. Gulati et al., “Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 83, no. 2, pp. 174–178, 2012.

(14) M. H. Lizer, R. L. Bogdan, and R. S. Kidd, “Comparison of the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in depressed versus nondepressed patients,” Journal of Psychiatric Practice, vol. 17, no. 6, pp. 404–409, 2011.

(15) M. D. Swartz, C. B. Peterson, P. J. Lupo et al., “Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer,” Plos One, vol. 8, no. 1, article e53475, 2013.

(16) G. Block, N. Shaikh, C. D. Jensen, V. Volberg, and N. Holland, “Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT,” The American Journal of Clinical Nutrition, vol. 94, no. 3, pp. 929–937, 2011.

(17) K. Maehashi and L. Huang, “Bitter peptides and bitter taste receptors,” Cellular and Molecular Life Sciences, vol. 66, no. 10, pp. 1661–1671, 2009.

(18) E. Feeney, S. O’Brien, A. Scannell,A.Markey, and E. R.Gibney, “Genetic variation in taste perception: does it have a role in healthy eating?” Proceedings of the Nutrition Society, vol. 70, no. 1, pp. 135–143, 2011.

(19) U. Görman, J. C. Mathers, K. A. Grimaldi, J. Ahlgren, and K. Nordström, “Do we know enough? A scientific and ethical analysis of the basis for genetic-based personalized nutrition,” Genes and Nutrition. In press.

MITOCHONDRIA

Joe Pizzorno: “Mitochondria – Fundamental to Life and Health”. Integr Med (Encinitas). 2014 Apr; 13(2): 8–15.

31. Wesselink et al. Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence. Clinical Nutrition 2018, Aug 31. pii: S0261-5614(18)32426-9. doi: 10.1016/j.clnu.2018.08.032.

Genes (Basel). 2018 Jan 9; 9(1). pii: E22. doi: 10.3390/genes9010022.

The Aging Mitochondria. Theurey P, Pizzo P.

Elsa Sanchez-Lopez et al. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metabolism, April 11, 2019; DOI: 10.1016/j.cmet.2019.03.011/.

Ale-Agha N, Goy C, Jakobs P, Spyridopoulos I, Gonnissen S, Dyballa-Rukes N, et al. (2018) CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system–New mode of action for caffeine. PLoS Biol 16(6): e2004408. https://doi.org/10.1371/journal.pbio.2004408

Nasca C et al. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8627-8632. doi: 10.1073/pnas.1801609115. Epub 2018 Jul 30. Acetyl-l-carnitine deficiency in patients with major depressive disorder.

CoQ10

1. Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992 Jun 26;1126(3):247-54.
2. Ross D et al. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact. 2000 Dec 1;129(1-2):77-97.
3. Kelsey KT, Ross D, Traver RD et al.  Ethnic variation in the prevalence of a common NAD(P)H:quinone oxidoreductase polymorphism and its implications for anticancer chemotherapy.  Br J Cancer 1997;76:852–854.

‘Game-changing’ study may open door to new cancer therapies’: Jamie Morton, NZ Herald, Nov 21, 2018:

https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=12163922.

Martina Bajzikova et al. Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metabolism, Volume 29, Issue 2, 5 February 2019, Pages 399-416.e10. doi:

https://doi.org/10.1016/j.cmet.2018.10.014.

GENETICS and NUTRITION

Vitamin D and magnesium

1. Genetics of hereditary disorders of magnesium homeostasis. Schlingmann, Karl P, Konrad, Martin and Seyberth, Hannsjorg W. 1, 2004, Pediatric Nephrology, Vol. 19, pp. 13-25.
2. What We Eat In America, NHANES 2005-2006, Usual Nutrient Intakes from Food and Water Compared to 1997 Dietary Reference Intakes for Vitamin D, Calcium, Phosphorus, and Magnesium. Moshfegh, A, et al. s.l. : U.S. Department of Agriculture, Agricultural Research Service, 2009.
3. Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging. Shah, N.C, et al. 3, s.l. : International Journal of Clinical and Experimental Medicine, Vol. 7, pp. 497-514.
4. Magnesium in Prevention and Therapy. Grober, Uwe, Schmidt, Joachim and Kisters, Klaus. 9, s.l. : Nutrients, Vol. 7, pp. 8199-8226.
5. Vitamin D: The “sunshine” vitamin. Nair, Rathish and Maseeh, Arun. 2, s.l. : Journal of Pharmacology & Pharmacotherapeutics, 2012, Vol. 3, pp. 118-126.
6. Genetics of Type 2 Diabetes – Pitfalls and Possibilities. Prasad, Rashmi B and Groop, Leif. 1, s.l. : Genes, 2015, Vol. 6, pp. 87-123.
7. Treatment of hypovitaminosis D in infants and toddlers. Gordon, CM, et al. s.l. : Journal of Clinical Endocrinology Metabolism, 2008, Vol. 93, pp. 2716-2721.
8. Fracture prevention with vitamin D supplementation: A meta-analysis of randomized controlled trials. Bischoff-Ferrari, HA, et al. s.l. : JAMA, 2005, Vol. 293, pp. 2257-2264.
9. Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women. Anderson, LN, et al. s.l. : American Journal of Clinical Nutrition, 2010, Vol. 91, pp. 1699-1707.
10. Vitamin D deficiency and risk of cardiovascular disease. Wang, TJ and Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. s.l. : Circulation, 2008, Vol. 117, pp. 503-511.
11. Novel CYP27B1 gene mutations in patients with vitamin D-dependent rickets type 1A. Demir, Korcan, et al. 7, s.l. : PLoS One, Vol. 10.
12. Genome-wide association study of circulating vitamin D levels. Ahn, Jiyoung, et al. 13, s.l. : Human Molecular Genetics, Vol. 19, pp. 2739-2745.
13. Inherited and acquired disorders of magnesium homeostasis. Wolf, Matthias Tilmann Florian. 2, s.l. : Current Opinion in Pediatrics, 2017, Vol. 29, pp. 187-198.
14. NIH U.S. National Library of Medicine. Gitelman Syndrome. Genetics Home Reference. [Online] [Cited: March 28, 2019.] https://ghr.nlm.nih.gov/condition/gitelman-syndrome.
15. Magnesium in cystic fibrosis – systemic review of the literature. Santi, M, et al. 2, s.l. : Paediatric Pulmonology, 2016, Vol. 51, pp. 196-202.
16. Oral magnesium supplementation in children with cystic fibrosis improves clinical and functional variables: a double-blind, randomized, placebo-controlled crossover trial. Gontijo-Amaral, Clesio, Guimaraes, Elizabet V and Camargos, Paulo. 1, s.l. : The American Journal of Clinical Nutrition, 2012, Vol. 96, pp. 50-56.
17. Magnesium Basics. Jahnen-Dechent, Wilhelm and Ketteler, Markus. 1, s.l. : Clinical Kidney Journal, 2012, Vol. 5, pp. i3-i14.
18. Vitamin D, the gut microbiome and inflammatory bowel disease. Tabatabaeizadeh, Seyed-Amir, et al. 75, s.l. : Journal of Research in Medical Sciences, 2018, Vol. 23.
19. Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids. Guo, C, et al. 3, s.l. : Molecular Nutrition & Food Research, 2014, Vol. 58, pp. 528-536.

Boxes
Ramagopalan SV et al. A ChIP-seq-defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution. Genome Res 2010, 20:1352-60.  doi:10.1101/gr.107920.110.

Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. The American Journal of Clinical Nutrition, 2018; 108 (6): 1249 DOI: 10.1093/ajcn/nqy274

D’ADAMO
Wang, et al. Gut microbiota have blood types as human. Science Bulletin. Volume 63, Issue 20, 30 October 2018, Pages 1311-1313.

RESEARCH

Metabolic health

A dataset quantifying polypharmacy in the United States. Katie J. Quinn and Nigam H. Shah. Sci Data. 2017; 4: 170167. doi: 10.1038/sdata.2017.167

Long-term conditions and multi-morbidity. The Kings Fund: https://www.kingsfund.org.uk.

The prevalence and determinants of polypharmacy at age 69: a British birth cohort study. Mark James Rawle et al. BMC Geriatr 2018; 18: 118. doi: 10.1186/s12877-018-0795-2

Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016. Araújo J, Cai J, Stevens J. Metab Syndr Relat Disord. 2019 Feb;17(1):46-52. doi: 10.1089/met.2018.0105.

Brain health

1. McManus, S., Meltzer, H., Brugha, T. S., Bebbington, P. E., & Jenkins, R. (2009). Adult psychiatric morbidity in England, 2007: results of a household survey. The NHS Information Centre for health and social care.
2. Praveetha Patalay, Suzanne H Gage, Changes in millennial adolescent mental health and health-related behaviours over 10 years: a population cohort comparison study, International Journal of Epidemiology, , dyz006, https://doi.org/10.1093/ije/dyz006
3. B. Bratsberg and O. Rogeberg, ‘Flynn effect and its reversal are both environmentally caused’, Proceedings of the National Academy of Sciences (2018), http://www.pnas.org/content/early/2018/06/05/1718793115.
4. ‘Metabolism of alpha-linolenic acid’ by Dr. Diane H. Morris, Flax Council, https://flaxcouncil.ca/wp-content/uploads/2015/03/Flax_FSht_Metabol08_R.pdf
5. Vogiatzoglou A1, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, Budge MM, Smith AD., ‘Vitamin B12 status and rate of brain volume loss in community-dwelling elderly’ Neurology 2008
6. Smith, David. (2017). Two nutrients are better than one: B-vitamins and omega-3 fatty acids in the prevention of dementia. Journal of Nutrition & Intermediary Metabolism. 8. 66. 10.1016/j.jnim.2017.04.018.

Alice L. Chen, Kenneth M. Lum, Pablo Lara-Gonzalez, Daisuke Ogasawara, Armand B Cognetta, Alan To, William H. Parsons, Gabriel M. Simon, Arshad Desai, Michael Petrascheck, Liron Bar-Peled, Benjamin F. Cravatt. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature Chemical Biology, 2019; DOI: 10.1038/s41589-019-0243-4.

Courtney R Chang, Monique E Francois, Jonathan P Little. Restricting carbohydrates at breakfast is sufficient to reduce 24-hour exposure to postprandial hyperglycemia and improve glycemic variability. The American Journal of Clinical Nutrition, 2019; DOI: 10.1093/ajcn/nqy261.

Adam Schaffner et al. Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection. Cell Research, 2019; 29 (4): 313 DOI: 10.1038/s41422-019-0153-8

Ng K et al. Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized Clinical Trial. JAMA. 2019 Apr 9;321(14):1370-1379. doi: 10.1001/jama.2019.2402.

Digestion feature:

1. The Global Fungal Red List Initiative (access: 29.03.2019)
2. Lu L et al. PCR-based sensitive detection of medicinal fungi Hericium species from ribosomal internal transcribed spacer (ITS) sequences. Biol Pharm Bull. 2002 Aug;25(8):975-80.
3. Wang M et al. Hericium erinaceus (Yamabushitake): a unique resource for developing functional foods and medicines. Food Funct. 2014 Dec;5(12):3055-64.
4. Shang XD et al. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms. 2013;15(2):165-74.
5. Liu JH et al. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of print]
6. Wang M et al. A polysaccharide from cultured mycelium of Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol Macromol. 2015 Nov;81:656-61. doi: 10.1016/j.ijbiomac.2015.08.043. Epub 2015 Aug 24.
7. Wong JY et al. Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976.
8. Wang M et al. A unique polysaccharide purified from Hericium erinaceus mycelium prevents oxidative stress induced H2O2 in human gastric mucosa cell. PloS One. 2017 Jul 24;12(7):e0181546. doi: 10.1371/journal.pone.0181546. eCollection 2017.
9. Chen DL et al. Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota. Oncotarget. 2017;8(49):85838-57.
10. Wang D. et al. A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function. Int J Biol Macromol. 2019 Mar 15;125:572-579. doi: 10. 1016/j.ijbiomac.2018.12.092. Epub 2018 Dec 10.

Sport feature:

1 Cordyceps Industry in China, Mycology An International Journal on fungal Biology

ISSN: 2150-1203 (Print) 2150-1211 (Online) Journal homepage: http://www.tandfonline.com/loi/tmyc20

 3 Life Sci. 2004 Dec 10;76(4):385-95. Pharmacological basis of ‘Yin-nourishing’ and ‘Yang-invigorating’ actions of Cordyceps, a Chinese tonifying herb.

Siu KM1, Mak DH, Chiu PY, Poon MK, Du Y, Ko KM.

4 Cordyceps can increase the ATP stores in the liver J Altern Complement Med. 2001 Jun;7(3):231-40)

5 Koh JH. Antifatigue and antistress effect of the hot-water fraction from mycelia of Cordyceps sinensis. Biol Pharm Bull. 2003 May;26(5):691-4.

6 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236007/

J Diet Suppl. Author manuscript; available in PMC 2018 Jan 13.

Published before final editing as: J Diet Suppl. : 1–13. Published online 2016 Jul 13. doi:  10.1080/19390211.2016.1203386 Cordyceps militaris improves tolerance to high intensity exercise after acute and chronic supplementation. Katie R. Hirsch,1 Abbie E. Smith-Ryan,1,2 Erica J. Roelofs,1,3 Eric T. Trexler,1,2 and Meredith G. Mock1

7 Nicodemus K, Hagan R, Zhu J, Baker C. Supplementation with Cordyceps Cs-4 fermentation product promotes fat metabolism during prolonged exercise. Medicine and science in sports and exercise. 2001;33:164.

Neurodegenerative feature:

Cohen N1, Cohen J1, Asatiani MD2, Varshney VK3, Yu HT4, Yang YC4, Li YH4, Mau JL5, Wasser SP6.

Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms. Int J Med Mushrooms. 2014;16(3):273-91.

Chin J H, Vora N,The global burden of neurologic diseases (2012) Int J Med Mushrooms. 2012;14(5):427-46.

Kevin Spelman et al. (2017) Neurlogical Activity of Lion´s Mane (Hericium erinaceus). Journal Compilation

Lai, P.-L., Naidu, M., Sabaratnam, V., Wong, K.-H., David, R. P., Kuppusamy, U. R., … Malek, S. N. A. (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. International Journal of Medicinal Mushrooms, 15(6), 539–554.

Li, I.-C., Lee, L.-Y., Tzeng, T.-T., Chen, W.-P., Chen, Y.-P., Shiao, Y.-J., & Chen, C.-C. (2018). Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behavioural Neurology, 2018, 5802634. http://doi.org/10.1155/2018/5802634

Menken, M., TL, M., & JF, T. (2000). The global burden of disease study: Implications for neurology. Archives of Neurology, 57(3), 418–420. Retrieved from http://dx.doi.org/10.1001/archneur.57.3.418

Mori K1, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N (2008)Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.Biol Pharm Bull. 2008 Sep;31(9):1727-32.

Tsai-Teng, T., Chin-Chu, C., Li-Ya, L., Wan-Ping, C., Chung-Kuang, L., Chien-Chang, S., … Shiao, Y.-J. (2016). Erinacine A-enriched Hericium erinaceusmycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice. Journal of Biomedical Science, 23, 49. http://doi.org/10.1186/s12929-016-0266-z

Zhang, C.-C., Cao, C.-Y., Kubo, M., Harada, K., Yan, X.-T., Fukuyama, Y., & Gao, J.-M. (2017). Chemical Constituents from Hericium erinaceus Promote Neuronal Survival and Potentiate Neurite Outgrowth via the TrkA/Erk1/2 Pathway. International Journal of Molecular Sciences, 18(8). https://doi.org/10.3390/ijms18081659

Promotional feature:

1. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589-94.
2. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589-94.
3. Cui XY, Cui SY, Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YH (2012). Extract of Ganoderma lucidum prolongs sleep time in rats. J Ethnopharmacol 139(3):796-800.
4. Dai Yu-C, Yang Z-L, Cui B-K, et al (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mush: 11: 287−302.
5. Horneber M1, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther. 2012 Sep;11(3):187-203. doi: 10.1177/1534735411423920. Epub 2011 Oct 21.
6. Li EK, Tam LS, Wong CK, Li WC, Lam CWK, Wachtel-Galor S, Benzie IFF, Bao YX, Leung PC, Tomlinson B (2007). Safety and Efficacy of Ganoderma lucidum (Lingzhi) and San Miao San Supplementation in Patients With Rheumatoid Arthritis: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial. Arthritis & Rheumatism (Arthritis Care & Research) 57, 1143–1150.
7. Oba K, Teramukai S, Kobayashi M,·Matsui T,·Kodera Y,·Sakamoto Y (2007) Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cáncer. Cancer Immunology, Immunotherapy 56, 905-911.
8. Ohwada S, Ogawa T, Makita F, Tanahashi Y, Ohya T, Tomizawa N, Satoh Y, Kobayashi I, Izumi M, Takeyoshi I, Hamada K, Minaguchi S, Togo Y, Toshihiko T, Koyama T, Kamio M (2006). Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters. Oncol Rep 15:861-8.
9. Okuno K, Uno K (2011). Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 12(7):1671-4.
10. Roca-Lema D, Martinez-Iglesias O, Fernández de Ana Portela C, Rodríguez-Blanco A, Valladares-Ayerbes M, Díaz-Díaz A, Casas-Pais A, Prego C, Figueroa A. In Vitro Anti-proliferative and Anti-invasive Effect of Polysaccharide-rich Extracts from Trametes Versicolor and Grifola Frondosa in Colon Cancer Cells. Int J Med Sci 2019; 16(2):231-240. doi:10.7150/ijms.28811
11. Sakamoto J, Morita S, Oba K, Matsui T, Kobayashi M, Nakazato H, Ohashi Y (2006) Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Cancer Immunology, Immunotherapy 55, 404-411.
12. Standish LJ, Alschuler LN, Weaver M, Nezami M (2014). Botanical and mycological medicine in integrative oncology, in Integrative Oncology ed. Donald I. Abrans, Andrew Weil Oxford University Press.
13. Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012). Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncol. 2012; 2012: 251632.

NEWS

Thermally Abused Frying Oil Potentiates Metastasis to Lung in a Murine Model of Late-Stage Breast Cancer. Anthony Cam et al. Cancer Prev Res March 18 2019. DOI: 10.1158/1940-6207.CAPR-18-0220.

Takashi Mori, Naoki Koyama, Jun Tan, Tatsuya Segawa, Masahiro Maeda, Terrence Town. Combined treatment with the phenolics (−)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice. Journal of Biological Chemistry, 2019; 294 (8): 2714 DOI: 10.1074/jbc.RA118.004280.

Lei Feng, Irwin Kee-Mun Cheah, Maisie Mei-Xi Ng, Jialiang Li, Sue Mei Chan, Su Lin Lim, Rathi Mahendran, Ee-Heok Kua, Barry Halliwell. The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore. Journal of Alzheimer’s Disease, 2019; 1 DOI: 10.3233/JAD-180959.

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality. Victor W. Zhong, PhD¹; Linda Van Horn, PhD¹; Marilyn C. Cornelis, PhD¹; et alJohn T. Wilkins, MD, MS¹; Hongyan Ning, MD, MS¹; Mercedes R. Carnethon, PhD¹; Philip Greenland, MD¹; Robert J. Mentz, MD^2,3; Katherine L. Tucker, PhD⁴; Lihui Zhao, PhD¹; Arnita F. Norwood, PhD⁵; Donald M. Lloyd-Jones, MD, ScM¹; Norrina B. Allen, PhD¹

JAMA. 2019;321(11):1081-1095. doi:10.1001/jama.2019.1572.

The effect of Lactobacillus reuteri supplementation in Helicobacter pylori

infection: a placebo-controlled, single-blind study. Martin Buckley et al. BMC Nutrition, 2018, 4:48: https://doi.org/10.1186/s40795-018-0257-4.

BEN BROWN

1. World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. 2002.
2. Baxter AJ, Scott KM, Vos T, Whiteford HA. Global prevalence of anxiety disorders: a systematic review and meta-regression. Psychol Med. 2013 May;43(5):897-910.
3. Smith K. Mental health: a world of depression. Nature. 2014 Nov 13;515(7526):181.
4. Dale E, Bang-Andersen B, Sánchez C. Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs. Biochem Pharmacol. 2015 May 15;95(2):81-97.
5. Pandarakalam JP. Challenges of Treatment-resistant Depression. Psychiatr Danub. 2018 Sep;30(3):273-284.
6. Liu B, Liu J, Wang M, Zhang Y, Li L. From Serotonin to Neuroplasticity:
7. Evolvement of Theories for Major Depressive Disorder. Front Cell Neurosci. 2017 Sep 28;11:305.
8. Jentsch MC, Van Buel EM, Bosker FJ, Gladkevich AV, Klein HC, Oude Voshaar RC,  Ruhé EG, Eisel UL, Schoevers RA. Biomarker approaches in major depressive disorder evaluated in the context of current hypotheses. Biomark Med. 2015;9(3):277-97.
9. Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanzá-Martínez V, Freeman MP,  Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN; International Society for Nutritional Psychiatry Research. Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry. 2015 Mar;2(3):271-4.
10. Manosso LM, Moretti M, Rodrigues AL. Nutritional strategies for dealing with depression. Food Funct. 2013 Dec;4(12):1776-93
11. Gadad BS, Jha MK, Czysz A, Furman JL, Mayes TL, Emslie MP, Trivedi MH. Peripheral biomarkers of major depression and antidepressant treatment response: Current knowledge and future outlooks. J Affect Disord. 2018 Jun;233:3-14.
12. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment  of mild cognitive impairment and mild Alzheimer’s disease. Int Clin Psychopharmacol. 2003 Mar;18(2):61-71.
13. Veronese N, Stubbs B, Solmi M, Ajnakina O, Carvalho AF, Maggi S. Acetyl-L-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis. Psychosom Med. 2018 Feb/Mar;80(2):154-159.
14. Nasca C, Bigio B, Lee FS, Young SP, Kautz MM, Albright A, Beasley J, Millington DS, Mathé AA, Kocsis JH, Murrough JW, McEwen BS, Rasgon N. Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):8627-8632.
15. Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R.  Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review. Neurosci Biobehav Rev. 2015 Aug;55:294-321.
16. Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J. Psychiatry Neurosci. 2011;36:78–86
17. Conus P, Seidman LJ, Fournier M, Xin L, Cleusix M, Baumann PS, Ferrari C, Cousins A, Alameda L, Gholam-Rezaee M, Golay P, Jenni R, Woo TW, Keshavan MS, Eap CB, Wojcik J, Cuenod M, Buclin T, Gruetter R, Do KQ. N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis. Schizophr Bull. 2018 Feb 15;44(2):317-327.
18. McNamara RK, Strawn JR. Role of Long-Chain Omega-3 Fatty Acids in Psychiatric  Practice. PharmaNutrition. 2013 Apr;1(2):41-49.
19. Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. 2018 Jun 6;10(6).
20. Rajizadeh A, Mozaffari-Khosravi H, Yassini-Ardakani M, Dehghani A. Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: A randomized, double-blind, placebo-controlled trial. Nutrition. 2017 Mar;35:56-60.
21. Zhang M, Robitaille L, Eintracht S, Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Nutrition. 2011 May;27(5):530-3.
22. Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39.
23. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients. 2016 Jan 27;8(2):68.
24. Petrilli MA, Kranz TM, Kleinhaus K, Joe P, Getz M, Johnson P, Chao MV, Malaspina D. The Emerging Role for Zinc in Depression and Psychosis. Front Pharmacol. 2017 Jun 30;8:414.
25. Karakuła-Juchnowicz H, Szachta P, Opolska A, Morylowska-Topolska J, Gałęcka M, Juchnowicz D, Krukow P, Lasik Z. The role of IgG hypersensitivity in the pathogenesis and therapy of depressive disorders. Nutr Neurosci. 2017 Feb;20(2):110-118.
26. Bayes A, Parker G. How to choose an antidepressant medication. Acta Psychiatr  Scand. 2019 Mar;139(3):280-291.

International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry. World Psychiatry. 2015 Oct; 14(3): 370–371, doi: 10.1002/wps.20223.

RESEARCH
Daniel F. Zegarra-Ruiz, Asmaa El Beidaq, Alonso J. Iñiguez, Martina Lubrano Di Ricco, Silvio Manfredo Vieira, William E. Ruff, Derek Mubiru, Rebecca L. Fine, John Sterpka, Teri M. Greiling, Carina Dehner, Martin A. Kriegel. A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity. Cell Host & Microbe, 2018; DOI: 10.1016/j.chom.2018.11.009

Christopher E. Zwilling, Tanveer Talukdar, Marta K. Zamroziewicz, Aron K. Barbey. Nutrient biomarker patterns, cognitive function, and fMRI measures of network efficiency in the aging brain. NeuroImage, 2019; 188: 239 DOI: 10.1016/j.neuroimage.2018.12.007

Limon et al. Malassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models. Cell Host & Microbe, 2019 DOI: 10.1016/j.chom.2019.01.007

Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling

Zeynep Madak-Erdogan et al. Cancer Research 2019, Published OnlineFirst March 12,
doi: 10.1158/0008-5472.CAN-18-2849.

PROBIOTICS

Akihito Harusato, Emilie Viennois, Lucie Etienne-Mesmin, Shingo Matsuyama, Hirohito Abo, Satoru Osuka, Nicholas W Lukacs, Yuji Naito, Yoshito Itoh, Jian-Dong Li, Didier Merlin, Andrew T. Gewirtz, Timothy L. Denning. Early-life microbiota exposure restricts myeloid-derived suppressor cell-driven colonic tumourigenesis. Cancer Immunology Research, 2019; canimm.0444.2018 DOI: 10.1158/2326-6066.CIR-18-0444

Human Gut Microbiome Response Induced by Fermented Dairy Product Intake in Healthy Volunteers. Olesya Volokh et al. Nutrients. 4 Mar 2019.

https://www.mdpi.com/2072-6643/11/3/547

 Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition. Research Letter. Antti E. Seppo et al. JAMA Pediatr. 2019;173(3):286-288. doi:10.1001/jamapediatrics.2018.4835.

Vienna E. Brunt et al. Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice. The Journal of Physiology, 2019; DOI: 10.1113/JP277336

ALLERGY

A genome-wide cross trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Zhaozhong Zhu, Phil Hyoun Lee, et al.  Nature Genetics 2018, DOI:10.1038/s41588-018-0121-0.

Daniel Reker, Steven M. Blum, Christoph Steiger, Kevin E. Anger, Jamie M. Sommer, John Fanikos and Giovanni Traverso. Inactive” ingredients in oral medications. Science Translational Medicine, 2019 DOI: 10.1126/scitranslmed.aau6753

Healthy infants harbor intestinal bacteria that protect against food allergy

Taylor Feehley et al. Nature Medicine 2019, 25:448–53.

Histamine-releasing factor enhances food allergy.

Ando T et al. J Clin Invest. 2017 Dec 1;127(12):4541-4553. doi: 10.1172/JCI96525.

Sarah Oboh:

1. Maintz, L and Novak, N. (2007) Histamine and histamine intolerance. Am J Clin Nutr. 85(5):1185-1196.
2. Izquierdo-Casas, J. et al. (2018) Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clin Nutr. doi: 10.1016/j.clnu.2018.01.013. [Epub ahead of print].
3. Schmidt WU, Sattler J, Hesterberg R, et al. .Human intestinal diamine oxidase (DAO) activity in Crohn’s disease: a new marker for disease assessment? Agents Actions 1990;30:267–70.
4. Mennigen R, Kusche J, Streffer C, Krakamp B. Diamine oxidase activities in the large bowel mucosa of ulcerative colitis patients. Agents Actions  1990;30:264–6.
5. Guslandi, M. et al. (2003) A pilot trial of Saccharomyces boulardii in ulcerative colitis. European Journal of Gastroenterology & Hepatology. Vol. 15 pp. 697 – 698.
6. McFarland L.V., (2010), ‘Systematic review and meta-analysis of Saccharomyces boulardii in adult patients’. World Journal of Gastroenterology, 16(18):2202–2222. 
7. Kotowska M. et al., (2005), ‘Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial’.Alimentary Pharmacology & Therapeutics, 21(5):583–590.
8. Krämer, S. et al. (2008). Selective Activation of Human Intestinal Mast Cells by Escherichia coli Hemolysin. J Immunol. 181 (2) 1438-1445. 
9. Hung, CR. (2005) Modulation of gastric hemorrhage and ulceration by oxidative stress and histamine release in Salmonella typhimurium-infected rats. Inflammopharmacology. 13(1-3):235-48. 
10. Vighi, G. et al (2008) Allergy and the gastrointestinal system. Clin. Exp. Immunol. Sept;153(1):3-6  
11. Dev, S., Mizuguchi, H., Das, A. K., Matsushita, C., Maeyama, K., Umehara, H., … & Fukui, H. (2008). Suppression of histamine signaling by probiotic Lac-B: a possible mechanism of its anti-allergic effect. Journal of pharmacological sciences, 107(2), 159-166
12. Galdeano CM et al., (2004) Role of viability of probiotic strains in their persistence in the gut and in mucosal immune stimulation. J Appl Microbiol. 2004;97(4):673-81

Penny Shaw:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991645/ (bland, J 2016)
https://www.gastrojournal.org/article/S0016-5085(14)01149-4/fulltext?referrer=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2F (Wallace, M 2014).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382133/ (Detzel, C 2015)
https://www.ncbi.nlm.nih.gov/pubmed/24944474 (Nebot-vivinus, M 2014)
https://www.ncbi.nlm.nih.gov/pubmed/21148400?dopt=Abstract (Marchbank, T 2011)
https://www.ncbi.nlm.nih.gov/pubmed/10468648?dopt=Abstract (Miller A, 1999)
https://www.ncbi.nlm.nih.gov/pubmed/8098788?dopt=Abstract (Van der Hulst, 1993)
https://www.physiology.org/doi/full/10.1152/ajpgi.00212.2015 (Deloose, 2016)
https://www.ncbi.nlm.nih.gov/pubmed/9712563?dopt=Abstract (Nieuwenhuji, V et al, 1998)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064777 ( Miyano, et al 2013)
https://www.ncbi.nlm.nih.gov/pubmed/3430163?dopt=Abstract (Adzet, T 1987)
https://www.sciencedirect.com/science/article/pii/S0944711397800499?via%3Dihub (Kraft, K 1998)

Aicacia Young:

1. Mosca A, et al. Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Front Microbiol. 2016;7:455.
2. Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541-546.
3. Lingheim L, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017;12(1):e0168390.
4. Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp & Molecular Med. 2018;50:e450.
5. Dao MC, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65:426-436.
6. Schneeberger M, et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific Reports. 2015; 5:16643.
7. Martin R, et al. Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic. Front Microbiol. 2017; 8: 1226.
8. Picard C, et al. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther.  2005;22:495–512.
9. Stenman LK, et al. Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Benef Microbes. 2014;5(4):437-445.
10. Collado MC, et al. Imbalances in fecal and duodenal Bifidobacterium species composition in active and non-active celiac disease. BMC Microbiol. 2008;8:232.
11. Gao X, et al. Obesity in school-aged children and its correlation with gut E. coli and Bifidobacteria: a case-control study. BMC Pediatr. 2015;15:64.
12. Akay HK, et al. The relationship between bifidobacterial and allergic asthma and/or allergic dermatitis: a prospective study of 0-3-year-old children in Turkey. Anaerobe. 2014;28:98-103.
13. Possemiers S, et al. Evaluation of the Bacillus subtilis strain HU-58 in the SHIME technology platform. ProDigest Final Report. 2013: 1-40.
14. Blatchford P, et al. Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomized controlled human trial. J Nutr Sci. 2017; 6: e52.
15. Everard A, Lazarevic V, Derrien M, et al. Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice. Diabetes. 2011 Nov; 60(11): 2775–2786.
16. Finegold SM, et al. Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food Funct. 2014;5(3):436-45.
17. Depeint F, et al. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study 1–3. Am J Clin Nutr. 2008;87(3):785-91.
18. Faure M, et al. Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium–Treated Rats. J Nutr. 2006;136(6):1558-64.

 

1. Citi S. Intestinal barriers protect against disease. Science. 2018;359(6380):1097-1098.

2. Michielan A, et al. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators Inflamm. 2015; 2015:628157.

3. Maes M, et al. The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuro Endocrinol Lett. 2008;29(1):117-24.

4. Paiardini M, et al. Mucosal immune dysfunction in AIDS pathogenesis. AIDS Rev. 2008;10(1):36-46.

5. Kandulski A, et al. Gastroesophageal reflux disease–from reflux episodes to mucosal inflammation. Nat Rev Gastroenterol Hepatol. 2011;9(1):15-22.

6. Liu H, et al. Early gut mucosal dysfunction in patients with acute pancreatitis. Pancreas. 2008;36(2):192-6.

7. de Punder K, et al. Stress Induces Endotoxemia and Low-Grade Inflammation by Increasing Barrier Permeability. Front Immunol. 2015;6:223.

8. Schmitz H, et al. Tumor necrosis factor alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. Journal of Cell Science. 1999;112(1):137–146.

9. Coskun M. Intestinal epithelium in inflammatory bowel disease. Front Med. 2014;1:24.

10. Su L, et al. TNFR2 activates mlck-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 2013;145(2):407–415.

11. Vinolo MAR, et al. Regulation of Inflammation by Short Chain Fatty Acids. Nutrients. 2011; 3(10): 858–876.

12. Matsuoka K, et al. The gut microbiota and inflammatory bowel disease. Semin Immunopathol. 2015; 37: 47–55.

13. Detzel CJ, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PloS one. 2015;10(4):e0120278.

14. Faure M, et al. Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium–Treated Rats. J Nutr. 2006;136(6):1558-64.

19. Mosca A, et al. Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Front Microbiol. 2016;7:455.
20. Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541-546.
21. Lingheim L, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017;12(1):e0168390.
22. Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp & Molecular Med. 2018;50:e450.
23. Dao MC, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65:426-436.
24. Schneeberger M, et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific Reports. 2015; 5:16643.
25. Martin R, et al. Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic. Front Microbiol. 2017; 8: 1226.
26. Picard C, et al. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther.  2005;22:495–512.
27. Stenman LK, et al. Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Benef Microbes. 2014;5(4):437-445.
28. Collado MC, et al. Imbalances in fecal and duodenal Bifidobacterium species composition in active and non-active celiac disease. BMC Microbiol. 2008;8:232.
29. Gao X, et al. Obesity in school-aged children and its correlation with gut E. coli and Bifidobacteria: a case-control study. BMC Pediatr. 2015;15:64.
30. Akay HK, et al. The relationship between bifidobacterial and allergic asthma and/or allergic dermatitis: a prospective study of 0-3-year-old children in Turkey. Anaerobe. 2014;28:98-103.
31. Possemiers S, et al. Evaluation of the Bacillus subtilis strain HU-58 in the SHIME technology platform. ProDigest Final Report. 2013: 1-40.
32. Blatchford P, et al. Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomized controlled human trial. J Nutr Sci. 2017; 6: e52.
33. Everard A, Lazarevic V, Derrien M, et al. Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice. Diabetes. 2011 Nov; 60(11): 2775–2786.
34. Finegold SM, et al. Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food Funct. 2014;5(3):436-45.
35. Depeint F, et al. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, double-blind, crossover, placebo-controlled intervention study 1–3. Am J Clin Nutr. 2008;87(3):785-91.
36. Mosca A, et al. Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Front Microbiol. 2016;7:455.
37. Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500:541-546.
38. Lingheim L, et al. Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study. PLoS One. 2017;12(1):e0168390.
39. Chelakkot C, et al. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp & Molecular Med. 2018;50:e450.
40. Shin N, et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2014;63:727-735.
41. Dao MC, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut. 2016;65:426-436.
42. Schneeberger M, et al. Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice. Scientific Reports. 2015; 5:16643.
43. Matsuoka K, et al. The gut microbiota and inflammatory bowel disease. Semin Immunopathol. 2015; 37: 47–55.
44. Martin R, et al. Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic. Front Microbiol. 2017; 8: 1226.
45. Picard C, et al. Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits. Aliment Pharmacol Ther.  2005;22:495–512.
46. Stenman LK, et al. Potential probiotic Bifidobacterium animalis ssp. lactis 420 prevents weight gain and glucose intolerance in diet-induced obese mice. Benef Microbes. 2014;5(4):437-445.
47. Collado MC, et al. Imbalances in fecal and duodenal Bifidobacterium species composition in active and non-active celiac disease. BMC Microbiol. 2008;8:232.
48. Gao X, et al. Obesity in school-aged children and its correlation with gut E. coli and Bifidobacteria: a case-control study. BMC Pediatr. 2015;15:64.
49. Akay HK, et al. The relationship between bifidobacterial and allergic asthma and/or allergic dermatitis: a prospective study of 0-3-year-old children in Turkey. Anaerobe. 2014;28:98-103.
50. Possemiers S, Van de Genachte N. Evaluation of the Bacillus subtilis strain HU-58 in the SHIME technology platform. ProDigest Final Report. 2013: 1-40.

Adrienne Benjamin:

[1] Dukowicz AC, Lacy BE & Levine GM (2007) Small Intestinal Bacterial Overgrowth: A Comprehensive Review Gasterenterol Hepatol 3(2):112-122

2 Bures J et al (2010) Small intestinal bacterial overgrowth syndrome World J Gastroenterol 16(24):2978-2990

3 Pyleris E et al (2012) The Prevalence of Overgrowth by Aerobic Bacteria in the Small Intestine by Small Bowel Culture: Relationship with Irritable Bowel Syndrome Dig Dis Sci 57:1321-1329

4 Shah A et al (2019) Systematic Review with meta-analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease Aliment Pharmacol Ther 49:624-635

5 Ghoshal UD, Srivastava D (2014) Irritable bowel syndrome and small intestinal bacterial overgrowth: Meaningful association or unnecessary hype World J Gastroenterol 20(10):2482-2491

6 Salem A & Ronald BC (2014) Small Intestinal Bacterial Overgrowth (SIBO) J Gastroint Dig Syst 4:225 http://dx.doi.org/10.4172/2161-069X.100225

7 Dukowicz AC, Lacy BE & Levine GM (2007) Small Intestinal Bacterial Overgrowth: A Comprehensive Review Gasterenterol Hepatol 3(2):112-122

8 Quigley EMM (2019) The Spectrum of Small Intestinal Bacterial Overgrowth (SIBO) Curr Gastroenterol Rep https://doi.org/10.1007/s11894-019-0671-z

9 Grace, E et al (2013) Review article: small intestinal bacterial overgrowth – prevalence, clinical features, current and developing diagnostic tests, and treatment Aliment Pharmacol Ther 38:674-688

10 Choung RS et al (2011) Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture

11 Chen B et al (2017) Prevalence and predictors of small intestinal bacterial overgrowth in irritable bowel syndrome: a systemic review and meta-analysis. J Gastroenterol https://doi.org/10.1007/s00535-018-1476-9

12 Su T et al (2018) Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth J of Gastroenterol 53(1):27-36

13 Adike A & DiBaise JK (2017) Small Intestinal Bacterial Overgrowth – Nutritional Implications, Diagnosis, and Management Gastroenterol Clin N Am https://doi.org/10.1016/j.gtc.2017.09.008

14 Gewecke K, Nannen-Ottens S (2017) Bacterial overgrowth: nutrition as part of the therapeutic concept Ernahrungs Umschau 64(4):67-73; 64(5):74-78

15 Chen WC & Quigley EMM (2014) Probiotics, prebiotics & synbiotics in small intestinal bacterial overgrowth:

16 Shah SC et al (2013) Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth Aliment Pharmacol Ther 2013 28:925-934

17 Gatta L & Scarpignato C (2017) Systematic review with meta-analysis: rifaximin is effective and safe for the treatment of small intestine bacterial overgrowth Aliment Pharmacol Ther 45:604-616

18 McIntosh K et al (2016) FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial Gut 0 :1-11

19 Magge S & Lembo A (2012) Low-FODMAP Diet for Treatment of Irritable Bowel Syndrome Gastroenterol Hepatol 8(11):739-745

20 Altobelli E et al (2017) Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Meta-Analysis Nutrients 9:940; doi:10.3390/nu9090940

21 Konturek PC, Brzozowski T, Konturek SJ (2011) Stress and the gut: Pathophysiology, clinical consequences, diagnostic approach and treatment options J Physiol Pharmacol 62(6):591-599

22 Chedid V et al Herbal Therapy Is Equivalent to Rifaximin for the Treatment of Small Intestinal Bacterial Overgrowth Global Adv Health Med 3(3):16-24

23 Zhong C et al (2017) Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence J Clin Gastroenterol 51:300-311

 

NEWS

Ana Rodriguez-Mateos, Geoffrey Istas, Lisa Boschek, Rodrigo P Feliciano, Charlotte E Mills, Céline Boby, Sergio Gomez-Alonso, Dragan Milenkovic, Christian Heiss. Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics. The Journals of Gerontology: Series A, 2019; DOI: 10.1093/gerona/glz047

Zgaga, L.; Laird, E.; Healy, M. 25-Hydroxyvitamin D Measurement in Human Hair: Results from a Proof-of-Concept study. Nutrients 2019, 11, 423.

Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Toufic Mayassi et al. Cell 2019, 176: 5. DOI: https://doi.org/10.1016/j.cell.2018.12.039.

Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data. David A. Jolliffe, Davaasambuu Ganmaa, Christian Wejse, Rubhana Raqib, Md. Ahsanul Haq, Nawal Salahuddin, Peter K. Daley, Anna P. Ralph, Thomas R. Ziegler and Adrian R. Martineau. European Respiratory Journal, Published online February 6, 2019.

https://doi.org/10.1183/13993003.02003-2018.

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross‐over trial. Shaun A. Mason et al. Diabetes, Obesity and Metabolism, First published: 04 November 2018. https://doi.org/10.1111/dom.13571.

Lund KS, Siersma V, Brodersen J, et al. Efficacy of a standardised acupuncture approach for women with bothersome menopausal symptoms: a pragmatic randomised study in primary care (the ACOM study). BMJ Open 2019;9:e023637. doi: 10.1136/bmjopen-2018-023637.

PCOS – BEN BROWN

1. Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016 Dec;31(12):2841-2855.
2. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May;14(5):270-284.
3. Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome. Fertil Steril. 2004 Sep;82(3):661-5.
4. Barber TM, Dimitriadis GK, Andreou A, Franks S. Polycystic ovary syndrome: insight into pathogenesis and a common association with insulin resistance. Clin  Med (Lond). 2016 Jun;16(3):262-6.
5. Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, Lizneva D, Natterson-Horowtiz B, Teede HJ, Yildiz BO. Polycystic ovary syndrome. Nat Rev Dis Primers. 2016 Aug 11;2:16057.
6. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May;14(5):270-284.
7. Dokras A, Saini S, Gibson-Helm M, Schulkin J, Cooney L, Teede H. Gaps in knowledge among physicians regarding diagnostic criteria and management of polycystic ovary syndrome. Fertil Steril. 2017 Jun;107(6):1380-1386.e1.
8. March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010 Feb;25(2):544-51.
9. Neven ACH, Laven J, Teede HJ, Boyle JA. A Summary on Polycystic Ovary Syndrome: Diagnostic Criteria, Prevalence, Clinical Manifestations, and Management According to the Latest International Guidelines. Semin Reprod Med. 2018 Jan;36(1):5-12.
10. Jarrett BY, Lin AW, Lujan ME. A Commentary on the New Evidence-Based Lifestyle Recommendations for Patients with Polycystic Ovary Syndrome and Potential Barriers to Their Implementation in the United States. J Acad Nutr Diet. 2019 Feb;119(2):205-210.
11. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018 May;14(5):270-284.
12. Arentz S, Abbott JA, Smith CA, Bensoussan A. Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complement Altern Med. 2014 Dec 18;14:511.
13. Moran LJ, et al. Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. J Acad Nutr Diet. 2013 Apr;113(4):520-45
14. Rondanelli M, Perna S, Faliva M, Monteferrario F, Repaci E, Allieri F. Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Arch Gynecol Obstet. 2014  Dec;290(6):1079-92.
15. Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. Nutritional management in women with polycystic ovary syndrome: A review study. Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S429-S432.
16. Moran LJ, Noakes M, Clifton PM, Tomlinson L, Galletly C, Norman RJ. Dietary composition in restoring reproductive and metabolic physiology in overweight women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003 Feb;88(2):812-9.
17. Stamets K, Taylor DS, Kunselman A, Demers LM, Pelkman CL, Legro RS. A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. Fertil Steril. 2004 Mar;81(3):630-7.
18. Glueck CJ, Goldenberg N. Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics. Metabolism. 2019 Mar;92:108-120.
19. Jarrett BY, Lujan ME. Impact of hypocaloric dietary intervention on ovulation  in obese women with PCOS. Reproduction. 2016 Oct 31. pii: REP-16-0385. (Epub ahead of print)
20. Frary JM, Bjerre KP, Glintborg D, Ravn P. The effect of dietary carbohydrates  in women with polycystic ovary syndrome: a systematic review. Minerva Endocrinol. 2016 Mar;41(1):57-69.
21. Sordia-Hernández LH, Ancer Rodríguez P, Saldivar Rodriguez D, Trejo Guzman S,Servín Zenteno ES, Guerrero González G, Ibarra Patiño R. Effect of a low glycemic diet in patients with polycystic ovary syndrome and anovulation – a randomized controlled trial. Clin Exp Obstet Gynecol. 2016;43(4):555-559.
22. Goss AM, Chandler-Laney PC, Ovalle F, Goree LL, Azziz R, Desmond RA, Wright Bates G, Gower BA. Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS. Metabolism. 2014 Oct;63(10):1257-64.
23. Phy JL, Pohlmeier AM, Cooper JA, Watkins P, Spallholz J, Harris KS, Berenson AB, Boylan M. Low Starch/Low Dairy Diet Results in Successful Treatment of Obesity and Co-Morbidities Linked to Polycystic Ovary Syndrome (PCOS). J Obes Weight Loss Ther. 2015 Apr;5(2).
24. McGrice M, Porter J. The Effect of Low Carbohydrate Diets on Fertility Hormones and Outcomes in Overweight and Obese Women: A Systematic Review. Nutrients. 2017 Feb 27;9(3).
25. Sutton P, Wallinga D, Perron J, Gottlieb M, Sayre L, Woodruff T. Reproductive  health and the industrialized food system: a point of intervention for health policy. Health Aff (Millwood). 2011 May;30(5):888-97.
26. Vagi SJ, Azziz-Baumgartner E, Sjödin A, Calafat AM, Dumesic D, Gonzalez L, Kato K, Silva MJ, Ye X, Azziz R. Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: a case-control study. BMC Endocr Disord. 2014 Oct 28;14:86.
27. Yang Q, Zhao Y, Qiu X, Zhang C, Li R, Qiao J. Association of serum levels of typical organic pollutants with polycystic ovary syndrome (PCOS): a case-control  study. Hum Reprod. 2015 Aug;30(8):1964-73.
28. Kandaraki E, Chatzigeorgiou A, Livadas S, Palioura E, Economou F, Koutsilieris M, Palimeri S, Panidis D, Diamanti-Kandarakis E. Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab. 2011 Mar;96(3):E480-4.
29. Zhou W, Fang F, Zhu W, Chen ZJ, Du Y, Zhang J. Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome. Int J Environ Res Public Health. 2016 Dec 27;14(1).
30. Hyland C, Bradman A, Gerona R, Patton S, Zakharevich I, Gunier RB, Klein K. Organic diet intervention significantly reduces urinary pesticide levels in U.S. children and adults. Environ Res. 2019 Jan 29. pii: S0013-9351(19)30024-6.
31. Rudel RA, Gray JM, Engel CL, et al. Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect. 2011 Jul;119(7):914-20. doi: 10.1289/ehp.1003170.
32. He C, Lin Z, Robb SW, Ezeamama AE. Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis. Nutrients. 2015 Jun 8;7(6):4555-77.
33. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a  pilot study. J Endocrinol Invest. 2011 Nov;34(10):757-63.
34. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, Taylor H. Therapeutic implications of vitamin D and calcium in overweight women with polycystic ovary syndrome. Gynecol Endocrinol. 2012 Dec;28(12):965-8.
35. Irani M, Seifer DB, Grazi RV, Irani S, Rosenwaks Z, Tal R. Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial. Nutrients. 2017 Mar 28;9(4).
36. Jamilian M, Foroozanfard F, Rahmani E, Talebi M, Bahmani F, Asemi Z. Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome. Nutrients. 2017 Nov 24;9(12).
37. Ostadmohammadi V, Jamilian M, Bahmani F, Asemi Z. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res. 2019 Jan 21;12(1):5.
38. Laganà AS, Garzon S, Casarin J, Franchi M, Ghezzi F. Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends Endocrinol Metab. 2018 Nov;29(11):768-780.
39. Papaleo E, et al. Myo-inositol in patients with polycystic ovary  syndrome: a novel method for ovulation induction. Gynecol Endocrinol. 2007 Dec;23(12):700-3.
40. Zeng L, Yang K. Effectiveness of myoinositol for polycystic ovary syndrome: a  systematic review and meta-analysis. Endocrine. 2018 Jan;59(1):30-38.
41. Raffone E, Rizzo P, Benedetto V. Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women. Gynecol Endocrinol. 2010 Apr;26(4):275-80.
42. Fruzzetti F, Perini D, Russo M, Bucci F, Gadducci A. Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome  (PCOS). Gynecol Endocrinol. 2017 Jan;33(1):39-42.
43. Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, Ferrari A. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009 Aug;25(8):508-13.
44. Pezza M. Inositol in women suffering from acne and PCOS: a randomized study. Glob Dermatol, 2017. Volume 4(1): 3-4.
45. Piotrowska A, Pilch W, Czerwińska-Ledwig O, Zuziak R, Siwek A, Wolak M, Nowak  G. The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of  Polycystic Ovary Syndrome. Biol Trace Elem Res. 2019 Feb 4. doi: 10.1007/s12011-019-1654-5. (Epub ahead of print)
46. Fazelian S, Rouhani MH, Bank SS, Amani R. Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis. J Trace Elem Med Biol. 2017 Jul;42:92-96.
47. Amooee S, Parsanezhad ME, Ravanbod Shirazi M, Alborzi S, Samsami A. Metformin versus chromium picolinate in clomiphene citrate-resistant patients with PCOs: A double-blind randomized clinical trial. Iran J Reprod Med 2013; 11: 611-8.
48. Amr N, Abdel-Rahim HE. The effect of chromium supplementation on polycystic ovary syndrome in adolescents. J Pediatr Adolesc Gynecol 2015; 28: 114-8.
49. Oner G, Muderris II. Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011 Nov;159(1):127-31.
50. Javanmanesh F, Kashanian M, Rahimi M, Sheikhansari N. A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine  characteristics of women with polycystic ovary syndrome. Gynecol Endocrinol. 2016;32(4):285-9.
51. Wang JG, Anderson RA, Graham GM 3rd, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007 Jul;88(1):240-3.
52. Kort DH, Lobo RA. Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: a randomized controlled trial. Am J Obstet Gynecol. 2014 Nov;211(5):487.e1-6.
53. Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial. Phytother Res. 2018 Feb;32(2):276-283.
54. Akdoğan M, Tamer MN, Cüre E, Cüre MC, Köroğlu BK, Delibaş N. Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytother Res. 2007 May;21(5):444-7.
55. Grant P. Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytother Res. 2010 Feb;24(2):186-8
56. Haj-Husein I, Tukan S, Alkazaleh F. The effect of marjoram (Origanum majorana) tea on the hormonal profile of women with polycystic ovary syndrome: a randomised controlled pilot study. J Hum Nutr Diet. 2016 Feb;29(1):105-11.
57. Heidary M, Yazdanpanahi Z, Dabbaghmanesh MH, Parsanezhad ME, Emamghoreishi M,  Akbarzadeh M. Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome. J Res  Med Sci. 2018 Apr 26;23:33.

HYBRID DIET – Patrick Holford

1. Sarah J. Hallberg et al Effectiveness and Safety of a Novel Care Model for the Management of Type 2 Diabetes at 1 Year: An Open-Label, Non-Randomized, Controlled Study

Diabetes Therapy April 2018, Volume 9, Issue 2, pp 583–612.

2. Courchesne-Loyer A, et al., ‘Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study.’ 2017 Jul;37(7):2485-2493; see also Cunnane SC et al., ‘Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease.’J Cereb Blood Flow Metab. 2017 Jul;37(7):2485-2493
3. https://idmprogram.com/fasting-and-autophagy-mtor-autophagy-1/
4. Wang C1 et al Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases.Curr Opin Neurobiol. 2018 Feb;48:52-58.
5. E. White, ‘Autophagy, metabolism, and cancer’, Clinical Cancer Research (2015), 21(22):5037–5046.
6. Bueno NB et al Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. 2013 Oct;110(7):1178-87.

 

7. David S. Ludwig The case against carbohydrates gets stronger LA Times Nov 14, 2018
8. J.M. Chan, et al., ‘Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study’, Science (1998), vol 279(5350):563–566; see also M.J. Gunter et al., ‘Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women’, Journal of the National Cancer Institute (2009), vol 101(1):48–60.=
9. Vandenberghe et al., ‘Tricaprylin alone increases plasma ketone response more than coconut oil or other medium-chain triglycerides: an acute crossover study in healthy adults’, Current Developments in Nutrition (2017), vol 1(4):e000257.
   10. C. Ebbeling et al., ‘Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial’ British Medical Journal 2018;363:k4583
10. P.M. Johnson and P.J. Kenny, ‘Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats’, Nature Neuroscience (2010), vol 13(5)–635–641.

EFAs

Kim Vriens et al. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. Nature, 2019; DOI: 10.1038/s41586-019-0904-1.

Jeewon Garcia-So, Xinwen Zhang, Xiaohua Yang, Mara Roxana Rubinstein, De Yu Mao, Jan Kitajewski, Kang Liu, Yiping W. Han. 

Omega-3 fatty acids suppress Fusobacterium nucleatum–induced placental inflammation originating from maternal endothelial cells. JCI Insight, 2019; 4 (3) DOI: 10.1172/jci.insight.125436.

Poorna ChandraRao Yalagala, Dhavamani Sugasini, Sridevi Dasarathi, Kalipada Pahan, Papasani V. Subbaiah. Dietary lysophosphatidylcholine-EPA enriches both EPA and DHA in the brain: Potential treatment for depression. Journal of Lipid Research, 2018; jlr.M090464 DOI: 10.1194/jlr.M090464.

Association of reported fish intake and supplementation status with the omega-3 index.

K.H. Jackson et al. Prostaglandins, Leukotrienes and Essential Fatty Acids

Vol142, March 2019, 4-10: DOI: https://doi.org/10.1016/j.plefa.2019.01.002.

Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors. JiajieLiu et al. The Journal of Nutritional Biochemistry

Volume 55, May 2018, Pages 41-52

LYME – Dr Bill Rawls.

1. Berende A, ter Hofstede HJ, Vos FJ, et al. Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease. N Engl J Med. 2016;374(13):1209-1220.
   2.Rudenko N, Golovchenko M, Vancova M, et al. Isolation of live Borrelia burgdorferi senso lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis. Clin Microb Infect. 2016;22(3):267. Epub 2015 Dec 8.
   3. Perez-Cobas AE, Gosalbes MJ, Friedrichs A, et al. Gut microbiota disturbance during antibiotic therapy, a multi-omic approach. Gut. 2013;62(11):1591-1601. Epub 2012 Dec 12.
   4. Morgun A, Dzutsev A, Dong X, et al. Uncovering effects of antibiotics on the host and microbiota using transkingdom gene networks. Gut. 2015;64(11):1732-1742. Epub 2015 Jan 22.
   5. Kalghatgi S, Spina CS, Costello JC, et al. Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. Sci Transl Med. 2013;5(192):192ra85.
   6. Macfarlane S, Woodmansey EJ, Macfarlane GT. Colonization of mucin by human intestinal bacteria and establishment of biofilm communities in a two-stage continuous culture system. Appl Environ Microbiol. 2005;71(11):7483-7492.
   7. Macfarlane S, Dillon JF. Microbial biofilms in the human gastrointestinal tract. J Appl Microbiol. 2007;102(5):1187-1196.
   8. Macfarlane S, Bahrami B, Macfarlane GT. Mucosal biofilm communities in the human intestinal tract. Adv Appl Microbiol. 2011;75:111-143.

RESEARCH

Ting Fu et al. FXR Regulates Intestinal Cancer Stem Cell Proliferation. Cell, 2019; 176 (5): 1098 DOI: 10.1016/j.cell.2019.01.036.

Xin Wu, Jing Shi, Wan-xia Fang, Xiao-yu Guo, Ling-yun Zhang, Yun-peng Liu, Zhi Li. Allium vegetables are associated with reduced risk of colorectal cancer: A hospital-based matched case-control study in China. Asia-Pacific Journal of Clinical Oncology, 2019; DOI: 10.1111/ajco.13133

 

Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Doua Azzouz et al. Annals of the Rheumatic Diseases. Published Online First: 19 February 2019. doi: 10.1136/annrheumdis-2018-214856.

 Old age-associated phenotypic screening for Alzheimer’s disease drug candidates identifies sterubin as a potent neuroprotective compound from Yerba santa

Wolfgang Fischer, Antonio Currais, Zhibin Liang, Antonio Pinto and Pamela Maher.

Redox Biology, Volume 21, February 2019, 101089

open access: https://doi.org/10.1016/j.redox.2018.101089

Haruki Nakamura, Akinori Hara, Hiromasa Tsujiguchi, Thao Thi Thu Nguyen, Yasuhiro Kambayashi, Sakae Miyagi, Yohei Yamada, Keita Suzuki, Yukari Shimizu, Hiroyuki Nakamura. Relationship between Dietary n-6 Fatty Acid Intake and Hypertension: Effect of Glycated Hemoglobin Levels. Nutrients, 2018; 10 (12): 1825 DOI: 10.3390/nu10121825

Stephen J. Carter, Gary R. Hunter, J. Walker Blackston, Nianjun Liu, Elliot J. Lefkowitz, William J. Van Der Pol, Casey D. Morrow, Jesseca A. Paulsen, Laura Q. Rogers. Gut microbiota diversity associates with cardiorespiratory fitness in post-primary treatment breast cancer survivors. Experimental Physiology, 2019; DOI: 10.1113/EP087404.

Philip Strandwitz, Ki Hyun Kim, Darya Terekhova, Joanne K. Liu, Anukriti Sharma, Jennifer Levering, Daniel McDonald, David Dietrich, Timothy R. Ramadhar, Asama Lekbua, Nader Mroue, Conor Liston, Eric J. Stewart, Marc J. Dubin, Karsten Zengler, Rob Knight, Jack A. Gilbert, Jon Clardy, Kim Lewis. GABA-modulating bacteria of the human gut microbiota. Nature Microbiology, 2018; DOI: 10.1038/s41564-018-0307-3.

Asher Preska Steinberg, Sujit S Datta, Thomas Naragon, Justin C Rolando, Said R Bogatyrev, Rustem F Ismagilov. High-molecular-weight polymers from dietary fibre drive aggregation of particulates in the murine small intestine. eLife, 2019 DOI: 10.7554/eLife.40387.001.

Luoping Zhang, Iemaan Rana, Rachel M. Shaffer, Emanuela Taioli, Lianne Sheppard. Exposure to Glyphosate-Based Herbicides and Risk for Non-Hodgkin Lymphoma: A Meta-Analysis and Supporting Evidence. Mutation Research/Reviews in Mutation Research, 2019; DOI: 10.1016/j.mrrev.2019.02.001.

Petra Bacher et al. Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans. Cell, 2019; DOI: 10.1016/j.cell.2019.01.041.

Puneet Seth, Paishiun N. Hsieh, Suhib Jamal, Liwen Wang, Steven P. Gygi, Mukesh K. Jain, Jeff Coller, Jonathan S. Stamler. Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation. Cell, Feb. 21, 2019; DOI: 10.1016/j.cell.2019.01.037

AONM Advertorial:

1. Moutailler S, Valiente Moro C, Vaumourin E, Michelet L, Tran FH, Devillers E, et al. (2016)
Co-infection of Ticks: The Rule Rather Than the Exception. PLoS Negl Trop Dis 10(3):
e0004539.
2. Johnson, L., Wilcox, S., Mankoff, J., & Stricker, R. B. (2014). Severity of chronic Lyme disease
compared to other chronic conditions: a quality of life survey. PeerJ, 2, e322.
doi:10.7717/peerj.322
3. Birtles, R. J., Laycock, G., Kenny, M. J., Shaw, S. E. & Day, M. J. (2002). Prevalence of
Bartonella species causing bacteraemia in domesticated and companion animals in the
United Kingdom. Vet Rec 151, 225–229.
4. https://rawlsmd.com/health-articles/understanding-bartonella
5. Davies, S, Abdullah, S, Helps, C, Tasker, S, Newbury, H & Wall, R 2017, ‘Prevalence of ticks
and tick-borne pathogens: Babesia and Borrelia species in ticks infesting cats of Great Britain’
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6. https://acmsf.food.gov.uk/sites/default/files/mnt/drupal_data/sources/files/multimedia/pd
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7. Mansfield, K. L., Jizhou, L., Phipps, L. P., & Johnson, N. (2017). Emerging Tick-Borne Viruses in
the Twenty-First Century. Frontiers in cellular and infection microbiology, 7, 298.

NEWS

Martami F et al The effects of a multispecies probiotic supplement on inflammatory markers and episodic and chronic migraine characteristics: A randomized double-blind controlled trial. Cephalalgia. Jan 2019.

Christian Timbol, James Baraniuk. Chronic fatigue syndrome in the emergency department. Open Access Emergency Medicine, 2019; Volume 11: 15 DOI: 10.2147/OAEM.S176843

Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. The American Journal of Clinical Nutrition, 2018; 108 (6): 1249 DOI: 10.1093/ajcn/nqy274

Anne Marie Uwitonze, Mohammed S. Razzaque. Role of Magnesium in Vitamin D Activation and Function. The Journal of the American Osteopathic Association, 2018; 118 (3): 181 DOI: 10.7556/jaoa.2018.037

Chester R, Khondoker M, Shepstone L, et al. Self-efficacy and risk of persistent shoulder pain: results of a Classification and Regression Tree (CART) analysis

Br J Sports Med Published Online First: 09 January 2019. doi: 10.1136/bjsports-2018-099450.

Kate L Mandeville, Rosie Barker, Alice Packham, Charlotte Sowerby, Kielan Yarrow, Hannah Patrick. Financial interests of patient organisations contributing to technology assessment at England’s National Institute for Health and Care Excellence: policy review.BMJ. DOI: 10.1136/BMJ.K5300

Hall, K et al. COMT modifies alpha-tocopherol effects in cancer prevention: gene-supplement interactions in two randomized clinical trials. JNCI, 2019 DOI: 10.1093/jnci/djy204.

Tamara Lucas, Richard Horton. The 21st-century great food transformation. The Lancet, 2019; DOI: 10.1016/S0140-6736(18)33179-9.

https://www.thelancet.com/commissions/EAT.

BEN BROWN

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BLOOD TYPE
1. Moonens et al. Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pylori. Cell Host & Microbe, January 2016 DOI: 10.1016/j.chom.2015.12.004.
2. Association Between ABO Blood Groups and Helicobacter pylori Infection: A Meta-Analysis. Zakaria Chakrani, Karen Robinson & Bineyam Taye. Scientific Reports, 2018,  Vol 8, article: 17604. https://www.nature.com/articles/s41598-018-36006-x.

RESEARCH

Yifan Wu, Shuqi Du, Jennifer L. Johnson, Hui-Ying Tung, Cameron T. Landers, Yuwei Liu, Brittany G. Seman, Robert T. Wheeler, Mauro Costa-Mattioli, Farrah Kheradmand, Hui Zheng, David B. Corry. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nature Communications, 2019; 10 (1) DOI: 10.1038/s41467-018-07991-4

Kristin M. Wall, William Kilembe, Bellington Vwalika, Cecile Dinh, Paul Livingston, Yeuk-Mui Lee, Shabir Lakhi, Debi Boeras, Htee Khu Naw, Ilene Brill, Elwyn Chomba, Tyronza Sharkey, Rachel Parker, Erin Shutes, Amanda Tichacek, W. Evan Secor, Susan Allen. Schistosomiasis is associated with incident HIV transmission and death in Zambia. PLOS Neglected Tropical Diseases, 2018; 12 (12): e0006902 DOI: 10.1371/journal.pntd.0006902.

Pilling Luke C, Tamosauskaite Jone, Jones Garan, Wood Andrew R, Jones Lindsay, Kuo Chai-Ling et al. Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank BMJ 2019; 364 :k5222.

Jone Tamosauskaite, Janice L Atkins, Luke C Pilling, Chia-Ling Kuo, George A Kuchel, Luigi Ferrucci, David Melzer; Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants, The Journals of Gerontology: Series A, gly270, https://doi.org/10.1093/gerona/gly270.

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal, Nature Immunology (2019). DOI: 10.1038/s41590-018-0292-y , https://www.nature.com/articles/s41590-018-0292-y.

Brooke C. Wilson, Tommi Vatanen, Wayne S. Cutfield, Justin M. O’Sullivan. The Super-Donor Phenomenon in Faecal Microbiota Transplantation. Frontiers in Cellular and Infection Microbiology, 2019; 9 DOI: 10.3389/fcimb.2019.00002

Suzanna Maria Zick, Ananda Sen, Afton Luevano Hassett, Andrew Schrepf, Gwen Karilyn Wyatt, Susan Lynn Murphy, John Todd Arnedt, Richard Edmund Harris. Impact of Self-Acupressure on Co-Occurring Symptoms in Cancer Survivors. JNCI Cancer Spectrum, 2018; 2 (4) DOI: 10.1093/jncics/pky064

Marta Gallego et al. Peptides with Potential Cardioprotective Effects Derived from Dry-Cured Ham Byproducts. Journal of Agricultural and Food Chemistry, 2019; DOI: 10.1021/acs.jafc.8b05888.

Maria A Lankinen, Alexander Fauland, Bun-ichi Shimizu, Jyrki Ågren, Craig E Wheelock, Markku Laakso, Ursula Schwab, Jussi Pihlajamäki. Inflammatory response to dietary linoleic acid depends on FADS1 genotype. The American Journal of Clinical Nutrition, 2019; DOI: 10.1093/ajcn/nqy287

Kenichiro Kinouchi, Christophe Magnan, Nicholas Ceglia, Yu Liu, Marlene Cervantes, Nunzia Pastore, Tuong Huynh, Andrea Ballabio, Pierre Baldi, Selma Masri, Paolo Sassone-Corsi. Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Reports, 2018; 25 (12): 3299 DOI: 10.1016/j.celrep.2018.11.077

IHCAN January 2018 references

WELCOME
“If You’ve Got a Pulse, You’re Sick”, by Gina Kolata, New York Times, May 21, 2006:

https://www.nytimes.com/2006/05/21/weekinreview/21kolata.html

NEWS
Neuron. 2018 Nov 21;100(4):994-1005.e4. doi: 10.1016/j.neuron.2018.10.047.

Attenuating Neural Threat Expression with Imagination.

Reddan MC, Wager TD, Schiller D.

Andrew W. Brooks, Sambhawa Priya, Ran Blekhman, Seth R. Bordenstein. Gut microbiota diversity across ethnicities in the United States. PLOS Biology, 2018; 16 (12): e2006842 DOI: 10.1371/journal.pbio.2006842.

Melatonin as a Hormone: New Physiological and Clinical Insights

José Cipolla-Neto Fernanda Gaspar do Amaral

Endocrine Reviews, Volume 39, Issue 6, 1 December 2018, Pages 990–1028.

Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women. Zeneng Wang et al. European Heart Journal, ehy799, 

https://doi.org/10.1093/eurheartj/ehy799. 10 December 2018.

 l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. Robert A. Koeth et al. J Clin Invest. 2018. https://doi.org/10.1172/JCI94601.

Effect of dried fruit on postprandial glycemia: a randomized acute-feeding trial

Effie Viguiliouk et al. Nutrition & Diabetes, volume 8, Article number: 59 (2018).

Alexander J Michels, Scott W Leonard, Sandra L Uesugi, Gerd Bobe, Balz Frei, Maret G Traber. Daily Consumption of Oregon Hazelnuts Affects α-Tocopherol Status in Healthy Older Adults: A Pre-Post Intervention Study. The Journal of Nutrition, 2018; 148 (12): 1924 DOI: 10.1093/jn/nxy210.

Marja Härkänen, Katri Vehviläinen-Julkunen, Trevor Murrells, Anne Marie Rafferty, Bryony Dean Franklin. Medication administration errors and mortality: Incidents reported in England and Wales between 2007 ̶ 2016. Research in Social and Administrative Pharmacy, 2018; DOI: 10.1016/j.sapharm.2018.11.010

CBD

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17. Benito et al (2008) CB2 receptors in human brain inflammation. Br J Pharmacol 153:277-285
18. Cheng et al (2014) Long-term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer’s disease transgenic mice. 42:1383-1396
19. Yiangou, Y., Facer, P., Durrenberger, P., Chessell, I. P., Naylor, A., Bountra, C., Anand, P. (2006). COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurology, 6, 12
20. Capasso et al (2001) Inhibitory effect of standardised cannabis sativa extract and its ingredient cannbidiols in rat and human bladder contractility. J Urology 77:1066-1009
21. Fichna, J., Bawa, M., Thakur, G. A., Tichkule, R., Makriyannis, A., McCafferty, D.-M., Storr, M. (2014). Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors. PLoS ONE, 9(10), e109115.
22. Burstein, S. H., & Zurier, R. B. (2009). Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation. The AAPS Journal 11:109
23. Christian et al (2016) Experimental cannbidiol treatment reduces early pancreatic inflammation in type 1 diabetes. Clin Hemorheology & Microcirculation 64:655-662.
24. Zuardi et al (2012) A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. Curr Pharm Des 18:5131-5140
25. Gomes, F. V., Llorente, R., Bel, E. A., Viveros, M., López-Gallardo, M., & Guimarães, F. S. (2015). Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol. Schizophrenia Research, 164(1-3), 155-163
26. Huang, W-J et al (2016) Endocannabinoid system: Role in depression, reward and pain control. Mol Med Reports 14:2899-2903
27. Hurd et al (2015) Early phase in the development of cannbidiol as a treatment for addiction: Opioid relapse takes initial centre stage. Neurotherapeutics 12:807-815
28. Blessing et al (2015) Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics 12:825-836
29. Kaur, R., Ambwani, S. R., & Singh, S. (2016). Endocannabinoid System: A Multi-Facet Therapeutic Target. Current Clinical Pharmacology, 11(2), 110-117
30. Massi et al (2012) Cannabidiol as a potential anticancer drug. Br J Clin Pharm 75:303-312
31. Romano et al (2014) Inhibition of colon carcinogenesis by a standardised Cannabis sativa extract rich in content of cannbidiol. Phytomedicine 21:631-639
32. Olah et al 92014) Cannbidiol exerts sebostatic and anti-inflammatory effects on human sebocytes. J Clin Invest 124:3713-3724
33. Rom et al (2013) CB2 receptor: Potential role in immunomodulation and neuroinflammation. J Neuroimmune Pharmacol 8:608-620
34. Cassano, T., Calcagnini, S., Pace, L., De Marco, F., Romano, A., & Gaetani, S. (2017). Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target. Frontiers in Neuroscience, 11, 30.
35. Benito et al (2008) CB2 receptors in human brain inflammation. Br J Pharmacol 153:277-285
36. https://www.theguardian.com/society/2018/jul/05/cannabis-oil-row-billy-caldwell-under-hospital-arrest-says-mother
37. https://www.theguardian.com/society/2018/jul/26/cannabis-based-medicines-get-green-light-as-uk-eases-rules?
38. Yamaori et al (2010) Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes. Biochem Pharmacol 79:1691-1698
39. Yamaori (2011) Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos 39:2049-2056
40. Stott et al (2013). A phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the phamacokinetics of THC/CBD oromucosal spray in healthy volunteers. SpringerPlus 2:236

Endocannabinoid deficiency

1. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes. Cannabis Cannabinoid Res.2016 Jul 1;1(1):154-165. doi: 10.1089/can.2016.0009. eCollection 2016.
2. Endocannabinoids in chronic migraine: CSF findings suggest a system failure.

Neuropsychopharmacology. 2007 Jun;32(6):1384-90. Epub 2006 Nov 22.

Sarchielli P et al.

3. Beyond Cannabis: Plants and the Endocannabinoid System. Russo EB¹.

Trends Pharmacol Sci. 2016 Jul;37(7):594-605. doi: 10.1016/j.tips.2016.04.005. Epub 2016 May 11.

HEART

1. https://www.nhlbi.nih.gov/health-topics/coronary-heart-disease.
2. Astrup T, et al: ‘Thromboplastic and Fibrinolytic Activity of the Human Aorta.‘ Circulation Research, Volume VII, November 1959.
3. https://www.sciencedirect.com/sdfe/pdf/download/eid/1-s2.0-0049384894900493/first-page-pdf
4. https://www.sciencedirect.com/sdfe/pdf/download/eid/1-s2.0-0049384894900493/first-page-pdf
5. http://www.onlinejacc.org/content/accj/69/18/2317.full.pdf
6. https://heart.bmj.com/content/heartjnl/69/4/338.full.pdf
7. https://www.ncbi.nlm.nih.gov/pubmed/12034401
8.  https://www.webmd.com/asthma/news/20041115/steroids-linked-to-higher-heart-disease-risk

RESEARCH
Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Meng Qu, Tomas Duffy, Tsuyoshi Hirota, and Steve A. Kay. PNAS published ahead of print December 10, 2018 https://doi.org/10.1073/pnas.1816411115

Oral Vitamin C (500 mg/day) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP): A Randomized Trial.

McEvoy CT et al. Am J Respir Crit Care Med. 2018 Dec 7. doi: 10.1164/rccm.201805-1011OC. [Epub ahead of print].

Noah Snyder-Mackler, Joaquín Sanz, Jordan N. Kohn, Tawni Voyles, Roger Pique-Regi, Mark E. Wilson, Luis B. Barreiro, and Jenny Tung. Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. PNAS, 2018 DOI: 10.1073/pnas.1811758115.

WELCOME

Estimation of global insulin use for type 2 diabetes, 2018–30: a microsimulation analysis. Sanjay Basu et al. The Lancet Diabetes & Endocrinology 2018. Published online Nov 20. DOI: https://doi.org/10.1016/S2213-8587(18)30303-6.

Expenditures and Prices of Antihyperglycemic Medications in the United States: 2002-2013. Xinyang Hua et al. JAMA. 2016;315(13):1400-1402. doi:10.1001/jama.2016.0126

NEWS
Gonzalez, PS et al. Mannose impairs tumour growth and enhances chemotherapy. Nature 2018, Nov 21. DOI: https://doi.org/10.1038/s41586-018-0729-3.

Carole A. Federico, Taiji Wang, Adélaïde Doussau, Jeffrey S. Mogil, Dean Fergusson, Jonathan Kimmelman. Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications. JAMA Internal Medicine, 2018; DOI: 10.1001/jamainternmed.2018.5705.

Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans. Manuel Stern et al. European Journal of Preventive Cardiology, 2018; 204748731880007 DOI: 10.1177/2047487318800072

BEN BROWN – Nature

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14. Sinatra ST, et al. Electric Nutrition: The Surprising Health and Healing Benefits of Biological Grounding (Earthing). Altern Ther Health Med. 2017 Sep;23(5):8-16.
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19. Komano Y, Shimada K, Naito H, Fukao K, Ishihara Y, Fujii T, Kokubo T, Daida H. Efficacy of heat-killed Lactococcus lactis JCM 5805 on immunity and fatigue during consecutive high intensity exercise in male athletes: a randomized, placebo-controlled, double-blinded trial. J Int Soc Sports Nutr. 2018 Aug 2;15(1):39.
20. Obregon-Tito AJ, Tito RY, Metcalf J, Sankaranarayanan K, Clemente JC, Ursell LK, Zech Xu Z, Van Treuren W, Knight R, Gaffney PM, Spicer P, Lawson P, Marin-Reyes L, Trujillo-Villarroel O, Foster M, Guija-Poma E, Troncoso-Corzo L, Warinner C, Ozga AT, Lewis CM. Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun. 2015 Mar 25;6:6505.
21. Diet-induced extinctions in the gut microbiota compound over generations.

Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL. Nature 2016, Jan 14;529(7585):212-5

1. Logan AC, Jacka FN, Prescott SL. Immune-Microbiota Interactions: Dysbiosis as a Global Health Issue. Curr Allergy Asthma Rep. 2016 Jan;16(2):13.

 NUTRIGENOMICS – Kara Fitzgerald

1. Understanding the regulatory and transcriptional complexity of the genome through structure. Tim R. Mercer and John S. Mattick. Genome Res. 2013 Jul; 23(7): 1081–1088.

doi: 10.1101/gr.156612.113.

2. Lobo, I. (2008) Epistasis: Gene interaction and the phenotypic expression of complex diseases like Alzheimer’s. Nature Education1(1):180.
3. Major Heart Disease Genes Prove Elusive. Jennifer Couzin-Frankel. Science 04 Jun 2010: Vol. 328, Issue 5983, pp. 1220-21. DOI: 10.1126/science.328.5983.1220.
   4. The Elusive ALS Genes. Ken Garber. Science 04 Jan 2008: Vol. 319, Issue 5859, pp. 20
   DOI: 10.1126/science.319.5859.20.
   5. Genes and Autoimmune Diseases — A Complex Inheritance. Highlights of the 54th Annual Meeting of the American Society of Human Genetics; October 26-30, 2004; Toronto, Ontario, Canada. Sara M Mariani, PhD. MedGenMed. 2004; 6(4): 18.
4. Combined effect of CYP1B1, COMT, GSTP1, and MnSODgenotypes and risk of postmenopausal breast cancer. J Gynecol Oncol. 2011 Jun 30; 22(2): 110–119.

doi: 10.3802/jgo.2011.22.2.110.

7. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. Fredrick R. Schumacher et al. Nature Genetics, 2018, 50: 928–936.
8. Heather M. Ochs-Balcom et al. Physical activity modifies genetic susceptibility to obesity in postmenopausal women. Menopause, 2018; 1 DOI: 10.1097/GME.0000000000001134.

BRAIN HEALTH
Ossenkoppele R, Rabinovici GD, Smith R, et al. Discriminative Accuracy of [¹⁸F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders. JAMA, 2018; 320 (11): 1151–1162 DOI: 10.1001/jama.2018.12917.

Adam P Spira, Yang An, Mark N Wu, Jocelynn T Owusu, Eleanor M Simonsick, Murat Bilgel, Luigi Ferrucci, Dean F Wong, Susan M Resnick. Excessive daytime sleepiness and napping in cognitively normal adults: associations with subsequent amyloid deposition measured by PiB PET. Sleep, 2018; DOI: 10.1093/sleep/zsy152.

Ross S. Mancini, Yanfei Wang, Donald F. Weaver. Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation. Frontiers in Neuroscience, 2018; 12 DOI: 10.3389/fnins.2018.00735.

 

Nutritional status, brain network organization, and general intelligence

Marta K.Zamroziewicz et al. NeuroImage, Volume 161, 1 November 2017, Pages 241-250.

Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs. Austin T Mudd et al. Current Developments in Nutrition, 2: 6, 1 June 2018, https://doi.org/10.1093/cdn/nzy015.

RESEARCH

Makrides, L Duley, SF Olsen. Fish oil and other prostaglandin precursor supplementation during pregnancy for reducing pre-eclampsia, preterm birth, low birth weight and intrauterine growth restriction. Cochrane Review, 2018 DOI: http://dx.doi.org/10.1002/14651858.CD003402

Long-term intake of vegetables and fruits and subjective cognitive function in US men.

Changzheng Yuan, Elinor Fondell, Ambika Bhushan, Alberto Ascherio, Olivia I. Okereke, Francine Grodstein, Walter C. Willett. Neurology 2018, first published Nov 21, 2018, DOI: https://doi.org/10.1212/WNL.0000000000006684

Angele M. De Silva, Rían W. Manville, Geoffrey W. Abbott. Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Science Advances, 2018; 4 (11): eaav0824 DOI: 10.1126/sciadv.aav0824

 Wahl D et al. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018 Nov 20;25(8):2234-2243.e6. doi: 10.1016/j.celrep.2018.10.070.

Salas-Huetos A et al. The Effect of Nutrients and Dietary Supplements on Sperm Quality Parameters: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Advances in Nutrition, 2018; 9(6), 833-848. DOI: 10.1093/advances/nmy057.

Calorie restriction
1.  Cash A. Oxaloacetic Acid Supplementation as a Mimetic of Calorie Restriction. Open Longevity Science. 2009;3:22-7.

2. Williams DS, Cash A, Hamadani L, Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009;8(6):765-8.
3. Shintani H, Shintani T, Ashida H, Sato M. Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism. Nutrients. 2018;10(12): open access at https://www.mdpi.com/2072-6643/10/12/1821.
4. Lane, M.A; Ingram, D.K; Roth, G.S. 2-Deoxy-D-glucose feeding in rats mimics physiologic effects of calorie restriction. J. Anti Aging Med. 1998, 1, 327-337.

Gut-brain mechanism
1. Pellegrini C et al (2018) Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases? Acta Neuropathol 136:345. doi:10.1007/s00401-018-1856-5.

2. Kaelberer et al (2018) A gut-brain neural circuit for nutrient sensory transduction. Science 361(6408):eaat5236. doi:10.1126/science.aat5236.
3. Bohórquez and Liddle (2015) The gut connectome: making sense of what you eat. J Clin Invest125(3):888–890. doi:10.1172/JCI81121.

 NEW RELEASES

1. Urolithin A induces mitophagy and prolongs lifespan in C. elegansand increases muscle function in rodents. Dongryeol Ryu et al. Nature Medicine 2016, 22: 879–88.
2. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Carine Dion, Eric Chappuis, and Christophe Ripoll. Nutr Metab (Lond) 2016, 13: 28, doi:  10.1186/s12986-016-0086-x.

NEWS

 Precision identification of diverse bloodstream pathogens in the gut microbiome. Tamburini FB, Andermann TM, Tkachenko E, Senchyna F, Banaei N, Bhatt AS. Nat Med. 2018 Oct 15. doi: 10.1038/s41591-018-0202-8.

Development of the Highly Processed Food Withdrawal Scale. Appetite 2018,

Vol 131, 1 December, 148-154. https://doi.org/10.1016/j.appet.2018.09.013.

Bruce N. Ames. Prolonging healthy ageing: Longevity vitamins and proteins, Proceedings of the National Academy of Sciences (2018). DOI: 10.1073/pnas.1809045115 

Bruce N. Ames. Low micronutrient intake may accelerate the degenerative diseases of ageing through allocation of scarce micronutrients by triage. PNAS November 21, 2006 103 (47) 17589-17594; https://doi.org/10.1073/pnas.0608757103.

BEN BROWN 

1. Zeisel S.H., Da Costa K.-A., Franklin P.D., Alexander E.A., Lamont J.T., Sheard N.F., Beiser A. Choline, an essential nutrient for humans. FASEB J. 1991;5:2093–2098.
2. Da Costa K.A., Badea M., Fischer L.M., Zeisel S.H. Elevated serum creatine phosphokinase in choline-deficient humans: Mechanistic studies in C2C12 mouse myoblasts. Am. J. Clin. Nutr. 2004;80:163–170.
3. Da Costa K.A., Niculescu M.D., Craciunescu C.N., Fischer L.M., Zeisel S.H. Choline deficiency increases lymphocyte apoptosis and DNA damage in humans. Am. J. Clin. Nutr. 2006;84:88–94.
4. Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009 Nov;67(11):615-23.
5. Bidulescu A, Chambless LE, Siega-Riz AM, Zeisel SH, Heiss G. Repeatability and measurement error in the assessment of choline and betaine dietary intake: the atherosclerosis risk in communities (ARIC) study. Nutr J 2009, 8(1): 14.
6. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies), 2016. Scientific opinion on Dietary Reference Values for choline. EFSA Journal 2016;14(8):4484, 70 pp.  doi:10.2903/j.efsa.2016.4484
7. Biasi E. The effects of dietary choline. Neurosci Bull. 2011 Oct;27(5):330-42.
8. Ganz AB, Klatt KC, Caudill MA. Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements. Nutrients. 2017 Aug 4;9(8).
9. Ganz AB, Shields K, Fomin VG, Lopez YS, Mohan S, Lovesky J, Chuang JC, Ganti A, Carrier B, Yan J, Taeswuan S, Cohen VV, Swersky CC, Stover JA, Vitiello GA, Malysheva OV, Mudrak E, Caudill MA. Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the  expense of betaine synthesis. FASEB J. 2016 Oct;30(10):3321-3333.
10. Fischer LM, da Costa KA, Galanko J, Sha W, Stephenson B, Vick J, Zeisel SH. Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. Am J Clin Nutr. 2010 Aug;92(2):336-46.
11. Kohlmeier M, da Costa K, Fischer LM, Zeisel SH. Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A 2005;102:16025–16030.
12. Zeisel SH. The supply of choline is important for fetal progenitor cells.Semin Cell Dev Biol. 2011 Aug;22(6):624-8.
13. Shaw GM, Carmichael SL, Yang W, Selvin S, Schaffer DM. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol. 2004;160:102–9.
14. Shaw GM, Finnell RH, Blom HJ, Carmichael SL, Vollset SE, Yang W, et al. Choline and Risk of Neural Tube Defects in a Folate-Fortified Population. Epidemiology. 2009epub:10.1097/EDE.0b013e3181ac9fe7
15. Shaw GM, Carmichael SL, Laurent C, Rasmussen SA. Maternal nutrient intakes and risk of orofacial clefts. Epidemiology. 2006;17:285–91.
16. Zeisel SH. Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health. 2013 Apr 22;5:193-9.
17. Jiang X, West AA, Caudill MA. Maternal choline supplementation: a nutritional  approach for improving offspring health? Trends Endocrinol Metab. 2014 May;25(5):263-73.
18. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S,  Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar;170(3):290-8.
19. Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2016 May 1;173(5):509-16.
20. Ideraabdullah FY, Zeisel SH. Dietary Modulation of the Epigenome. Physiol Rev. 2018 Apr 1;98(2):667-695.
21. Stephenson J, Heslehurst N, Hall J, Schoenaker DAJM, Hutchinson J, Cade JE, Poston L, Barrett G, Crozier SR, Barker M, Kumaran K, Yajnik CS, Baird J, Mishra  GD. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet. 2018 May 5;391(10132):1830-1841.

MENOPAUSE

Mingfei Zhao, Brian W Whitcomb, Alexandra C Purdue-Smithe, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Elizabeth R Bertone-Johnson. Physical activity is not related to risk of early menopause in a large prospective study. Human Reproduction, 2018; DOI: 10.1093/humrep/dey267.

Yashvee Dunneram, Darren Charles Greenwood, Victoria J Burley, Janet E Cade. Dietary intake and age at natural menopause: results from the UK Women’s Cohort Study. Journal of Epidemiology and Community Health, 2018; DOI: 10.1136/jech-2017-209887

1. Reduce hot flashes and other menopausal symptoms: a beneficial proprietary Siberian rhubarb root extract, Kristen Haabala, ND, and Mark Kaye, DC. Naturopathic Doctor News and Review, posted Dec 7, 2012: https://ndnr.com.
   2. A Non-Hormone Approach to Menopause Management, by Stephanie Clark. Life Extension Magazine, October 2018.
2. metagenicsinstitute.com/ce-education/science-sheets/science-review-err-731.

RESEARCH
Fiona S Atkinson, Dale Hancock, Peter Petocz, Jennie C Brand-Miller. The physiologic and phenotypic significance of variation in human amylase gene copy number. The American Journal of Clinical Nutrition, 2018; 108 (4): 737 DOI: 10.1093/ajcn/nqy164

10. Falchi et al. Low copy number of the salivary amylase gene predisposes to obesity. Nature Genetics, 2014 DOI: 10.1038/ng.2939

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-06158-5.

Suleiman Furmli, Rami Elmasry, Megan Ramos, Jason Fung. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Reports, 2018; bcr-2017-221854 DOI: 10.1136/bcr-2017-221854

White J, Xiong S, Malvin N, Khoury-Hanold W, Heuckeroth R, Stappenbeck T, Diamond MS. Intestinal dysmotility syndromes following system infection by flaviviruses. Cell. Oct, 4, 2018.

SELF-CARE

1. https://www.telegraph.co.uk/finance/newsbysector/mediatechnologyandtelecoms/11610959/Is-your-daily-social-media-usage-higher-than-average.html.
   2. https://www.networkworld.com/article/3092446/smartphones/we-touch-our-phones-2617-times-a-day-says-study.html.

NEWS

Jørgensen L, Gøtzsche P, Jefferson T. The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias. BMJ Evid Based Med 2018, Jul 27.
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors. Cochrane Database Syst Rev2018;5:CD009069.pmid:29740819.

Index of the human papillomavirus (HPV) vaccine industry clinical study programmes and non-industry funded studies: a necessary basis to address reporting bias in a systematic review. Syst Rev 2018;7:8. doi:10.1186/s13643-018-0675-z pmid:29347995.

HPV vaccine safety: Cochrane launches urgent investigation into review after criticisms. BMJ 2018; 362 doi: https://doi.org/10.1136/bmj.k3472 (Published 09 August 2018).

Greenhalgh T, Howick J, Maskrey N; Evidence Based Medicine Renaissance Group. Evidence based medicine: a movement in crisis? BMJ. 2014 Jun 13;348:g3725. doi: 10.1136/bmj.g3725.

 Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study. Published Online ahead of print Journal of Medicinal Food, August 30, 2018: https://doi.org/10.1089/jmf.2017.4176. (Free access to October 17.)

Cell 2018 Sep 6;174(6):1388-1405.e21. doi: 10.1016/j.cell.2018.08.041.

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features.

A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation

(Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome.

Ishaque et al. BMC Gastroenterology 2018, 18:71: https://doi.org/10.1186/s12876-018-0788-9.

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

Gastroenterology, Volume 153, Issue 2, August 2017, Pages 448-459.e8.

Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis 

European Journal of Public Health, cky185, https://doi.org/10.1093/eurpub/cky185

Published: 14 September 2018.

Qingqing Zhang, Yucheng Wu, Xiaoqiang Fei. Effect of probiotics on body weight and body-mass index: a systematic review and meta-analysis of randomized, controlled trials. International Journal of Food Sciences and Nutrition, 2016; 67 (5): 571 DOI: 10.1080/09637486.2016.1181156.

Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

Anna G. Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density – a randomized, placebo-controlled, double-blind, clinical trial. Journal of Internal Medicine, 2018; DOI: 10.1111/joim.12805.

BEN BROWN

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8. Akobeng AK, Miller V, Stanton J, Elbadri AM, Thomas AG. Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn’s disease. J Pediatr Gastroenterol Nutr. 2000 Jan;30(1):78-84.
9. Alpers DH. Glutamine: do the data support the cause for glutamine supplementation in humans? Gastroenterology. 2006 Feb;130(2 Suppl 1):S106 16.
10. Zhou Q, Costinean S, Croce CM, et al. MicroRNA 29 targets nuclear factor-kappaB-repressing factor and Claudin 1 to increase intestinal permeability. Gastroenterology 2015; 148:158-169.e8
11. Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2018 Aug 14. pii: gutjnl-2017-315136.
12. Ford AC, Lacy BE, Talley NJ. Longo DL, editor. Irritable bowel syndrome. N Engl J Med2017;376:2566–78
13. Olden K. Targeted therapies for diarrhea-predominant irritable bowel syndrome. Clin Exp Gastroenterol 2012;5:69–100
14. Schoenfeld P, Pimentel M, Chang L, Lembo A, Chey WD, Yu J, Paterson C, Bortey  E, Forbes WP. Safety and tolerability of rifaximin for the treatment of irritable bowel syndrome without constipation: a pooled analysis of randomised, double-blind, placebo-controlled trials. Aliment Pharmacol Ther. 2014 May;39(10):1161-8.
15. Pimentel M, Lembo A, Chey WD, et al Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 2011; 364: 22–32
16. Ishaque SM, Khosruzzaman SM, Ahmed DS, Sah MP. A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome. BMC Gastroenterol. 2018 May 25;18(1):71.
17. Hod K, Sperber AD, Ron Y, Boaz M, Dickman R, Berliner S, Halpern Z, Maharshak  N, Dekel R. A double-blind, placebo-controlled study to assess the effect of a probiotic mixture on symptoms and inflammatory markers in women with diarrhea-predominant IBS. Neurogastroenterol Motil. 2017 Jul;29(7).
18. Bertiaux-Vandaele N, Youmba SB, Belmonte L, et al. The expression and the cellular distribution of the tight junction proteins are altered in irritable bowel syndrome patients with differences according to the disease subtype. Am J Gastroenterol 2011; 106:2165-2173.

Glutamine not for cancer
Gaurav Pathria, David A Scott, Yongmei Feng, Joo Sang Lee, Yu Fujita, Gao Zhang, Avinash D Sahu, Eytan Ruppin, Meenhard Herlyn, Andrei L Osterman, Ze’ev A Ronai. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. The EMBO Journal, 2018; e99735 DOI: 10.15252/embj.201899735

PARASITES – EMMA LANE

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Auricular Acupuncture and Vagal Regulation. Wei He, Xiaoyu Wang, Hong Shi, Hongyan Shang, Liang Li, Xianghong Jing, and Bing Zhu. Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 786839, http://dx.doi.org/10.1155/2012/786839

Autonomic nervous function during whole-body cold exposure before and after cold acclimation. Mäkinen TM1, Mäntysaari M, Pääkkönen T, Jokelainen J, Palinkas LA, Hassi J, Leppäluoto J, Tahvanainen K, Rintamäki H. Pubmed. 79(9):875-82. Published online 2008 sept. PMID: 18785356. 2008.

Bonaz, B. “Vagal tone: effects on sensitivity, motility, and inflammation.” Neurogastroenterology & motility 28 no. 4 :455-62. 2016.

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Cardiovascular and Respiratory Effect of Yogic Slow Breathing in the Yoga Beginner: What Is the Best Approach? Heather Mason, Matteo Vandoni, Giacomo deBarbieri, Erwan Codrons, Veena Ugargol, and Luciano Bernardi. Evidence-Based Complementary and Alternative Medicine. 2013. Volume 2013, Article ID 743504, 7; Published 22 March 2013.

Changes in Autonomic Variables Following Two Meditative States Described in Yoga Texts. Shirley Telles, Bhat Ramachandra Raghavendra, Kalkuni Visweswaraiah Naveen, Nandi Krishnamurthy Manjunath, Sanjay Kumar, Pailoor Subramanya. J Altern Complement Med. 19(1): 35–42. doi: 10.1089/acm.2011.0282. PMCID: PMC3546358. Jan 2013.

Chloe Faith Wordsworth, Spiral Up, ISBN:978-1-937710-03-3

Could Vagus Nerve Stimulation Target Hippocampal Hyperactivity to Improve Cognition in Schizophrenia? Jason Smucny, Adrienne Visani, Jason R. Tregellas. Front Psychiatry. 6: 43. Published online 2015 Mar 24. doi: 10.3389/fpsyt.2015.00043. PMCID: PMC4371554. 2015.

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Effect of laughter yoga on mood and heart rate variability in patients awaiting organ transplantation: a pilot study. Dolgoff-Kaspar R1, Baldwin A, Johnson MS, Edling N, Sethi GK. Pubmed. (5):61-6. Published online 2012 sept-oct PMID: 22894892. 2012.

Grontved A, Hu FB. Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis. JAMA. 2011;305:2448-55.

He, X., et al. “Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases.” British Journal of Pharmacology 172 no. 23: 5489-500. 2015.

Healy, GN. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care. 2008 Apr;31(4):661-6. doi: 10.2337/dc07-2046. Epub 2008 Feb 5. Accessed 7th October 2016.

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http://www.bu.edu/news/2012/03/07/researchers-find-yoga-helps-ease-stress-related-medical-and-psychological-conditions/

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Proc Natl Acad Sci U S A.108(38):16050-5.  Epub 2011 Aug 29. PMID:21876150. Sep 20 2011.

Jessen NA., et al. The Glymphatic System: A Beginner’s Guide. Neurochem Res. 2015 Dec;40(12):2583-99. doi: 10.1007/s11064-015-1581-6. Epub 2015 May 7. Accessed 14th September 2016.

Just Breathe: Body Has A Built-In Stress Reliever, Gretchen Cuda. NPR article December 6^th 2010.

Katy Bowman, Move Your DNA, Edition 1, ISBN:978-1905367573

Music structure determines heart rate variability of singers. Björn Vickhoff, Helge Malmgren, Rickard Åström, Gunnar Nyberg, Seth-Reino Ekström, Mathias Engwall, Johan Snygg, Michael Nilsson, Rebecka Jörnsten. Front Psychol. 2013; 4: 334. Published online Jul 9 2013. doi: 10.3389/fpsyg.2013.00334. PMCID: PMC3705176.

Neurohemodynamic correlates of ‘OM’ chanting: A pilot functional magnetic resonance imaging study. Bangalore G Kalyani, Ganesan Venkatasubramanian, Rashmi Arasappa, Naren P Rao, Sunil V Kalmady, Rishikesh V Behere, Hariprasad Rao, Mandapati K Vasudev, Bangalore N Gangadhar. Int J Yoga.; 4(1): 3–6. doi: 10.4103/0973-6131.78171. PMCID: PMC3099099. Jan-Jun 2011.

Omega-3 Polyunsaturated Fatty Acids and Heart Rate Variability. Jeppe Hagstrup Christensen Front Physiol. 2: 84. Published online Nov 16 2011. Prepublished online 2011 Oct 4. doi:  10.3389/fphys.2011.00084. 2011.

Parasympathetic nervous system activity predicts mood repair use and its effectiveness among adolescents with and without histories of major depression. Ilya Yaroslavsky, Jonathan Rottenberg, Lauren M. Bylsma, J. Richard Jennings, Charles George, Ildikó Baji, István Benák, Roberta Dochnal, Kitti Halas, Krisztina Kapornai, J Abnorm Psychol. Author manuscript; available in PMC Published online 2016 Mar 7. doi: 10.1037/abn0000149. PMCID: PMC5025532. Apr 1 2017.

Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone  Bethany E. Kok, Kimberly A. Coffey, Michael A. Cohn. Volume: 24 issue: 7, page(s): 1123-1132.  Article first published online: May 6, 2013; Issue published: July 1, 2013. https://doi.org/10.1177/0956797612470827.

Pilorz V., et al. Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light. PLOS Biology. June 8, 2016. doi: 10.1371/journal.pbio.1002482. Accessed 14th September 2016.

Role of the vagus nerve in the development and treatment of diet‐induced obesity. Guillaume de Lartigue. J Physiol. 594(20): 5791–5815. Published online 2016 May 29. doi: 10.1113/JP271538. PMCID: PMC5063945. Oct 15 2016.

Rosenburg S, Accessing the Healing power of the Vagus Nerve, North Atlantic Books, California, ISBN 978-1-62317-024-0. 2017.

The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Marilia Carabotti, Annunziata Scirocco, Maria Antonietta Maselli, Carola Severi. Ann Gastroenterol. 2015 Apr-Jun; 28(2): 203–209. Correction in: Ann Gastroenterol. 29(2): 240.  PMCID: PMC4367209. Apr-Jun 2016.

Tyaqi, A., et al. “Yoga and heart rate variability: A comprehensive review of the literature.” International journal of yoga 9, no. 2  97-113. 2016.

Vagal nerve regulation is essential for the increase in gastric motility in response to mild exercise. Wang Y1, Kondo T, Suzukamo Y, Oouchida Y, Izumi S. Pubmed. 2:155-63. Published online Oct 22 2010.  PMID: 20948179. 2010.

Vagus Nerve Stimulation (VNS) and Treatment of Depression: To the Brainstem and Beyond. John P. O’Reardon, Pilar Cristancho, Andrew D. Peshek. Psychiatry (Edgmont) 3(5): 54–63. Published online 2006 May. PMCID: PMC2990624. May 2006.

Wiley T.S., Lights Out, Edition,1, ISBN:0-671-03868-0

Wilfred R Pigeon, Sleep manual, Edition,1, ISBN:978-0-76419737-6

Xie, L., et al. (2013). Sleep Drives Metabolite Clearance from the Adult Brain. Science, 342(6156), 373-377.

Yoga and heart rate variability: A comprehensive review of the literature. Anupama Tyagi, Marc Cohen. Int J Yoga. 9(2): 97–113. doi: 10.4103/0973-6131.183712. PMCID: PMC4959333. Jul-Dec 2016.

Picture caption

10. Xie, H. Kang, Q. Xu, M. J. Chen, Y. Liao, M. Thiyagarajan, J. O’Donnell, D. J. Christensen, C. Nicholson, J. J. Iliff, T. Takano, R. Deane, M. Nedergaard. Sleep Drives Metabolite Clearance from the Adult Brain. Science, 2013; 342 (6156): 373 DOI: 10.1126/science.1241224.

SUPERFOODS
Microalgae, a Potential Natural Functional Food Source – a Review. Angélica Villarruel-López , Felipe Ascencio , Karla Nuño. Pol. J. Food Nutr. Sci 2017, Vol. 67, 4, 251–263. DOI: 10.1515/pjfns-2017-0017.
Elizabeth Stanley Shepherd, William C. DeLoache, Kali M. Pruss, Weston R. Whitaker, Justin L. Sonnenburg. An exclusive metabolic niche enables strain engraftment in the gut microbiota. Nature 2018; DOI: 10.1038/s41586-018-0092-4

Fernando F Anhê et al. Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice. Gut, 2018; gutjnl-2017-315565 DOI: 10.1136/gutjnl-2017-315565.
A Double-Blind Placebo-Controlled Trial of Maca Root as Treatment for Antidepressant-Induced Sexual Dysfunction in Women. Christina M. Dording et al.

Evid Based Complement Alternat Med. 2015; 2015: 949036. DOI: 10.1155/2015/949036.

Mushrooms
Abdullah N, et al Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities . Evid Based Complement Alternat Med. (2012)

Abdulla MA., Noor S., Sabaratnam V., N. Abdullah, Wong KH., Ali HM.. Effect of Culinary-Medicinal Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-Induced Gastric Ulcers in Rats. International Journal for Medicinal Mushrooms.DOI: 10.1615/IntJMedMushr.v10.i4.40. 325-330 pages

Kodama N, Komuta K, Nanba H. Can maitake MD-fraction aid cancer patients?

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Çağlarirmak N., 2011. Edible mushrooms: an alternative food item, mushroom biology and mushroom products — In: Proceedings of the 7th International Conference on Mushroom Biology and Mushroom Products. Arcachon, France, pp. 553–559.

Ganoderma lucidum and its pharmaceutically active compounds. Boh B, Berovic M, Zhang J, ZhiBinL. Biotechnol Annu Rev. 2007;13:265-301.

Jayachandran M, Xiao J, Xu B. A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. International Journal of Molecular Sciences. 2017;18(9):1934. doi:10.3390/ijms18091934.

Nanba H. Antitumor activity of orally administered “D-Fraction” from maitake mushroom (Grifola frondosa). J Naturopathic Med 1993;1:10-15.

Tang W, Gao Y, Chen G, Gao H, Dai X, et al. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food. 2005 Spring;8(1):53-8. PubMed PMID: 15857210.

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Siu K.C., Chen X., Wu J.Y. Constituents actually responsible for the antioxidant

activities of crude polysaccharides isolated from mushrooms. Journal of Functional Foods; 11: 548-556: (2014)

Wong YY, Moon A, Duffin R, Barthet-Barateig A, Meijer HA, Clemens MJ, de Moor CH (2010). Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem 285(4):2610-21.

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RESEARCH

Ageing

2018. Jay Olshansky. From Lifespan to Healthspan. JAMA, 2018. DOI: 10.1001/jama.2018.12621

The Future of Health. S. Jay Olshansky PhD. Controversies in Geriatrics and Gerontology,  First published 5 December 2017. https://doi.org/10.1111/jgs.15167.

10. Kaluza, N. Håkansson, H. R. Harris, N. Orsini, K. Michaëlsson, A. Wolk. Influence of anti-inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies. Journal of Internal Medicine, 2018; DOI: 10.1111/joim.12823

Sarah S. Stith, Jacob M. Vigil, Franco Brockelman, Keenan Keeling, Branden Hall. Patient-Reported Symptom Relief Following Medical Cannabis Consumption. Frontiers in Pharmacology, 2018; 9 DOI: 10.3389/fphar.2018.00916

Jacob Vigil, Sarah Stith, Jegason Diviant, Franco Brockelman, Keenan Keeling, Branden Hall. Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions. Medicines, 2018; 5 (3): 75 DOI: 10.3390/medicines5030075.

Joseph H. Skalski, Jose J. Limon, Purnima Sharma, Matthew D. Gargus, Christopher Nguyen, Jie Tang, Ana Lucia Coelho, Cory M. Hogaboam, Timothy R. Crother, David M. Underhill. Expansion of commensal fungus Wallemia mellicola in the gastrointestinal mycobiota enhances the severity of allergic airway disease in mice. PLOS Pathogens, 2018; 14 (9): e1007260 DOI: 10.1371/journal.ppat.1007260.

Chao Jiang, Xin Wang, Xiyan Li, Jingga Inlora, Ting Wang, Qing Liu, Michael Snyder. Dynamic Human Environmental Exposome Revealed by Longitudinal Personal Monitoring. Cell, 2018; 175 (1): 277 DOI: 10.1016/j.cell.2018.08.060.

Matcha green tea (MGT) inhibits the propagation of cancer stem cells (CSCs), by targeting mitochondrial metabolism, glycolysis and multiple cell signalling pathways. Aging 2018, 10 (8): 1867-83. Gloria Bonuccelli  , Federica Sotgia  , Michael P. Lisant.

J Bernadette Moore, Annabelle Horti, Barbara A Fielding. Evaluation of the nutrient content of yoghurts: a comprehensive survey of yoghurt products in the major UK supermarkets. BMJ Open, 2018; 8 (8): e021387 DOI: 10.1136/bmjopen-2017-021387.

WELCOME

Ileocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study

Larry S Miller, Anil K Vegesna, Aiswerya Madanam Sampath, Shital Prabhu, Sesha Krishna Kotapati, and Kian Makipour

World J Gastroenterol. 2012 Dec 14; 18(46): 6801–6808.

Published online 2012 Dec 14. doi:  10.3748/wjg.v18.i46.6801

Low ileocecal valve pressure is significantly associated with small intestinal bacterial overgrowth (SIBO).

Roland BC¹, Ciarleglio MM, Clarke JO, Semler JR, Tomakin E, Mullin GE, Pasricha PJ.

Dig Dis Sci. 2014 Jun;59(6):1269-77. doi: 10.1007/s10620-014-3166-7. Epub 2014 May 3.

NEWS

Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort. Am J Psychiatry. Published Online:16 Aug 2018. https://doi.org/10.1176/appi.ajp.2018.17101129

The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity. Immunity 2018, 49, 2: 353-62. E5. Open Access Published: August 14. DOI: https://doi.org/10.1016/j.immuni.2018.07.010.

Zhou QQ, et al “Randomised placebo-controlled trial of dietary glutamine supplements for post infectious irritable bowel syndrome” Gut 2018; DOI:10.1136/gutjnl-2017-315136.

Avoidable food losses and associated production-phase greenhouse gas emissions arising from application of cosmetic standards to fresh fruit and vegetables in Europe and the UK. Journal of Cleaner Production, 201, 10 November 2018, 869-878, Stephen D. Porter, David S. Reay, Elizabeth Bomberg, Peter Higgins. https://doi.org/10.1016/j.jclepro.2018.08.079.

Lycopene

Lycopene Inhibits Disease Progression in Patients with Benign Prostate Hyperplasia. Silke Schwarz Ute C. Obermüller-Jevic Eva Hellmis Winfried Koch Günther JacobiHans-Konrad Biesalski. The Journal of Nutrition, Volume 138, Issue 1, 1 January 2008, Pages 49–53,https://doi.org/10.1093/jn/138.1.49

Rowles JL 3rd, Ranard KM, Smith JW, et al.: Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis 20 (4): 361-377, 2017.

Nrf2 signaling pathway: Pivotal roles in inflammation. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Vol 1863, 2, February 2017, 585-97.

Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2. Ludmila F et al. , Biochimie (2013), http://dx.doi.org/10.1016/j.biochi.2013.04.012.

Holzapfel NP, Holzapfel BM, Champ S, Feldthusen J, Clements J, Hutmacher DW. The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence. Int J Mol Sci. 2013;14(7):14620-14646.

Gann PH, Ma J, Giovannucci E, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. 1999; 59(6):1225–1230.

Kirsh VA, Mayne ST, Peters U, et al. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006; 15(1):92–98.

Dahan K, Fennal M, Kumar NB. Lycopene in the prevention of prostate cancer. J Soc Integr Oncol. 2008; 6(1):29–36.

Etminan M, Takkouche B, Caamano-Isorna F. The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev. 2004;13(3):340-345

Acupuncture
¹⁾ Coyne KS, Sexton CC, Vats V, Thompson C, Kopp ZS, Milsom I. National community prevalence of overactive bladder in the United States stratified by sex and age. Urology. 2011;77(5):1081–1087.

²⁾ Irwin DE, Milsom I, Hunskaar S, et al. Population-based survey of urinary incontinence, overactive bladder and other lower urinary tract symptoms in five countries: results of the EPIC study. Eur Urol. 2006;50(6):1306–1315.

³⁾ Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol. 2003;20(6):327–336.

⁴⁾ Milsom I, Abrams P, Cardozo L, Roberts RG, Thüroff J, Wein AJ. How widespread are the symptoms of an overactive bladder and how are they managed? A population based prevalence study. BJU Int.
2001;87(9):760–766.

⁵⁾ Coyne, KS, Sexton, CC, Thompson, C et al. (2009) The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the Epidemiology of LUTS (EpiLUTS) study. BJU Int. 104 (3) 352-60.

⁶⁾ National Institute for Health and Care Excellence (NICE) (­­­­­2015) Urinary Incontinence: The Management of Urinary Incontinence in Women. NICE Clinical Guideline 171. National Institute for Health and Care Excellence, London

⁷⁾ Forde, J.C., Jaffe, E., Stone, B.V., Te, A.E., Espinosa, G. and Chughtai, B. (2016) The role of acupuncture in managing overactive bladder; a review of the literature. Int. Urogynecol. J. 27: 1645-1651.

⁸⁾ Aydogmus, Y. et al. (2014) Acupuncture versus solifenacin for treatment of overactive bladder and its correlation with urine nerve growth factor levels: a randomised, placebo-controlled clinical trial. Urol Int. 93 (4) 437-43.

⁹⁾ Yuan, Z. et al. (2015) Acupuncture for overactive bladder in female adult: a randomised controlled trial. World J. Urol. 33(9):1303-8

¹⁰⁾ Kelleher, C.J., Burton, C., Khullar, V. and Cardozo, L.D. (1994) Acupuncture in the treatment of irritative bladder symptoms. Acupunct. Med. 12 (1) 9-12.

¹¹⁾ Moossdorff-Steinhauser, H.F.A. and Berghmans, B. (2013) Effects of Percutaneous Tibial Nerve Stimulation on Adult Patients with Overactive Bladder Syndrome: A Systematic Review. Neurourology and Urodynamics, 32: 206-214.

¹²⁾ Wang, Y., Liu, B., Yu, J., Wu, J., Wang, J. and Liu, Z. (2013) Electroacupuncture for moderate and severe benign prostatic hyperplasia: a randomised controlled trial. Plos One, 8 (4) e59449.

¹³⁾ Yu JS, Shen KH, Chen WC, Her JS, Hsieh CL (2011) Effects of Electroacupuncture on Benign Prostate Hyperplasia Patients with Lower Urinary Tract Symptoms: A Single-Blinded, Randomized Controlled Trial. Evidence-Based Complementary and Alternative Medicine 20: 303198

¹⁴⁾ Wang H et al (2012) Acupuncture of the sacral vertebrae suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center. Neurosci Res 72(1):43–9

¹⁵⁾ Paik, S-H., Han, S-R., Kwon, O.J. et al. (2010) Acupuncture for the treatment of urinary incontinence: a review of randomised controlled trials. Experimental and Therapeutic Medicine, 6 (3) 773-780.

BEN BROWN

1. Jeffery IB, O’Toole PW, Ohman L, et al. An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut 2012;61: 997–1006.
2. Rodiño-Janeiro BK, Vicario M, Alonso-Cotoner C, Pascua-García R, Santos J. A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies. Adv Ther. 2018 Mar;35(3):289-310.
3. Ford AC, Quigley EM, Lacy BE, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014 Oct;109(10):1547-61; quiz 1546, 1562.
4. Sanders ME. Probiotics and microbiota composition. BMC Med. 2016 Jun 2;14(1):82. doi: 10.1186/s12916-016-0629-z.
5. del Campo R, et al. Scarce evidence of yogurt lactic acid bacteria in human feces after daily yogurt consumption by healthy volunteers. Appl Environ Microbiol 2005;71:547–9.
6. Cirstea M, Radisavljevic N, Finlay BB. Good Bug, Bad Bug: Breaking through Microbial Stereotypes. Cell Host Microbe. 2018 Jan 10;23(1):10-13.
7. Derrien M, Belzer C, de Vos WM. Akkermansia muciniphila and its role in regulating host functions. Microb Pathog. 2017 May;106:171-181.
8. Ottman N, Geerlings SY, Aalvink S, de Vos WM, Belzer C. Action and function of Akkermansia muciniphila in microbiome ecology, health and disease. Best Pract Res Clin Gastroenterol. 2017 Dec;31(6):637-642.
9. Gómez-Gallego C, Pohl S, Salminen S, De Vos WM, Kneifel W. Akkermansia muciniphila: a novel functional microbe with probiotic properties. Benef Microbes. 2016 Sep;7(4):571-84.
10. Heintz-Buschart A, Pandey U, Wicke T, Sixel-Döring F, Janzen A, Sittig-Wiegand E, Trenkwalder C, Oertel WH, Mollenhauer B, Wilmes P. The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder. Mov Disord. 2018 Jan;33(1):88-98.
11. Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10719-10724.
12. Gerhardt S, Mohajeri MH. Changes of Colonic Bacterial Composition in Parkinson’s Disease and Other Neurodegenerative Diseases. Nutrients. 2018 Jun 1;10(6).
13. Claesson MJ, Clooney AG, O’Toole PW. A clinician’s guide to microbiome analysis. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):585-595.
14. Langille MG, Zaneveld J, Caporaso JG, et al. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat Biotechnol 2013;31(9):814–21.
15. Gingras BA, Duncan SB, Scheuller NJ, Schreckenberber PC. Assessment of diagnostic accuracy of recently introduced DNA stool screening test. International Journal of Human Nutrition and Functional Medicine 2014: 2 (1); 1
16. Pollock J, Glendinning L, Wisedchanwet T, Watson M. The Madness of Microbiome: Attempting To Find Consensus “Best Practice” for 16S Microbiome Studies. Appl Environ Microbiol. 2018 Mar 19;84(7).
17. O’Toole PW, Flemer B. From Culture to High-Throughput Sequencing and Beyond: A Layperson’s Guide to the “Omics” and Diagnostic Potential of the Microbiome.Gastroenterol Clin North Am. 2017 Mar;46(1):9-17.
18. Sommer MO. Advancing gut microbiome research using cultivation. Curr Opin Microbiol. 2015 Oct;27:127-32.
19. Quigley EMM. Gut microbiome as a clinical tool in gastrointestinal disease management: are we there yet? Nat Rev Gastroenterol Hepatol. 2017 May;14(5):315-320.
20. Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E. Safety assessment of probiotics for human use. Gut Microbes. 2010 May-Jun;1(3):164-85.
21. Sheedy JR, Wettenhall RE, Scanlon D, Gooley PR, Lewis DP, McGregor N, Stapleton DI, Butt HL, DE Meirleir KL. Increased d-lactic Acid intestinal bacteria in patients with chronic fatigue syndrome. In Vivo. 2009 Jul-Aug;23(4):621-8.
22. Munakata S, et al. A case of D-lactic acid encephalopathy associated with use of probiotics. Brain. Dev. 2010;32:691–694.
23. Rao SSC, Rehman A, Yu S, Andino NM. Brain fogginess, gas and bloating: a link  between SIBO, probiotics and metabolic acidosis. Clin Transl Gastroenterol. 2018  Jun 19;9(6):162.
24. Zheng Y, Lu Y, Wang J, et al. Probiotic properties of Lactobacillus strains isolated from Tibetan kefir grains. PLoS One. 2013;8(7):e69868.
25. Han K, Bose S, Wang JH, et al. Contrasting effects of fresh and fermented kimchi consumption on gut microbiota composition and gene expression related to metabolic syndrome in obese Korean women. Mol Nutr Food Res. 2015;59(5):1004-1008.
26. Raak C, Ostermann T, Boehm K, Molsberger F. Regular consumption of sauerkraut  and its effect on human health: a bibliometric analysis. Glob Adv Health Med. 2014 Nov;3(6):12-8.
27. Villarreal-Soto SA, Beaufort S, Bouajila J, Souchard JP, Taillandier P. Understanding Kombucha Tea Fermentation: A Review. J Food Sci. 2018 Mar;83(3):580-588.
28. Holbourn A, Hurdman J. Kombucha: is a cup of tea good for you? BMJ Case Rep. 2017 Dec 2;2017.
29. SungHee Kole A, Jones HD, Christensen R, Gladstein J. A case of Kombucha tea toxicity. J Intensive Care Med. 2009 May-Jun;24(3):205-7.
30. Srinivasan R, Smolinske S, Greenbaum D. Probable gastrointestinal toxicity of  Kombucha tea: is this beverage healthy or harmful? J Gen Intern Med. 1997 Oct;12(10):643-4.
31. Egger GJ, Binns AF, Rossner SR. The emergence of “lifestyle medicine” as a structured approach for management of chronic disease. Med J Aust. 2009 Feb 2;190(3):143-5.
32. Murtaza N, Ó Cuív P, Morrison M. Diet and the Microbiome. Gastroenterol Clin North Am. 2017 Mar;46(1):49-60.
33. Prescott SL, Wegienka G, Logan AC, Katz DL. Dysbiotic drift and biopsychosocial medicine: how the microbiome links personal, public and planetary health. Biopsychosoc Med. 2018 May 3;12:7.

 

MICROBIOME

Duranti et al. Obesity and Microbiota and example of an intricate relationship, Genes & Nutrition (2017)

Foster et al., Stress & the gut-brain axis: Regulation by the microbiome, Neurobiology of Stress, (2017)

Harper et al., The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome, Foods (2018)

Lin et al., Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms, PLoS One (2012).

Healey et al., Interindividual variability in gut microbiota and host response to dietary interventions, Emerging Science, (2017).

Nagpal et al., Gut microbiome and aging: Physiological and mechanistic insights, Nutrition and Healthy Aging (2018).

O’Sullivan et al., Exercise and the microbiota, Gut Microbes, (2015).
Rajilić-Stojanović, Vos, The first 1000 cultured species of the human gastrointestinal microbiota, FEMS Microbiology Reviews, (2014).

Spector, et al., Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women, Scientific Report, (2017).

Toribio-Mateas, M., Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions, Microorganisms, (2018).

Valdes et al., Role of the gut microbiota in nutrition and health, BMJ, (2018).

PROBIOTICS RESEARCH

Catherine R. Lammert, Elizabeth L. Frost, Ashley C. Bolte, Matt J. Paysour, Mariah E. Shaw, Calli E. Bellinger, Thaddeus K. Weigel, Eli R. Zunder, John R. Lukens. Cutting Edge: Critical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of Autism. The Journal of Immunology, 2018; ji1701755 DOI: 10.4049/jimmunol.1701755.

Anna G. Nilsson, Daniel Sundh, Fredrik Bäckhed, Mattias Lorentzon. Lactobacillus reuteri reduces bone loss in older women with low bone mineral density – a randomized, placebo-controlled, double-blind, clinical trial. Journal of Internal Medicine, 2018; DOI: 10.1111/joim.12805

Rick Kapur, Michael Kim, Johan Rebetz, Björn Hallström, Jonas T. Björkman, Alisa Takabe-French, Noel Kim, Jonathan Liu, Shanjeevan Shanmugabhavananthan, Stefan Milosevic, Mark J. McVey, Edwin R. Speck, John W. Semple. Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury. Blood Advances, 2018; 2 (13): 1651 DOI: 10.1182/bloodadvances.2018018903

Annabelle M. Watts, Amanda J. Cox, Peter K. Smith, Isolde Besseling-van der Vaart, Allan W. Cripps, and Nicholas P. West. The Journal of Alternative and Complementary Medicine. Aug 2018, ahead of print: http://doi.org/10.1089/acm.2017.0342.

SIBO
Satish S. C. Rao, Abdul Rehman, Siegfried Yu, Nicole Martinez de Andino. Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. Clinical and Translational Gastroenterology, 2018; 9 (6) DOI: 10.1038/s41424-018-0030-7.

Am J Gastroenterol. 2003 Feb;98 (2):412-9. Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study. Pimentel M, Chow EJ, Lin HC.

Chedid V, Dhalla S, Clarke JO, et al. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Global Adv Health Med. 2014;3(3):16-24.

RESEARCH
Cindy W Leung, Teresa T Fung, Claire T McEvoy, Jue Lin, Elissa S Epel. Diet Quality Indices and Leukocyte Telomere Length among Healthy US Adults: Data from the National Health and Nutrition Examination Surveys (NHANES) 1999-2002. American Journal of Epidemiology, 2018; DOI: 10.1093/aje/kwy124.

Pre-Exercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men. American Journal of Physiology-Endocrinology and Metabolism, 2018; DOI: 10.1152/ajpendo.00163.2018

The relationship between adiposity and cognitive function in a large community-dwelling population: data from the Trinity Ulster Department of Agriculture (TUDA) ageing cohort study. British Journal of Nutrition, 2018: https://doi.org/10.1017/S0007114518001848.

Dementia
Kennedy KM, Rodrigue KM, Devous MD Sr, Hebrank AC, Bischof GN, Park DC. Effects of beta-amyloid accumulation on neural function during encoding across the adult lifespan. Neuroimage. 2012 Aug 1;62(1):1-8. Epub 2012 May 1 PubMed.

Bischof GN, Rodrigue KM, Kennedy KM, Devous MD Sr, Park DC. Amyloid deposition in younger adults is linked to episodic memory performance. Neurology. 2016 Dec 13;87(24):2562-2566. Epub 2016 Nov 11 PubMed.

Farrell ME, Kennedy KM, Rodrigue KM, Wig G, Bischof GN, Rieck JR, Chen X, Festini SB, Devous MD Sr, Park DC.Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults: Evidence for a Dose-Response Relationship. JAMA Neurol. 2017 Jul 1;74(7):830-838. PubMed.

Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N, Sullivan C, Maye JE, Gidicsin C, Pepin LC, Sperling RA, Johnson KA, Rentz DM. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 2012 Oct;50(12):2880-6. PubMed.

Phylogeny-corrected identification of microbial gene families relevant to human gut colonization. PLOS Computational Biology, August 9, 2018: https://doi.org/10.1371/journal.pcbi.1006242

A Phenome-Wide Association Study Uncovers a Role for Autoimmunity in the Development of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology, 2018; 58 (6): 777 DOI: 10.1165/rcmb.2017-0409LE

Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery. Cell Metabolism, 2018,

Published: August 02: https://doi.org/10.1016/j.cmet.2018.07.003.

WELCOME

Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers

JAMA Oncol. Published online July 19, 2018. doi:10.1001/jamaoncol.2018.2487

Am J Orthop (Belle Mead NJ). 2011 May;40(5):E92-5.

Underreporting of complementary and alternative medicine use among arthritis patients in an orthopedic clinic.

NEWS

Jahnabi Roy et al. Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides, Journal of Medicinal Chemistry (2018). DOI: 10.1021/acs.jmedchem.8b00243

Gut Microbiota Composition is Related to Cardiorespiratory Fitness in Healthy Young Adults. International Journal of Sport Nutrition and Exercise Metabolism, 2018; 1 DOI: 10.1123/ijsnem.2018-0024

Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA). British Journal of Nutrition, 2018; 120 (01): 111 DOI: 10.1017/S0007114518001356.

Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality. BMJ Open, 8:6. http://dx.doi.org/10.1136/bmjopen-2017-021161.

Long-Term Acupuncture Therapy for Low-Income Older Adults with Multimorbidity: A Qualitative Study of Patient Perceptions.

J Altern Complement Med. 2018 Feb;24(2):161-167. doi: 10.1089/acm.2017.0239. Epub 2017 Oct 23.

SIMON MILLS

Bower MR, Aiyer HS, Li Y, Martin RCG (2010) Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids. World J Gastroenterol vol 16, no 33, pp 4152-4158

Camilleri M (2015) Bile Acid Diarrhea: Prevalence, Pathogenesis, and Therapy. Gut Liver. 2015 May; 9(3): 332–339

Camilleri M (2014) Physiological underpinnings of irritable bowel syndrome: neurohormonal mechanisms. J Physiol. vol 592, Pt 14, pp 2967–2980

Cavaleri, F (2018) Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. International Journal of Inflammation. Article ID 5023429, 18 pages.

Cho JA. Park E (2015) Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion. Nutrition Research and Practice vol 9, no 2, pp 117-122

Dey N, Wagner VE, Blanton LV (2015) Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to traveling. Cell vol 163, no 1, pp 95-107

Ghosh SS, Gehr TWB, Ghosh S (2014) Curcumin and Chronic Kidney Disease (CKD): Major Mode of Action through Stimulating Endogenous Intestinal Alkaline Phosphatase. Molecules vol 19, 20139-20156; doi:10.3390/molecules191220139

Gilani AH, Shah AJ, Ghayur MN, Majeed K (2005) Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sciences vol 76 pp 3089–3105

Hucklenbroich J Klein R, Neumaier B et al (2014). Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Research & Therapy vol 5, p 100.  http://stemcellres.com/content/5/4/100

Kashyap P (2015) Eat your curry Cell Host Microbe. vol 18, no 4, pp 385-387

Lopresti, A (2018) The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? Adv Nutr vol 9, pp 41–50

Marciani L, Cox EF, Hoad CL et al (2013). Effects of various food ingredients on gall bladder emptying. Eur J Clin Nutr. vol 11, pp 1182-7.

Martelli L, Ragazzi E, Di Mario F et al (2007) Potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. Neurogastroenterol Motil vol 19, pp 668–674

McFadden RM, Larmonier CB, Shehab KW, et al. (2015) The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis. Vol 21, pp 2483–94

Orellana-Paucar AM, Afrikanova T, Thomas J, et al: Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS One 2013, 8:e81634

Park SY^a, Jin ML, Kim YH et al (2012) Anti-inflammatory effects of aromatic-turmerone through blocking of NF-κB, JNK, and p38 MAPK signaling pathways in amyloid β-stimulated microglia. International Immunopharmacology vol 14, pp 13–20

Park SY^b, Kim YH, Kim Y, Lee S-J (2012) Aromatic-turmerone’s anti-inflammatory effects in microglial cells are mediated by protein kinase A and heme oxygenase-1 signaling. Neurochemistry International vol 61 pp 767–777

Patcharatrakul P, Gonlachanvit S (2016) Chili Peppers, Curcumins, and Prebiotics in Gastrointestinal Health and Disease. Curr Gastroenterol Rep vol 18, no 19

Pole, S (2103) Ayurvedic Medicine: the principals of traditional practice. Churchill Livingstone, Elsevier, London and Philadelphia. pp 282-83

Rasyid A, Rahman AR, Jaalam K, Lelo A (2002) Effect of different curcumin dosages on human gall bladder. Asia Pac J Clin Nutr. vol 11, no 4, pp 314-8

Schneider A^, Hossain I, Van der Molen J, Nicol K (2017) Comparison of remicade to curcumin for the treatment of Crohn’s disease: A systematic review. Complementary Therapies in Medicine vol 33, pp 32-38

Shen L, Ji HF. (2012) The pharmacology of curcumin: is it the degradation products? Trends Mol Med. vol 18, no 3, pp 138-44

Shen L, Liu L, Ji HF. (2017) Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications. Food Nutr Res. vol 61, no 1, 1361780

Shimouchi A, Nose K, Takaoka M, et al. (2009) Effect of dietary turmeric on breath hydrogen. Dig Dis Sci. vol 54, no 8, pp 1725-9

Shin A, Camilleri M, Vijayvargiya P et al (2013) Bowel Functions, Fecal Unconjugated Primary and Secondary Bile Acids, and Colonic Transit in Patients with Irritable Bowel Syndrome. Clin Gastroenterol Hepatol. vol 11, no 10, pp 1270–1275

Sreedhar R, Arumugam S, Thandavarayan RA, et al (2016) Curcumin as a therapeutic agent in the chemoprevention of inflammatory bowel disease. Drug Discovery Today vol 21, no 5, pp 843-849

Wang Y, Wang L, Zhu X et al (2016) Choleretic Activity of Turmeric and its Active Ingredients. Journal of Food Science vol 81, No 7, pp 1800-06

Yu Y, Wu S, Li J et al (2015) The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signalling. Metab Brain Dis vol 30, pp 47–55

Yue G G-L, Kwok H-F, Julia Kin-Ming Lee J K-M, Jiang L (2015) Novel anti-angiogenic effects of aromatic turmerone, essential oil isolated from spice turmeric. Journal of Functional Foods vol 15, pp 243–253

BREDESEN

Reversal of cognitive decline: A novel therapeutic program

Dale E. Bredesen. Aging (Albany NY). 2014 Sep; 6(9): 707–717.

Published online 2014 Sep 27. doi:  10.18632/aging.100690.

Brain training: https://www.brainhq.com.

Dr Ritchie Shoemaker (author of Surviving Mold): https://www.survivingmold.com.

Cyrex 2 and 3: available in the UK from Regenerus: http://regeneruslabs.com/page/cyrex.

HEART HEALTH
Joonseok Kim, Jaehyoung Choi, Soo Young Kwon, John W. McEvoy, Michael J. Blaha, Roger S. Blumenthal, Eliseo Guallar, Di Zhao, Erin D. Michos. Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease. Circulation: Cardiovascular Quality and Outcomes, 2018; 11 (7): e004224 DOI: 10.1161/CIRCOUTCOMES.117.004224

Supplemental Vitamins and Minerals for CVD Prevention and Treatment. Journal of the American College of Cardiology, 2018; 71 (22): 2570 DOI: 10.1016/j.jacc.2018.04.020

Roberto Sansone, Ana Rodriguez-Mateos, Jan Heuel, David Falk, Dominik Schuler, Rabea Wagstaff, Gunter G. C. Kuhnle, Jeremy P. E. Spencer, Hagen Schroeter, Marc W. Merx, Malte Kelm, Christian Heiss. Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study. British Journal of Nutrition, 2015; 1 DOI: 10.1017/S0007114515002822.

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. BMJ Open Heart, 2018, 5:1. http://dx.doi.org/10.1136/openhrt-2017-000668.

25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population. Archives of Internal Medicine, 2008; 168 (15): 1629 DOI: 10.1001/archinte.168.15.1629

Zwakenberg SR, den Braver NR, Engelen AIP, Feskens, EJM, Vermeer C, Boer JMA, Verschuren WMM, van der Schouw YT, Beulens JWJ. Vitamin K intake and all-cause and cause specific mortality. Clinical Nutrition. 2016 Aug 30. Pii: S0261-5614(16)30216-3. 15-20. DOI: 10.1016/j.clnu.2016.08.017.

Knapen MH et al, Braam LAJL, Drummen NE, Bekers O, Hoeks APG, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomised clinical trial. Thrombosis and Haemostasis. 2015 113 5: 1135-1144. doi: 10.1160/TH14-08-0675.

Br J Nutr. 2012 May;107(10):1505-13. doi: 10.1017/S0007114511004703. Epub 2011 Nov 9. Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults.

Eur J Clin Nutr. 2012 Nov;66(11):1234-41. doi: 10.1038/ejcn.2012.126. Epub 2012 Sep 19. Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial.

Exp Diabetes Res. 2012;2012:902917. doi: 10.1155/2012/902917. Epub 2012 May 3.

Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases.

J Clin Endocrinol Metab. 2013 Jul;98(7):2944-51. doi: 10.1210/jc.2012-4262. Epub 2013 Apr 22. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial

Ann N Y Acad Sci. 2011 Jan;1215:22-33. doi: 10.1111/j.1749-6632.2010.05843.x.

Resveratrol in cardiovascular health and disease.

Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.

Cardiovascular protective effects of resveratrol.

 

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. Ann Intern Med 2009;151(4):264-269.

DOI: 10.7326/0003-4819-151-4-200908180-00135

IN PRACTICE

Emma Lane on Blastocystis hominis: full article with references at https://www.integrativehealth.co.uk/parasites-and-ibs.

LAB TEST

1. Gulati, P., & Yeo, G. S. H. (2013). The biology of FTO: from nucleic acid demethylase to amino acid sensor. Diabetologia, 56(10), 2113–2121. http://doi.org/10.1007/s00125-013-2999-5
2. Kilpeläinen, T. O., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., … Loos, R. J. F. (2011). Physical Activity Attenuates the Influence of FTOVariants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Medicine, 8(11), e1001116. http://doi.org/10.1371/journal.pmed.1001116
3. Huang, T., Qi, Q., Li, Y., Hu, F. B., Bray, G. A., Sacks, F. M., … Qi, L. (2014). FTOgenotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. The American Journal of Clinical Nutrition, 99(5), 1126–1130. http://doi.org/10.3945/ajcn.113.082164
4. Yang, X., Yin, L., Li, T., & Chen, Z. (2014). Green tea extracts reduce adipogenesis by decreasing expression of transcription factors C/EBPα and PPARγ. International Journal of Clinical and Experimental Medicine, 7(12), 4906–4914.
5. Wei Ren, Jianjin Guo, Feng Jiang, et al., 2014 “CCAAT/Enhancer-Binding Protein αIs a Crucial Regulator of Human Fat Mass and Obesity Associated Gene Transcription and Expression,” BioMed Research International, vol. 2014, https://doi.org/10.1155/2014/406909.
6. Loos, R. J. F., Lindgren, C. M., Li, S., Wheeler, E., Zhao, J. H., Prokopenko, I., … Mohlke, K. L. (2008). Common variants near MC4Rare associated with fat mass, weight and risk of obesity. Nature Genetics, 40(6), 768–775. http://doi.org/10.1038/ng.140
7. Goni, L., García-Granero, M., Milagro, F. I., Cuervo, M., & Martínez, J. A. (2018). Phenotype and genotype predictors of BMI variability among European adults. Nutrition & Diabetes, 8, 27. http://doi.org/10.1038/s41387-018-0041-1
8. Tao, Y.-X. (2010). The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology. Endocrine Reviews, 31(4), 506–543. http://doi.org/10.1210/er.2009-0037
9. Klaauw, A. A., Keogh, J. M., Henning, E., Stephenson, C., Kelway, S., Trowse, V. M., . . . Farooqi, I. S. (2016). Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Communications, 7, 13055. doi:10.1038/ncomms13055
10. Meal Frequencies Modify the Effect of Common Genetic Variants on Body Mass Index in Adolescents of the Northern Finland Birth Cohort 1986
    Jääskeläinen A, Schwab U, Kolehmainen M, Kaakinen M, Savolainen MJ, et al. (2013) https://dx.doi.org/10.1371%2Fjournal.pone.0073802
11. McDaniel, F. K., Molden, B. M., Mohammad, S., Baldini, G., McPike, L., Narducci, P., … Baldini, G. (2012). Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH). The Journal of Biological Chemistry, 287(26), 21873–21890. http://doi.org/10.1074/jbc.M112.346890
12. Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior
    Horstmann A, Kovacs P, Kabisch S, Boettcher Y, Schloegl H, et al. (2013) Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior.PLOS ONE 8(9): e73802. https://doi.org/10.1371/journal.pone.0073802

 

Fecal Gluten Peptides Reveal Limitations of Serological Tests and Food Questionnaires for Monitoring Gluten-Free Diet in Celiac Disease Patients

The American Journal of Gastroenterology, volume111,1456–65 (2016).

Comparison of Clinical Methods with the Faecal Gluten Immunogenic Peptide to Assess Gluten Intake in Coeliac Disease. Gerasimidis, Konstantinos et al.

Journal of Pediatric Gastroenterology and Nutrition: June 18, 2018 – Volume Publish Ahead of Print. doi: 10.1097/MPG.0000000000002062.

Curr Med Res Opin. 2012 Nov;28(11):1819-30. doi: 10.1185/03007995.2012.742878.

Coronary risk assessment among intermediate risk patients using a clinical and biomarker based algorithm developed and validated in two population cohorts.

RESEARCH
Amaia Arranz-Otaegui, Lara Gonzalez Carretero, Monica N. Ramsey, Dorian Q. Fuller, Tobias Richter. Archaeobotanical evidence reveals the origins of bread 14,400 years ago in northeastern Jordan. Proceedings of the National Academy of Sciences, 2018; 201801071 DOI: 10.1073/pnas.1801071115.

Eur J Clin Nutr. 2003 Oct;57(10):1254-61.

Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing.

J Gen Intern Med. 2018 Jul;33(7):1131-1138. doi: 10.1007/s11606-018-4377-y. Epub 2018 Mar 5.

Underdiagnosis of Dementia: an Observational Study of Patterns in Diagnosis and Awareness in US Older Adults

Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality. Gut, 2018; gutjnl-2018-316483 DOI: 10.1136/gutjnl-2018-316483

Uri Ladabaum. Occult blood in faeces: a window into health beyond the colorectum? Gut, 2018; gutjnl-2018-316762 DOI: 10.1136/gutjnl-2018-316762

Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States. PLOS ONE, 2018; 13 (7): e0199644 DOI: 10.1371/journal.pone.0199644

Dietary flavonoids and the prevalence and 15-y incidence of age-related macular degeneration. American Journal of Clinical Nutrition, 2018 DOI: 10.1093/ajcn/nqy114

Effects of an Antioxidant-enriched Multivitamin in Cystic Fibrosis: Randomized, Controlled, Multicenter Trial. American Journal of Respiratory and Critical Care Medicine, 2018; DOI: 10.1164/rccm.201801-0105OC

NEWS

Ishaque SM, Khosruzzaman SM, Ahmed DS, Sah MP. A randomized placebo-controlled clinical trial of a multi-strain probiotic formulation (Bio-Kult®) in the management of diarrhea-predominant irritable bowel syndrome. BMC
Gastroenterol 2018;18(1):71.

Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. JNCI: Journal of the National Cancer Institute, 2018; DOI: 10.1093/jnci/djy087

Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study. Nutrition and Healthy Aging, 2018; 4 (4): 345 DOI: 10.3233/NHA-170036

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114. Parra MD, Martínez de Morentin BE, Alfredo Martínez J. Impact of weight loss on cortisol secretion in obese men with and without metabolic syndrome features. Nutr Metab Cardiovasc Dis. 2006 Jan;16(1):28-34.
115. García-Prieto MD, Tébar FJ, Nicolás F, Larqué E, Zamora S, Garaulet M. Cortisol secretary pattern and glucocorticoid feedback sensitivity in women from a Mediterranean area: relationship with anthropometric characteristics, dietary intake and plasma fatty acid profile. Clin Endocrinol (Oxf). 2007 Feb;66(2):185-91.
116. Opie RS, Itsiopoulos C, Parletta N, Sanchez-Villegas A, Akbaraly TN, Ruusunen A, Jacka FN. Dietary recommendations for the prevention of depression. Nutr Neurosci. 2017 Apr;20(3):161-171.
117. García-Toro M, Vicens-Pons E, Gili M, Roca M, Serrano-Ripoll MJ, Vives M, Leiva A, Yáñez AM, Bennasar-Veny M, Oliván-Blázquez B. Obesity, metabolic syndrome and Mediterranean diet: Impact on depression outcome. J Affect Disord. 2016 Apr;194:105-8.
118. de Melo LGP, Nunes SOV, Anderson G, Vargas HO, Barbosa DS, Galecki P, Carvalho AF, Maes M. Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Aug 1;78:34-50.
119. Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905.
120. Huang CW, Chien YS, Chen YJ, Ajuwon KM, Mersmann HM, Ding ST. Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans. Int J Mol Sci. 2016 Oct 9;17(10).
121. Barbadoro P, Annino I, Ponzio E, Romanelli RM, D’Errico MM, Prospero E, Minelli A. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr Food Res. 2013 Jun;57(6):1110-4.
122. Simopoulos AP. Dietary omega-3 fatty acid deficiency and high fructose intake in the development of metabolic syndrome, brain metabolic abnormalities, and non-alcoholic fatty liver disease. Nutrients. 2013 Jul 26;5(8):2901-23.
123. Mazaherioun M, Saedisomeolia A, Javanbakht MH, Koohdani F, Zarei M, Ansari S, Khoshkhoo Bazargani F, Djalali M. Long Chain n-3 Fatty Acids Improve Depression Syndrome in Type 2 Diabetes Mellitus. Iran J Public Health. 2018 Apr;47(4):575-583.
124. Shishtar E, Sievenpiper JL, Djedovic V, Cozma AI, Ha V, Jayalath VH, Jenkins DJ, Meija SB, de Souza RJ, Jovanovski E, Vuksan V. The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials. PLoS One. 2014 Sep 29;9(9):e107391.
125. Lee HW, Lim HJ, Jun JH, Choi J, Lee MS. Ginseng for Treating Hypertension: A Systematic Review and Meta-Analysis of Double Blind, Randomized, Placebo-Controlled Trials. Curr Vasc Pharmacol. 2017;15(6):549-556.
126. Jung DH, Lee YJ, Kim CB, Kim JY, Shin SH, Park JK. Effects of ginseng on peripheral blood mitochondrial DNA copy number and hormones in men with metabolic syndrome: A randomized clinical and pilot study. Complement Ther Med. 2016 Feb;24:40-6.
127. Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec;20(12):901-8.
128. Choudhary D, Bhattacharyya S, Joshi K. Bodyweight management in adults under chronic stress through treatment with Ashwagandha root extract: a double blind randomized, placebo controlled trial. J Evid based complementary altern med. 2017;22:96–106.

LEARNING ZONE
affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Journal of Affective Disorders, May 2018, 232, 349–357.

KERRY BONE

1. Akhondzaheh S, Tahmacebi-Pour N, Noorbala AA et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005; 19(2): 148-151.
2. Moshiri E, Basti AA, Noorbala AA et al. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine 2006; 13(9-10): 607-611.
3. Akhondzadeh S, Fallah-Pour H, Afkham K et al. Comparison of Crocus sativus L and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med 2004; 4: 12.
4. Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N et al. Hydro-alcoholic extract of Crocus sativus L versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol 2005; 97(2): 281-284
5. Akhondzadeh Basti A, Moshiri E, Noorbala AA et al. Comparison of petal of Crocus sativus L and fluoxetine in the treatment of depressed outpatients: a pilot double-blind randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 439-442
6. Modabbernia A, Sohrabi H, Nasehi AA et al. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl) 2012; 223(4): 381-388
7. Kashani L, Raisi F, Saroukhani S et al. Saffron for treatment of fluoxetine-induced sexual dysfunction in women: randomized double-blind placebo-controlled study. Hum Psychopharmacol 2012 [Epub ahead of print]
8. Lechtenberg M, Schepmann D, Niehues M et al. Quality and functionality of saffron: quality control, species assortment and affinity of extract and isolated saffron compounds to NMDA and sigma1 (sigma-1) receptors. Planta Med 2008; 74(7): 764-772
9. Berger F, Hensel A, Nieber K. Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience 2011; 180: 238-247
10. Hosseinzadeh H, Sadeghnia HR. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 2007; 14(4): 256-26.
11. Sadeghnia HR, Cortez MA, Liu D et al. Antiabsence effects of safranal in acute experimental seizure models: EEG and autoradiography. J Pharm Pharm Sci 2008; 11(3): 1-14.

12. Akhondzadeh S, Shafiee Sabet M, Harirchian MH et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology (Berl) 2010; 207(4): 637-643
13. Akhondzadeh S, Sabet MS, Harirchian MH et al. Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo- controlled trial. J Clin Pharm Ther 2010; 35(5): 581-588
14. Agha-Hosseini M, Kashani L, Aleyaseen A et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo- controlled trial. BJOG 2008; 115(4):
515-519

15. Nahid K, Fariborz M, Ataolah G et al. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 2009; 54(5):
401-404.
16. Gout B, Bourges C, Paineau-Dubreuil S. Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study
of mildly overweight, healthy women. Nutr Res. 2010 May;30(5):305-13. doi: 10.1016/j.nutres.2010.04.008.
17. Falsini B, Piccardi M, Minnella A et al. Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration. Invest Ophthalmol Vis Sci 2010; 51(12): 6118-6124
18. Professor Silvia Bisti. Researchers strike gold – saffron found to help vision loss in elderly. The University of Sydney News, 5 February 2010. http://sydney.edu. au/news/84.html?newsstoryid=4452. Accessed January 2013.
19. Piccardi M, Marangoni D, Minnella AM et al. A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function. Evid Based Complement Alternat Med 2012; 2012: 429124

NEW RELEASES

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nature Immunology, 2016; DOI: 10.1038/ni.3345

GUT HEALTH

Miguel’s food challenge:
Pdf: https://www.dropbox.com/s/s9ngpw95o5r3kwb/50%20foods.pdf?dl=0
Powerpoint: https://www.dropbox.com/s/wfnl4hmwcx820qp/50%20foods.pptx?dl=0

Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions
by Miguel Toribio-Mateas. Microorganisms 2018, 6(2), 35; https://doi.org/10.3390/microorganisms6020035.

American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018 May 15;3(3). pii: e00031-18. doi: 10.1128/mSystems.00031-18. eCollection 2018 May-Jun.

Martin, C. M. and Felix-Bortolotti, M. (2010) ‘W(h)ither complexity? The emperor’s new toolkit? Or elucidating the evolution of health systems knowledge?’, J Eval Clin
Pract, 16(3), pp. 415-20.

Daniel McDonald et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems, 2018; 3 (3): e00031-18 DOI: 10.1128/mSystems.00031-18

Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth.
Probiotics Antimicrob Proteins. 2018 Mar 5. doi: 10.1007/s12602-018-9401-3. [Epub ahead of print]

RESEARCH

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine. PLOS Biology, 2018; 16 (6): e2004408 DOI: 10.1371/journal.pbio.2004408

Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus. Neuron, 2018; DOI: 10.1016/j.neuron.2018.05.023

NEWS

Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults. Neurology. Online April 13, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005527.

Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area. BMJ Open. 2018 Mar 23;8(3):e019362. doi: 10.1136/bmjopen-2017-019362.

Counting the Cost: http://www.meassociation.org.uk/wp-content/uploads/2020Health-Counting-the-Cost-Sept-2017.pdf.

Bernie Sanders opioid bill: https://www.sanders.senate.gov/newsroom/recent-business/sanders-introduces-legislation-to-hold-opioid-makers-accountable-.

BEN BROWN – IBD interventions

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8. Baumgart DC, Sandborn WJ. Crohn’s disease. Lancet. 2012 Nov 3;380(9853):1590-605
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22. Chiba M, Abe T, Tsuda H, et al. Lifestyle-related disease in Crohn’s disease: relapse prevention by a semi-vegetarian diet. World J Gastroenterol. 2010 May 28;16(20):2484-95.
23. Chiba M, Tsuda S, Komatsu M, Tozawa H, Takayama Y. Onset of Ulcerative Colitis during a Low-Carbohydrate Weight-Loss Diet and Treatment with a Plant-Based Diet: A Case Report. Perm J. 2016 Winter;20(1):80-4.
24. Chiba M, Tsuji T, Nakane K, Tsuda S, Ishii H, Ohno H, Watanabe K, Ito M, Komatsu M, Sugawara T. Induction with Infliximab and a Plant-Based Diet as First-Line (IPF) Therapy for Crohn Disease: A Single-Group Trial. Perm J. 2017;21.
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26. Mutlu EA, Susan Mikolaitis S, Sedghi S, et al. Dietary treatment of Crohn’s disease: a randomized, placebo-controlled, double-blinded clinical trial. Am J Gastroenterol 2016;150(4 Supplement 1):S778.
27. Konijeti GG, Kim N, Lewis JD, et al. Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017  Nov;23(11):2054-2060.
28. Hunter J. Elemental diet and the nutritional treatment of Crohn’s disease. Gastroenterol Hepatol Bed Bench. 2015 Winter;8(1):4-5
29. Riordan AM, et al. Treatment of active Crohn’s disease by exclusion diet: East Anglian multicentre controlled trial. Lancet. 1993 Nov 6;342(8880):1131-4.
30. Cai C, et al. Serological investigation of food specific immunoglobulin G antibodies in patients with inflammatory bowel diseases. PLoS One. 2014 Nov 13;9(11):e112154.
31. Kawaguchi T, Mori M, Saito K, Suga Y, Hashimoto M, Sako M, Yoshimura N, Uo M,  Danjo K, Ikenoue Y, Oomura K, Shinozaki J, Mitsui A, Kajiura T, Suzuki M, Takazoe M. Food antigen-induced immune responses in Crohn’s disease patients and experimental colitis mice. J Gastroenterol. 2015 Apr;50(4):394-405.
32. Bentz S, et al. Clinical relevance of IgG antibodies against food antigens in Crohn’s disease: a double-blind cross-over diet intervention study. Digestion. 2010;81(4):252-64
33. Rajendran N, Kumar D. Food-specific IgG4-guided exclusion diets improve symptoms in Crohn’s disease: a pilot study. Colorectal Dis. 2011 Sep;13(9):1009-13.
34. Gunasekeera V, Mendall MA, Chan D, Kumar D. Treatment of Crohn’s Disease with an IgG4-Guided Exclusion Diet: A Randomized Controlled Trial. Dig Dis Sci. 2016 Apr;61(4):1148-57.
35. Wang G, Ren J, Li G, Hu Q, Gu G, Ren H, Hong Z, Li J. The utility of food antigen test in the diagnosis of Crohn’s disease and remission maintenance after  exclusive enteral nutrition. Clin Res Hepatol Gastroenterol. 2018 Apr;42(2):145-152.
36. Aziz I, Branchi F, Pearson K, Priest J, Sanders DS. A study evaluating the bidirectional relationship between inflammatory bowel disease and self-reported non-celiac gluten sensitivity. Inflamm Bowel Dis. 2015 Apr;21(4):847-53.
37. Carroccio A, D’Alcamo A, Cavataio F, Soresi M, Seidita A, Sciumè C, Geraci G,  Iacono G, Mansueto P. High Proportions of People With Nonceliac Wheat Sensitivity Have Autoimmune Disease or Antinuclear Antibodies. Gastroenterology. 2015 Sep;149(3):596-603.e1.
38. Rostami-Nejad M, et al. Gluten-free Diet for Refractory Inflammatory Bowel Disease; A Case Report. International Journal of Celiac Disease. 2017, 5(4), 168-170. DOI: 10.12691/ijcd-5-4-4.
39. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmune Rev. 2015 Jun;14(6):479-89.
40. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
41. Swidsinski A, Ung V, Sydora BC, et al. Bacterial overgrowth and inflammation of small intestine after carboxymethyl cellulose ingestion in genetically susceptible mice. Inflamm Bowel Dis 2009;15(3):359–64.
42. Roberts CL, Keita AV, Duncan SH, et al. Translocation of Crohn’s disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers. Gut 2010;59:1331–9.
43. Martino JV, Van Limbergen J, Cahill LE. The role of carrageenan and carboxymethyl cellulose in the development of intestinal inflammation. Front Pediatr 2017;(5):96.
44. Martino JV, Van Limbergen J, Cahill LE. The Role of Carrageenan and Carboxymethylcellulose in the Development of Intestinal Inflammation. Front Pediatr. 2017 May 1;5:96.
45. Rodriguez-Palacios A, Harding A, Menghini P, et al. The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease-Like Ileitis. Inflamm Bowel Dis. 2018 Mar 15. doi: 10.1093/ibd/izy060. [Epub ahead of  print]
46. Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017 Jun 8;12(6):e0178426.
47. Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 May 1. pii: S0278-6915(17)30223-5.
48. Nickerson KP, et al. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-8
49. Ruiz PA, Morón B, Becker HM, et al. Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3  inflammasome. Gut. 2017 Jul;66(7):1216-1224.
50. Lerner A, Aminov R, Matthias T. Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity. Front Microbiol. 2017 Jan 24;8:66.
51. Bhattacharyya S, Shumard T, Xie H, Dodda A, Varady KA, Feferman L, Halline AG, Goldstein JL, Hanauer SB, Tobacman JK. A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity. Nutr Healthy Aging. 2017 Mar 31;4(2):181-192.
52. Lomer MCE, Harvey RSJ, Evans SM, Thompson RPH, Powell JJ. Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn’s disease. Eur J Gastroenterol Hepatol 2001; 13:101–106.
53. Lomer MC, Grainger SL, Ede R, et al. Lack of efficacy of a reduced microparticle diet in a multi-centred trial of patients with active Crohn’s disease. Eur J Gastroenterol Hepatol. 2005  Mar;17(3):377-84.
54. Powell JJ, Thoree V, Pele LC. Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract. Br J Nutr. 2007 Oct;98 Suppl 1:S59-63.
55. Nickerson KP, Chanin R, McDonald C. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-83.
56. Nickerson KP, Chanin R, McDonald C. Deregulation of intestinal anti-microbial  defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-83.
57. Nickerson KP, Homer CR, Kessler SP, et al. The dietary polysaccharide maltodextrin promotes Salmonella survival and mucosal colonization in mice. PLoS One. 2014 Jul 7;9(7):e101789.
58. Nickerson KP, McDonald C. Crohn’s disease-associated adherent-invasive Escherichia coli adhesion is enhanced by exposure to the ubiquitous dietary polysaccharide maltodextrin. PLoS One. 2012;7(12):e52132.
59. Bartel G, et al. Ingested matter affects intestinal lesions in Crohn’s disease. Inflamm Bowel Dis. 2008 Mar;14(3):374-82.
60. HAAS SV, HAAS MP. The treatment of celiac disease with the specific carbohydrate diet; report on 191 additional cases. Am J Gastroenterol. 1955 Apr;23(4):344-60.
61. Gottschall E. Breaking the Vicious Cycle: Intestinal Health Through Diet. Baltimore, Canada: Kirkton Press; 1987
62. Walters SSQA, Rolston M. Analysis of gut microbiome and diet modification in patients with Crohn’s disease. SOJ Microbiol Infect Dis 2014;2:1–13.
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67. Khandalavala BN, Nirmalraj MC. Resolution of Severe Ulcerative Colitis with the Specific Carbohydrate Diet. Case Rep Gastroenterol. 2015 Aug 7;9(2):291-5.
68. Cohen SA, Gold BD, Oliva S, Lewis J, Stallworth A, Koch B, Eshee L, Mason D. Clinical and mucosal improvement with specific carbohydrate diet in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2014 Oct;59(4):516-21.

INFLAMMATION

1. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2014.131.
Bonkovsky also quoted in “When Green Tea Is a Bad Thing”, by Charlotte Hilton Andersen, SHAPE: https://www.shape.com/blogs/shape-your-life/when-green-tea-bad-thing.
2. Determination of Catechin and Epicatechin Content in Chocolates by High-Performance Liquid Chromatography. Int Sch Res Notices. 2014; 2014: 628196. Published online 2014 Oct 28. doi:  10.1155/2014/628196.

3. Green Tea Catechins and Cardiovascular Health: An Update. Curr Med Chem. 2008; 15(18): 1840–1850. Pon Velayutham, Anandh Babu, and Dongmin Liu.
4. Suppressive Effects of Tea Catechins on Breast Cancer. Nutrients. 2016 Aug; 8(8): 458. Published online 2016 Jul 28. doi:  10.3390/nu8080458
5. Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats. PLoS One. 2013; 8(6): e65029.

Published online 2013 Jun 3. doi:  10.1371/journal.pone.0065029

Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet-Fed Rats. J Nutr. 2018 Feb 1;148(2):209-219. doi: 10.1093/jn/nxx027.

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity. Physiology & Behavior, 2017; 173: 305 DOI: 10.1016/j.physbeh.2017.02.027

Oral NaHCO₃ Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells. The Journal of Immunology, 2018; ji1701605 DOI: 10.4049/jimmunol.1701605

Calanus
Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr, 2013, doi: 10.3945/jn.113.182501.
Oil from the marine zooplankton Calanus finmarchicus improves the cardiometabolic phenotype of diet-induced obese mice. British Journal of Nutrition 2013, 110 (12): 2186-93.

Wax Esters from the Marine Copepod Calanus finmarchicus Reduce Diet-Induced Obesity and Obesity-Related Metabolic Disorders in Mice. J Nutr 2014, 144 (2): 164-169.

Extract from the Marine Copepod Calanus finmarchicus Attenuates Atherogenesis in Female Apolipoprotein E-Deficient Mice. J Nutr 2012, 142: 508-512.
Dietary and pharmacological anti-obesogenic treatments improve myocardial metabolism in diet-induced obese mice. Poster presented at 2017 Annual Scientific Sessions, Society for Heart and Vascular Metabolism. P2.11.

MUSHROOMS

1. Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. Michael D. Kalaras, John P. Richie, Ana Calcagnotto, Robert B. Beelman.  Food Chemistry, 2017; 233: 429 DOI: 10.1016/j.foodchem.2017.04.109
2. The Complexity of Fungal β-Glucan in Health and Disease: Effects on the Mononuclear Phagocyte System. Camilli G, Tabouret G, Quintin J. Front Immunol.2018 Apr 16;9:673. doi: 10.3389/fimmu.2018.00673. eCollection 2018.
3. Anti-inflammatory properties of the medicinal mushroom Cordyceps militaris might be related to its linear (1→3)-β-D-glucan. PLoS One.2014 Oct 17;9(10):e110266. doi: 10.1371/journal.pone.0110266. eCollection 2014.
   4. β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance. Cell, 2016; 167 (5): 1354 DOI: 10.1016/j.cell.2016.09.034
4. http://www.superbetaglucan.com.
5. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl.2016 Jul 13:1-13. [Epub ahead of print]
6. Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. Journal of Medicinal FoodVOL. 20, NO. 1 |

Published Online: 1 Jan 2017 https://doi.org/10.1089/jmf.2016.3740

8. Article online at MRL’s website: https://www.mycologyresearch.com/articles/link-between-herpes-simplex-virus-and-alzheimers-disease-potential-role-of-mushroom-nutrition-supplementation-in-prevention.

RESEARCH
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging. Cell Stem Cell, 2018; 22 (5): 769 DOI: 10.1016/j.stem.2018.04.001.

Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. Cell Metab. 2016 Apr 12;23(4):663-74. doi: 10.1016/j.cmet.2016.03.001. Epub 2016 Mar 31.

Natural polyphenols as sirtuin 6 modulators. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-22388-5.

Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients. American Journal of Hypertension, 2018; 31 (6): 735 DOI: 10.1093/ajh/hpy049.

Effect of a high-egg diet on cardiometabolic risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) Study—randomized weight-loss and follow-up phase.  American J of Clinical Nutrition, 2018; DOI: 10.1093/ajcn/nqy048

Microglial control of astrocytes in response to microbial metabolites. Nature, 2018; DOI: 10.1038/s41586-018-0119-x

The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Dig Liver Dis. 2017 Nov;49(11):1171-1176. doi: 10.1016/j.dld.2017.08.025. Epub 2017 Oct 4.

Vitamin D Switches BAF Complexes to Protect β Cells. Cell, 2018; DOI: 10.1016/j.cell.2018.04.013.

NEWS
JAMA Intern Med. 2018 Jan 1;178(1):17-26. doi: 10.1001/jamainternmed.2017.5038.

Association Between Pesticide Residue Intake From Consumption of Fruits and Vegetables and Pregnancy Outcomes Among Women Undergoing Infertility Treatment With Assisted Reproductive Technology.

Chiu YH^1,2, Williams PL^2,3, Gillman MW^4,5, Gaskins AJ^1,6, Mínguez-Alarcón L⁷, Souter I⁸, Toth TL⁸, Ford JB⁷, Hauser R^2,7,8, Chavarro JE^1,2,6; EARTH Study Team.

Hum Reprod. 2015 Jun;30(6):1342-51. doi: 10.1093/humrep/dev064. Epub 2015 Mar 30. Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic.

Chiu YH¹, Afeiche MC², Gaskins AJ³, Williams PL⁴, Petrozza JC⁵, Tanrikut C⁶, Hauser R⁷, Chavarro JE⁸.

CNN Exclusive: “The more opioids doctors prescribe, the more money they make”

Story by Aaron Kessler, Elizabeth Cohen and Katherine Grise. Updated 8:45 AM ET, Mon March 12, 2018: https://www.cnn.com/2018/03/11/health/prescription-opioid-payments-eprise/index.html.

Jonathan C Hill, David GT Whitehurst, Martyn Lewis, Stirling Bryan, Kate M Dunn, Nadine E Foster, Kika Konstantinou, Chris J Main, Elizabeth Mason, Simon Somerville, Gail Sowden, Kanchan Vohora, Elaine M Hay. Comparison of stratified primary care management for low back pain with current best practice (STarT Back): a randomised controlled trial. The Lancet, 2011; 378 (9802): 1560 DOI: 10.1016/S0140-6736(11)60937-9

What low back pain is and why we need to pay attention. Jan Hartvigsen, Mark J Hancock, Alice Kongsted, Quinette Louw, Manuela L Ferreira, Stéphane Genevay, Damian Hoy, Jaro Karppinen, Glenn Pransky, Joachim Sieper, Rob J Smeets, Martin Underwood on behalf of the Lancet Low Back Pain Series Working Group

The Lancet, March 21, 2018. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30480-X/fulltext.

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Tonatiuh Pena-Centeno, Gaurav Jain, Roman Manuel Stilling, Md Rezaul Islam, Vincenzo Capece, Qihui Zhou, Dieter Edbauer, Camin Dean, André Fischer. RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment. Cell Reports, 2018; 23 (2): 546 DOI: 10.1016/j.celrep.2018.03.059.

NEWS – CALORIE RESTRICTION

1. Redman, L.M., et al., Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metab, 2018. http://www.cell.com/cell-metabolism/pdf/S1550-4131(18)30130-X.pdf.
2. Williams, D.S., et al., Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell, 2009. 8(6): p. 765-8.
3. Edwards, C.B., et al., Malate and Fumarate Extend Lifespan in Caenorhabditis elegans. PLoS One, 2013. 8(3): p. e58345.
4. Nogueira, L., Acute Oxaloacetate Exposure Enhances Resistance to Fatigue in in vitro Mouse Soleus Muscle. FASEB Journal, 2011. 25(1104.5).

Christopher R. Martens, Blair A. Denman, Melissa R. Mazzo, Michael L. Armstrong,

Nichole Reisdorph, Matthew B. Mcqueen, Michel Chonchol, Douglas R. Seals. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD in healthy middle-aged and older adults. Nature Communications, 2018; DOI: 10.1038/s41467-018-03421-7.

Hypertension – BEN BROWN

1. Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM; American Heart Association. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension. 2006 Feb;47(2):296-308.
2. Schwingshackl L, Schwedhelm C, Hoffmann G, Knüppel S, Iqbal K, Andriolo V, Bechthold A, Schlesinger S, Boeing H. Food Groups and Risk of Hypertension: A Systematic Review and Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2017 Nov 15;8(6):793-803.
3. Lennon SL, DellaValle DM, Rodder SG, Prest M, Sinley RC, Hoy MK, Papoutsakis C. 2015 Evidence Analysis Library Evidence-Based Nutrition Practice Guideline for the Management of Hypertension in Adults. J Acad Nutr Diet. 2017 Sep;117(9):1445-1458.e17.
4. Ndanuko RN, Tapsell LC, Charlton KE, Neale EP, Batterham MJ. Dietary Patterns  and Blood Pressure in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Adv Nutr. 2016 Jan 15;7(1):76-89.
5. Champagne CM. Dietary interventions on blood pressure: the Dietary Approaches  to Stop Hypertension (DASH) trials. Nutr Rev. 2006 Feb;64(2 Pt 2):S53-6.
6. Appel LJ, Moore TJ, Obarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24.
7. Saneei P, Salehi-Abargouei A, Esmaillzadeh A, Azadbakht L. Influence of Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure: a systematic review and meta-analysis on randomized controlled trials. Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1253-61.
8. Gay HC, Rao SG, Vaccarino V, Ali MK. Effects of Different Dietary Interventions on Blood Pressure: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hypertension. 2016 Apr;67(4):733-9.
9. Siervo M, Lara J, Chowdhury S, Ashor A, Oggioni C, Mathers JC. Effects of the  Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis. Br J Nutr. 2015 Jan 14;113(1):1-15.
10. Salehi-Abargouei A, Maghsoudi Z, Shirani F, Azadbakht L. Effects of Dietary Approaches to Stop Hypertension (DASH)-style diet on fatal or nonfatal cardiovascular diseases–incidence: a systematic review and meta-analysis on observational prospective studies. Nutrition. 2013 Apr;29(4):611-8.
11. Tuso P, Stoll SR, Li WW. A plant-based diet, atherogenesis, and coronary artery disease prevention. Perm J. 2015 Winter;19(1):62-7.
12. Yokoyama Y, Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T, Miyamoto Y. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med. 2014 Apr;174(4):577-87.
13. Mozaffarian D, Fahimi S, Singh GM, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med 2014;371(7):624–34.
14. Anderson CA, Johnson RK, Kris-Etherton PM, Miller EA. Commentary on Making Sense of the Science of Sodium. Nutr Today. 2015 Mar;50(2):66-71.
15. Heaney RP. Making Sense of the Science of Sodium. Nutr Today. 2015 Mar;50(2):63-66.
16. Rexhaj E, Messerli FH, Cerny D, Bohlender J. Salt and Blood Pressure: Cutting Through the Scientific Fog. Curr Hypertens Rep. 2017 Jun;19(6):47.
17. DiNicolantonio JJ, Mehta V, O’Keefe JH. Is Salt a Culprit or an Innocent Bystander in Hypertension? A Hypothesis Challenging the Ancient Paradigm. Am J Med. 2017 Aug;130(8):893-899.
18. DiNicolantonio JJ, O’Keefe JH. Hypertension Due to Toxic White Crystals in the Diet: Should We Blame Salt or Sugar? Prog Cardiovasc Dis. 2016 Nov-Dec;59(3):219-225.
19. Jenkins DJ, Kendall CW, Faulkner DA, Kemp T, Marchie A, Nguyen TH, Wong JM, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Josse RG, Leiter LA, Singer  W. Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. Eur J Clin Nutr. 2008 Jun;62(6):781-8.
20. Sauder KA, McCrea CE, Ulbrecht JS, Kris-Etherton PM, West SG. Pistachio nut consumption modifies systemic hemodynamics, increases heart rate variability, and reduces ambulatory blood pressure in well-controlled type 2 diabetes: a randomized trial. J Am Heart Assoc. 2014 Jun 30;3(4).
21. Bays H, Weiter K, Anderson J. A randomized study of raisins versus alternative snacks on glycemic control and other cardiovascular risk factors in patients with type 2 diabetes mellitus. Phys Sportsmed. 2015 Feb;43(1):37-43.
22. Barona J, Aristizabal JC, Blesso CN, Volek JS, Fernandez ML. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr. 2012 Sep;142(9):1626-32.
23. Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BH. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre-  and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J Acad Nutr Diet. 2015 Mar;115(3):369-77.
24. Toscano LT, da Silva CS, Toscano LT, de Almeida AE, Santos Ada C, Silva AS. Chia flour supplementation reduces blood pressure in hypertensive subjects. Plant Foods Hum Nutr. 2014 Dec;69(4):392-8.
25. Rodriguez-Leyva D, Weighell W, Edel AL, LaVallee R, Dibrov E, Pinneker R, Maddaford TG, Ramjiawan B, Aliani M, Guzman R, Pierce GN. Potent antihypertensive action of dietary flaxseed in hypertensive patients. Hypertension. 2013 Dec;62(6):1081-9.
26. Moreno-Luna R, Muñoz-Hernandez R, Miranda ML, Costa AF, Jimenez-Jimenez L, Vallejo-Vaz AJ, Muriana FJ, Villar J, Stiefel P. Olive oil polyphenols decrease blood pressure and improve endothelial function in young women with mild hypertension. Am J Hypertens. 2012 Dec;25(12):1299-304.
27. Serban C, et al. Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials. J Hypertens. 2015 Jun;33(6):1119-27
28. Sahebkar A, Ferri C, Giorgini P, Bo S, Nachtigal P, Grassi D. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017 Jan;115:149-161.
29. Moran JP, Cohen L, Greene JM, Xu G, Feldman EB, Hames CG, Feldman DS. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 1993;57:213–7
30. Chen GC, Lu DB, Pang Z, Liu QF. Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies. J Am Heart Assoc. 2013 Nov 27;2(6):e000329.
31. Juraschek SP, Guallar E, Appel LJ, Miller ER 3rd. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2012 May;95(5):1079-88.
32. Moser MA, Chun OK. Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies. Int J Mol Sci. 2016 Aug 12;17(8).
33. Sato K, Dohi Y, Kojima M, Miyagawa K, Takase H, Katada E, Suzuki S. Effects of ascorbic acid on ambulatory blood pressure in elderly patients with refractory hypertension. Arzneimittelforschung. 2006;56(7):535-40.
34. McNulty H, Strain JJ, Hughes CF, Ward M. Riboflavin, MTHFR genotype and blood  pressure: A personalized approach to prevention and treatment of hypertension. Mol Aspects Med. 2017 Feb;53:2-9.
35. Han H, Fang X, Wei X, Liu Y, Jin Z, Chen Q, Fan Z, Aaseth J, Hiyoshi A, He J,  Cao Y. Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies. Nutr J. 2017 May 5;16(1):26.
36. Kass L, Weekes J, Carpenter L. Effect of magnesium supplementation on blood pressure: a meta-analysis. Eur J Clin Nutr. 2012 Apr;66(4):411-8.
37. Rosanoff A., Plesset M.R. Oral magnesium supplements decrease high blood pressure (SBP > 155 mm Hg) in hypertensive subjects on anti-hypertensive medications: A targeted meta-analysis. Magnes. Res. 2013;26:93–99
38. Cunha AR, D’El-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz RM, Neves MF. Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. J Hypertens.  2017 Jan;35(1):89-97.
39. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses. BMJ. 2013 Apr 3;346:f1378.
40. Poorolajal J, Zeraati F, Soltanian AR, Sheikh V, Hooshmand E, Maleki A. Oral potassium supplementation for management of essential hypertension: A meta-analysis of randomized controlled trials. PLoS One. 2017 Apr 18;12(4):e0174967.
41. Houston MC. The importance of potassium in managing hypertension. Curr Hypertens Rep. 2011 Aug;13(4):309-17.
42. Houston MC, Harper KJ. Potassium, magnesium, and calcium: their role in both the cause and treatment of hypertension. J Clin Hypertens 2008; 10 (7 S2): 3–11
43. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Blood pressure lowering and anti-inflammatory effects of hesperidin in type 2 diabetes; a randomized double-blind controlled clinical trial. Phytother Res. 2018 Feb 22. doi: 10.1002/ptr.6046. [Epub ahead of print]
44. Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C, Quon MJ. Citrus polyphenol hesperidin stimulates  production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 2011 May;96(5):E782-92.
45. Homayouni F, Haidari F, Hedayati M, Zakerkish M, Ahmadi K. Hesperidin Supplementation Alleviates Oxidative DNA Damage and Lipid Peroxidation in Type 2  Diabetes: A Randomized Double-Blind Placebo-Controlled Clinical Trial. Phytother  Res. 2017 Oct;31(10):1539-1545.

 Toxins – Dr BEN LYNCH

1. PLoS One.2014 Sep 24;9(9):e108098. doi: 10.1371/journal.pone.0108098. eCollection 2014. Dietary sources of methylated arsenic species in urine of the United States population, NHANES 2003-2010. deCastro BR¹, Caldwell KL¹, Jones RL¹, Blount BC¹, Pan Y¹, Ward C¹, Mortensen ME¹.

Evidence-Based Medicine – Dr JASON FUNG

1. N Engl J Med.2007 Apr 12;356(15):1503-16. Epub 2007 Mar 26.

Optimal medical therapy with or without PCI for stable coronary disease.

Boden WE¹, O’Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, Knudtson M, Dada M, Casperson P, Harris CL, Chaitman BR, Shaw L, Gosselin G, Nawaz S, Title LM, Gau G, Blaustein AS, Booth DC, Bates ER, Spertus JA, Berman DS, Mancini GB, Weintraub WS; COURAGE Trial Research Group.

2. Lancet.2018 Jan 6;391(10115):31-40. doi: 10.1016/S0140-6736(17)32714-9. Epub 2017 Nov 2.

Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial.

Al-Lamee R¹, Thompson D¹, Dehbi HM², Sen S¹, Tang K³, Davies J³, Keeble T³, Mielewczik M⁴, Kaprielian R⁵, Malik IS⁵, Nijjer SS⁵, Petraco R¹, Cook C¹, Ahmad Y¹, Howard J¹, Baker C⁵, Sharp A⁶, Gerber R⁷, Talwar S⁸, Assomull R⁵, Mayet J¹, Wensel R⁴, Collier D⁹, Shun-Shin M¹, Thom SA¹, Davies JE¹⁰, Francis DP¹; ORBITA investigators.

3. Offline: What is medicine’s 5 sigma?

Richard Horton. The Lancet, 11 April 2015. DOI: https://doi.org/10.1016/S0140-6736(15)60696-1.

4. Drug Companies & Doctors: A Story of Corruption

Marcia Angell. New York Review of Books, Jan 15, 2009.

5. New Repub.2002 Dec 16;227(25):27-41.

America’s other drug problem: how the drug industry distorts medicine and politics. Relman AS, Angell M.

7. Ann Intern Med.2010 Aug 3;153(3):158-66. doi: 10.7326/0003-4819-153-3-201008030-00006. Outcome reporting among drug trials registered in ClinicalTrials.gov. Bourgeois FT, Murthy S, Mandl KD.
8. N Engl J Med.2008 Jan 17;358(3):252-60. doi: 10.1056/NEJMsa065779.

Selective publication of antidepressant trials and its influence on apparent efficacy. Turner EH, Matthews AM, Linardatos E, Tell RA, Rosenthal R.

8. N Engl J Med.2010 May 13;362(19):1761-71. doi: 10.1056/NEJMoa1001086. Epub 2010 Mar 24. Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. Black DM, Kelly MP, Genant HK, Palermo L, Eastell R, Bucci-Rechtweg C, Cauley J, Leung PC, Boonen S, Santora A, de Papp A, Bauer DC; Fracture Intervention Trial Steering Committee; HORIZON Pivotal Fracture Trial Steering Committee.

9. PLoS Med. 2010 Oct; 7(10): e1000355. Published online 2010 Oct 26. doi:  10.1371/journal.pmed.1000355

Editors, Publishers, Impact Factors, and Reprint Income. Harvey Marcovitch^.

12. Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study. BMJ2017; 359 doi: https://doi.org/10.1136/bmj.j4619(Published 26 October 2017).
13. Eur J Neurol.2017 Aug;24(8):1071-1076. doi: 10.1111/ene.13336. Epub 2017 Jun 21. Discontinuation and non-publication of neurodegenerative disease trials: a cross-sectional analysis. Stefaniak JD¹, Lam TCH², Sim NE³, Al-Shahi Salman R⁴, Breen DP.
14. N Engl J Med.2007 Apr 26;356(17):1742-50. A national survey of physician-industry relationships. Campbell EG¹, Gruen RL, Mountford J, Miller LG, Cleary PD, Blumenthal D.
15. WMJ.2010 Jun;109(3):142-8. Medical student exposure to and attitudes about pharmaceutical companies. Soyk C¹, Pfefferkorn B, McBride P, Rieselbach R.
16. BMJ.2010 Mar 18;340:c1344. doi: 10.1136/bmj.c1344.

Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. Wang AT¹, McCoy CP, Murad MH, Montori VM.

SPORTS NUTRITION – SIMON MARTIN

1. https://www.marksdailyapple.com/should-i-supplement-testosterone.
2. https://www.wada-ama.org/en/what-we-do/science-medical/therapeutic-use-exemptions
3. https://bengreenfieldfitness.com/article/brain-articles/what-is-qualia.
4. Lactate metabolism: historical context, prior misinterpretations, and current understanding. Brian S. Ferguson, Matthew J. Rogatzki, Matthew L. Goodwin, Daniel A. Kane, Zachary Rightmire, L. Bruce Gladden. European Journal of Applied Physiology. Published online Jan 2018. https://doi.org/10.1007/s00421-017-3795-6.
5. Exercise-Induced Inflammatory Response: To Use or Not use Anti-Inflammatory Medication. Albená Nunes-Silva. Journal of Sports Medicine & Doping Studies 2014, 4:142. doi: 10.4172/2161-0673.1000142. Experimental Gerontology, Volume 69, September 2015, Pages 159-169.
6. Exp Gerontol.2015 Sep;69:159-69. A standardized randomized 6-month aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes.

Iyalomhe O¹, Chen Y², Allard J³, Ntekim O⁴, Johnson S³, Bond V¹, Goerlitz D⁵, Li J⁵, Obisesan TO⁶. https://doi.org/10.1016/j.exger.2015.05.005

7. “Chapter 7 – Supplemental Antioxidants and Adaptation to Physical Training”,

Micah Gross and Oliver Baum in Antioxidants in Sport Nutrition, Lamprecht M, editor.

Boca Raton (FL): CRC Press/Taylor & Francis; 2015.

8. http://www.velon.cc/en/news/2017/10/team-behind-the-team-cannondale-drapac-nigel-mitchell.
9. Phys Sportsmed.2014 Sep;42(3):45-52. doi: 10.3810/psm.2014.09.2075.

Validation of musculoskeletal ultrasound to assess and quantify muscle glycogen content. A novel approach. Hill JC¹, Millán IS.

10. J Acad Nutr Diet.2016 Mar;116(3):501-528. doi: 10.1016/j.jand.2015.12.006.

Position of the Academy of Nutrition and Dietetics, Dietitians of Canada, and the American College of Sports Medicine: Nutrition and Athletic Performance.

Thomas DT¹, Erdman KA², Burke LM³.

11. Eur J Appl Physiol.2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD¹, Myers SD¹, Gault ML¹, Edwards VC¹, Willems ME².
12. Int J Sport Nutr Exerc Metab. 2015 Aug;25(4):367-74. doi: 10.1123/ijsnem.2014-0233. Epub 2015 Mar 26. Beneficial Physiological Effects With Blackcurrant Intake in Endurance Athletes. Willems ME¹, Myers SD, Gault ML, Cook MD.

13. Adv Ther.2011 Dec;28(12):1078-88. doi: 10.1007/s12325-011-0083-4. Epub 2011 Nov 24. A new ginkgo fresh plant extract increases microcirculation and radical scavenging activity in elderly patients. Suter A¹, Niemer W, Klopp R.
14. Relationship between Vitamin D deficiency and athletic performance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289217.
15. Sports Med.2007;37(4-5):412-5. Marathon training and immune function. Nieman DC¹.
    16. Int J Sport Nutr Exerc Metab.2013 Apr;23(2):161-9. Epub 2012 Dec 7.

Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race.

Santos VC¹, Levada-Pires AC, Alves SR, Pithon-Curi TC, Curi R, Cury-Boaventura MF.

17. Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running—a pilot investigation. Lygeri Dimitriou,Jessica A Hill, Ahmed Jehnali, Joe Dunbar, James Brouner, Malachy P. McHugh, and Glyn Howatson. J Int Soc Sports Nutr. 2015; 12: 22.

Published online 2015 May 11. doi:  10.1186/s12970-015-0085-8.

18. McNaughton, L, Bentley, D and Koeppel, P, The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. J Sports Med Phys Fitness46: 112-118, 2007.
    19. Ostojic, SM and Obrenovic, M. Sublingual nucleotides and immune response to exercise. J IntSoc Sports Nutr 9: 31, 2012.
19. Asian Journal of Pharmaceutical Sciences. Volume 12, Issue 3, May 2017, Pages 209-215. The role of serratiopeptidase in the resolution of inflammation. Review.

ManjuTiwari

21. J Clin Exp Dent.2015 Apr 1;7(2):e197-202. doi: 10.4317/jced.51868. eCollection 2015 Apr. Comparison of clinical efficacy of methylprednisolone and serratiopeptidase for reduction of postoperative sequelae after lower third molar surgery. Chappi D M¹, Suresh KV², Patil MR³, Desai R⁴, Tauro DP⁵, Bharani K N S S⁶, Parkar MI⁷, Babaji HV⁸.
22. J Maxillofac Oral Surg.2018 Jun;17(2):122-128. doi: 10.1007/s12663-017-0996-9. Epub 2017 Jan 18. Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis. Sivaramakrishnan G¹, Sridharan K².
23. http://sportsscientists.com/2018/01/team-sky-marginal-games.

NEWS
‘The epidemiology of multimorbidity in primary care: a retrospective cohort study‘. Anna Cassell, Duncan Edwards, Amelia Harshfield, Kirsty Rhodes, James Brimicombe, Rupert Payne and Simon Griffin. British Journal of General Practice 12 March 2018

BEN BROWN

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1.      Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet. 2007 Aug 18;370(9587):591-603.2.      Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, Chen J, He J. Global Disparities of Hypertension Prevalence and Control: A Systematic Analysis  of Population-Based Studies From 90 Countries. Circulation. 2016 Aug 9;134(6):441-50.3.      Hajjar I, Kotchen TA. Trends in prevalence, awareness, treatment, and control  of hypertension in the United States, 1988-2000. JAMA. 2003 Jul 9;290(2):199-206.4.      Centers for Disease Control and Prevention (CDC). Vital signs: prevalence, treatment, and control of hypertension–United States, 1999-2002 and 2005-2008. MMWR Morb Mortal Wkly Rep. 2011 Feb 4;60(4):103-8.5.      Chobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC  7 report. JAMA. 2003 May 21;289(19):2560-72.6.      Lawes CM, Vander Hoorn S, Rodgers A; International Society of Hypertension. Global burden of blood-pressure-related disease, 2001. Lancet. 2008 May 3;371(9623):1513-8.

7. Cutler JA, Sorlie PD, Wolz M, Thom T, Fields LE, Roccella EJ. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988-1994 and 1999-2004. Hypertension2008;52:818-827

8.      Sarafidis PA, Georgianos P, Bakris GL. Resistant hypertension—its identification and epidemiology. Nat Rev Nephrol. 2013 Jan;9(1):51-8.9.      Gurven M, Blackwell AD, Rodríguez DE, Stieglitz J, Kaplan H. Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists. Hypertension. 2012 Jul;60(1):25-33.10.  Bolívar JJ. Essential hypertension: an approach to its etiology and neurogenic pathophysiology. Int J Hypertens. 2013;2013:547809.11.  Beevers G, Lip GY, O’Brien E. ABC of hypertension: The pathophysiology of hypertension. BMJ. 2001 Apr 14;322(7291):912-6.12.  Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol. 2014 Feb 26;6(2):38-66.13.  James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). 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49. Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev2009; 4: CD007435.

50.  Safar ME. Arterial stiffness as a risk factor for clinical hypertension. Nat Rev Cardiol. 2018 Feb;15(2):97-105.51.  Jamwal S, Sharma S. Vascular endothelium dysfunction: a conservative target in metabolic disorders. Inflamm Res. 2018 Jan 25. doi: 10.1007/s00011-018-1129-8.52.  Castro-Ferreira R, Cardoso R, Leite-Moreira A, Mansilha A. The Role of Endothelial Dysfunction and Inflammation in Chronic Venous Disease. Ann Vasc Surg. 2018 Jan;46:380-393.53.  Bruno RM, Masi S, Taddei M, Taddei S, Virdis A. Essential Hypertension and Functional Microvascular Ageing. High Blood Press Cardiovasc Prev. 2018 Mar;25(1):35-40.54.  Macready AL, George TW, Chong MF, Alimbetov DS, Jin Y, Vidal A, Spencer JP, Kennedy OB, Tuohy KM, Minihane AM, Gordon MH, Lovegrove JA; FLAVURS Study Group.  Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease–FLAVURS: a randomized controlled trial. Am J Clin Nutr. 2014 Mar;99(3):479-89.55.  John JH, Ziebland S, Yudkin P, Roe LS, Neil HA; Oxford Fruit and Vegetable Study Group. Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet. 2002 Jun 8;359(9322):1969-74.56.  Varadharaj S, Kelly OJ, Khayat RN, Kumar PS, Ahmed N, Zweier JL. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation  of Health and Disease. Front Cardiovasc Med. 2017 Nov 1;4:64.57.  Machha A, Schechter AN. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr. 2011 Aug;50(5):293-303.58.  d’El-Rei J, Cunha AR, Trindade M, Neves MF. Beneficial Effects of Dietary Nitrate on Endothelial Function and Blood Pressure Levels. Int J Hypertens. 2016;2016:6791519.

59. Boger RH. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the “L-arginine paradox” and acts as a novel cardiovascular risk factor. J Nutr. 2004 Oct;134(10 Suppl):2842S-2847S

60.  Dong JY, Qin JQ, Zhang ZL, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162:959–65.

 

CONSULTATION – Garner Thomson

^1. Beckman HB, Frankel RM (1984) The effect of physician behavior on the collection of data. Annals of Internal Medicine 101:692-6

^2. Marvel MK (1999) Soliciting the patient’s agenda: have we improved? JAMA; 281: 283–7.

 

^3. Svab I (1993) The time used by the patient when he/she talks without interruptions. Aten Primaria; 11: 175–7

 

^4. Little M (1995) Humane Medicine. Cambridge:Cambridge University Press

 

^5. Thomson G, Khan K (2016) Magic in Practice, London:Hammersmith Health Books

 

^6.Hagger, M. S., Koch, S., Chatzisarantis, N. L. D., & Orbell, S. (2017). The common sense model of self-regulation: Meta-analysis and test of a process model. Psychological Bulletin, 143(11), 1117-1154.

ALLERGY and INFLAMMATION

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Milica Vukmanovic-Stejic, Emma S. Chambers, Mayte Suárez-Fariñas, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil Patel, Elaine Agius, Katie E. Lacy, Carolin T. Turner, Anis Larbi, Veronique Birault, Mahdad Noursadeghi, Neil A. Mabbott, Malcolm H.A. Rustin, James G. Krueger, Arne N. Akbar. Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation. Journal of Allergy and Clinical Immunology, 2017; DOI: 10.1016/j.jaci.2017.10.032

RESEARCH

Leanne M. Redman, Steven R. Smith, Jeffrey H. Burton, Corby K. Martin, Dora Il’yasova, Eric Ravussin. Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.02.019

10. Parvez, R. R. Gerona, C. Proctor, M. Friesen, J. L. Ashby, J. L. Reiter, Z. Lui, P. D. Winchester. Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study. Environmental Health, 2018; 17 (1) DOI: 10.1186/s12940-018-0367-0

Erzsebet Polyak, Julian Ostrovsky, Min Peng, Stephen D. Dingley, Mai Tsukikawa, Young Joon Kwon, Shana E. McCormack, Michael Bennett, Rui Xiao, Christoph Seiler, Zhe Zhang, Marni J. Falk. N -acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. Molecular Genetics and Metabolism, 2018; DOI: 10.1016/j.ymgme.2018.02.013

Eneida Boteon Schmitt, Jorge Nahas-Neto, Flavia Bueloni-Dias, Priscila Ferreira Poloni, Claudio Lera Orsatti, Eliana Aguiar Petri Nahas. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas, 2018; 107: 97 DOI: 10.1016/j.maturitas.2017.10.011

Smruti Pushalkar, Mautin Hundeyin, Donnele Daley, Constantinos P. Zambirinis, Emma Kurz, Ankita Mishra, Navyatha Mohan, Berk Aykut, Mykhaylo Usyk, Luisana E. Torres, Gregor Werba, Kevin Zhang, Yuqi Guo, Qianhao Li, Neha Akkad, Sarah Lall, Benjamin Wadowski, Johana Gutierrez, Juan Andres Kochen Rossi, Jeremy W. Herzog, Brian Diskin, Alejandro Torres-Hernandez, Josh Leinwand, Wei Wang, Pardeep S. Taunk, Shivraj Savadkar, Malvin Janal, Anjana Saxena, Xin Li, Deirdre Cohen, R. Balfour Sartor, Deepak Saxena, George Miller. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Cancer Discovery, 2018; DOI: 10.1158/2159-8290.CD-17-1134

Brandon H Hidaka, Jocelynn M Thodosoff, Elizabeth H Kerling, Holly R Hull, John Colombo, Susan E Carlson. Intrauterine DHA exposure and child body composition at 5 y: exploratory analysis of a randomized controlled trial of prenatal DHA supplementation. The American Journal of Clinical Nutrition, 2018; 107 (1): 35 DOI: 10.1093/ajcn/nqx007

Current Opinion in Food Science, Volume 20, April 2018, Pages 19-23. CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods YongboShe¹²Dylan SMacKay²³James DHouse²Peter JHJones^. https://doi.org/10.1016/j.cofs.2018.02.013

COMMENT by Dr Eve Pearce:

Abdullah, M. M., Cyr, A., Lépine, M.-C., Eck, P. K., Couture, P., Lamarche, B., & Jones, P. J. (2016). Common Variants in Cholesterol Synthesis– and Transport–Related Genes Associate with Circulating Cholesterol Responses to Intakes of Conventional Dairy Products in Healthy Individuals. The Journal of Nutrition, 146(5), 1008–1016. http://doi.org/10.3945/jn.115.222208

De Castro-Orós, I., Pampín, S., Cofán, M., Mozas, P., Pintó, X., Salas-Salvadó, J., … Pocoví, M. (2011). Promoter variant −204A > C of the cholesterol 7α-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells. Clinical Nutrition, 30(2), 239–246. http://doi.org/10.1016/j.clnu.2010.07.020

Jenkins, D. J. A., Kendall, C. W. C., Faulkner, D., Vidgen, E., Trautwein, E. A., Parker, T. L., … Connelly, P. W. (2002). A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism: Clinical and Experimental, 51(12), 1596–604. http://doi.org/10.1053/meta.2002.35578

Juzyszyn, Z., Kurzawski, M., Lener, A., Modrzejewski, A., Pawlik, A., & Droździk, M. (2008). Cholesterol 7α-Hydrolase ( CYP7A1 ) c.−278A>C Promoter Polymorphism in Gallstone Disease Patients. Genetic Testing, 12(1), 97–100. http://doi.org/10.1089/gte.2007.0067

MacKay, D. S., Eck, P. K., Gebauer, S. K., Baer, D. J., & Jones, P. J. (2015). CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. The American Journal of Clinical Nutrition, 102(4), 951–957. http://doi.org/10.3945/ajcn.115.109231

Rideout, T. C., Harding, S. V, & Mackay, D. S. (2012). Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy. Canadian Journal of Physiology and Pharmacology, 90(5), 509–14. http://doi.org/10.1139/y2012-060

Russell, D. W. (2003). The enzymes, regulation, and genetics of bile acid synthesis. Annual Review of Biochemistry, 72(1), 137–74. http://doi.org/10.1146/annurev.biochem.72.121801.161712

She, Y., MacKay, D. S., House, J. D., & Jones, P. J. (2018). CYP7A1-rs3808607: a single nucleotide polymorphism associated with cholesterol response to functional foods. Current Opinion in Food Science, 20, 19–23. http://doi.org/10.1016/j.cofs.2018.02.013

 

 

 

IHCAN March references

NEWS

Fiolet Thibault, Srour Bernard, Sellem Laury, Kesse-Guyot Emmanuelle, Allès Benjamin, Méjean Caroline et al. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. BMJ 2018; 360 :k322.

Yumi Hurst, Haruhisa Fukuda. Effects of changes in eating speed on obesity in patients with diabetes: a secondary analysis of longitudinal health check-up data. BMJ Open, 2018; 8 (1): e019589 DOI: 10.1136/bmjopen-2017-019589.

Christopher D. Gardner, John F. Trepanowski, Liana C. Del Gobbo, Michelle E. Hauser, Joseph Rigdon, John P. A. Ioannidis, Manisha Desai, Abby C. King. Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial. JAMA, 2018; 319 (7): 667-679 DOI: 10.1001/jama.2018.0245.

Adelaida Esteban-Fernández, Irene Zorraquín-Peña, Maria D. Ferrer, Alex Mira, Begoña Bartolomé, Dolores González de Llano, M. Victoria Moreno-Arribas. Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic. Journal of Agricultural and Food Chemistry, 2018; DOI: 10.1021/acs.jafc.7b05466

BEN BROWN PSYCHOBIOTICS

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4. Dinan TG, Stanton C, Cryan JF. Psychobiotics: A Novel Class of Psychotropic. Biol Psychiatry. 2013 Nov 15;74(10):720-6.
5. https://psmag.com/news/could-probiotics-replace-prozac

6.      Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PW. Psychobiotics and  the Manipulation of Bacteria-Gut-Brain Signals. Trends Neurosci. 2016 Nov;39(11):763-781.7.      Shanks N, Greek R, Greek J. Are animal models predictive for humans? Philos Ethics Humanit Med. 2009 Jan 15;4:2. doi: 10.1186/1747-5341-4-2.8.      Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, Guyonnet D, Legrain-Raspaud S, Trotin B, Naliboff B, Mayer EA. Consumption of fermented milk  product with probiotic modulates brain activity. Gastroenterology. 2013 Jun;144(7):1394-401, 1401.e1-4.9.      Romijn AR, Rucklidge JJ. Systematic review of evidence to support the theory of psychobiotics. Nutr Rev. 2015 Oct;73(10):675-93.

10. Rucklidge J, Kaplan B. Can Probiotics be Used for the Treatment of Mental Health Problems? Mad in America. September 15, 2015.
11. Ng QX, Peters C, Ho CYX, Lim DY, Yeo WS. A meta-analysis of the use of probiotics to alleviate depressive symptoms. J Affect Disord. 2018 Mar 1;228:13-19. doi: 10.1016/j.jad.2017.11.063.

12.  Kelly JR, Allen AP, Temko A, Hutch W, Kennedy PJ, Farid N, Murphy E, Boylan G, Bienenstock J, Cryan JF, Clarke G, Dinan TG. Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects. Brain Behav Immun. 2017 Mar;61:50-59.13.  Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, Taghizadeh M, Memarzadeh MR, Asemi Z, Esmaillzadeh A. Clinical and metabolic response to probiotic administration in patients with major depressive disorder:  A randomized, double-blind, placebo-controlled trial. Nutrition. 2016 Mar;32(3):315-20.

14. Jacka FN, et al. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial). BMC Medicine 2017 15:23. Published: 30 January 2017

15.  Sarris J, O’Neil A, Coulson CE, Schweitzer I, Berk M. Lifestyle medicine for depression. BMC Psychiatry. 2014 Apr 10;14:107. LYME LONG-TERM

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MUSHROOM NUTRITION1             American Chemical Society (2000, May 12). New Evidence Found Linking Herpes and Alzheimer’s. Science Daily. Retrieved July 26, 2013, from http:// www.sciencedaily.com/releases/2000/05/000512083302.htm.2             University of Manchester (2008, December 7). Cold Sore Virus Linked To Alzheimer’s Disease: New Treatment, Or Even Vaccine Possible. Science- Daily. Retrieved July 26, 2013, from http://www.sciencedaily.com /releas- es/2008/12/081207134109.htm3             MA Wozniak, AP Mee and RF Itzhaki. Herpes simplex virus type I DNA is located within Alzheimer’s disease amyloid plaques. The Journal of Pathology, Volume 217, Issue 1 , Pages131 – 138 2009 DOI: 10.1002/path.24494             Carter CJ. Alzheimer´s disease plaques and tangles:cemeteries of phyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction.Neurochem Int. 2011 Feb 58(3):301-20 doi 10 1016/j.neuint 2010.12.20.003Epub 2010 Dec 15.5             Wozniak MA, Frost AL, Preston CM, Itzhaki RF.  Antivirals reduce the forma- tion of key Alzheimer´s disease molecules in cell cultures acutely infected with herpes simplex virus type 1. PLoS One. 2011:6(10) e25152 doi 10 1371/ journal. pone.0025152. EPUB 2011 Oct 7.6             Pandley JP. Immunoglobulin GM genese as functional risk and protective fac- tors for the development of Alzheimer´s disease. J. Alzheimers Dis 2009;17(4) 753-6 doi 10.3222/JAD-2009-1094.7             Wozniak MA, Itzhaki RF. Intravenous immounoglobulin reduces amyloid and abnormal tau formation caused by herpes simplex virus type 1. J Neuroimmunol 2013 Apr 15:257 (1-2):7-12 doi 10. 1016/ jnmeuroim 2013.01.005 Epub 2013Feb 4.8             Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs  OH, LaFerla FM. Aspirin-triggered  lipoxin  A4  stimulates  alternative  activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol. 2013 May, 182(5);1740-9 ..9             Jean A. Monro, Chronic Fatigue Immune Dysfunction Syndrome. J Integrative Medicine 2004; 8:101-10810           Jean A. Monro. Treatment of Cancer with Mushroom Products. Arch Env Health 2003;58:533-537.11           Silva Couto J, Pereira da Silva D. Evaluation of the Efficacy of Coriolus versicolor Supplementation in HPV Lesions (LSIL) . Poster presented at the 20th European Congress of Obstetrics and Gynecology, Lisbon, Portugal March4-8th, 2008.12           Cornelius C. , Cavallaro M., Cambria M.T., Toscano M.A., Calabrese V. Com- parative Enzyme Analysis of Polyporus umbellatus, Agaricus blazei, Pleurotus osteratus and Hericium erinaceus . Clinical Journal of Mycology 2009 Vol II Page 4 to 7.13           Kulmann I, Minihane Am, Huebbe P, Nebel A , Rimbach G. Apolipoprotien  E genotype and hepatitis c, HIV and herpes simplex diseae risk: a literature review. Lipids Health Dis. 2010 Jan 28.9.8 doi 10.1186/1476-511-9.614           Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Rev Mol Med. 2011 Sept 20; 13 e 30 doi 10 1017/S14623994 1 1002006.  Also relevant:
Calabrese, V. Fernandes, T. Excerpt from Clinical Journal of Mycology Vol IV, Pages 10-12, Nov 2013, Aneid Press.
Trovato A, et al. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. Neurotoxicology (2015):  http://dx.doi.org/10.1016/ j.neuro.2015.09.012.

Trovato et al. Redox modulation of cellular stress response and lipoxin A4 expression byHericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis. Immunity & Ageing (2016) 13:23.  DOI 10.1186/s12979-016-0078-8. Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus. Elisabete Ferreiro, Inês Pita, Nuno R. Ferreira , Carlos A Fontes-Ribeiro , Frederico C. Pereira , A. Cristina Rego. Abstract  presented February 5, 2018, at the 48th Annual Meeting of the Portuguese Society of Pharmacology, at the University of Lisbon.

RESEARCH
Attia Anwar, Provvidenza Maria Abruzzo, Sabah Pasha, Kashif Rajpoot, Alessandra Bolotta, Alessandro Ghezzo, Marina Marini, Annio Posar, Paola Visconti, Paul J. Thornalley, Naila Rabbani. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism – a source of biomarkers for clinical diagnosis. Molecular Autism, 2018; 9 (1) DOI: 10.1186/s13229-017-0183-3.

 

Kathleen F. Holton, Peter K. Ndege, Daniel J. Clauw. Dietary correlates of chronic widespread pain in meru, Kenya. Nutrition, 2018; DOI: 10.1016/j.nut.2018.01.016.

Adil Mardinoglu, Hao Wu, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M. Räsänen, Sunjae Lee, Rosellina M. Mancina, Mattias Bergentall, Kirsi H. Pietiläinen, Sanni Söderlund, Niina Matikainen, Marcus Ståhlman, Per-Olof Bergh, Martin Adiels, Brian D. Piening, Marit Granér, Nina Lundbom, Kevin J. Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, Göran Bergström, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik Bäckhed, Marja-Riitta Taskinen, Jan Borén. An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.01.005.

Nicola McCleary, Bright I. Nwaru, Ulugbek B. Nurmatov, Hilary Critchley, Aziz Sheikh. Endogenous and exogenous sex steroid hormones in asthma and allergy in females: A systematic review and meta-analysis. Journal of Allergy and Clinical Immunology, 2018; DOI: 10.1016/j.jaci.2017.11.034

 

MAGNESIUM – Mike Ash

1. Thomas D. The mineral depletion of foods available to us as a nation (1940-2002) –a review of the 6th Edition of McCance and Widdowson. Nutr Health. 2007;19(1-2):21-55. 
   2. Loladze I. Hidden shift of the ionome of plants exposed to elevated CO₂ depletes minerals at the base of human nutrition. Elife. 2014 May 7.
2. DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart 2018;5:e000668. doi: 10.1136/openhrt-2017-000668.

 

 

 

 

 

NEWS
Woodcock B A, Ridding L, Freeman S N, Pereira M G, Sleep D, Redhead J, et al. (2018) Neonicotinoid residues in UK honey despite European Union moratorium. DOI: 10.1371/journal.pone.0189681 (open access)

Katarina Ondrusova, Mohammad Fatehi, Amy Barr, Zofia Czarnecka, Wentong Long, Kunimasa Suzuki, Scott Campbell, Koenraad Philippaert, Matthew Hubert, Edward Tredget, Peter Kwan, Nicolas Touret, Martin Wabitsch, Kevin Y. Lee, Peter E. Light. Subcutaneous white adipocytes express a light sensitive signaling pathway mediated via a melanopsin/TRPC channel axis. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16689-4

Anas Raed, Jigar Bhagatwala, Haidong Zhu, Norman K. Pollock, Samip J. Parikh, Ying Huang, Robyn Havens, Ishita Kotak, De-Huang Guo, Yanbin Dong. Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424

NEWS EXTRA

Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community. PNAS 2018 ; published ahead of print January 18, 2018, doi:10.1073/pnas.1716561115. 

Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients

Robert A. DiSilvestro et al. Journal of the International Society of Sports Nutrition 201714:42. https://doi.org/10.1186/s12970-017-0199-2

BEN BROWN

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4. Yary T, Lehto SM, Tolmunen T, et al. Dietary magnesium intake and the incidence of depression: A 20-year follow-up study. J Affect Disord. 2016 Mar 15;193:94-8.
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8. Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium  supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017 Jun 27;12(6):e0180067.

9.      Dmitrašinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes following Magnesium Supplementation. J Med Biochem. 2016 Nov 2;35(4):375-384.

10. Cinar V, Mogulkoc R, Baltaci AK, Polat Y. Adrenocorticotropic hormone and cortisol levels in athletes and sedentary subjects at rest and exhaustion: effects of magnesium supplementation. Biol Trace Elem Res. 2008;(121):215–20.

11.  Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012 Dec;17(12):1161-9.

12. Brody S. High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial. Biol Psychiatry. 2002;52(4):371–4.
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14.  Zhang M, Robitaille L, Eintracht S, Hoffer LJ. Vitamin C provision improves mood in acutely hospitalized patients. Nutrition. 2011 May;27(5):530-3.15.  Wang Y, Liu XJ, Robitaille L, Eintracht S, MacNamara E, Hoffer LJ. Effects of  vitamin C and vitamin D administration on mood and distress in acutely hospitalized patients. Am J Clin Nutr. 2013 Sep;98(3):705-11.

16. Yeom HH, et al. Changes In Worker Fatigue After Vitamin C Administration. JOM. 2008; 28:205-209.
17. Mazloom Z, Ekramzadeh M, Hejazi N. Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, single-blind, placebo-controlled trial. Pak J Biol Sci. 2013 Nov 15;16(22):1597-600

18.  de Oliveira IJ, de Souza VV, Motta V, Da-Silva SL. Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial. Pak J Biol Sci. 2015 Jan;18(1):11-8.

19. Cocchi P, Silenzi M, Calabri G, Salvi G. Antidepressant effect of vitamin C. 1980;65(4):862–3.
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21.  Amr M, El-Mogy A, Shams T, Vieira K, Lakhan SE. Efficacy of vitamin C as an adjunct to fluoxetine therapy in pediatric major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Nutr J. 2013 Mar 9;12:31.

22. Smythies JR. The role of ascorbate in brain: therapeutic implications. J R Soc Med. 1996 May;89(5):241.

23.  Brody S, Preut R, Schommer K, Schürmeyer TH. A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology (Berl). 2002 Jan;159(3):319-24.24.  Plotnick MD, D’Urzo KA, Gurd BJ, Pyke KE. The influence of vitamin C on the interaction between acute mental stress and endothelial function. Eur J Appl Physiol. 2017 Aug;117(8):1657-1668.

25. Yeom HH, et al. Changes In Worker Fatigue After Vitamin C Administration. JOM. 2008; 28:205-209.

26.  Lindblad M, Tveden-Nyborg P, Lykkesfeldt J. Regulation of vitamin C homeostasis during deficiency. Nutrients. 2013 Jul 25;5(8):2860-79.27.  Schectman G, Byrd JC, Hoffmann R. Ascorbic acid requirements for smokers: analysis of a population survey. Am J Clin Nutr. 1991 Jun;53(6):1466-70.

28. Gan R, Eintracht S, Hoffer LJ. Vitamin C deficiency in a university teaching hospital. J Am Coll Nutr. 2008 Jun;27(3):428-33.
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30.  Crawford MA, Bazinet RP, Sinclair AJ. Fat intake and CNS functioning: ageing and disease. Ann Nutr Metab. 2009;55(1-3):202-28.31.  Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, Drago F, Caraci F. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905.32.  Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega- supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34.33.  Liu JJ, Galfalvy HC, Cooper TB, Oquendo MA, Grunebaum MF, Mann JJ, Sublette ME. Omega-3 polyunsaturated fatty acid (PUFA) status in major depressive disorder with comorbid anxiety disorders. J Clin Psychiatry. 2013 Jul;74(7):732-8.34.  Mocking RJ, Ruhé HG, Assies J, Lok A, Koeter MW, Visser I, Bockting CL, Schene AH. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. Psychoneuroendocrinology. 2013 Sep;38(9):1607-17.35.  Mocking RJ, Verburg HF, Westerink AM, Assies J, Vaz FM, Koeter MW, Ruhé HG, Schene AH. Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response. Psychoneuroendocrinology. 2015 Sep;59:1-13. 36.  Delarue J, Matzinger O, Binnert C, Schneiter P, Chioléro R, Tappy L. Fish oil  prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab. 2003 Jun;29(3):289-95. 37.  Jazayeri S, Keshavarz SA, Tehrani-Doost M, Djalali M, Hosseini M, Amini H, Chamari M, Djazayery A. Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder. Psychiatry Res. 2010 Jun 30;178(1):112-5.38.  Barbadoro P, Annino I, Ponzio E, Romanelli RM, D’Errico MM, Prospero E, Minelli A. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. Mol Nutr  Food Res. 2013 Jun;57(6):1110-4.39.  von Schacky C. Omega-3 index and cardiovascular health. Nutrients. 2014 Feb 21;6(2):799-814. 40.  Harris WS, Pottala JV, Lacey SM, et al. Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study. Atherosclerosis. 2012 Dec;225(2):425-31.41.  Flock MR, Skulas-Ray AC, Harris WS, et al. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. J Am Heart Assoc. 2013 Nov 19;2(6):e000513.

42. Harris WS. The omega-3 index: clinical utility for therapeutic intervention. Curr Cardiol Rep. 2010 Nov;12(6):503-8.

43.  Pottala JV, Yaffe K, Robinson JG, et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 2014 Feb 4;82(5):435-42.44.  Pottala JV, Talley JA, Churchill SW, et al. Red blood cell fatty acids are associated with depression in a case-control study of  adolescents. Prostaglandins Leukot Essent Fatty Acids. 2012 Apr;86(4-5):161-5.45.  Baghai TC, Varallo-Bedarida G, Born C, et al. Major depressive disorder is associated with cardiovascular risk factors and low Omega-3 Index. J Clin Psychiatry. 2011 Sep;72(9):1242-7.46.  Johnston DT, Deuster PA, Harris WS, et al. Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. Nutr Neurosci. 2013 Jan;16(1):30-8.47.  Türközü D, Şanlier N. L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Crit Rev Food Sci Nutr. 2017 May 24;57(8):1681-1687.48.  Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J  Physiol Anthropol. 2012 Oct 29;31:28.

49. Unno K, Tanida N, Ishii N, et al. Anti-stress effect of theanine on students during  pharmacy practice: Positive correlation among salivary α-amylase activity, trait  anxiety and subjective stress. Pharmacol Biochem Behav. 2013 Sep 16;111C:128-135.

50.  Ritsner MS, Miodownik C, Ratner Y, et al.L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind,  placebo-controlled, 2-center study. J Clin Psychiatry. 2011 Jan;72(1):34-42

51. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an  open-label study. Acta Neuropsychiatr. 2017 Apr;29(2):72-79.

52.  Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-4553.  Yin C, Gou L, Liu Y, Yin X, Zhang L, Jia G, Zhuang X. Antidepressant-like Effects of L-theanine in the Forced Swim and Tail Suspension Tests in Mice. Phytother Res. 2011 Mar 21. doi: 10.1002/ptr.3456.54.  Unno K, Fujitani K, Takamori N, Takabayashi F, Maeda K, Miyazaki H, Tanida N,  Iguchi K, Shimoi K, Hoshino M. Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice. Free Radic Res. 2011 Aug;45(8):966-74.

55. Yokogoshi H, Terashima T. Effect of theanine, d-glutamylethylamide, on brain monoamines, striatal dopamine release and some kinds of behaviour in rats. Nutrition 2000;16:776–777.

56.  [1] Miodownik C, Maayan R, Ratner Y, et al. Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of  dehydroepiandrosterone molar ratio associated with clinical response to l-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients. Clin Neuropharmacol. 2011 Jul-Aug;34(4):155-60.

57. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45

58.  Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A. Saffron in the treatment of depression, anxiety and other mental disorders: Current evidence and potential mechanisms of action. J Affect Disord. 2017 Nov 7;227:330-337.59.  Lopresti AL, Drummond PD. Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol. 2014 Nov;29(6):517-27.

60. Basiri-Moghadam M, et al. Comparison of the Anxiolytic Effects of Saffron (Crocus sativus. L) and Diazepam Before Herniorrhaphy Surgery: A Double Blind Randomized Clinical Trial. Zahedan J Res Med Sci. 2016 March; 18(3):e6248.

61.  Kell G, Rao A, Beccaria G, Clayton P, Inarejos-García AM, Prodanov M. affron(®) a novel saffron extract (Crocus sativus L.) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial. Complement Ther Med. 2017 Aug;33:58-64.62.  Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med. 2016 Jun 1;13(2):195-9.63.  Ghajar A, Neishabouri SM, Velayati N, et al. Crocus sativus L. versus Citalopram in the Treatment of Major Depressive Disorder with Anxious Distress: A Double-Blind, Controlled Clinical Trial. Pharmacopsychiatry. 2017 Jul;50(4):152-160.64.  Hooshmandi Z, Rohani AH, Eidi A, Fatahi Z, Golmanesh L, Sahraei H. Reduction of metabolic and behavioral signs of acute stress in male Wistar rats by saffron  water extract and its constituent safranal. Pharm Biol. 2011 Sep;49(9):947-54.65.  Fukui H, Toyoshima K, Komaki R. Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus). Phytomedicine. 2011 Jun 15;18(8-9):726-30.66.  Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. – A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol. 2016 Jul 21;188:204-28.67.  Kennedy DO, Scholey AB, Tildesley NT, Perry EK, Wesnes KA. Modulation of mood  and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav. 2002 Jul;72(4):953-64.68.  Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in  humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom  Med. 2004 Jul-Aug;66(4):607-13.69.  Kennedy DO, Wake G, Savelev S, et al.  Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.70.  Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011 Dec;4(3):211-218.71.  Akbarzadeh M, Dehghani M, Moshfeghy Z, Emamghoreishi M, Tavakoli P, Zare N. Effect of Melissa officinalis Capsule on the Intensity of Premenstrual Syndrome Symptoms in High School Girl Students. Nurs Midwifery Stud. 2015 Jun;4(2):e27001.72.  Ibarra A, Feuillere N, Roller M, Lesburgere E, Beracochea D. Effects of chronic administration of Melissa officinalis L. extract on anxiety-like reactivity and on circadian and exploratory activities in mice. Phytomedicine. 2010 May;17(6):397-403.73.  Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014 Dec;20(12):901-8. doi: 10.1089/acm.2014.0177.74.  Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under  Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106.

75. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62.
76. Auddy B, et al. A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of the American Nutraceutical Association. 2008;11(1):50-56.

77.  Amsterdam JD, Panossian AG. Rhodiola rosea L. as a putative botanical antidepressant. Phytomedicine. 2016 Jun 15;23(7):770-83.

78. Darbinyan, A. Kteyan, A. Panossian, E. Gabrielian, G. Wikman, H. Wagner. 2000. Rhodiola rosea in stress induced fatigue — A double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. PhytomedicineVolume 7, Issue 5, October 2000, Pages 365–371.
79. A. Spasov, G.K. Wikman, V.B. Mandrikov, I.A. Mironova, V.V. Neumoin. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. Volume 7, Issue 2, April 2000, Pages 85–89.
80. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493.
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86. Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD. Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial. Phytomedicine. 2015 Mar 15;22(3):394-9.
87. Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol. 2009 Aug;29(4):378-82.

88.  Amsterdam JD, Shults J, Soeller I, Mao JJ, Rockwell K, Newberg AB. Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Altern Ther Health Med. 2012 Sep-Oct;18(5):44-9.89.  Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD. Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine. 2016 Dec 15;23(14):1699-1705.

90. Keefe JR, Guo W, Li QS, Amsterdam JD, Mao JJ. An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder. J Psychiatr Res. 2018 Jan;96:189-195.

1. Delarue J, Matzinger O, Binnert C, Schneiter P, Chioléro R, Tappy L. Fish oil  prevents the adrenal activation elicited by mental stress in healthy men. Diabetes Metab. 2003 Jun;29(3):289-95.

 

GUT RESEARCH

Kourosh Kalantar-Zadeh, Kyle J. Berean, Nam Ha, Adam F. Chrimes, Kai Xu, Danilla Grando, Jian Zhen Ou, Naresh Pillai, Jos L. Campbell, Robert Brkljača, Kirstin M. Taylor, Rebecca E. Burgell, Chu K. Yao, Stephanie A. Ward, Chris S. McSweeney, Jane G. Muir, Peter R. Gibson. A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gut. Nature Electronics, 2018; 1 (1): 79 DOI: 10.1038/s41928-017-0004-x.

Paleo diet: material supplied by Umeå universitet: http://www.umu.se/english – dissertation available there.

Stephen A. Fleming, Supida Monaikul, Alexander J. Patsavas, Rosaline V. Waworuntu, Brian M. Berg, Ryan N. Dilger. Dietary polydextrose and galactooligosaccharide increase exploratory behavior, improve recognition memory, and alter neurochemistry in the young pig. Nutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1415280.

Giuseppe Faraco, David Brea, Lidia Garcia-Bonilla, Gang Wang, Gianfranco Racchumi, Haejoo Chang, Izaskun Buendia, Monica M. Santisteban, Steven G. Segarra, Kenzo Koizumi, Yukio Sugiyama, Michelle Murphy, Henning Voss, Joseph Anrather, Costantino Iadecola. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nature Neuroscience, 2018; DOI: 10.1038/s41593-017-0059-z

Salt stats: https://www.gov.uk/government/news/new-phe-data-on-salt-consumption-levels.

Irina Leonardi et al. CX3CR1 mononuclear phagocytes control immunity to intestinal fungi. Science, 2018 DOI: 10.1126/science.aao1503.

Sébastien Lucas, Yasunori Omata, Jörg Hofmann, Martin Böttcher, Aida Iljazovic, Kerstin Sarter, Olivia Albrecht, Oscar Schulz, Brenda Krishnacoumar, Gerhard Krönke, Martin Herrmann, Dimitrios Mougiakakos, Till Strowig, Georg Schett, Mario M. Zaiss. Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-017-02490-4

RESEARCH UPDATE

Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang. Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17487-8

Aura Raulo, Lasse Ruokolainen, Avery Lane, Katherine Amato, Rob Knight, Steven Leigh, Rebecca Stumpf, Bryan White, Karen E. Nelson, Andrea L. Baden, Stacey R. Tecot. Social behaviour and gut microbiota in red-bellied lemurs (Eulemur rubriventer): In search of the role of immunity in the evolution of sociality. Journal of Animal Ecology, 2017; DOI: 10.1111/1365-2656.12781

Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.

Ayyadurai S, Gibson AJ, D’Costa S, Overman EL, Sommerville LJ, Poopal AC, Mackey E, Li Y, Moeser AJ. J Leukoc Biol. 2017 Dec;102(6):1299-1312. doi: 10.1189/jlb.2HI0317-088RR.

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide.

Gulledge TV¹, Collette NM¹, Mackey E², Johnstone SE¹, Moazami Y³, Todd DA⁴, Moeser AJ², Pierce JG⁵, Cech NB⁴, Laster SM⁶. J Ethnopharmacol. 2018 Feb 15;212:166-174. doi: 10.1016/j.jep.2017.10.012. Epub 2017 Oct 14.

Evilena Anastasiou, Anastasia Papathanasiou, Lynne A. Schepartz, Piers D. Mitchell. Infectious disease in the ancient Aegean: Intestinal parasitic worms in the Neolithic to Roman Period inhabitants of Kea, Greece. Journal of Archaeological Science: Reports, 2017; DOI: 10.1016/j.jasrep.2017.11.006

Catherine Vilchèze, John Kim, William R. Jacobs. Vitamin C potentiates the killing of Mycobacterium tuberculosis by the first-line tuberculosis drugs isoniazid and rifampicin in mice. Antimicrobial Agents and Chemotherapy, 2018; AAC.02165-17 DOI: 10.1128/AAC.02165-17

NEWS

Lean, Michael EJ et al. Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. The Lancet, 5 December 2017. DOI: http://dx.doi.org/10.1016/S0140-6736(17)33102-1

Elisabetta Lauretti, Domenico Pratic�. Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer’s disease. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-17373-3

Monica E. Embers, Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, Lara A. Doyle-Meyers, Mario T. Philipp, Emir Hodzic. Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding. PLOS ONE, 2017; 12 (12): e0189071 DOI: 10.1371/journal.pone.0189071

Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers. Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.11.005

J Public Health Policy. 2017 Nov 27. doi: 10.1057/s41271-017-0095-7. [Epub ahead of print]. Complexity and conflicts of interest statements: a case-study of emails exchanged between Coca-Cola and the principal investigators of the International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE).

Stuckler D¹, Ruskin G², McKee M³. Open Access: https://link.springer.com/article/10.1057%2Fs41271-017-0095-7.

JOINTS and BONES

Louisa E. Jeffery, Peter Henley, Nefisa Marium, Andrew Filer, David M. Sansom, Martin Hewison, Karim Raza. Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint. Journal of Autoimmunity, 2017; DOI: 10.1016/j.jaut.2017.10.001

Shweta Khanna, Kumar Sagar Jaiswal, Bhawna Gupta. Managing Rheumatoid Arthritis with Dietary Interventions. Frontiers in Nutrition, 2017; 4 DOI: 10.3389/fnut.2017.00052

10. Loukov, S. Karampatos, M.R. Maly, D.M.E. Bowdish. Monocyte activation is elevated in women with knee-osteoarthritis and associated with inflammation, BMI and pain. Osteoarthritis and Cartilage, 2017; DOI: 10.1016/j.joca.2017.10.018

Diddier Prada, Jia Zhong, Elena Colicino, Antonella Zanobetti, Joel Schwartz, Nicholas Dagincourt, Shona C Fang, Itai Kloog, Joseph M Zmuda, Michael Holick, Luis A Herrera, Lifang Hou, Francesca Dominici, Benedetta Bartali, Andrea A Baccarelli. Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies. The Lancet Planetary Health, 2017; 1 (8): e337 DOI: 10.1016/S2542-5196(17)30136-5

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3503-3508. doi: 10.1073/pnas.1618545114. Epub 2017 Mar 13.

B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial.

Zhong J1, Karlsson O2,3, Wang G4, Li J5,6, Guo Y7, Lin X8, Zemplenyi M7, Sanchez-Guerra M9, Trevisi L10, Urch B11,12,13,14, Speck M11, Liang L7, Coull BA7, Koutrakis P10, Silverman F11,12,13,14, Gold DR10,15, Wu T5,6, Baccarelli AA16.

A.A. Macintosh et al. Prehistoric women’s manual labor exceeded that of athletes through the first 5500 years of farming in Central Europe. Science Advances, 2017 DOI: 10.1126/sciadv.aao3893

 

Omar Al Rifai, Jacqueline Chow, Julie Lacombe, Catherine Julien, Denis Faubert, Delia Susan-Resiga, Rachid Essalmani, John W.M. Creemers, Nabil G. Seidah, Mathieu Ferron. Proprotein convertase furin regulates osteocalcin and bone endocrine function. Journal of Clinical Investigation, 2017; 127 (11): 4104 DOI: 10.1172/JCI93437

K2
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2 Knapen MH et al. Osteoporos Int. 2013 Sep;24(9):2499-507.

3 Knapen MH et al. Thrombosis and Haemostasis. 2015; 19;113(5).

4 J Nutr Sci. 2015; 4: e35. Published online 2015 Oct 16. doi:  10.1017/jns.2015.25

PMCID: PMC4611080. Yogurt drink fortified with menaquinone-7 improves vitamin K status in a healthy population

Marjo H. J. Knapen,¹ Lavienja A. J. L. M. Braam,¹ Kirsten J. Teunissen,¹ Renate M. L. Zwijsen,² Elke Theuwissen,¹ andCees Vermeer^1,*

5 Cummings SR et al. Lancet.1993 Jan 9;341(8837):72–5.

6 Shea MK et al. J Nutr. 2011 Aug;141(8):1529-34.

7 Theuwissen E et al. Food & Function 2014 The Royal Society of Chemistry.

8 van Summeren MJH et al. Br J Nutr. 2009; 102(8):1171-8.

AUTOIMMUNITY – Dr Andrew Campbell

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RESEARCH
Romy Conzade, Wolfgang Koenig, Margit Heier, Andrea Schneider, Eva Grill, Annette Peters, Barbara Thorand. Prevalence and Predictors of Subclinical Micronutrient Deficiency in German Older Adults: Results from the Population-Based KORA-Age Study. Nutrients, 2017; 9 (12): 1276 DOI: 10.3390/nu9121276.

Yftach Gepner et al. Effect of Distinct Lifestyle Interventions on Mobilization of Fat Storage Pools: The CENTRAL MRI Randomized Controlled Trial. Circulation, 2017; CIRCULATIONAHA.117.030501 DOI: 10.1161/CIRCULATIONAHA.117.030501

NEW RELEASES

Kass L, et al. Effect of transdermal magnesium cream on serum and urinary magnesium levels in humans: A pilot study. PLOS One 2017: https://doi.org/10.1371/journal.pone.0174817

IHCAN December 2017 references

NEWS

Renzi-Hammond LM, Bovier ER, et al. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. Nutrients. 2017 November 14;9(11). pii: E1246. doi: 10.3390/nu9111246.

The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Jyrki K. Virtanen, Jaakko Mursu, Sari Voutilainen, Tomi-Pekka Tuomainen .
European Journal of Clinical Nutrition, published online 6.11.2017
doi:10.1038/s41430-017-0009-6
https://www.nature.com/articles/s41430-017-0009-6

Monti D et al. Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer. Seminars in Oncology 2017: http://www.seminoncol.org/article/S0093-7754(17)30136-7/fulltext

Experiences of healing therapy in patients with irritable bowel syndrome and inflammatory bowel disease. Andrew Soundy et al. BMC Complementary and Alternative Medicine 2015, 15:106: https://doi.org/10.1186/s12906-015-0611-x
Main, quantitative paper:
http://www.sciencedirect.com/science/article/pii/S187638201630422X
Secondary, qualitative paper:
https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0611-x.

Joseph L. Dieleman, PhD. Factors Associated With Increases in US Health Care Spending, 1996-2013. JAMA, November 2017 DOI: 10.1001/jama.2017.15927

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49. Kato-Kataoka A, Nishida K, Takada M, Suda K, Kawai M, Shimizu K, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K. Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress. Benef Microbes. 2016;7(2):153-6.
50. Klein LC, Bennett JM, Whetzel CA, Granger DA, Ritter FE. Caffeine and stress alter salivary alpha-amylase activity in young men. Hum Psychopharmacol. 2010 Jul;25(5):359-67.
51. Lane JD, Pieper CF, Phillips-Bute BG, Bryant JE, Kuhn CM. Caffeine affects cardiovascular and neuroendocrine activation at work and home. Psychosom Med. 2002 Jul-Aug;64(4):595-603.
52. Lovallo WR, Whitsett TL, al’Absi M, Sung BH, Vincent AS, Wilson MF. Caffeine stimulation of cortisol secretion across the waking hours in relation to caffeine intake levels. Psychosom Med. 2005 Sep-Oct;67(5):734-9.
53. Lovallo WR, Al’Absi M, Blick K, Whitsett TL, Wilson MF. Stress-like adrenocorticotropin responses to caffeine in young healthy men. Pharmacol Biochem Behav. 1996 Nov;55(3):365-9.
54. Klein LC, Whetzel CA, Bennett JM, Ritter FE, Nater UM, Schoelles M. Caffeine administration does not alter salivary α-amylase activity in young male daily caffeine consumers. BMC Res Notes. 2014 Jan 13;7:30.
55. Lovallo WR, Farag NH, Vincent AS, Thomas TL, Wilson MF. Cortisol responses to mental stress, exercise, and meals following caffeine intake in men and women. Pharmacol Biochem Behav. 2006 Mar;83(3):441-7.
56. MacKenzie T, Comi R, Sluss P, Keisari R, Manwar S, Kim J, Larson R, Baron JA. Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial. Metabolism. 2007 Dec;56(12):1694-8.
57. Gavrieli A, Yannakoulia M, Fragopoulou E, Margaritopoulos D, Chamberland JP, Kaisari P, Kavouras SA, Mantzoros CS. Caffeinated coffee does not acutely affect energy intake, appetite, or inflammation but prevents serum cortisol concentrations from falling in healthy men. J Nutr. 2011 Apr 1;141(4):703-7.
58. Papakonstantinou E, Kechribari I, Sotirakoglou Κ, Tarantilis P, Gourdomichali T, Michas G, Kravvariti V, Voumvourakis K, Zampelas A. Acute effects of coffee consumption on self-reported gastrointestinal symptoms, blood pressure and stress indices in healthy individuals. Nutr J. 2016 Mar 15;15:26.
59. Steptoe A, Gibson EL, Vuononvirta R, Williams ED, Hamer M, Rycroft JA, Erusalimsky JD, Wardle J. The effects of tea on psychophysiological stress responsivity and post-stress recovery: a randomised double-blind trial. Psychopharmacology.(Berl) 2007 Jan;190(1):81-9.
60. Haskell CF, Dodd FL, Wightman EL, Kennedy DO. Behavioural effects of compounds co-consumed in dietary forms of caffeinated plants. Nutr Res Rev. 2013 Jun;26(1):49-70.
61. Lara DR. Caffeine, mental health, and psychiatric disorders. J Alzheimers Dis. 2010;20 Suppl 1:S239-48.

62. Johnstone AM, Faber P, Andrew R, Gibney ER, Elia M, Lobley G, Stubbs RJ, Walker BR. Influence of short-term dietary weight loss on cortisol secretion and metabolism in obese men. Eur J Endocrinol. 2004 Feb;150(2):185-94.

STRESS – Catalina Fernández de Ana Portela

1. Suzanne C. Segerstrom and Gregory E. Miller, Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry, Psychol Bull. Author manuscript; available in PMC Feb 7, 2006.
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3. Zimmerman RS1, Frohlich ED. Stress and hypertension. J Hypertens Suppl. 1990 Sep;8(4):S103-7.
4. Annika Rosengren et al. Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study. The Lancet 2004, Volume 364, Issue 9438, 11–17 September, 953-962.
5. Su, C.Y., Shiao, M.S., and Wang, C.T., Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen, Biochim. Biophys. Acta, 1437, 223–234, 1999.
6. Komoda, Y. et al. 1989. Ganoderic Acid and Its Derivatives as Cholesterol Synthesis Inhibitors. Chem. Pharm. Bull. 37(2): 531-533.
7. Shu-Ting Chang and John Buswell. Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)−A Mushrooming Medicinal Mushroom. Int J Medicinal Mushrooms 1999, v1.i2.30, 139-146. DOI: 10.1615/IntJMedMushrooms.
8. Tsuno A, Taketomo N, Hiroyuki I. Healthful composition obtained from the hot water extract of Cordyceps sinensis mycelia. J Lab Clin Med 1995, 8:134–7.
9. I.J. Elenkov. Glucocorticoids and the Th1/Th2 balance. Ann. N. Y. Acad. Sci 2004, 1024, 138-146.
10. Hadj-Kacem H et al. Autoimmune thyroid diseases: genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions. Int J Immunogenet 2009, Apr; 36(2):85-96. doi: 10.1111/j.1744-313X.2009.00830.x.
11. Falgarone G, et al. Mechanisms in endocrinology. Role of emotional stress in the pathophysiology of Graves’ disease. Eur J Endocrinol 2013.
12. S.-Y. Wang, M.-L. Hsu, and H.-C. Hsu. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. International Journal of Cancer 1997, vol. 70, no. 6, pp. 699–705.
13. JH Koh, et al., Antifatigue and Anti-stress Effect of the Hot-Water Fraction from Mycelia of Cordyceps sinensis. Biol. Pharm. Bull 2003, 26 (5), 691–4.
14. Rossi P et al. Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation. Evid Based Complement Alt Med 2014, 979613.DOI: 10.1155/2014/979613. Epub 2014 Apr 1.
15. Akinobu Tsunoo et al, Meiji institute of Health Science. Cordyceps Sinensis: Its diverse effects on mammals in vitro and in vivo. Third International Symposium of the Mycological Society of Japan, 1995.
16. Guowei Dai, Tiantong Bao, Changfu Xu, Raymond Cooper, and Jia-Shi Zhu. CordyMax™ Cs-4 Improves Steady-State Bioenergy Status in Mouse Liver.
JACM 2004, July, 7(3): 231-240. https://doi.org/10.1089/107555301300328106
17. Holm JE, Lamberty K, McSherry WC 2nd, Davis PA The stress response in headache sufferers: physiological and psychological reactivity. Headache 1997, Apr;37(4):221-7.
18. Fukui PT et al. Trigger factors in migraine patients. Arq Neuropsiquiatr 2008, Sep; 66(3A):494-9.
19. Sun T-F et al. Mindfulness meditation in the control of severe headache. Chang Gung Med J, 2002, 25, 8.
20. Yi Liu, Jihui Wang. The Chemical Constituents and Pharmacological Actions of Cordyceps sinensis. Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 575063, https://www.hindawi.com/journals/ecam/2015/575063.
21. Nagano et al.. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Research 2010, 31, 231-237.
22. Lee J. M, Kwon H, Jeong H, editors. et al. Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res 2001, 15:245–9.
23. Ji DB et al. Phytother Res 2009, Jan, 23(1):116-22. doi: 10.1002/ptr.2576.
Antiaging effect of Cordyceps sinensis extract.
24. Dancey CP, Taghavi M, Fox RJ. The relationship between daily stress and symptoms of irritable bowel: a time-series approach. J Psychosom Res 1998, May;44(5):537-45.
25. Shaw G et al. Stress management for irritable bowel syndrome: a controlled trial.
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26. Koh J. H, Suh H. J, Ahn T. Hot-water extract from mycelia of Cordyceps sinensis as a substitute for antibiotic growth promoters. Biotechnol Lett 2003a, 25:585–90.
27. Macpherson AJ, Marrinic MM, Harris N. The functions of mucosal T-cells in containing the indigenous commensal flora of the intestine. Cell Mol Life Sci 2002, 59:2088–96.

NUTRIGENOMICS – Bernie Williams
References:
I. Hara K et al., The Pro12Ala Polymorphism in PPAR?2 may confer resistance to type 2 diabetes. Biochem Biophys. Res. Comm. (2000) 29:212-216
II. Stefan N. et al., Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene. Diabetes. (2001) 50:1143–1148
III. Vaquero AR et al. Using gene-network landscape to dissect genotype effects of TCF7L2 genetic variant on diabetes and cardiovascular risk. Physiol. Genomics. (2012) 44:903–14
IV. Shaffer S A et al. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 gene polymorphisms. Diabetes. (2007)12: 2443-50
V. Grant S et al. Variant of Transcription factor 7-like 2 gene confers risk of type 2 diabetes. Nature. (2006) 38: 320-323
VI. Scheller J et al., The pro-and-anti-inflammatory properties of the cytokine interleukin-6. Biochim et Biophys Acta – Mol Cell Res. (2011) 1813:5 878-888
VII. Ligthart S et al., DNA methylation signatures of chronic low grade inflammation are associated with complex diseases. (2016) Genome Biology 17:255
VIII. Brustolin S et al., Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res (2010) 43:1-7
IX. Lim U & Song M, Dietary and Lifestyle Factors of DNA methylation. Cancer Epigenetics (2012) 863:359-376
X. Bokor S et al., Single nucleotide polymorphism in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. Journal of Lipid Research (2010) 51:2325-33.
XI. Vessby B et al,. Desaturation and elongation of Fatty acids and insulin action. Ann N Y Acad Sci. (2002) 967:183-95.
XII. Leffler D et al., Extraintestinal manifestations of coeliac disease. Nat. Rev. Gastroenterol.Hepatol. (2015) 12: 561-571
XIII. Monsuur et al., Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms. PLoS ONE. (2008) 3:e2270
XIV. Withoff S, et al., Understanding celiac disease by genomics. Trends in Genetics. (2016) 32:295-308.

FRONTIERS – Simon Mills
Aggarwal BB.(2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6(3): 203-208.
Barnard RJ, Aronson WJ. (2009) Benign prostatic hyperplasia: does lifestyle play a role? Phys Sportsmed 37(4): 141-146.
Barry MJ, Meleth S, Lee JY, et al (2011). Effect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trial. Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Study Group. JAMA. 306(12):1344-51.
Bombardelli E, Morazzoni P. (1997) Cucurbita pepo L. Fitoterapia 68(4): 291-302.
Bone K, Mills S. (2013) Principles and Practice of Phytotherapy; 2nd Edition. Churchill Livingstone, Edinburgh
Capodice JL, Gorroochurn P, Cammack S et al. (2009) Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. J Soc Integr Oncol 7(2): 43-51.
Demark-Wahnefried W, Polascik TJ, George SL et al. (2008) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev 17(12): 3577-3587.
Freedland SJ, Aronson WJ. (2009) Dietary intervention strategies to modulate prostate cancer risk and prognosis. Curr Opin Urol 19(3): 263-267.
Gardner CD, Oelrich B, Liu JP et al. (2009) Prostatic soy isoflavone concentrations exceed serum levels after dietary supplementation. Prostate 69(7): 719-726.
Jacobs EJ, Rodriguez C, Mondul AM et al. (2005) A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence. J Natl Cancer Inst 97(13): 975-980.
John H, Barghorn A, Funke G et al. (2001) Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue. Eur Urol 39(1): 72-78.
Kell JS. (2010) Prostate-specific antigen tests and prostate cancer screening: an update for primary care physicians. Can J Urol 17(Suppl 1): 18-25.
Kramer G, Mitteregger D, Marberger M (2007). Is benign prostatic hyperplasia (BPH) an immune inflammatory disease? Eur Urol 51(5): 1202-1216.
Krieger JN. (2004) Classification, epidemiology and implications of chronic prostatitis in North America, Europe and Asia. Minerva Urol Nefrol 56(2): 99-107.
McCann MJ, Gill CI, Linton T et al. (2008) Enterolactone restricts the proliferation of the LNCaP human prostate cancer cell line in vitro. Mol Nutr Food Res 52(5): 567-580.
Mehik A, Hellstrom P, Sarpola A et al. (2001) Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland. BJU Int 88(1): g35-38.
Mills S. (2001) Benign prostatic disease: herbal approaches in Boyd & Hamilton-Stewart eds. Key advances in the effective management of benign prostatic disease. Journal of the Royal Society of Medicine, London. 35-40
Moul S, McVary KT. (2010) Lower urinary tract symptoms, obesity and the metabolic syndrome. Curr Opin Urol 20(1): 7-12.
Parsons JK, Im R. (2009) Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia. J Urol 182(4): 1463-1468.
Parsons JK, Sarma AV, McVary K et al. (2009) Obesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions. J Urol 182(6 Suppl): S27-S31.
Parsons JK. (2007) Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems. J Urol 178(2): 395-401.
Patel AR, Klein EA. (2009) Risk factors for prostate cancer. Nat Clin Pract Urology 6(2): 87-95.
Ranjan P, Dalela D, Sankhwar SN. (2006) Diet and benign prostatic hyperplasia: implications for prevention. Urology 68(3): 470-476.
Roehrbornb CG (2008). Pathology of benign prostatic hyperplasia. Int J Impot Res 20(Suppl 3): S11-S18.
Safarinejad MR. (2005) Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. J Herbal Pharmacother 5(4): 1-11.
Sarma AV, Kellogg Parsons J. (2009) Diabetes and benign prostatic hyperplasia: emerging clinical connections. Curr Urol Rep 10(4): 267-275.
Sarma AV, Parsons JK, McVary K et al. (2009) Diabetes and benign prostatic hyperplasia/lower urinary tract symptoms-what do we know? J Urol 182(6 Suppl): S32-S37.
Schoonen WM, Salinas CA, Kiemeney LALM et al. (2005) Alcohol consumption and risk of prostate cancer in middle-aged men. Int J Cancer 113(1): 133-140.
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Singh RP, Tyagi AK, Dhanalakshmi S et al. (2004) Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer 108(5): 733-740.
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Yan L, Spitznagel EL. (2009) Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr 89(4): 1155-1163.
Yassin AA, El-Sakka AI, Saad F et al. (2008) Lower urinary-tract symptoms and testosterone in elderly men. World J Urol 26(4): 359-364.

IN PRACTICE – Daniela Lawler.

Atkinson, W et al 2004. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut, 53 Pp: 1391-1393. http://gut.bmj.com/content/53/10/1459.short.
Cantorna, M. Mahon, B. 2004. Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence. EBM, 229(11). http://journals.sagepub.com/doi/pdf/10.1177/153537020422901108.
Heitzer, T et al 2001. Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients with Coronary Artery Disease. Circulation, 104 Pp: 2673-2678. June 2017. http://circ.ahajournals.org/content/104/22/2673?download=true.
Hyde, J. (2015). The Gut Makeover. (Great Britain. Quercus).
Kharrazian, D (2010). Why Do I Still Have Thyroid Symptoms?. (California. Elephant Press) p25, 31.
Lewis, C. (2016). Enteroimmunology. 3rd ed (Carrabelle Florida. PsyPress), p246.
Liblau, R. 1995. Th1 and Th2 CD4+ T cells in the pathogenesis of organ specific autoimmune disease. Immunology Today, 16(1). Pp: 34-38. http://www.sciencedirect.com/science/article/pii/0167569995800689.

RESEARCH

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

Lori D’Ortenzio, Isabelle Ribot, Bonnie Kahlon, Benoit Bertrand, Emmy Bocaege, Emeline Raguin, Annabelle Schattmann, Megan Brickley. The rachitic tooth: The use of radiographs as a screening technique. International Journal of Paleopathology, 2017; DOI: 10.1016/j.ijpp.2017.10.001

Haris Majeed, G. W. K. Moore. Impact of Multidecadal Climate Variability on United Kingdom Rickets Rates. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-16058-1
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort. Diabetologia, 2017; DOI: 10.1007/s00125-017-4489-7

Nicola Wilck et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature, 2017; DOI: 10.1038/nature24628

NEWS
Joseph Jamnik, Christopher R Villa, Sirbarinder Bryn Dhir, David J A Jenkins, Ahmed El-Sohemy. Prevalence of positive coeliac disease serology and HLA risk genotypes in a multiethnic population of adults in Canada: a cross-sectional study. BMJ Open, 2017; 7 (10): bmjopen-2017-017678 DOI: 10.1136/bmjopen-2017-017678.

Luke T. Stewart, Anas U. Khan, Kai Wang, Diana Pizarro, Sandipan Pati, Susan C. Buckingham, Michelle L. Olsen, John C. Chatham, Lori L. McMahon. Acute Increases in Protein O-GlcNAcylation Dampen Epileptiform Activity in Hippocampus. The Journal of Neuroscience, 2017; 37 (34): 8207 DOI: 10.1523/JNEUROSCI.0173-16.2017.

Ken-ichi Kudo, Tadashi Hanafusa and Toshiro Ono.  In vitro analysis of radioprotective effect of monoterpenes. J Radioanal Nucl Chem (2017) 313: 169.
DOI: https://doi.org/10.1007/s10967-017-5268-0.
https://link.springer.com/article/10.1007/s10967-017-5268-0.

Laura M. Kemppainen, Teemu T. Kemppainen, Jutta A. Reippainen, Suvi T. Salmenniemi, Pia H. Vuolanto. Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants. Scandinavian Journal of Public Health, 2017; 140349481773386 DOI: 10.1177/1403494817733869.

Olga Bednarska, Susanna A. Walter, Maite Casado-Bedmar, Magnus Ström, Eloísa Salvo-Romero, Maria Vicario, Emeran A. Mayer, Åsa V Keita. VIP and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.06.051

BEN BROWN – Nickel

1.             Schram SE, Warshaw EM, Laumann A. Nickel hypersensitivity: a clinical review and call to action. Int J Dermatol. 2010 Feb;49(2):115-25.2.             Yoshihisa Y, Shimizu T. Metal allergy and systemic contact dermatitis: an overview. Dermatol Res Pract. 2012;2012:749561.3.             Torres F, das Graças M, Melo M, Tosti A. Management of contact dermatitis due to nickel allergy: an update. Clin Cosmet Investig Dermatol. 2009 Apr 17;2:39-48.4.             Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.5.             Jensen CS, Menné T, Lisby S, Kristiansen J, Veien NK. Experimental systemic contact dermatitis from nickel: a dose-response study. Contact Dermatitis. 2003 Sep;49(3):124-32.6.             Ysart G, Miller P, Crews H, Robb P, Baxter M, De L’Argy C, Lofthouse S, Sargent C, Harrison N. Dietary exposure estimates of 30 elements from the UK Total Diet Study. Food Addit Contam. 1999 Sep;16(9):391-403. 7.             Krecisz B, Chomiczewska D, Kiec-Swierczynska M, Kaszuba A. Systemic contact dermatitis to nickel present in cocoa in 14-year-old boy. Pediatr Dermatol. 2011 May-Jun;28(3):335-6. 8.             Silvestri DL, Barmettler S. Pruritus ani as a manifestation of systemic contact dermatitis: resolution with dietary nickel restriction. Dermatitis. 2011  Jan-Feb;22(1):50-5.

9. Rizzi A, Nucera E, Laterza L, et al. Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? J Neurogastroenterol Motil. 2017 Jan 30;23(1):101-108.

10.         Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007 Sep-Oct;73(5):307-12.11.         Saito M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Ishimaru N. Molecular Mechanisms of Nickel Allergy. Int J Mol Sci. 2016 Feb 2;17(2).12.         Minelli M, Schiavino D, Musca F, et al. Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):193-201.

13. Picarelli A, Di Tola M, Vallecoccia A, Libanori V, Magrelli M, Carlesimo M, et al. Oral mucosa patch test: a new tool to recognize and study the adverse effects of dietary nickel exposure. Biol Trace Elem Res 2011; 139: 151-9.

14.         Braga M, Quecchia C, Perotta C, Timpini A, Maccarinelli K, Di Tommaso L, Di Gioacchino M. Systemic nickel allergy syndrome: nosologic framework and usefulness of diet regimen for diagnosis. Int J Immunopathol Pharmacol. 2013 Jul-Sep;26(3):707-16.15.         Borghini R, Donato G, Alvaro D, Picarelli A. New insights in IBS-like disorders: Pandora’s box has been opened; a review. Gastroenterol Hepatol Bed Bench. 2017 Spring;10(2):79-89.

16. Tammaro A, De Marco G, Persechino S, Narcisi A, Camplone G. Allergy to nickel: first results on patients administered with an oral hyposensitization therapy. Int J Immunopathol Pharmacol. 2009 Jul-Sep;22(3):837-40.

DIGESTIVE HEALTH update

Roopa Hebbandi Nanjundappa, Francesca Ronchi, Jinguo Wang, Xavier Clemente-Casares, Jun Yamanouchi, Channakeshava Sokke Umeshappa, Yang Yang, Jesús Blanco, Helena Bassolas-Molina, Azucena Salas, Hamza Khan, Robyn M. Slattery, Madeleine Wyss, Catherine Mooser, Andrew J. Macpherson, Laura K. Sycuro, Pau Serra, Derek M. McKay, Kathy D. McCoy, Pere Santamaria. A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. Cell, 2017; 171 (3): 655 DOI: 10.1016/j.cell.2017.09.022

Membrane Lipid Replacement – Mike Ash
[i] Nicolson GL, Ash ME.  Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore phospholipid function in cellular membranes, organelles, cells and tissues. Biochim. Biophys. Acta  2017; 1859: 1704-1724.  View Full Paper
[ii] Nicolson GL.  Membrane Lipid Replacement: clinical studies using a natural medicine approach to restoring membrane function and improving health.  Intern. J. Clin. Med. 2016; 7: 133-143. View Full Paper
[iii] Nicolson GL, Rosenblatt S, Ferreira de Mattos G, Settineri R, Breeding PC, Ellithorpe RR,  Ash ME.  Clinical uses of Membrane Lipid Replacement supplements in restoring membrane function and reducing fatigue in chronic diseases and cancer.  Discoveries 2016; 4(1): e54. View Full Paper
[iv] Singer, SJ, Nicolson GL The fluid mosaic model of the structure of cell membranes, Science 1972; 175: 720-731. View Abstract
[v] Nicolson GL. The Fluid—Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years. Biochim. Biophys. Acta 2014; 1838: 1451-1466. View Full Paper

Rosshart et al. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance. Cell, 2017 DOI: 10.1016/j.cell.2017.09.016.

Troy D. Hubbard, Iain A. Murray, Robert G. Nichols, Kaitlyn Cassel, Michael Podolsky, Guray Kuzu, Yuan Tian, Phillip Smith, Mary J. Kennett, Andrew D. Patterson, Gary H. Perdew. Dietary broccoli impacts microbial community structure and attenuates chemically induced colitis in mice in an Ah receptor dependent manner. Journal of Functional Foods, 2017; 37: 685 DOI: 10.1016/j.jff.2017.08.038.

Christopher L. Hager, Mahmoud A. Ghannoum. The mycobiome: Role in health and disease, and as a potential probiotic target in gastrointestinal disease. Digestive and Liver Disease, 2017; DOI: 10.1016/j.dld.2017.08.025.

Tiffani Alvey Jones, Diane Z. Hernandez, Zoë C. Wong, Anica M. Wandler, Karen Guillemin. The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut. PLOS Pathogens, 2017; 13 (10): e1006631 DOI: 10.1371/journal.ppat.1006631

RESEARCH UPDATE

Dorothy K. Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John (Jesse) Dills, James Luther, Amy Yang, Jody D. Ciolino, Howard Seltman, Stephen R. Wisniewski, Michael Terman, Katherine L. Wisner. Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial. American Journal of Psychiatry, 2017; appi.ajp.2017.1 DOI: 10.1176/appi.ajp.2017.16101200

Xiangyun Zhu et al. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutrition & Metabolism 2017,14:60. https://doi.org/10.1186/s12986-017-0217-z.

Kootte et al. Improvement of insulin sensitivity after lean donor feces in metabolic syndrome is driven by baseline intestinal microbiota composition. Cell Metabolism, 2017 DOI: 10.1016/j.cmet.2017.09.008

Katherine McGuire, J.Antonio Avina-Zubieta, John M. Esdaile, Mohsen Sadatsafavi, Eric C. Sayre, Michal Abrahamowicz, Diane Lacaille. Risk of Incident Chronic Obstructive Pulmonary Disease (COPD) in Rheumatoid Arthritis: A Population Based Cohort Study. Arthritis Care & Research, 2017; DOI: 10.1002/acr.23410.

Ian J. Wallace et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century PNAS 2017 114 (35) 9332-9336; doi:10.1073/pnas.1703856114

Timothy Heisel, Emmanuel Montassier, Abigail Johnson, Gabriel Al-Ghalith, Yi-Wei Lin, Li-Na Wei, Dan Knights, Cheryl A. Gale. High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut. mSphere, October 2017 DOI: 10.1128/mSphere.00351-17.

Wendy S White, Yang Zhou, Agatha Crane, Philip Dixon, Frits Quadt, Leonard M Flendrig. Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables. The American Journal of Clinical Nutrition, 2017; 106 (4): 1041 DOI: 10.3945/%u200Bajcn.117.153635

IHCAN October references

NEWS

Nisha Rao, Henry A. Spiller, Nichole L. Hodges, Thiphalak Chounthirath, Marcel J. Casavant, Amrit K. Kamboj, Gary A. Smith. An Increase in Dietary Supplement Exposures Reported to US Poison Control Centers. Journal of Medical Toxicology, 2017; DOI: 10.1007/s13181-017-0623-7.

Crawley EM, Gaunt DM, Garfield K, et al. Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for paediatric chronic fatigue syndrome: randomised controlled trial. Archives of Disease in Childhood. Published Online First: 20 September 2017. doi: 10.1136/archdischild-2017-313375.

Chunxu Gao, Bhanu Priya Ganesh, Zhongcheng Shi, Rajesh Rasik Shah, Robert Fultz, Angela Major, Susan Venable, Monica Lugo, Kathleen Hoch, Xiaowei Chen, Anthony Haag, Timothy C. Wang, James Versalovic. Gut Microbe–Mediated Suppression of Inflammation-Associated Colon Carcinogenesis by Luminal Histamine Production. The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.06.011

NEW RELEASES – migraine

Lidiane Lima Florencio, Anamaria Siriani de Oliveira, Gabriela Ferreira Carvalho, Fabiola Dach, Marcelo Eduardo Bigal, César Fernández-de-las-Peñas, Débora Bevilaqua-Grossi. Association Between Severity of Temporomandibular Disorders and the Frequency of Headache Attacks in Women With Migraine: A Cross-Sectional Study. Journal of Manipulative and Physiological Therapeutics, 2017; 40 (4): 250 DOI: 10.1016/j.jmpt.2017.02.006.

BEN BROWN: Alzheimer’s

 

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4. Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh- Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric restriction on neurocognition in overweight adults with high blood pressure. Hypertension 2010;55:1331–8.

5.             Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, Sanchez-Tainta A, Ros E, Valls-Pedret C, Martinez-Gonzalez MÁ. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomized trial. J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1318-25.6.             Valls-Pedret C, Sala-Vila A, Serra-Mir M, Corella D, de la Torre R, Martínez-González MÁ, Martínez-Lapiscina EH, Fitó M, Pérez-Heras A, Salas-Salvadó J, Estruch R, Ros E. Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial. JAMA Intern Med. 2015 Jul;175(7):1094-103.7.             Knight A, Bryan J, Wilson C, Hodgson JM, Davis CR, Murphy KJ. The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study. Nutrients. 2016 Sep 20;8(9).8.             Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015 Sep;11(9):1015-22.9.             Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement. 2015 Sep;11(9):1007-14.

10. Morris MC. MIND Diet Intervention and Cognitive Decline (MIND). Accessed on ClinicalTrials.gov on September 15^th, 2017.

11.         Bland J. Mild Cognitive Impairment, Neurodegeneration, and Personalized Lifestyle Medicine. Integr Med (Encinitas). 2016 Apr;15(2):12-4.12.         Schelke MW, Hackett K, Chen JL, Shih C, Shum J, Montgomery ME, Chiang GC, Berkowitz C, Seifan A, Krikorian R, Isaacson RS. Nutritional interventions for Alzheimer’s prevention: a clinical precision medicine approach. Ann N Y Acad Sci. 2016 Mar;1367(1):50-6.13.         Bredesen DE. Reversal of cognitive decline: a novel therapeutic program. Aging (Albany NY). 2014 Sep;6(9):707-17. 14.         Bredesen DE, Amos EC, Canick J, Ackerley M, Raji C, Fiala M, Ahdidan J. Reversal of cognitive decline in Alzheimer’s disease. Aging (Albany NY). 2016 Jun;8(6):1250-8.15.         Koppel SJ, Swerdlow RH. Neuroketotherapeutics: A modern review of a century-old therapy. Neurochem Int. 2017 Jun 1. pii: S0197-0186(17)30227-9.16.         Cunnane SC, Courchesne-Loyer A, St-Pierre V, Vandenberghe C, Pierotti T, Fortier M, Croteau E, Castellano CA. Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Ann N Y Acad Sci. 2016 Mar;1367(1):12-20.17.         Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. Ketones block amyloid entry and improve cognition in an Alzheimer’s model. Neurobiol Aging. 2016 Mar;39:25-37.18.         Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol. 2006 Aug;60(2):223-35.19.         Yang X, Cheng B. Neuroprotective and anti-inflammatory activities of ketogenic diet on MPTP-induced neurotoxicity. J Mol Neurosci. 2010 Oct;42(2):145-53.20.         Krikorian R, Shidler MD, Dangelo K, Couch SC, Benoit SC, Clegg DJ. Dietary ketosis enhances memory in mild cognitive impairment. Neurobiol Aging. 2012

21. Henderson ST, Vogel JL, Barr L, Garvin F, Jones JJ, Costantini LG. Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer’s disease: a randomized, double-blind, placebo-controlled, multicenter trial. Nutrition & Metabolism. 2009;6:31.

22.         Maynard SD, Gelblum J. Retrospective cohort study of the efficacy of caprylic triglyceride in patients with mild-to-moderate alzheimer’s disease. Neuropsychiatr Dis Treat. 2013;9:1619-27.23.         Farah BA. Effects of caprylic triglyceride on cognitive performance and cerebral glucose metabolism in mild Alzheimer’s disease: a single-case observation. Front Aging Neurosci. 2014 Jul 16;6:133.24.         Ohnuma T, Toda A, Kimoto A, et al. Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study. Clin Interv Aging. 2016 Jan 8;11:29-36.

25. Gandotra S, Kour J, Van der Waag A. Efficacy of Adjunctive Extra Virgin Coconut Oil Use in Moderate to Severe Alzheimer’s Disease. Int J Sch Cog Psychol 2014, 1:2

26.         Kapogiannis D, Mattson MP. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer’s disease. Lancet Neurol. 2011 Feb;10(2):187-98.

27. Mattson MP. Challenging oneself intermittently to improve health. Dose Response. 2014 Oct 20;12(4):600-18.

28.         Wahl D, Cogger VC, Solon-Biet SM, Waern RV, Gokarn R, Pulpitel T, Cabo Rd, Mattson MP, Raubenheimer D, Simpson SJ, Le Couteur DG. Nutritional strategies to optimise cognitive function in the aging brain. Ageing Res Rev. 2016 Nov;31:80-92.29.         Witte AV, Fobker M, Gellner R, Knecht S, Flöel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1255-60.30.         Martin CK, Anton SD, Han H, York-Crowe E, Redman LM, Ravussin E, Williamson DA. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial. Rejuvenation Res. 2007 Jun;10(2):179-90.31.         Scott TM, Rasmussen HM, Chen O, Johnson EJ. Avocado Consumption Increases Macular Pigment Density in Older Adults: A Randomized, Controlled Trial. Nutrients. 2017 Aug 23;9(9). 32.         Krikorian R, Shidler MD, Nash TA, Kalt W, Vinqvist-Tymchuk MR, Shukitt-Hale B, Joseph JA. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010 Apr 14;58(7):3996-4000.

33. Rita Cardoso B, Apolinário D, da Silva Bandeira V, et al. Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial.Eur J Nutr. 2016 Feb;55(1):107-16.

34.         Kent K, Charlton K, Roodenrys S, et al. Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia. Eur J Nutr. 2017 Feb;56(1):333-341.

35. Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010 Mar;103(5):730-4.

36.         Krikorian R, Boespflug EL, Fleck DE, Stein AL, Wightman JD, Shidler MD, Sadat-Hossieny S. Concord grape juice supplementation and neurocognitive function in human aging. J Agric Food Chem. 2012 Jun 13;60(23):5736-42.37.         Ide K, Yamada H, Takuma N, Park M, Wakamiya N, Nakase J, Ukawa Y, Sagesaka YM. Green tea consumption affects cognitive dysfunction in the elderly: a pilot study. Nutrients. 2014 Sep 29;6(10):4032-42.38.         Parachikova A, Green KN, Hendrix C, LaFerla FM. Formulation of a medical food cocktail for Alzheimer’s disease: beneficial effects on cognition and neuropathology in a mouse model of the disease. PLoS One. 2010 Nov 17;5(11):e14015. 39.         Chan A, Paskavitz J, Remington R, et al. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer’s disease: a 1 year, open-label pilot study with an 16-month caregiver extension. Am J Alzheimers Dis Other Demen. 2008 Dec-2009 Jan;23(6):571-85. 40.         Remington R, Bechtel C, Larsen D, et al. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer’s Disease. J Alzheimers Dis. 2015;45(2):395-405.41.         Remington R, Bechtel C, Larsen D, et al. Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study. J Alzheimers Dis. 2016;51(4):991-5. 42.         Zanotta D, Puricelli S, Bonoldi G. Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study. Neuropsychiatr Dis Treat. 2014 Feb 3;10:225-30.43.         Galasko DR, Peskind E, Clark CM, Quinn JF, Ringman JM, Jicha GA, Cotman C, Cottrell B, Montine TJ, Thomas RG, Aisen P; Alzheimer’s Disease Cooperative Study. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch Neurol. 2012 Jul;69(7):836-41.44.         Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39.45.         Douaud G, Refsum H, de Jager CA, Jacoby R, Nichols TE, Smith SM, Smith AD. Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9523-8.

46. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: A randomized controlled trial. Int J Geriatr Psychiatry. 2012;27(6):592–600.

47.         Cheng D, Kong H, Pang W, Yang H, Lu H, Huang C, Jiang Y. B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia. Nutr Neurosci. 2016 Dec;19(10):461-466.48.         Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(2):547-57.49.         Ma F, Wu T, Zhao J, Han F, Marseglia A, Liu H, Huang G. Effects of 6-Month Folic Acid Supplementation on Cognitive Function and Blood Biomarkers in Mild Cognitive Impairment: A Randomized Controlled Trial in China. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1376-83.50.         Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, Zheng M, Zhang M, Xu W, Huang G. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016;2016:5912146.51.         Werder SF. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatr Dis Treat. 2010 May 6;6:159-95.52.         Eastley R, Wilcock GK, Bucks RS. Vitamin B12 deficiency in dementia and cognitive impairment: the effects of treatment on neuropsychological function. Int J Geriatr Psychiatry. 2000 Mar;15(3):226-33.53.         Kwok T, Lee J, Lam L, Woo J. Vitamin B(12) supplementation did not improve cognition but reduced delirium in demented patients with vitamin B(12) deficiency. Arch Gerontol Geriatr. 2008 May-Jun;46(3):273-82.54.         van Dyck CH, Lyness JM, Rohrbaugh RM, Siegal AP. Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study. Int Psychogeriatr. 2009 Feb;21(1):138-47.55.         Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS, Wang Q, Wang JZ, Liu GP. Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem. 2013 Feb;124(3):388-96.56.         Sun J, Wen S, Zhou J, Ding S. Association between malnutrition and hyperhomocysteine in Alzheimer’s disease patients and diet intervention of betaine. J Clin Lab Anal. 2016 Nov 7. doi: 10.1002/jcla.22090. [Epub ahead of print]57.         Wu S, Ding Y, Wu F, Li R, Hou J, Mao P. Omega-3 fatty acids intake and risks of dementia and Alzheimer’s disease: a meta-analysis. Neurosci Biobehav Rev. 2015 Jan;48:1-9.58.         Ammann EM, Pottala JV, Robinson JG, Espeland MA, Harris WS. Erythrocyte omega-3 fatty acids are inversely associated with incident dementia: Secondary analyses of longitudinal data from the Women’s Health Initiative Memory Study (WHIMS). Prostaglandins Leukot Essent Fatty Acids. 2017 Jun;121:68-75.59.         Pottala JV, Yaffe K, Robinson JG, Espeland MA, Wallace R, Harris WS. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. Neurology. 2014 Feb 4;82(5):435-42.60.         Fraga VG, Carvalho MDG, Caramelli P, de Sousa LP, Gomes KB. Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review. J Neuroimmunol. 2017 Sep 15;310:111-119.61.         Freund Levi Y, Vedin I, Cederholm T, Basun H, Faxén Irving G, Eriksdotter M, Hjorth E, Schultzberg M, Vessby B, Wahlund LO, Salem N Jr, Palmblad J. Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer’s disease: the OmegAD study. J Intern Med. 2014 Apr;275(4):428-36.62.         Eriksdotter M, Vedin I, Falahati F, Freund-Levi Y, Hjorth E, Faxen-Irving G, Wahlund LO, Schultzberg M, Basun H, Cederholm T, Palmblad J. Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer’s Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. J Alzheimers Dis. 2015;48(3):805-12.63.         Vedin I, Cederholm T, Freund-Levi Y, Basun H, Garlind A, Irving GF, Eriksdotter-Jönhagen M, Wahlund LO, Dahlman I, Palmblad J. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLoS One. 2012;7(4):e35425.64.         Nock TG, Chouinard-Watkins R, Plourde M. Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline. Biochim Biophys Acta. 2017 Oct;1862(10 Pt A):1068-1078.65.         Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Münch G. Lipoic acid as a novel treatment for Alzheimer’s disease and related dementias. Pharmacol Ther. 2007 Jan;113(1):154-64.

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67.         Shinto L, Quinn J, Montine T, et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer’s disease. J Alzheimers Dis. 2014;38(1):111 20.68.         Pepeu G, Pepeu IM, Amaducci L. A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain?Pharmacol Res. 1996 Feb;33(2):73-80.69.         Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging. 2013;8:557-63.70.         Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin Interv Aging. 2010 Nov 2;5:313-6.71.         Moré MI, Freitas U, Rutenberg D. Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia. Adv Ther. 2014 Dec;31(12):1247-672.         Kato-Kataoka A, Sakai M, Ebina R, Nonaka C, Asano T, Miyamori T. Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr. 2010 Nov;47(3):246-5573.         Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, Fernandes BS, Berk M, Marriott A. The effect of N-acetylcysteine (NAC) on human cognition – A systematic review. Neurosci Biobehav Rev. 2017 Jul;78:44-56.

74. Pocernich CB, Butterfield DA. Elevation of glutathione as a therapeutic strategy in Alzheimer disease. Biochim Biophys Acta. 2012 May;1822(5):625-30.

75.         Adair JC, Knoefel JE, Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease. Neurology. 2001 Oct 23;57(8):1515-7.76.         Chan A, Remington R, Kotyla E, Lepore A, Zemianek J, Shea TB. A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. J Nutr Health Aging. 2010 Mar;14(3):224-30.77.         Remington R, Chan A, Paskavitz J, Shea TB. Efficacy of a vitamin/nutraceutical formulation for moderate-stage to later-stage Alzheimer’s disease: a placebo-controlled pilot study. Am J Alzheimers Dis Other Demen. 2009 Feb-Mar;24(1):27-33.

HEART RESEARCH UPDATE Simon Martin

1. DiNicolantonio JJ et al. Targeting aspirin resistance with nutraceuticals: A possible strategy for reducing cardiovascular morbidity and mortality. Open Heart 2017, 4(2).
2. Hydrogen Peroxide Watery Fuel for Change in Vascular Biology,

Frank M. Faraci. Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26:1931-1933. https://doi.org/10.1161/01.ATV.0000238355.56172.b3.

3. Zagli G et al. Hydrogen sulfide inhibits human platelet aggregation. European Journal of Pharmacology 2007, 559(1): 65-68. https://doi.org/10.1016/j.ejphar.2006.12.011.
   4. Larson MK at al. Omega-3 fatty acids modulate collagen signaling in human platelets. Prostaglandins Leukot Essent Fatty Acids 2011;84:93–8.doi:10.1016/j.plefa.2010.11.004.

Devries S et al. A deficiency of nutrition education and practice in cardiology. Am J Med 2017, 127: 9. http://www.amjmed.com/article/S0002-9343(17)30527-2/fulltext.

Maryam Sharifi‐Sanjani, Nicholas M. Oyster, Elisia D. Tichy, Kenneth C. Bedi, Ofer Harel, Kenneth B. Margulies, Foteini Mourkioti. Cardiomyocyte‐Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans. Journal of the American Heart Association, September 2017 DOI: 10.1161/JAHA.116.005086.

FRONTIERS: Simon Mills
1. Bennett HD et al. Health coaching for patients with chronic illness. Fam Pract Manag 210, 17, 5, 24-9.
2. www.dh.gov.uk/selfcare.

RESEARCH UPDATE

Paul Gellert, Petra von Berenberg, Monika Oedekoven, Maria Klemt, Christine Zwillich, Stefan Hörter, Adelheid Kuhlmey, Dagmar Dräger. Centenarians Differ in Their Comorbidity Trends During The 6 Years Before Death Compared to Individuals Who Died in Their 80s or 90s. The Journals of Gerontology: Series A, 2017; DOI: 10.1093/gerona/glx136.

Ashley A. Ross, Andrew C. Doxey, Josh D. Neufeld. The Skin Microbiome of Cohabiting Couples. mSystems, July 2017 DOI: 10.1128/mSystems.00043-17 .

Claire T. McEvoy, Heidi Guyer, Kenneth M. Langa, Kristine Yaffe. Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study. Journal of the American Geriatrics Society, 2017; DOI: 10.1111/jgs.14922.

Eric L. Garland, Anne K. Baker, Paula Larsen, Michael R. Riquino, Sarah E. Priddy, Elizabeth Thomas, Adam W. Hanley, Patricia Galbraith, Nathan Wanner, Yoshio Nakamura. Randomized Controlled Trial of Brief Mindfulness Training and Hypnotic Suggestion for Acute Pain Relief in the Hospital Setting. Journal of General Internal Medicine, 2017; DOI: 10.1007/s11606-017-4116-9.

Ather Ali, Theresa R Weiss, Douglas McKee, Alisa Scherban, Sumiya Khan, Maxine R Fields, Damian Apollo, Wajahat Z Mehal. Efficacy of individualised diets in patients with irritable bowel syndrome: a randomised controlled trial. BMJ Open Gastroenterology, 2017; 4 (1): e000164 DOI: 10.1136/bmjgast-2017-000164

Ling Wu, Paul Velander, Dongmin Liu, Bin Xu. Olive component oleuropein promotes β-cell insulin secretion and protects β-cells from amylin amyloid induced cytotoxicity. Biochemistry, 2017; DOI: 10.1021/acs.biochem.7b00199.

M F Hjorth, H M Roager, T M Larsen, S K Poulsen, T R Licht, M I Bahl, Y Zohar, A Astrup.

Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. International Journal of Obesity, 2017; DOI: 10.1038/ijo.2017.220.

 

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[1] Envita medical Centre (2017) Symptoms of Lyme Disease—the Great Imitator. Available at: https://www.envita.com  [Accessed 6^th September 2017][1] Ingram C (2015) Lyme Disease Mimics a Vast Number of Other Diseases.   Available at: https://cassingram.com   [Accessed 7^th September 2017][1] Gülçin I, Oktay M, Kireçci E, Küfrevioğlu I (2003) Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts.  Food Chemistry 83:371-382

 

 

[1] Francis G, Karem Z, Makkar HP, Becker K (2002) The biological action of saponins in animal systems: a review.  Br J Nutr 88:587-605.

 

 

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[1] Arthur S (2007) The effectiveness of Samento, Cumanda, Burbur and Dr Lee Cowden’s Protocol in the treatment of chronic Lyme disease.  Townsend Letter for Doctors and Patients 285:101

 

 

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[1] Guliani BP, Kuman S, Chawla N, Mehta A (2017) Neuroretinitis as presenting and the only presentation of Lyme disease: Diagnosis and management.  Indian Journal of Ophthalmology 65(3) 250-252

 

 

[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231Klig

 

 

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[1] World Health Organization (2017) Trachoma.  Available at:    http://www.who.int/gho/neglected_diseases/trachoma/en    [Accessed 6^th September 2017][1] Envita Medical Centre (2017)  Bartonella, a chronic Lyme disease coinfection, is more causing chronic fatigue problems.   Available at: https://www.envita.com  [Accessed 6^th September 2017][1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231

 

 

[1] Klig JE (2008) Ophthalmologic Complications of Systemic Disease.  Emerg Med Clin N. Am 26:217-231

 

 

[1] Denniston AK, Keane PA (2015) Letter: Paravascular Pathways in the Eye: Is there an ‘Ocular Glymphatic System’?   Invest Ophthalmol Vis Sci 56:3955-3956

 

 

---

 

Lyme Disease and linked conditions:

References

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2. Stricker RB, Middelveen MJ (2015) Sexual transmission of Lyme disease: challenging the tickborne disease paradigm. Expert review of anti-infective therapy 13 (11):1303-1306.
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NEWS

Baker H, DeAngelis B, Holland B, Gittens-Williams L, Barrett T Jr. Vitamin Profile of 563 Gravidas during Trimesters of Pregnancy. Journal of the American College of Nutrition 2002;21(1):33–7.

 NAD Deficiency, Congenital Malformations, and Niacin Supplementation

Hongjun Shi et al. N Engl J Med 2017; 377:544-552. August 10, 2017 DOI: 10.1056/NEJMoa1616361.

 Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial

Kuang-Chih Hsiao et al. The Lancet, Child and Adolescent Health, 15 August 2017.

DOI: http://dx.doi.org/10.1016/S2352-4642(17)30041-X

 Luisa Cimmino et al. Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell, 2017; DOI: 10.1016/j.cell.2017.07.032.

 BEN BROWN

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29.  Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A. Vitamin C, Aging  and Alzheimer’s Disease. Nutrients. 2017 Jun 27;9(7).

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31.  Dominiak A, Wilkaniec A, Wroczyński P, Adamczyk A. Selenium in the Therapy of  Neurological Diseases. Where is it Going? Curr Neuropharmacol. 2016;14(3):282-99.

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34.  Wilkins HM, Morris JK. New Therapeutics to Modulate Mitochondrial Function in  Neurodegenerative Disorders. Curr Pharm Des. 2017;23(5):731-752.

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36.  Murugaiyah V, Mattson MP. Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective. Neurochem Int. 2015 Oct;89:271-80.

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 PATRICK HOILFORD

SEVEN ESSENTIALS FOR 100% HEALTH

 1. See www.patrickholford.com/advice/chromium-the-evidence

 2. Guimaraes M etal.’Effect of chromium supplementation on the glucose homeostasis and anthropometry of type 2 diabetic patients: Double blind, randomized clinical trial.’ J Trace Elem Med Biol. 2016 Jul;36:65-72

3. Paiva AN et al., ‘Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.‘J Trace Elem Med Biol. 2015 Oct;32:66-72 -/26302914

4. H. Hemila et al., ‘Vitamin C and Infections’ Nutrients. 2017 Mar 29;9(4).

5. T Spector, ‘Epigenetics of discordant monozygotic twins: implications for disease’ Genome Med. 2014; 6(7): 60

6. Harrison S et al, ‘Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis.’ Cancer Causes Control. 2017 Jun;28(6):497-528.

7. Bao J et al, ‘Prediction of postprandial glycemia and insulinemia in lean, young, healthy adults: glycemic load compared with carbohydrate content alone.’Am J Clin Nutr. 2011 May;93(5):984-96

8. Bischoff-Ferrari H. ‘Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.’ Adv Exp Med Biol. 2014 ;810:500-25;  also Pludowski P et al., ‘Vitamin D supplementation guidelines.’ J Steroid Biochem 2017 Feb 12. pii: S0960-0760(17)30031-6.

9. Fan S et al, ‘BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.’ Br J Cancer. 2006 Feb 13;94(3):407-26/16434996

10. https://www.holfordirect.com/100-health-survey-patrick-holford.html

 AGEING

Andrew Kingston, Pia Wohland, Raphael Wittenberg, Louise Robinson, Carol Brayne, Fiona E Matthews, Carol Jagger, E Green, L Gao, R Barnes, A Arthur, C Baldwin, L E Barnes, C Brayne, A Comas-Herrera, T Dening, G Forster, S Harrison, P G Ince, C Jagger, F E Matthews, I G McKeith, B Parry, J Pickett, L Robinson, B C M Stephan, S Wharton, R Wittenberg, B Woods, R Weller. Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). The Lancet, 2017; DOI: 10.1016/S0140-6736(17)31575-1.  

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.

Xu M, Tchkonia T, Ding H, Ogrodnik M, Lubbers ER, Pirtskhalava T, White TA, Johnson KO, Stout MB, Mezera V, Giorgadze N, Jensen MD, LeBrasseur NK, Kirkland JL. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. doi: 10.1073/pnas.1515386112. Epub 2015 Nov 2.

 Natural products targeting STAT3 signaling pathways in cancer cells. Biodesign 2016, 4 (1), 004 (01), 1-17. Yena Jin, Younghwan Kim,  Yu-Jin Lee, Dong Cho Han, Byoung-Mog Kwon. http://www.bdjn.org/APP_PDF/BDJN004-01-01.pdf.  

 Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial. Lindbergh CA, Renzi-Hammond LM, Hammond BR, Terry DP, Mewborn CM, Puente AN, Miller LS.  J Int Neuropsychol Soc. 2017 Jul 11:1-14. doi: 10.1017/S1355617717000534. [Epub ahead of print]

RESEARCH UPDATE

Robert Sonowal, Alyson Swimm, Anusmita Sahoo, Liping Luo, Yohei Matsunaga, Ziqi Wu, Jui A. Bhingarde, Elizabeth A. Ejzak, Ayush Ranawade, Hiroshi Qadota, Domonica N. Powell, Christopher T. Capaldo, Jonathan M. Flacker, Rhienallt M. Jones, Guy M. Benian, and Daniel Kalman. Indoles from commensal bacteria extend healthspan. PNAS, August 21, 2017 DOI: 10.1073/pnas.1706464114

Olga Theou, Joanna M. Blodgett, Judith Godin, Kenneth Rockwood. Association between sedentary time and mortality across levels of frailty. Canadian Medical Association Journal, 2017; 189 (33): E1056 DOI: 10.1503/cmaj.161034.

Austin T. Mudd, Kirsten Berding, Mei Wang, Sharon M. Donovan, Ryan N. Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus and brain N-acetylaspartate in the young pig. Gut Microbes, 2017; 1 DOI: 10.1080/19490976.2017.1353849

 Pinaki Panigrahi, Sailajanandan Parida, Nimai C. Nanda, Radhanath Satpathy, Lingaraj Pradhan, Dinesh S. Chandel, Lorena Baccaglini, Arjit Mohapatra, Subhranshu S. Mohapatra, Pravas R. Misra, Rama Chaudhry, Hegang H. Chen, Judith A. Johnson, J. Glenn Morris, Nigel Paneth, Ira H. Gewolb. A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature, 2017; DOI: 10.1038/nature23480

 Claire E Berryman, Jennifer A Fleming, Penny M Kris-Etherton. Inclusion of Almonds in a Cholesterol-Lowering Diet Improves Plasma HDL Subspecies and Cholesterol Efflux to Serum in Normal-Weight Individuals with Elevated LDL Cholesterol. The Journal of Nutrition, 2017; 147 (8): 1517 DOI: 10.3945/jn.116.245126

 

 

 

 

 

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Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK (2017). Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol 55, 1041-1046.

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[1] Tannock GW et al (2013) Comparison of the compositions of the stool microbiotas of infants fed goat milk formula, cow milk-based formula, or breast milk. Appl Environ Microbiol 79:3040-8
[1] Hussey S et al (2012) Parenteral antibiotics reduce bifidobacteria colonization and diversity in neonates. Int J Microbiol doi: 10/1155/2011/130574
[1] Chow J et al (2010) Host-Bacterial Symbiosis in Health and Disease. Adv Immunol 107:243-274

 

[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033

 

[1] Clemente JC et al (2012) The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 148: 1258-1270

 

[1] Vangay P et al (2015) Antibiotics, Pediatric Dysbiosis, and Disease. Cell Host Microbe 17(5):553-564

 

[1] Dethlefsen L & Relman DA (2011) Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. PNAS 108(1):4554-4561
[1] Clemente JC et al (2012) The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 148: 1258-1270
[1] Francino MP (2016). Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances. Front Microbiol 6:1543

 

[1] Reid G (2006) Probiotics to prevent the need for, and augment the use of, antibiotics. Can J Infect Dis Med Microbiol 17(5):291-295

 

[1] Plummer SF et al (2005) Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy. Int J Antimicrob Agents 26:69-74

 

[1] Madden JAJ et al (2005) Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind placebo-controlled pilot study. Int Immunopharmacol 5:1091-1097

 

[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033

 

[1] Petersen C & Round JL (2014) Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 16(7):1024-1033
[1] Conlon MA & Bird AR (2015) The Impact of Diet and Lifestyle on Gut Microbiota and Human Health. Nutrients 7(1):17-44

 

NEWS

Am J Clin Nutr. 2017 Jul 5. pii: ajcn138693. doi: 10.3945/ajcn.116.138693. [Epub ahead of print]. Daily supplementation with 15 μg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial.

Tripkovic L¹, Wilson LR², Hart K², Johnsen S³, de Lusignan S⁴, Smith CP⁵, Bucca G⁵, Penson S⁶, Chope G⁶, Elliott R², Hyppönen E⁷, Berry JL⁸, Lanham-New SA².

 

Frontiers in Aging Neuroscience 2017; 9 : 168. Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants. Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Jawad Ahmed. PMID: 28611658.

Osada H, Okamoto T, Kawashima H, Toda, E, Miyake S, Nagai N, et al. (2017) Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina. PLoS ONE 12(6): e0178627. https://doi.org/10.1371/journal.pone.0178627.

Kirsten E. Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M. Phillips. A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial. PLOSONE, 2017; 12 (7): e0181387 DOI: 10.1371/journal.pone.0181387.

Timothy J. Wilt, Karen M. Jones, Michael J. Barry, Gerald L. Andriole, Daniel Culkin, Thomas Wheeler, William J. Aronson, Michael K. Brawer. Follow-up of Prostatectomy versus Observation for Early Prostate Cancer. New England Journal of Medicine, 2017; 377 (2): 132 DOI: 10.1056/NEJMoa1615869.

Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Canadian Medical Association Journal, 2017; 189 (28): E929 DOI: 10.1503/cmaj.161390

NEWS EXTRA
Rebecca Spain, Katherine Powers, Charles Murchison, Elizabeth Heriza, Kimberly Winges, Vijayshree Yadav, Michelle Cameron, Ed Kim, Fay Horak, Jack Simon, Dennis Bourdette. Lipoic acid in secondary progressive MS. Neurology – Neuroimmunology Neuroinflammation, 2017; 4 (5): e374 DOI: 10.1212/NXI.0000000000000374

BEN BROWN endotoxin

1. Laveti D, Kumar M, Hemalatha R, Sistla R, Naidu VG, Talla V, Verma V, Kaur N, Nagpal R. Anti-inflammatory treatments for chronic diseases: a review. Inflamm Allergy Drug Targets. 2013 Oct;12(5):349-61.
2. Saad MJ, Santos A, Prada PO. Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology (Bethesda). 2016 Jul;31(4):283-93.
3. Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL, Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BH, Sterkman L, Vafeiadou K, Benedetti MM, Williams CM, Calder PC. Low-grade inflammation, diet composition and health: current research evidence and its translation. Br J Nutr. 2015 Oct 14;114(7):999-1012.
4. Calder PC, Albers R, Antoine JM, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009 May;101 Suppl 1:S1-45.
5. Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM. Intestinal permeability–a new target for disease prevention and therapy. BMC Gastroenterol. 2014 Nov 18;14:189.
6. Erridge C, Duncan SH, Bereswill S, Heimesaat MM. The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5. PLoS ONE 2010;5:e9125.
7. Erridge C. The capacity of foodstuffs to induce innate immune activation of human monocytes in vitro is dependent on food content of stimulants of Toll-like receptors 2 and 4. Br J Nutr. 2011 Jan;105(1):15-23.
8. Erridge C. Stimulants of Toll-like receptor (TLR)-2 and TLR-4 are abundant in certain minimally-processed vegetables. Food Chem Toxicol. 2011 Jun;49(6):1464-7.
9. Erridge C. Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease. Atherosclerosis. 2011 May;216(1):1-6.
10. Herieka M, Faraj TA, Erridge C. Reduced dietary intake of pro-inflammatory Toll-like receptor stimulants favourably modifies markers of cardiometabolic risk in healthy men. Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):194-200.

Endotoxin and atherosclerosis (Simon Martin)

1. Clett Erridge, Teresa Attina, Corinne M Spickett and David J Webb. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. Am J Clin Nutr 2007, 86 (5):1286-92. Online at http://ajcn.nutrition.org/content/86/5/1286.long.
   2. Swaroop Pendyala, Jeanne M. Walker, and Peter R. Holt

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut.

Gastroenterology. 2012 May; 142(5): 1100–1101.e2.

Published online 2012 Feb 8. doi:  10.1053/j.gastro.2012.01.034

Ice Man
M. Kox, L. T. van Eijk, J. Zwaag, J. van den Wildenberg, F. C. G. J. Sweep, J. G. van der Hoeven, P. Pickkers. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1322174111

SIMON MILLS – Cinnamon

1. Dalby, A (2000). Dangerous Tastes: The Story of Spices.  British Library, London.
2. Vincent, W (1800) The Periplus of the Erythrean Sea: Part the First. London
3. He ZD, Qiao CF Han QB et al (2005). Authentication and quantitative analysis on the chemical profile of cassia bark (cortex cinnamomi) by high-pressure liquid chromatography. J Agric Food Chem vol 53, no 7, pp 2424-8
4. EFSA (European Food Safety Authority) (2008) Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC): Question No EFSA-Q-2008-677. “Coumarin in flavourings and other food ingredients with flavouring properties”. The EFSA Journal, vol 793, pp 1-15
5. Crawford P, Thai C, Obholz J, et al (2016) Assessment of the effect of lIfestyle intervention plus water-soluble cinnamon extract on lowering blood glucose in pre-diabetics, a randomized, double-blind, multicenter, placebo controlled trial: study protocol for a randomized controlled trial. vol 5, no 17,p 9
6. Zhang Z, Ye F, Wiseman N, and Mitchell, C (1999). Shang Han Lun: On Cold Damage, Translation and Commentaries. Paradigm Publications
7. Ravindran PN, Nirmal-Babu K, Shylaja M eds (2005) Cinnamon and Cassia: The Genus Cinnamomum. CRC Press
8. Perry LM (1980) Medicinal plants of East and Southeast Asia: attributed properties and uses. MIT Press

EFA research

Aram Asatryan, Nicolas G. Bazan. Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. Journal of Biological Chemistry, 2017; jbc.R117.783076 DOI: 10.1074/jbc.R117.783076

Daniel R. McDougle, Josephine E. Watson, Amr A. Abdeen, Reheman Adili, Megan P. Caputo, John E. Krapf, Rodney W. Johnson, Kristopher A. Kilian, Michael Holinstat, Aditi Das. Anti-inflammatory ω-3 endocannabinoid epoxides. Proceedings of the National Academy of Sciences, 2017; 201610325 DOI: 10.1073/pnas.1610325114

Abdo Alnabulsi et al. The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance, British Journal of Cancer (2017). DOI: 10.1038/bjc.2017.135

Jana Trebatická, et al. Emulsified omega-3 fatty-acids modulate the symptoms of depressive disorder in children and adolescents: a pilot study. Child and Adolescent Psychiatry and Mental Health201711:30. DOI: 10.1186/s13034-017-0167-2. Online at

https://capmh.biomedcentral.com/articles/10.1186/s13034-017-0167-2.

Benjamin J. Andreone, Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, Chenghua Gu. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 2017; 94 (3): 581 DOI: 10.1016/j.neuron.2017.03.043

RESEARCH

Victoria A. Acosta-Rodríguez, Marleen H.M. de Groot, Filipa Rijo-Ferreira, Carla B. Green, Joseph S. Takahashi. Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake as Revealed by an Automated Feeder System. Cell Metabolism, 2017; 26 (1): 267 DOI: 10.1016/j.cmet.2017.06.007

Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie, Sheng-Cai Lin. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature, 2017; DOI: 10.1038/nature23275.

 

Jeffrey Lienert, Christopher Steven Marcum, John Finney, Felix Reed-Tsochas, Laura Koehly. Social influence on 5-year survival in a longitudinal chemotherapy ward co-presence network. Network Science, 2017; 1 DOI: 10.1017/nws.2017.16

Colter Mitchell, Sara McLanahan, Lisa Schneper, Irv Garfinkel, Jeanne Brooks-Gunn, Daniel Notterman. Father Loss and Child Telomere Length. Pediatrics, 2017; e20163245 DOI: 10.1542/peds.2016-3245.

Alexander L. Carlson, Kai Xia, M. Andrea Azcarate-Peril, Barbara D. Goldman, Mihye Ahn, Martin A. Styner, Amanda L. Thompson, Xiujuan Geng, John H. Gilmore, Rebecca C. Knickmeyer. Infant Gut Microbiome Associated with Cognitive Development. Biological Psychiatry, 2017; DOI: 10.1016/j.biopsych.2017.06.021.

David C. Emery, Deborah K. Shoemark, Tom E. Batstone, Christy M. Waterfall, Jane A. Coghill, Tanya L. Cerajewska, Maria Davies, Nicola X. West, Shelley J. Allen. 16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain. Frontiers in Aging Neuroscience, 2017; 9 DOI: 10.3389/fnagi.2017.00195

NEWS

Marc M Cohen, De Villiers Smit, Nick Andrianopoulos, Michael Ben-Meir, David McD Taylor, Shefton J Parker, Chalie C Xue, Peter A Cameron. Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial. The Medical Journal of Australia, 2017; 206 (11): 494 DOI: 10.5694/mja16.00771

Annika S. Axelsson et al. Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Science Translational Medicine, 2017 DOI: 10.1126/scitranslmed.aah4477

Daniel G. Amen, William S. Harris, Parris M. Kidd, Somayeh Meysami, and Cyrus A. Raji. Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels Are Related to Higher Regional Cerebral Blood Flow on Brain SPECT. Journal of Alzheimer’s Disease, May 2017 DOI: 10.3233/JAD-17028

Higher Antioxidant Activity, Total Flavonols, and Specific Quercetin Glucosides in Two Different Onion (Allium cepa L.) Varieties Grown under Organic Production: Results from a 6-Year Field Study. Feiyue Ren Kim Reilly, Joseph P. Kerry, Michael Gaffney, Mohammad Hossain, and Dilip K. Rai

10. Agric. Food Chem., DOI: 10.1021/acs.jafc.7b01352.

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association. Frank M. Sacks, Alice H. Lichtenstein, Jason H.Y. Wu, Lawrence J. Appel, Mark A. Creager, Penny M. Kris-Etherton, Michael Miller, Eric B. Rimm, Lawrence L. Rudel, Jennifer G. Robinson, Neil J. Stone, Linda V. Van Horn, On behalf of the American Heart Association. https://doi.org/10.1161/CIR.0000000000000510

Circulation. 2017; originally published June 15, 2017.

“Study Confirms: Trans Fats Policy Killed Millions”: http://articles.mercola.com/sites/articles/archive/2017/06/07/trans-fats-policy-killed-millions.aspx

BEN BROWN

1.Ruemmele FM. Role of Diet in Inflammatory Bowel Disease. Ann Nutr Metab. 2016;68 Suppl 1:33-41.

2.Vindigni SM, Zisman TL, Suskind DL, Damman CJ. The intestinal microbiome,  barrier function, and immune system in inflammatory bowel disease: a tripartite pathophysiological circuit with implications for new therapeutic directions. Therap Adv Gastroenterol. 2016 Jul;9(4):606-25

3. Lee D, Albenberg L, Compher C, Baldassano R, Piccoli D, Lewis JD, Wu GD. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 2015 May;148(6):1087-106.
4. Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. Ultra-processed products are becoming dominant in the global food system. Obes Rev. 2013 Nov;14 Suppl 2:21-8.
5. Lerner A, Matthias T. Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev. 2015 Jun;14(6):479-89.
6. Roberts CL, Rushworth SL, Richman E, Rhodes JM. Hypothesis: Increased consumption of emulsifiers as an explanation for the rising incidence of Crohn’s disease. J Crohns Colitis. 2013 May;7(4):338-41.
7. Chassaing B, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 2015 Mar 5;519(7541):92-6
8. Martino JV, Van Limbergen J, Cahill LE. The Role of Carrageenan and Carboxymethylcellulose in the Development of Intestinal Inflammation. Front Pediatr. 2017 May 1;5:96.
9. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Oct 9;514(7521):181-6.
10. Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017 Jun 8;12(6):e0178426.
11. Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 May 1. pii: S0278-6915(17)30223-5.
12. Nickerson KP, et al. Deregulation of intestinal anti-microbial defense by the dietary additive, maltodextrin. Gut Microbes. 2015;6(1):78-8
13. Lerner A, Aminov R, Matthias T. Transglutaminases in Dysbiosis As Potential Environmental Drivers of Autoimmunity. Front Microbiol. 2017 Jan 24;8:66.
14. Tobacman JK. Review of harmful gastrointestinal effects of carrageenan in animal experiments. Environ Health Perspect. 2001 Oct;109(10):983-94.
15. Bhattacharyya S, Shumard T, Xie H, Dodda A, Varady KA, Feferman L, Halline AG, Goldstein JL, Hanauer SB, Tobacman JK. A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity. Nutr Healthy Aging. 2017 Mar 31;4(2):181-192.

LEARNING ZONE

Garner Thomson

Kelley JM et al. The Influence of the Patient-Clinician Relationship on Healthcare Outcomes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. PLOS ONE 2014, 9(6): e101191. https://doi.org/10.1371/journal.pone.0101191.

Pennebaker, James W (2013) The Secret Life of Pronouns: What Your Words Say About You. New York: Bloomsbury Publishing.

ANTHOCYANINS

Eur J Appl Physiol. 2017 Feb;117(2):247-254. doi: 10.1007/s00421-016-3512-x. Epub 2016 Dec 24. Cardiovascular function during supine rest in endurance-trained males with New Zealand blackcurrant: a dose-response study.

Cook MD, Myers SD, Gault ML, Edwards VC^, Willems ME.

Nutrients. 2017 May 29;9(6). pii: E556. doi: 10.3390/nu9060556.

Blackcurrant Alters Physiological Responses and Femoral Artery Diameter during Sustained Isometric Contraction. Cook MD, Myers SD, Gault ML, Willems MET.

Br J Nutr. 2015 Jun 14;113(11):1697-703. doi: 10.1017/S0007114515001105. Epub 2015 Apr 22. Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol.

Benn T, Kim B, Park YK, Yang Y, Pham TX, Ku CS, Farruggia C, Harness E, Smyth JA, Lee JY.

GUT
Ranjit Kumar, Nengjun Yi, Degui Zhi, Peter Eipers, Kelly T. Goldsmith, Paula Dixon, David K. Crossman, Michael R. Crowley, Elliot J. Lefkowitz, J. Martin Rodriguez, Casey D. Morrow. Identification of donor microbe species that colonize and persist long term in the recipient after faecal transplant for recurrent Clostridium difficile. npj Biofilms and Microbiomes, 2017; 3 (1) DOI: 10.1038/s41522-017-0020-7

Alissa C. Nicolucci, Megan P. Hume, Inés Martínez, Shyamchand Mayengbam, Jens Walter, Raylene A. Reimer. Prebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity. Gastroenterology, 2017; DOI: 10.1053/j.gastro.2017.05.055.

Becattini et al. Commensal microbes provide first line defense against Listeria monocytogenes infection. J. Exp. Med, 2017 DOI: 10.1084/jem.20170495

Hao Wu, Eduardo Esteve, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Mannerås-Holm, Marcus Ståhlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real, Fredrik Bäckhed. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. Nature Medicine, 2017; DOI: 10.1038/nm.4345

Zehra Esra Ilhan, John K DiBaise, Nancy G Isern, David W Hoyt, Andrew K Marcus, Dae-Wook Kang, Michael D Crowell, Bruce E Rittmann, Rosa Krajmalnik-Brown. Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.71

The Gut Microbiota and Autism Spectrum Disorders. Front Cell Neurosci. 2017; 11: 120. Published online 2017 Apr 28. doi:  10.3389/fncel.2017.00120

PMCID: PMC5408485. Qinrui Li,¹ Ying Han,^1,* Angel Belle C. Dy,² and Randi J. Hagerman^.

Free online at: http://journal.frontiersin.org/article/10.3389/fncel.2017.00120/full.

Dr David Perlmutter comments from: Autism and Gut Bacteria – Hope Moving Forward at http://www.drperlmutter.com/autism-and-gut-bacteria-hope-moving-forward.

Buffington et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell, 2016 DOI: 10.1016/j.cell.2016.06.001

PROSTATE

German New Medicine: http://germannewmedicine.ca/home.html

Dr Gilbert Renaud: http://recallhealing.com.

Dr Bruce Lipton: https://www.brucelipton.com/books/biology-of-belief

http://www.survivingprostatecancer.org/trailer.html

RESEARCH UPDATE

Irene Roncero-Ramos, Mónica Mendiola-Lanao, Margarita Pérez-Clavijo, Cristina Delgado-Andrade. Effect of different cooking methods on nutritional value and antioxidant activity of cultivated mushrooms. International Journal of Food Sciences and Nutrition, 2016; 68 (3): 287 DOI: 10.1080/09637486.2016.1244662

Microglia-dependent synapse loss in type I interferon-mediated lupus. Allison R. Bialas et al. Nature 2017, doi:10.1038/nature22821.

Stefan Amisten, Israa Mohammad Al-Amily, Arvind Soni, Ross Hawkes, Patricio Atanes, Shanta Jean Persaud, Patrik Rorsman, Albert Salehi. Anti-diabetic action of all-trans retinoic acid and the orphan G protein coupled receptor GPRC5C in pancreatic β-cells. Endocrine Journal, 2017; 64 (3): 325 DOI: 10.1507/endocrj.EJ16-0338

Omowunmi Aibana, Molly F. Franke, Chuan-Chin Huang, Jerome T. Galea, Roger Calderon, Zibiao Zhang, Mercedes C. Becerra, Emily R. Smith, Alayne G. Ronnenberg, Carmen Contreras, Rosa Yataco, Leonid Lecca, Megan B. Murray. Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression. Clinical Infectious Diseases, 2017; DOI: 10.1093/cid/cix476

Kaixiong Ye, Feng Gao, David Wang, Ofer Bar-Yosef, Alon Keinan. Dietary adaptation of FADS genes in Europe varied across time and geography. Nature Ecology & Evolution, 2017; 1: 0167 DOI: 10.1038/s41559-017-0167

Santosh Kumar, Angela Downie Ruiz Velasco, Gracjan Michlewski. Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex. Journal of Molecular Biology, 2017; 429 (11): 1638 DOI: 10.1016/j.jmb.2017.05.001

Weronica E. Ek, Elmar W. Tobi, Muhammad Ahsan, Erik Lampa, Erica Ponzi, Soterios A. Kyrtopoulos, Panagiotis Georgiadis, L.H Lumey, Bastiaan T. Heijmans, Maria Botsivali, Ingvar A. Bergdahl, Torgny Karlsson, Mathias Rask-Andersen, Domenico Palli, Erik Ingelsson, Åsa K. Hedman, Lena M. Nilsson, Paolo Vineis, Lars Lind, James M. Flanagan, Åsa Johansson. Tea and coffee consumption in relation to DNA methylation in four European cohorts. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx194

L Pizzuti et al. GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer. Journal of Cell Physiology, May 2017 DOI: 10.1002/jcp.26023

Marta K. Zamroziewicz, Erick J. Paul, Chris E. Zwilling, Aron K. Barbey. Determinants of fluid intelligence in healthy aging: Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure. Nutritional Neuroscience, 2017; 1 DOI: 10.1080/1028415X.2017.1324357

 

 

IHCAN June references

NEWS

10. Aggarwal, T. Fojo, C. Chamberlain, C. Davis, R. Sullivan. Do patient access schemes for high-cost cancer drugs deliver value to society?—lessons from the NHS Cancer Drugs Fund. Annals of Oncology, 2017; DOI: 10.1093/annonc/mdx110.Flory T. Muanda, Odile Sheehy, Anick Bérard. Use of antibiotics during pregnancy and risk of spontaneous abortion. Canadian Medical Association Journal, 2017; 189 (17): E625 DOI: 10.1503/cmaj.161020

Nicholas S. Downing, Nilay D. Shah, Jenerius A. Aminawung et al. Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010. JAMA, 2017 DOI: 10.1001/jama.2017.5150.

Lucas Morin, Davide L. Vetrano, Debora Rizzuto, Amaia Calderón-Larrañaga, Johan Fastbom, Kristina Johnell. Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study. The American Journal of Medicine, 2017; DOI: 10.1016/j.amjmed.2017.02.028.

Silverman M, Povitz M, Sontrop JM, Li L, Richard L, Cejic S, Shariff SZ. Antibiotic prescribing for acute non-bacterial upper-respiratory infections in the elderly. Annals of Internal Medicine, 2017 DOI: 10.7326/M16-1131.

Rohit Loomba, Victor Seguritan, Weizhong Li, Tao Long, Niels Klitgord, Archana Bhatt, Parambir Singh Dulai, Cyrielle Caussy, Richele Bettencourt, Sarah K. Highlander, Marcus B. Jones, Claude B. Sirlin, Bernd Schnabl, Lauren Brinkac, Nicholas Schork, Chi-Hua Chen, David A. Brenner, William Biggs, Shibu Yooseph, J. Craig Venter, Karen E. Nelson. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Cell Metabolism, 2017; 25 (5): 1054 DOI: 10.1016/j.cmet.2017.04.001.

Daniela Barone, Letizia Cito, Giuseppina Tommonaro, Agnese Anna Abate, Danila Penon, Rocco De Prisco, Antonella Penon, Iris Maria Forte, Elisabetta Benedetti, Annamaria Cimini, Paola Indovina, Barbara Nicolaus, Francesca Pentimalli, Antonio Giordano. Antitumoral Potential, Antioxidant Activity and Carotenoid Content of Two Southern Italy Tomato Cultivars Extracts: San Marzano and Corbarino. Journal of Cellular Physiology, 2017; DOI: 10.1002/jcp.25995.

Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women

Kim Dreyer, et al, N ENgl J Med, May 18, 2017. DOI: 10.1056/NEJMoa1612337.

Nina Cabezas-Wallscheid, Florian Buettner, Pia Sommerkamp, Daniel Klimmeck, Luisa Ladel, Frederic B. Thalheimer, Daniel Pastor-Flores, Leticia P. Roma, Simon Renders, Petra Zeisberger, Adriana Przybylla, Katharina Schönberger, Roberta Scognamiglio, Sandro Altamura, Carolina M. Florian, Malak Fawaz, Dominik Vonficht, Melania Tesio, Paul Collier, Dinko Pavlinic, Hartmut Geiger, Timm Schroeder, Vladimir Benes, Tobias P. Dick, Michael A. Rieger, Oliver Stegle, Andreas Trumpp. Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell, 2017; DOI: 10.1016/j.cell.2017.04.018

SIBO – BEN BROWN

1.             Sachdev AH, Pimentel M. Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance. Ther Adv Chronic Dis. 2013 Sep;4(5):223-31. 2.             Ghoshal UC, Ghoshal U. Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders. Gastroenterol Clin North Am. 2017 Mar;46(1):103-120.3.             Ghoshal UC, Shukla R, Ghoshal U. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy. Gut Liver. 2017 Mar 15;11(2):196-208.4.             Pimentel M. Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther. 2016 Jan;43 Suppl 1:37-49.

5. Patricio Ibanez MP, Melmed GY, Ippoliti A, Targan SR, Vasiliauskas EA. Fatigue and abdominal bloating predict small intestinal bacterial overgrowth (SIBO) in patients with ulcerative colitis (UC). Gastroenterology. 2008;134:A-350.

6.             Ricci JE Júnior, Chebli LA, et al. Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn’s Disease Patients. J Clin Gastroenterol. 2017 Jan 27.

7. George NS, Sankineni A, Parkman HP. Small intestinal bacterial overgrowth in gastroparesis. Dig Dis Sci. 2014;59:645–52.

8.             Teo M, Chung S, Chitti L, Tran C, Kritas S, Butler R, Cummins A. Small bowel bacterial overgrowth is a common cause of chronic diarrhea. J Gastroenterol Hepatol. 2004 Aug;19(8):904-9.9.             Losurdo G, Marra A, Shahini E, et al. Small intestinal bacterial overgrowth and celiac disease: A systematic review with pooled-data analysis. Neurogastroenterol Motil. 2017 Feb 12.10.         Signoretti M, Stigliano S, Valente R, Piciucchi M, Delle Fave G, Capurso G. Small intestinal bacterial overgrowth in patients with chronic pancreatitis. J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S52-5. 11.         Therrien A, Bouchard S, Sidani S, et al. Prevalence of Small Intestinal Bacterial Overgrowth among Chronic Pancreatitis Patients: A Case-Control Study. Can J Gastroenterol Hepatol. 2016;2016:7424831.12.         Kim KM, Kim BT, Lee DJ, Park SB, Joo NS, Kim YS, Kim KN. Erosive esophagitis may be related to small intestinal bacterial overgrowth. Scand J Gastroenterol. 2012 May;47(5):493-8.

13. Yang CY, Chang CS, Chen GH. Small-intestinal bacterial overgrowth in patients with liver cirrhosis, diagnosed with glucose H2 or CH4 breath tests. Scand J Gastroenterol. 1998;33:867–71.
14. Gunnarsdottir SA, Sadik R, Shev S, et al. Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension. Am J Gastroenterol. 2003;98:1362–70.
15. Parodi A, Paolino S, Greco A, et al. Small intestinal bacterial overgrowth in rosacea: clinical effectiveness of its eradication. Clin Gastroenterol Hepatol. 2008;6:759–64.
16. Campanati A, Gesuita R, Giannoni M, et al. Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticaria: a prospective analysis. Acta Derm Venereol 2013; 93:161–164.
17. Pimentel M, Wallace D, Hallegua D, et al. A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing. Ann Rheum Dis. 2004;63:450–2.

18.         Weinstock LB, Fern SE, Duntley SP. Restless legs syndrome in patients with irritable bowel syndrome: response to small intestinal bacterial overgrowth therapy. Dig Dis Sci. 2008 May;53(5):1252-6.19.         Henriksson AE, Blomquist L, Nord CE, et al. Small intestinal bacterial overgrowth in patients with rheumatoid arthritis. Ann Rheum Dis. 1993 Jul;52(7):503-10.

20. Lauritano EC, Bilotta AL, Gabrielli M, Scarpellini E, Lupascu A, Laginestra A, et al. Association between hypothyroidism and small intestinal bacterial overgrowth.J Clin Endocrinol Metab. 2007;92:4180–4.
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23. Ponziani, et al. Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms. World J Gastroenterol. 2017 Feb 21;23(7):1241-1249.

24.         Fialho A, Fialho A, Schenone A, Thota P, McCullough A, Shen B. Association between small intestinal bacterial overgrowth and deep vein thrombosis. Gastroenterol Rep (Oxf). 2016 Nov;4(4):299-303.25.         Cheng X, Zhang L, Xie NC, Xu HL, Lian YJ. Association between small-intestinal bacterial overgrowth and deep vein thrombosis in patients with spinal cord injuries. J Thromb Haemost. 2017 Feb;15(2):304-311.26.         Niu XL, Liu L, Song ZX, Li Q, Wang ZH, Zhang JL, Li HH. Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease. J Neural Transm (Vienna). 2016 Dec;123(12):1381-1386.27.         Zhang Y, Liu G, Duan Y, Han X, Dong H, Geng J. Prevalence of Small Intestinal  Bacterial Overgrowth in Multiple Sclerosis: a Case-Control Study from China. J Neuroimmunol. 2016 Dec 15;301:83-87. 28.         Quigley EM. Small intestinal bacterial overgrowth: what it is and what it is not. Curr Opin Gastroenterol. 2014 Mar;30(2):141-6. 29.         Krajicek EJ, Hansel SL. Small Intestinal Bacterial Overgrowth: A Primary Care Review. Mayo Clin Proc. 2016 Dec;91(12):1828-1833.

30. Krajicek EJ, Hansel SL. Small Intestinal Bacterial Overgrowth: A Primary Care Review. Mayo Clin Proc. 2016 Dec;91(12):1828-1833

31.         Miazga A, Osiński M, Cichy W, Żaba R. Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO. Adv Med Sci. 2015 Mar;60(1):118-24.32.         Deloose E, Tack J. Redefining the functional roles of the gastrointestinal migrating motor complex and motilin in small bacterial overgrowth and hunger signaling. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15;310(4):G228-33.33.         Deloose E, Janssen P, Depoortere I, Tack J. The migrating motor complex: control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol. 2012 Mar 27;9(5):271-85.

34. Pimentel M, Soffer EE, Chow EJ, et al. Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth. Dig Dis Sci 2002;47:2639–43.

35.         Ghoshal UC, Srivastava D, Verma A, Misra A. Slow transit constipation associated with excess methane production and its improvement following rifaximin therapy: a case report. J Neurogastroenterol Motil. 2011 Apr;17(2):185-8.36.         Pimentel M, Chatterjee S, Chow EJ, Park S, Kong Y. Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent  on the presence of methane gas: subanalysis of a double-blind randomized controlled study. Dig Dis Sci. 2006 Aug;51(8):1297-301.37.         Pimentel M, Mathur R, Chang C. Gas and the microbiome. Curr Gastroenterol Rep. 2013 Dec;15(12):356.38.         Yin J, Levanon D, Chen JD. Inhibitory effects of stress on postprandial gastric myoelectrical activity and vagal tone in healthy subjects. Neurogastroenterol Motil. 2004 Dec;16(6):737-44.39.         Devanarayana NM, de Silva DG, de Silva HJ. Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain. J Gastroenterol Hepatol. 2008 Nov;23(11):1672-7. 40.         Pimentel M, Morales W, Lezcano S, Sun-Chuan D, Low K, Yang J. Low-dose nocturnal tegaserod or erythromycin delays symptom recurrence after treatment of  irritable bowel syndrome based on presumed bacterial overgrowth. Gastroenterol Hepatol (N Y). 2009 Jun;5(6):435-42.41.         Madisch A, Vinson BR, Abdel-Aziz H, et al. Modulation of gastrointestinal motility beyond metoclopramide and domperidone: Pharmacological and clinical evidence for phytotherapy in functional gastrointestinal disorders. Wien Med Wochenschr. 2017 May;167(7-8):160-168

42. Jacob A. Treatment and Management of SIBO — Taking a Dietary Approach Can Control Intestinal Fermentation and Inflammation. Today’s Dietitian. 2012 14 No. 12 P. 16.

43.         Beasley DE, Koltz AM, Lambert JE, Fierer N, Dunn RR. The Evolution of Stomach  Acidity and Its Relevance to the Human Microbiome. PLoS One. 2015 Jul 29;10(7):e0134116. 44.         Urita Y, Watanabe T, Maeda T, et al. Extensive atrophic gastritis linked to increased levels of intraluminal hydrogen gas. Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1645-8.45.         Enko D, Kriegshäuser G. Functional (13)C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection. Clin Biochem. 2017 Jan;50(1-2):46-49.46.         Lo WK, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol. 2013 May;11(5):483-90

47. Husebye E, Skar V, Hoverstad T, Melby K. Fasting Hypochlorhydria with gram positive gastric flora is highly prevalent in healthy old people. Gut. 1992;33(10):1331-1337
48. Kelly G. Hydrochloric Acid: Physiological Functions and Clinical Implications. Alt Med Rev 1997; 2(2):116-127.

49.         Yago MR, Frymoyer AR, Smelick GS, et al. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7.

50. Knöss, W.,Stolte, F. 2009b. Community herbal monographon Gentian lutea L., radix. European Medicines Agency, London.

51.         Capurso G, Signoretti M, Archibugi L, Stigliano S, Delle Fave G. Systematic review and meta-analysis: Small intestinal bacterial overgrowth in chronic pancreatitis. United European Gastroenterol J. 2016 Oct;4(5):697-705.52.         Leeds JS, Hopper AD, Sidhu R, et al. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. Clin Gastroenterol Hepatol. 2010 May;8(5):433-8.53.         Bures J, Cyrany J, Kohoutova D, et al. Small intestinal bacterial overgrowth syndrome. World J Gastroenterol. 2010 Jun 28;16(24):2978-90.54.         Domínguez-Muñoz JE. Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency: when is it indicated, what is the goal and how to do it?  Adv Med Sci. 2011;56(1):1-5.55.         Money ME, Walkowiak J, Virgilio C, Talley NJ. Pilot study: a randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea. Frontline Gastroenterol. 2011 Jan;2(1):48-56.56.         David L, Babin A, Picos A, et al. Small Intestinal Bacterial Overgrowth is Associated with Intestinal Inflammation in the Irritable Bowel Syndrome. Clujul Med. 2014;87(3):163-5.57.         Ricci JE Júnior, Chebli LA,et al. Small-Intestinal Bacterial Overgrowth is Associated With Concurrent Intestinal Inflammation But Not With Systemic Inflammation in Crohn’s Disease Patients. J Clin Gastroenterol. 2017 Jan 27. doi: 10.1097/MCG.0000000000000803.[Epub ahead of print] 58.         Winter SE, Bäumler AJ. Dysbiosis in the inflamed intestine: chance favors the prepared microbe. Gut Microbes. 2014 Jan-Feb;5(1):71-3. 59.         Agus A, Denizot J, Thévenot J, Martinez-Medina M, Massier S, Sauvanet P, Bernalier-Donadille A, Denis S, Hofman P, Bonnet R, Billard E, Barnich N. Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation. Sci Rep. 2016 Jan 8;6:19032.

60. Olendzki BC, et al. An anti-inflammatory diet as treatment for inflammatory bowel disease: a case series report. Nutr J. 2014 Jan 16;13:5.

61.         Zhong C, Qu C, Wang B, Liang S, Zeng B. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300-311.62.         Celiberto LS, Bedani R, Rossi EA, et al. Probiotics: The scientific evidence in the context of inflammatory bowel disease. Crit Rev Food Sci Nutr. 2017 Jun 13;57(9):1759-1768.63.         Ierardi E, Losurdo G, Sorrentino C, Giorgio F, Rossi G, Marinaro A, Romagno KR, Di Leo A, Principi M. Macronutrient intakes in obese subjects with or without small intestinal bacterial overgrowth: an alimentary survey. Scand J Gastroenterol. 2016 Mar;51(3):277-80.

64. Parlesak A, Klein B, Schecher K, et al. Prevalence of small bowel bacterial overgrowth and its association with nutrition intake in nonhospitalized older adults. J Am Geriatr Soc. 2003;51:768–773
65. Nucera G, Gabrielli M, Lupascu A, Lauritano EC, Santoliquido A, Cremonini F, Cammarota G, Tondi P, Pola P, Gasbarrini G, Gasbarrini A. Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2005 Jun 1;21(11):1391–5.

66.         Enko D, Halwachs-Baumann G, Stolba R, et al. Refining small intestinal bacterial overgrowth diagnosis by means of carbohydrate specificity: a proof-of-concept study. Therap Adv Gastroenterol. 2016 May;9(3):265-72.67.         Rezaie A, Pimentel M, Rao SS. How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach. Curr Gastroenterol Rep. 2016 Feb;18(2):8.68.         Ciampa BP, Reyes Ramos E, Borum M, Doman DB. The Emerging Therapeutic Role of  Medical Foods for Gastrointestinal Disorders. Gastroenterol Hepatol (N Y). 2017 Feb;13(2):104-115. 69.         Pimentel M, Constantino T, Kong Y, et al. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73-7.

70. Hunter J. Elemental diet and the nutritional treatment of Crohn’s disease. Gastroenterol Hepatol Bed Bench. 2015 Winter;8(1):4-5
71. Logan AC, Beaulne TM. The treatment of small intestinal bacterial overgrowth with enteric-coated peppermint oil: a case report. Altern Med Rev. 2002;7:410–7.

72.         Khanna R, MacDonald JK, Levesque BG. Peppermint oil for the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Clin Gastroenterol. 2014 Jul;48(6):505-12.

73. Chedid V, Dhalla S, Clarke JO, et al. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Glob Adv Health Med. 2014 May;3(3):16-24.
74. Brown K, Scott-Hoy B, Jennings L. Efficacy of a Quebracho, Conker Tree, and M. balsamea Willd blended extract in patients with irritable bowel syndrome with constipation.J Gasterenterol Hepatol Res. 2015;4:1762–1767.
75. Brown K, Scott-Hoy B, Jennings LW. Response of irritable bowel syndrome with constipation patients administered a combined quebracho/conker tree/M. balsamea Willd extract. World J Gastrointest Pharmacol Ther. 2016 Aug 6;7(3):463-8.
76. Zhong C, Qu C, Wang B, et al. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300-311
77. Khalighi AR, Khalighi MR, Behdani R, et al. Evaluating the efficacy of probiotic on treatment in patients with small intestinal bacterial overgrowth (SIBO) – A pilot study. Indian J Med Res. 2014 Nov;140(5):604-8
78. Scarpellini, E., et al. “Bacillus clausii treatment of small intestinal bacterial overgrowth in patients with irritable bowel syndrome.” Digestive and Liver Disease 38 (2006): S32.

79.         Gabrielli M, Lauritano EC, Scarpellini E, et al. Bacillus clausii as a treatment of small intestinal bacterial overgrowth. Am J Gastroenterol. 2009 May;104(5):1327-8.

80. Barrett, Jacqueline S., et al. “Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome.” World J Gastroenterol 14.32 (2008): 5020-5024.

81.         Lunia MK, Sharma BC, Sharma P, et al. Probiotics prevent hepatic encephalopathy in patients with cirrhosis: a randomized controlled trial. Clin Gastroenterol Hepatol. 2014 Jun;12(6):1003-8.e1.82.         Kwak DS, Jun DW, Seo JG, et al. Short-term probiotic therapy alleviates small intestinal bacterial overgrowth, but does not improve intestinal permeability in chronic liver disease. Eur J Gastroenterol Hepatol. 2014 Dec;26(12):1353-9.

 Zhong C, Qu C, Wang B, et al. Probiotics for Preventing and Treating Small Intestinal Bacterial Overgrowth: A Meta-Analysis and Systematic Review of Current Evidence. J Clin Gastroenterol. 2017 Apr;51(4):300-311

 MYCOLOGY

Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP (2004). Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer 14:589-94.

 

Chiu HF, Fu HY, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK (2017). Triterpenoids and polysaccharide peptides-enriched Ganoderma lucidum: a randomized, double-blind placebo-controlled crossover study of its antioxidation and hepatoprotective efficacy in healthy volunteers. Pharm Biol 55, 1041-1046.

Dai Yu-C, Yang Z-L, Cui B-K, et al (2009). Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mush:  11: 287−302.

Deng G, Lin H, Seidman A, Fornier M, D’Andrea G, Wesa K, Yeung S, Cunningham-Rundles S, Vickers AJ, Cassileth B (2002). A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. J Cancer Res Clin Oncol  135(9):1215-21.

Ina K, Furuta R, Kataoka T, Kayukawa S, Ina H, Yoneda M (2016). Chemo-Immunotherapy Using Lentinan for the Treatment of Gastric Cancer with Liver Metastases. Med. Sci. 2016, 4(2), 8

Ivanova TS, Krupodorova TA, Barshteyn VY, Artamonova AB, Shlyakhovenko VA (2014). Anticancer substances of mushroom origin. Exp Oncol 36(2):58-66.

 

Jiang J1, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling. Int J Mol Med. 2008 May;21(5):577-84.

Kimura Y1, Kido T, Takaku T, Sumiyoshi M, Baba K. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions. Cancer Sci. 2004 Sep;95(9):758-64.

Ulrike Lindequist, Timo H. J. Niedermeyer, and Wolf-Dieter Jülich. Evidence-Based Complementary and Alternative Medicine,Volume 2 (2005), Issue 3, Pages 285-299 http://dx.doi.org/10.1093/ecam/neh107

Ohwada S, Ogawa T, Makita F, Tanahashi Y, Ohya T, Tomizawa N, Satoh Y, Kobayashi I, Izumi M, Takeyoshi I, Hamada K, Minaguchi S, Togo Y, Toshihiko T, Koyama T, Kamio M (2006). Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters. Oncol Rep 15:861-8.

Okuno K, Uno K (2011). Efficacy of orally administered Lentinula edodes mycelia extract for advanced gastrointestinal cancer patients undergoing cancer chemotherapy: a pilot study. Asian Pac J Cancer Prev. 12(7):1671-4.

Patel S & Goyal A (2012). Recent developments in mushrooms as anti-cancer therapeutics: a review. 3 Biotech 2(1):1-15.

Shing MK, Leung TF, Chu YL, Li CY, Chik KW, Leung PC, Lee V, Yuen PM and Li CK (2008). Randomized, double-blind and placebo-controlled study of the immunomodulatory effects of Lingzhi in children with cancers. J Clin Oncol ASCO Vol 26, No 15S (May 20 Supplement), 2008: 1402

Sze DM, Chan GC (2009). Supplements for immune enhancement in hematologic malignancies. Hematology Am Soc Hematol Educ Program. 2009:313-9.

Torkelson CJ,  Sweet E, Martzen MR,  Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012). Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. ISRN Oncol. 2012; 2012: 251632.

Wu X, Zeng J, Hu J, Liao Q, Zhou R, Zhang P, Chen Z (2013). Hepatoprotective effects of aqueous extract from lingzhi or Reishi medicinal mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin-induced liver injury in mice. Int J Med Mushrooms 15 383-391.

Wu SJ, Lu TM, Lai MN, Ng LT. Immunomodulatory activities of medicinal mushroom Grifola frondosa extract and its bioactive constituent. Am J Chin Med. 2013;41(1):131-44

Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X (2012). Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.

Zhao S, Gang Y, Fu G, Cheng J-X, Ynag BB & Peng C (2011). Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol 38, 1319-1327.

RESEARCH

10. Pfotenhauer, Jay H. Shubrook. Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations. The Journal of the American Osteopathic Association, 2017; 117 (5): 301 DOI: 10.7556/jaoa.2017.055.

María-Antonia Serrano, Javier Cañada, Juan Carlos Moreno, Gonzalo Gurrea. ‘Solar ultraviolet doses and vitamin D in a northern mid-latitude’. Science of the Total Environment 574 (2017) 744–750.

Benjamin J. Andreone, Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, Chenghua Gu. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 2017; 94 (3): 581 DOI: 10.1016/j.neuron.2017.03.043

Yun-Gi Kim, Kei Sakamoto, Sang-Uk Seo, Joseph M. Pickard, Merritt G. Gillilland, Nicholas A. Pudlo, Matthew Hoostal, Xue Li, Thomas D. Wang, Taylor Feehley, Andrew T. Stefka, Thomas M. Schmidt, Eric C. Martens, Shinji Fukuda, Naohiro Inohara, Cathryn R. Nagler, Gabriel Núñez. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science, 2017; 356 (6335): 315 DOI: 10.1126/science.aag2029

10. Marm Kilpatrick, Andrew D. M. Dobson, Taal Levi, Daniel J. Salkeld, Andrea Swei, Howard S. Ginsberg, Anne Kjemtrup, Kerry A. Padgett, Per M. Jensen, Durland Fish, Nick H. Ogden, Maria A. Diuk-Wasser. Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control. Philosophical Transactions of the Royal Society B: Biological Sciences, 2017; 372 (1722): 20160117 DOI: 10.1098/rstb.2016.0117

Stella C. Watson, Yan Liu, Robert B. Lund, Jenna R. Gettings, Shila K. Nordone, Christopher S. McMahan, Michael J. Yabsley. A Bayesian spatio-temporal model for forecasting the prevalence of antibodies to Borrelia burgdorferi, causative agent of Lyme disease, in domestic dogs within the contiguous United States. PLOS ONE, 2017; 12 (5): e0174428 DOI: 10.1371/journal.pone.0174428

Heather Greenlee, Melissa J. DuPont-Reyes, Lynda G. Balneaves, Linda E. Carlson, Misha R. Cohen, Gary Deng, Jillian A. Johnson, Matthew Mumber, Dugald Seely, Suzanna M. Zick, Lindsay M. Boyce, Debu Tripathy. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA: A Cancer Journal for Clinicians, 2017; DOI: 10.3322/caac.21397

Bice et al. Environmental Enrichment Induces Pericyte and IgA-Dependent Wound Repair and Lifespan Extension in a Colon Tumour Model. Cell Reports, April 2017 DOI: 10.1016/j.celrep.2017.04.006.

Wouter van Marken Lichtenbelt, Mark Hanssen, Hannah Pallubinsky, Boris Kingma, Lisje Schellen. Healthy excursions outside the thermal comfort zone. Building Research & Information, 2017; 1 DOI: 10.1080/09613218.2017.1307647.

Bojing Liu, Fang Fang, Nancy L. Pedersen, Annika Tillander, Jonas F. Ludvigsson, Anders Ekbom, Per Svenningsson, Honglei Chen, and Karin Wirdefeldt. Vagotomy and Parkinson disease: A Swedish register–based matched-cohort study. Neurology, April 2017 DOI: 10.1212/WNL.0000000000003961.

10. Heytens, A. De Sutter, L. Coorevits, P. Cools, J. Boelens, L. Van Simaey, T. Christiaens, M. Vaneechoutte, G. Claeys. Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases. Clinical Microbiology and Infection, 2017; DOI: 10.1016/j.cmi.2017.04.004.

Lactose Intolerance (LCT-13910C>T) Genotype Is Associated with Plasma 25-Hydroxyvitamin D Concentrations in Caucasians: A Mendelian Randomization Study,. Ohood Alharbi and Ahmed El-Sohemy*. J Nutrition 2017, doi: 10.3945/​jn.116.246108.

Jennifer S. Labus, Emily B. Hollister, Jonathan Jacobs, Kyleigh Kirbach, Numan Oezguen, Arpana Gupta, Jonathan Acosta, Ruth Ann Luna, Kjersti Aagaard, James Versalovic, Tor Savidge, Elaine Hsiao, Kirsten Tillisch, Emeran A. Mayer. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome, 2017; 5 (1) DOI: 10.1186/s40168-017-0260-z Open Access: https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0260-z.

 

PROF GEORGE LEWITH
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Brien, Sarah; Lewith, George; Bryant, Trevor (August 2003). “Ultramolecular homeopathy has no observable clinical effects. A randomized, double-blind, placebo-controlled proving trial of Belladonna 30C” (PDF). British Journal of Clinical Pharmacology. 56 (5): 562–568. doi:10.1046/j.1365-2125.2003.01900.x. 

Brien SB, Lachance L, Prescott P, et al. (June 2011). “Homeopathy has clinical benefits in rheumatoid arthritis patients which are attributable to the consultation process not the homeopathic remedy. A randomised controlled clinical trial”. Rheumatology 50 (6): 1070-82. doi:10.1093/rheumatology/keq234.

Sunderajhan Sekar et al. Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats. Scientific Reports 7, Article number: 46457 (2017), doi:10.1038/srep46457.

Anika K Smith, Alex R Wade, Kirsty EH Penkman, Daniel H Baker. Dietary modulation of cortical excitation and inhibition. Journal of Psychopharmacology, 2017; 026988111769961 DOI: 10.1177/0269881117699613

BEN BROWN

1. Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009 Oct;18(10):821-32.
2. Zouboulis CC, Jourdan E, Picardo M. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol. 2014 May;28(5):527-32.
3. Oudenhoven MD, Kinney MA, McShane DB, Burkhart CN, Morrell DS. Adverse effects of acne medications: recognition and management. Am J Clin Dermatol. 2015 Aug;16(4):231-42.
4. Gollnick HP. From new findings in acne pathogenesis to new approaches in

treatment. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 5:1-7.

5. [1]Melnik BC. Linking diet to acne metabolomics, inflammation, and comedogenesis: an update. Clin Cosmet Investig Dermatol. 2015 Jul 15;8:371-88.
6. [1] Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis -back to the future? Gut Pathog. 2011 Jan 31;3(1):1.
7. [1] Bowe W, Patel NB, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014 Jun 1;5(2):185-99.
8. [1] Kim J, Ko Y, Park YK, et al. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition. 2010 Sep;26(9):902-9.
9. [1] Jung GW, Tse JE, Guiha I,et al. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013 Mar-Apr;17(2):114-22.
10. [1] Fabbrocini G, Bertona M, Picazo Ó, et al. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes. 2016 Nov 30;7(5):625-630.
11. [1] Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol. 2012 Jun;11(6):742-6.
12. [1] Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne

vulgaris: old wine in new bottles. Lipids Health Dis. 2010 Dec 9;9:141.

13. [1] l-Shobaili HA, Alzolibani AA, Al Robaee AA, et al. Biochemical markers of oxidative and nitrosative stress in acne vulgaris: correlation with disease activity. J Clin Lab Anal. 2013 Jan;27(1):45-52.
14. [1] Michaëlsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol. 1984;64(1):9-14.
15. [1] Sardana K, Garg VK. An observational study of methionine-bound zinc with

antioxidants for mild to moderate acne vulgaris. Dermatol Ther. 2010

Jul-Aug;23(4):411-8.

16. [1] Działo M, Mierziak J, Korzun U, et al. The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders. Int J Mol Sci. 2016 Feb 18;17(2):160.
17. [1] Napolitano M, Megna M, Monfrecola G. Insulin resistance and skin diseases. 2015;2015:479354.
18. [1] Kim H, Moon SY, Sohn MY, et al. Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes. Ann Dermatol. 2017 Feb;29(1):20-25.
19. [1] Emiroğlu N, Cengiz FP, Kemeriz F. Insulin resistance in severe acne vulgaris. Postepy Dermatol Alergol. 2015 Aug;32(4):281-5.
20. [1] Melnik BC, John SM, Plewig G. Acne: risk indicator for increased body mass index and insulin resistance. Acta Derm Venereol. 2013 Nov;93(6):644-9.
21. [1] Fabbrocini G, Izzo R, Faggiano A, et al. Low glycaemic diet and metformin therapy: a new approach in male subjects with acne resistant to common treatments. Clin Exp Dermatol. 2016 Jan;41(1):38-42.
22. [1] Cordain L, Lindeberg S, Hurtado M, et al. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002 Dec;138(12):1584-90.
23. [1] Smith RN, Mann NJ, Braue A, et al. A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. Am J Clin Nutr. 2007 Jul;86(1):107-15.
24. [1] Smith RN, Mann NJ, Braue A, et al. The effect of a

high-protein, low glycemic-load diet versus a conventional, high glycemic-load diet on biochemical parameters associated with acne vulgaris: a randomized, investigator-masked, controlled trial. J Am Acad Dermatol. 2007 Aug;57(2):247-56.

25. [1] Smith RN, Braue A, Varigos GA, et al. The effect of a low glycemic load diet on acne vulgaris and the fatty acid composition of skin surface triglycerides. J Dermatol Sci. 2008 Apr;50(1):41-52.
26. [1] Kwon HH, Yoon JY, Hong JS, et al. Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: a randomized, controlled trial. Acta Derm Venereol. 2012 May;92(3):241-6.
27. [1] Reynolds RC, Lee S, Choi JY, et al. Effect of the glycemic index of carbohydrates on Acne vulgaris. Nutrients. 2010 Oct;2(10):1060-72.
28. [1] Adebamowo CA, Spiegelman D, Berkey CS, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol 2008; 58: 787–793.
29. [1] Adebamowo CA, Spiegelman D, Berkey CS, et al. Milk consumption and acne in adolescent girls. Dermatol Online J 2006; 12: 1.
30. [1] Adebamowo CA, Spiegelman D, Danby FW, et al. High school dietary dairy intake and teenage acne. J Am Acad Dermatol 2005; 52: 207–214
31. [1] Di Landro A, Cazzaniga S, Parazzini F, et al. Family history, body mass index, selected dietary factors, menstrual history, and risk of moderate to severe acne in adolescents and young adults. J Am Acad Dermatol 2012; 67: 1129–1135.
32. [1] Grossi E, Cazzaniga S, Crotti S, et al. The constellation of dietary factors in adolescent acne: a semantic connectivity map approach. J Eur Acad Dermatol Venereol. 2016 Jan;30(1):96-100.
33. [1] LaRosa CL, Quach KA, Koons K, et al. Consumption of dairy in teenagers with and without acne. J Am Acad Dermatol. 2016 Aug;75(2):318-22.
34. [1] Silverberg Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes. Cutis. 2012 Aug;90(2):70-2.
35. [1] Simonart T. Acne and whey protein supplementation among bodybuilders. Dermatology. 2012;225(3):256-8.
36. [1] Melnik BC. Evidence for acne-promoting effects of milk and other insulinotropic dairy products. Nestle Nutr Workshop Ser Pediatr Program.

2011;67:131-45.

37. [1] Hoyt G, Hickey MS, Cordain L. Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk. Br J Nutr. 2005 Feb;93(2):175-7.
38. [1] Jeske S, Zannini E, Arendt EK. Evaluation of Physicochemical and Glycaemic Properties of Commercial Plant-Based Milk Substitutes. Plant Foods Hum Nutr. 2017 Mar;72(1):26-33.
39. [1] Goh W, Kallianpur KJ, Chow D, et al. Chocolate  and acne: how valid was the original study? Clin Dermatol. 2011 Jul-Aug;29(4):459-60.
40. [1] Block SG, Valins WE, Caperton CV, et al. Exacerbation of facial acne vulgaris after consuming pure chocolate. J Am Acad Dermatol. 2011;65(4):ell4–ell5.
41. [1] Caperton C, Block S, Viera M, et al. Double-blind, Placebo-controlled Study Assessing the Effect of Chocolate Consumption in Subjects with a History of Acne Vulgaris. J Clin Aesthet Dermatol. 2014 May;7(5):19-23.
42. [1] Netea SA, Janssen SA, Jaeger M, et al. Chocolate consumption modulates cytokine production in healthy individuals. Cytokine. 2013 Apr;62(1):40-3.

43.         [1] Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. 2013 Mar;168(3):474-85.44.         [1] Holzmann R, Shakery K. Postadolescent acne in females. Skin Pharmacol Physiol. 2014;27 Suppl 1:3-8.45.         [1] Gieler U, Gieler T, Kupfer JP. Acne and quality of life – impact andmanagement. J Eur Acad Dermatol Venereol. 2015 Jun;29 Suppl 4:12-4.46.         [1] Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012 Jan28;379(9813):361-72.

47. [1] Picardo M, Eichenfield LF, Tan J. Acne and Rosacea. Dermatol Ther (Heidelb). 2017 Jan;7(Suppl 1):43-52.

 

PROBIOTICS RESEARCH UPDATE

 

Emily G. Severance et al. Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study. Brain, Behavior, and Immunity, 2017; 62: 41 DOI: 10.1016/j.bbi.2016.11.019.

 

Emily G Severance et al. Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder. npj Schizophrenia, 2016; 2: 16018 DOI: 10.1038/npjschz.2016.18.

 

Choi JW et al. Kefir prevented excess fat accumulation in diet-induced obese mice. Biosci Biotechnol Biochem. 2017 May; 81(5):958-965. doi: 10.1080/09168451.2016.1258984.

Netusha Thevaranjan et al. Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction. Cell Host & Microbe, 2017; 21 (4): 455 DOI: 10.1016/j.chom.2017.03.002

Vanessa D. de Mello et al. Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Scientific Reports, 2017; 7: 46337 DOI: 10.1038/srep46337

Chihaya Yamada et al. Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum. Cell Chemical Biology, 2017; DOI: 10.1016/j.chembiol.2017.03.012

 

DETOX and PARASITES

Influence of a 10-Day Mimic of Our Ancient Lifestyle on Anthropometrics and Parameters of Metabolism and Inflammation: The “Study of Origin”

Leo Pruimboom, Begoña Ruiz-Núñez, Charles L. Raison, and Frits A. J. Muskiet. BioMed Research International, V 2016 (2016), Article ID 6935123, 9 pages

http://dx.doi.org/10.1155/2016/6935123.

 

 

New Scientist, March 29, 2017.  Chelsea Whyte: Lyme disease is set to explode and we still don’t have a vaccine

https://www.newscientist.com/article/mg23431195-800-lyme-disease-is-set-to-explode-and-you-cant-protect-yourself/ s

 

Bret M. Boyd, Julie M. Allen, Nam-phuong Nguyen, Pranjal Vachaspati, Zach Quicksall, Tandy Warnow, Lawrence Mugisha, Kevin P. Johnson, David L. Reed. Primates, lice and bacteria: speciation and genome evolution in the symbionts of hominid lice. Molecular Biology and Evolution, 2017; DOI: 10.1093/molbev/msx117

RESEARCH UPDATE

Setor Kwadzo Kunutsor, Michael Richard Whitehouse, Ashley William Blom, Jari Antero Laukkanen. Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study. European Journal of Epidemiology, 2017; DOI: 10.1007/s10654-017-0242-2.

Thomas M. Stubbs, Marc Jan Bonder, Anne-Katrien Stark, Felix Krueger, Ferdinand von Meyenn, Oliver Stegle, Wolf Reik. Multi-tissue DNA methylation age predictor in mouse. Genome Biology, 2017; 18 (1) DOI: 10.1186/s13059-017-1203-5 .

Jamshid Tabeshpour, Bibi Marjan Razavi, Hossein Hosseinzadeh. Effects of Avocado (Persea americana ) on Metabolic Syndrome: A Comprehensive Systematic Review. Phytotherapy Research, 2017; DOI: 10.1002/ptr.5805.

Yung-Chih Chen, Rebecca L. Travers, Jean-Philippe Walhin, Javier T. Gonzalez, Francoise Koumanov, James A. Betts, Dylan Thompson. Feeding Influences Adipose Tissue Responses To Exercise In Overweight Men. American Journal of Physiology – Endocrinology And Metabolism, 2017; ajpendo.00006.2017 DOI: 10.1152/ajpendo.00006.2017.

Lamb DJ¹, Reeves GL, Taylor A, Ferns GA.
Dietary copper supplementation reduces atherosclerosis in the cholesterol-fed rabbit. Atherosclerosis. 1999 Sep;146(1):33-43.

William G. Elder, Niki Munk, Margaret M. Love, Geza G. Bruckner, Kathryn E. Stewart, Kevin Pearce. Real-World Massage Therapy Produces Meaningful Effectiveness Signal for Primary Care Patients with Chronic Low Back Pain: Results of a Repeated Measures Cohort Study. Pain Medicine, 2017; DOI: 10.1093/pm/pnw347

Omar M. El-Halfawy, Javier Klett, Rebecca J. Ingram, Slade A. Loutet, Michael E. P. Murphy, Sonsoles Martín-Santamaría, Miguel A. Valvano. Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance. mBio, 2017; 8 (2): e00225-17 DOI: 10.1128/mBio.00225-17.

Daniel Brugger, Wilhelm M Windisch. Short-Term Subclinical Zinc Deficiency in Weaned Piglets Affects Cardiac Redox Metabolism and Zinc Concentration. The Journal of Nutrition, 2017; 147 (4): 521 DOI: 10.3945/jn.116.240804

Zinc and the eye:
¹ “Zinc,” June 2015, http://lpi.oregonstate.edu/mic/minerals/zinc

² “Review: Zinc’s Functional Significance in the Vertebrate Retina,” July 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119231/

³ “Study Shows New Role of Zinc in Optic Nerve Injury,” January 2017, http://www.news-medical.net/news/20170103/Study-shows-new-role-of-zinc-in-optic-nerve-injury.aspx.

⁴ “Mobile Zinc Increases Rapidly in the Retina After Optic Nerve Injury and Regulates Ganglion Cell Survival and Optic Nerve Regeneration,” January 2017, https://www.ncbi.nlm.nih.gov/pubmed/28049831.

Eveliina Munukka, Anniina Rintala, Raine Toivonen, Matts Nylund, Baoru Yang, Anna Takanen, Arno Hänninen, Jaana Vuopio, Pentti Huovinen, Sirpa Jalkanen, Satu Pekkala. Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice. The ISME Journal, 2017; DOI: 10.1038/ismej.2017.24

Joshua D. Schoenfeld, et al. O 2 ⋅− and H 2 O 2 -Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell, 2017; DOI: 10.1016/j.ccell.2017.02.018

IHCAN April references

NEWS

B VITS

Jia Zhong et al. B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial. PNAS 2017 ; published ahead of print March 13, 2017,

HELEN MONK on BANT Supervision

1. Despenser S (2011) What is Supervision? British Association for Counselling and Psychotherapy (BACP).
2. Hawkins P Shohet R and Hawkins R (2012) Supervision In The Helping Professions Open University Press; 4th edition.

BEN BROWN – PSORIASIS

1. Raychaudhuri SK, Maverakis E, Raychaudhuri SP. Diagnosis and classification of psoriasis. Autoimmun Rev 2014;13(495):490.

2.             Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009 Jul 30;361(5):496-509.3.             Hedrich CM. Shaping the spectrum – From autoinflammation to autoimmunity. Clin Immunol. 2016 Apr;165:21-8.4.             Christophers E, Metzler G, Röcken M. Bimodal immune activation in psoriasis. Br J Dermatol. 2014 Jan;170(1):59-65.5.             Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007 Jul 21;370(9583):263-71. 6.             Oliveira Mde F, Rocha Bde O, Duarte GV. Psoriasis: classical and emerging comorbidities. An Bras Dermatol. 2015 Jan-Feb;90(1):9-20.7.             Lotti T, Hercogova J, Prignano F. The concept of psoriatic disease: can cutaneous psoriasis any longer be separated by the systemic comorbidities? Dermatol Ther. 2010 Mar-Apr;23(2):119-22.8.             Lebwohl M. Psoriasis. Lancet. 2003 Apr 5;361(9364):1197-204.9.             Griffiths CE, van de Kerkhof P, Czarnecka-Operacz M. Psoriasis and Atopic Dermatitis. Dermatol Ther (Heidelb). 2017 Jan;7(Suppl 1):31-41.Barrea L, Nappi F, Di Somma C, et al. Environmental Risk Factors in Psoriasis: The Point of View of the Nutritionist. Int J Environ Res Public Health. 2016 Jul 22;13(5).10.         Kim D, Yoo SA, Kim WU. Gut microbiota in autoimmunity: potential for clinical  applications. Arch Pharm Res. 2016 Nov;39(11):1565-1576.11.         Fry L, Baker BS, Powles AV, Engstrand L. Psoriasis is not an autoimmune disease? Exp Dermatol. 2015 Apr;24(4):241-4. 12.         Zákostelská Z, Málková J, Klimešová K, et al. Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response. PLoS One. 2016 Jul 19;11(7):e0159539.13.         Groeger D, O’Mahony L, Murphy EF, et al. Bifidobacterium infantis 35624 modulates host inflammatory processes  beyond the gut. Gut Microbes. 2013 Jul-Aug;4(4):325-39.14.         Pietrzak A, Jastrzebska I, Chodorowska G, et al. Psoriasis vulgaris and digestive system disorders: is there a linkage? Folia Histochem Cytobiol. 2009 Jan;47(3):517-24.15.         Bowe W, Patel NB, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014 Jun 1;5(2):185-99.16.         Festi D, Schiumerini R, Eusebi LH, et al. Gut microbiota and metabolic syndrome. World J Gastroenterol. 2014 Nov 21;20(43):16079-94.17.         Humbert P, Bidet A, Treffel P, et al. Intestinal permeability in patients with psoriasis. J Dermatol Sci. 1991 Jul;2(4):324-6.18.         Brown AC, Hairfield M, Richards DG, et al. Medical nutrition therapy as a potential complementary treatment for psoriasis–five case reports. Altern Med Rev. 2004 Sep;9(3):297-307.

19. Alwan W, Nestle FO. Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine. Clin Exp Rheumatol 2015;33(5 Suppl 93): S2–6.

20.         Coates LC, FitzGerald O, Helliwell PS, Paul C. Psoriasis, psoriatic arthritis, and rheumatoid arthritis: Is all inflammation the same? Semin Arthritis Rheum. 2016 Dec;46(3):291-304. 21.         Sticherling M. Psoriasis and autoimmunity. Autoimmun Rev. 2016 Dec;15(12):1167-1170.22.         Deng Y, Chang C, Lu Q. The Inflammatory Response in Psoriasis: a Comprehensive Review. Clin Rev Allergy Immunol. 2016 Jun;50(3):377-89.23.         Puig L. The role of IL 23 in the treatment of psoriasis. Expert Rev Clin Immunol. 2017 Feb 6. doi: 10.1080/1744666X.2017.1292137. [Epub ahead of print]24.         Owczarczyk-Saczonek A, Placek W. Interleukin-17 as a factor linking the pathogenesis of psoriasis with metabolic disorders. Int J Dermatol. 2017 Mar;56(3):260-268.25.         Eder L, Jayakar J, Pollock R, et al. Serum adipokines in patients with psoriatic arthritis and psoriasis alone and their correlation with disease activity. Ann Rheum Dis. 2013  Dec;72(12):1956-61.26.         Calder PC, Albers R, Antoine JM, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr. 2009 May;101 Suppl 1:S1-45.27.         Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, Gelfand  JM. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol. 2017 Mar;76(3):393-403.28.         Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M. Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum  Levels in Patients with Psoriasis Vulgaris. Biomed Res Int. 2015;2015:283634.29.         Beygi S, Lajevardi V, Abedini R. C-reactive protein in psoriasis: a review of  the literature. J Eur Acad Dermatol Venereol. 2014 Jun;28(6):700-11.30.         Peluso I, Cavaliere A, Palmery M. Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis. J Biomed Sci. 2016 Jul 4;23(1):52.31.         Zhou Q, Mrowietz U, Rostami-Yazdi M. Oxidative stress in the pathogenesis of psoriasis. Free Radic Biol Med. 2009 Oct 1;47(7):891-905.32.         Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and its role in  skin disease. Antioxid Redox Signal. 2002 Aug;4(4):665-73.33.         Lin X, Huang T. Oxidative stress in psoriasis and potential therapeutic use of antioxidants. Free Radic Res. 2016 Jun;50(6):585-95.34.         Kharaeva Z, Gostova E, De Luca C, et al. Clinical and biochemical effects of coenzyme Q(10), vitamin E, and selenium supplementation to psoriasis patients. Nutrition. 2009 Mar;25(3):295-302.35.         Fairris GM, Lloyd B, Hinks L, Perkins PJ, Clayton BE. The effect of supplementation with selenium and vitamin E in psoriasis. Ann Clin Biochem. 1989  Jan;26 ( Pt 1):83-8.36.         Harvima RJ, Jägerroos H, Kajander EO, et al. Screening of effects of selenomethionine-enriched yeast supplementation on various immunological and chemical parameters of skin and blood in psoriatic patients. Acta Derm Venereol.  1993 Apr;73(2):88-91.37.         Serwin AB, Wasowicz W, Chodynicka B. Selenium supplementation, soluble tumor necrosis factor-alpha receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Nutrition. 2006 Sep;22(9):860-4.38.         Gyldenløve M, Storgaard H, Holst JJ, et al. Patients with psoriasis are insulin resistant. J Am Acad Dermatol. 2015 Apr;72(4):599-605.39.         Praveenkumar U, Ganguly S, Ray L,et al. Prevalence of40.         Metabolic Syndrome in Psoriasis Patients and its Relation to Disease Duration: A  Hospital Based Case-Control Study. J Clin Diagn Res. 2016 Feb;10(2):WC01-5. 41.         Napolitano M, Megna M, Monfrecola G. Insulin resistance and skin diseases. ScientificWorldJournal. 2015;2015:479354.42.         Boehncke S, Thaci D, Beschmann H,et al. Psoriasis patients show signs of insulin resistance. Br J Dermatol.  2007 Dec;157(6):1249-51.43.         Moore AF, Soper T, Jones N,et al. Psoriatic exacerbation associated with insulin therapy. Diabetes Care. 2008 May;31(5):e31.44.         Wu CY, Shieh JJ, Shen JL,et al. Association between antidiabetic drugs and psoriasis risk in diabetic patients: results from a nationwide nested case-control study in Taiwan. J Am Acad Dermatol. 2015 Jan;72(1):123-30.

45. Brewer G, Turkay A, Yuzbasiyan-Gurkan V, et al. Chromium supplementation and insulin sensitivity in psoriasis. J Am Coll Nutr 1993;12:588

46.         Moon HS, Mizara A, McBride SR. Psoriasis and psycho-dermatology. Dermatol Ther (Heidelb). 2013 Dec;3(2):117-30.47.         Hunter HJ, Griffiths CE, Kleyn CE. Does psychosocial stress play a role in the exacerbation of psoriasis? Br J Dermatol. 2013 Nov;169(5):965-74.

48. Pacan P, Szepietowski JC, Kiejna A. Stressful life events and depression in patients suffering from psoriasis vulgaris. Dermatol Psychosom 2003; 4: 142-5

49.         Lakshmy S, Balasundaram S, Sarkar S,et al. A Cross-sectional Study of Prevalence and Implications of Depression and Anxiety in Psoriasis. Indian J Psychol Med. 2015 Oct-Dec;37(4):434-40.50.         de Brouwer SJ, van Middendorp H, Stormink C, et al. The psychophysiological stress response in psoriasis and rheumatoid arthritis. Br J Dermatol. 2014 Apr;170(4):824-31.51.         Richards HL, Ray DW, Kirby B, et al. Response of the hypothalamic-pituitary-adrenal axis to psychological stress in patients with psoriasis. Br J Dermatol. 2005 Dec;153(6):1114-20. 52.         Brunoni AR, Santos IS, Sabbag C, et al. Psoriasis severity and hypothalamic-pituitary-adrenal axis function: results from the CALIPSO study. Braz J Med Biol Res. 2014 Dec;47(12):1102-6.53.         Evers AW, Verhoeven EW, Kraaimaat FW, det al. How stress gets under the skin: cortisol and stress reactivity in psoriasis. Br J Dermatol. 2010 Nov;163(5):986-91.54.         Amatya B, El-Nour H, Holst M, et al. Expression of tachykinins and their receptors in plaque psoriasis with pruritus. Br J Dermatol. 2011 May;164(5):1023-9.55.         Schwartz J, Evers AW, Bundy C, Kimball AB. Getting under the Skin: Report from the International Psoriasis Council Workshop on the Role of Stress in Psoriasis.  Front Psychol. 2016 Feb 2;7:87.56.         Barrea L, Macchia PE, Tarantino G, et al. Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day  food-frequency questionnaire. J Transl Med. 2015 Sep 16;13:303.

57. Barrea L, Balato N, Di Somma C, et al. Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?J Transl Med. 2015;13:18–27

58.         Festugato M. Pilot study on which foods should be avoided by patients with psoriasis. An Bras Dermatol. 2011 Nov-Dec;86(6):1103-8.59.         Wong AP, Kalinovsky T, Niedzwiecki A, Rath M. Efficacy of nutritional treatment in patients with psoriasis: A case report. Exp Ther Med. 2015 Sep;10(3):1071-1073. 60.         Carrascosa JM, Rocamora V, Fernandez-Torres RM, et al. Obesity and psoriasis: inflammatory nature of obesity, relationship between psoriasis and obesity, and therapeutic implications. Actas Dermosifiliogr. 2014 Jan-Feb;105(1):31-44.61.         Upala S, Sanguankeo A. Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis. Int J Obes (Lond). 2015 Aug;39(8):1197-202.62.         Jensen P, Zachariae C, Christensen R, et al. Effect of weight loss on the severity of psoriasis: a randomized clinical study. JAMA Dermatol. 2013 Jul;149(7):795-801.63.         Rucević I, Perl A, Barisić-Drusko V, Adam-Perl M. The role of the low energy diet in psoriasis vulgaris treatment. Coll Antropol. 2003;27 Suppl 1:41-8.64.         Guida B, Napoleone A, Trio R, et al. Energy-restricted, n-3 polyunsaturated fatty acids-rich diet improves the clinical response to immuno-modulating drugs in obese patients with plaque-type psoriasis: a randomized control clinical trial. Clin Nutr. 2014 Jun;33(3):399-405.65.         Bhatia BK, Millsop JW, Debbaneh M, et al. Diet and psoriasis, part II: celiac disease and role of a gluten-free diet. J Am Acad Dermatol. 2014  Aug;71(2):350-8.66.         Ungprasert P, Wijarnpreecha K, Kittanamongkolchai W. Psoriasis and Risk of Celiac Disease: A Systematic Review and Meta-analysis. Indian J Dermatol. 2017 Jan-Feb;62(1):41-46.67.         Akbulut S, Gür G, Topal F, et al. Coeliac disease-associated antibodies in psoriasis. Ann Dermatol. 2013 Aug;25(3):298-303.68.         Bonciolini V, Bianchi B, Del Bianco E, et al. Cutaneous Manifestations of Non-Celiac Gluten Sensitivity: Clinical Histological and Immunopathological Features. Nutrients. 2015 Sep 15;7(9):7798-805.

69. Michaëlsson G, Ahs S, Hammarström I, et al. Gluten-free diet in psoriasis patients with antibodies to gliadin results in decreased expression of tissue transglutaminase and fewer Ki67+ cells in the dermis.Acta Derm Venereol. 2003;83:425–9.
70. Addolorato G, Parente A, de Lorenzi G, et al. Rapid regression of psoriasis in a coeliac patient after gluten-free diet. A case report and review of the literature. 2003;68:9–12.
71. Frikha F, Snoussi M, Bahloul Z. Osteomalacia associated with cutaneous psoriasis as the presenting feature of coeliac disease: a case report.Pan Afr Med J. 2012;11:58.

72.         De Bastiani R, Gabrielli M, Lora L, et al. Association between coeliac disease and psoriasis: Italian primary care multicentre study. Dermatology. 2015;230(2):156-60.

73. Michaëlsson G, Gerdén B, Hagforsen E, et al. Psoriasis patients with antibodies to gliadin can be improved by a gluten-free diet. Br J Dermatol. 2000 Jan;142(1):44-51.

RESEARCH

Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz, Michael P. Lisanti. NADH autofluorescence, a new metabolic biomarker for cancer stem cells: Identification of Vitamin C and CAPE as natural products targeting “stemness”. Oncotarget, 2015; DOI: 10.18632/oncotarget.15400.

Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas. Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(17)30752-3.

Mark Jones, Susan Tett, Geeske M. E. E. Peeters, Gita D. Mishra, Annette Dobson. New-Onset Diabetes After Statin Exposure in Elderly Women: The Australian Longitudinal Study on Women’s Health. Drugs & Aging, 2017; 34 (3): 203 DOI: 10.1007/s40266-017-0435-0.

Emma Lefrançais, Guadalupe Ortiz-Muñoz, Axelle Caudrillier, Beñat Mallavia, Fengchun Liu, David M. Sayah, Emily E. Thornton, Mark B. Headley, Tovo David, Shaun R. Coughlin, Matthew F. Krummel, Andrew D. Leavitt, Emmanuelle Passegué, Mark R. Looney. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature, 2017; DOI: 10.1038/nature21706

Didier Ndeh, Artur Rogowski, Alan Cartmell, Ana S. Luis, Arnaud Baslé, Joseph Gray, Immacolata Venditto, Jonathon Briggs, Xiaoyang Zhang, Aurore Labourel, Nicolas Terrapon, Fanny Buffetto, Sergey Nepogodiev, Yao Xiao, Robert A. Field, Yanping Zhu, Malcolm A. O’Neill, Breeanna R. Urbanowicz, William S. York, Gideon J. Davies, D. Wade Abbott, Marie-Christine Ralet, Eric C. Martens, Bernard Henrissat, Harry J. Gilbert. Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Nature, 2017; DOI: 10.1038/nature21725.

Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino. Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism. Molecular Systems Biology, 2017; 13 (3): 921 DOI: 10.15252/msb.20167356

Stuart G. Snowden, Amera A. Ebshiana, Abdul Hye, Yang An, Olga Pletnikova, Richard O’Brien, John Troncoso, Cristina Legido-Quigley, Madhav Thambisetty. Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLOS Medicine, 2017; 14 (3): e1002266 DOI: 10.1371/journal.pmed.1002266

Stephanie Vuillermot, Wei Luan, Urs Meyer, Darryl Eyles. Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation. Molecular Autism, 2017; 8 (1) DOI: 10.1186/s13229-017-0125-0

Tatiana E. Salazar et al, Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells. STEM CELLS, 2017; DOI: 10.1002/stem.2613

BEN BROWN Detoxification

1. Liska D, Lyon M, Jones DS. Detoxification and biotransformational imbalances. Explore (NY). 2006 Mar;2(2):122-40.

2.             Cline JC. Nutritional aspects of detoxification in clinical practice. Altern Ther Health Med. 2015 May-Jun;21(3):54-62.3.             Klein AV, Kiat H. Detox diets for toxin elimination and weight management: a critical review of the evidence. J Hum Nutr Diet. 2015 Dec;28(6):675-86.4.             Edwards TM, Myers JP. Environmental exposures and gene regulation in disease etiology. Environ Health Perspect. 2007 Sep;115(9):1264-70.5.             Crinnion WJ. The CDC fourth national report on human exposure to environmental chemicals: what it tells us about our toxic burden and how it assist environmental medicine physicians. Altern Med Rev. 2010 Jul;15(2):101-9.6.             Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ. Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int. 2013 Sep;59:328-35.7.             Di Renzo GC, Conry JA, Blake J, et al. International Federation of Gynecology and Obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet. 2015 Dec;131(3):219-25.8.             Goldman LR, Koduru S. Chemicals in the environment and developmental toxicity  to children: a public health and policy perspective. Environ Health Perspect. 2000 Jun;108 Suppl 3:443-8.9.             Chevalier N, Fénichel P. Endocrine disruptors: new players in the pathophysiology of type 2 diabetes? Diabetes Metab. 2015 Apr;41(2):107-15.10.         Heindel JJ, Newbold R, Schug TT. Endocrine disruptors and obesity. Nat Rev Endocrinol. 2015 Nov;11(11):653-61. 11.         Zeliger HI. Lipophilic chemical exposure as a cause of cardiovascular disease. Interdiscip Toxicol. 2013 Jun;6(2):55-62.12.         Teitelbaum SL, Belpoggi F, Reinlib L. Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations. Reprod Toxicol. 2015 Jul;54:141-7. 13.         Barragán-Martínez C, Speck-Hernández CA, Montoya-Ortiz G, Mantilla RD, Anaya JM, Rojas-Villarraga A. Organic solvents as risk factor for autoimmune diseases:  a systematic review and meta-analysis. PLoS One. 2012;7(12):e51506.14.         Brown BI. Chronic fatigue syndrome: a personalized integrative medicine approach. Altern Ther Health Med. 2014 Jan-Feb;20(1):29-40. 15.         Wang N, Zhou Y, Fu C, Wang H, Huang P, Wang B, Su M, Jiang F, Fang H, Zhao Q,  Chen Y, Jiang Q. Influence of Bisphenol A on Thyroid Volume and Structure Independent of Iodine in School Children. PLoS One. 2015 Oct 23;10(10):e0141248.16.         Akın L, Kendirci M, Narin F, Kurtoglu S, Saraymen R, Kondolot M, Koçak S, Elmali F. The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Acta Paediatr. 2015 Apr;104(4):e171-7. 17.         Anger DL, Foster WG. The link between environmental toxicant exposure and endometriosis. Front Biosci. 2008 Jan 1;13:1578-93.18.         Tzivian L, Winkler A, Dlugaj M, et al. Effect of long-term outdoor air pollution and noise on cognitive and  psychological functions in adults. Int J Hyg Environ Health. 2015 Jan;218(1):1-11.19.         Genuis SJ, Kelln KL. Toxicant exposure and bioaccumulation: a common and potentially reversible cause of cognitive dysfunction and dementia. Behav Neurol. 2015;2015:620143. 20.         Genuis SJ. Elimination of persistent toxicants from the human body. Hum Exp Toxicol. 2011 Jan;30(1):3-18. 21.         Jandacek RJ, Tso P. Factors affecting the storage and excretion of toxic lipophilic xenobiotics. Lipids. 2001 Dec;36(12):1289-305.22.         Jandacek RJ, Heubi JE, Buckley DD, Khoury JC, Turner WE, Sjödin A, Olson JR, Shelton C, Helms K, Bailey TD, Carter S, Tso P, Pavuk M. Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial. J Nutr Biochem. 2014 Apr;25(4):483-8.

23. Jandacek RJ, Genuis SJ. An assessment of the intestinal lumen as a site for intervention in reducing body burdens of organochlorine compounds. ScientificWorldJournal. 2013;2013:205621.

24.         Sato M, Kondoh M. Recent studies on metallothionein: protection against toxicity of heavy metals and oxygen free radicals. Tohoku J Exp Med. 2002 Jan;196(1):9-22.25.         Hu R, Hebbar V, Kim BR, Chen C, Winnik B, Buckley B, Soteropoulos P, Tolias P, Hart RP, Kong AN. In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. J Pharmacol Exp Ther. 2004 Jul;310(1):263-71.26.         Swindell WR. Metallothionein and the biology of aging. Ageing Res Rev. 2011 Jan;10(1):132-45.27.         Lamb JJ, Konda VR, Quig DW, et al. A program consisting of a phytonutrient-rich medical food and an elimination diet ameliorated fibromyalgia symptoms and promoted toxic-element detoxification in a pilot trial. Altern Ther  Health Med. 2011 Mar-Apr;17(2):36-44.

28. Ibrahim F, Halttunen T, Tahvonen R, Salminen S. 2006. Probiotic bacteria as potential detoxification tools: assessing their heavy metal binding isotherms.  J. Microbiol. 52:877–885. 10.1139/w06-043

29.         Breton J, Daniel C, Dewulf J, Pothion S, Froux N, Sauty M, Thomas P, Pot B, Foligné B. Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol Lett. 2013 Oct 24;222(2):132-8.30.         Trinder M, McDowell TW, Daisley BA, Ali SN, Leong HS, Sumarah MW, Reid G. Probiotic Lactobacillus rhamnosus Reduces Organophosphate Pesticide Absorption and Toxicity to Drosophila melanogaster. Appl Environ Microbiol. 2016 Sep 30;82(20):6204-6213. 31.         Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Burton JP, Gloor GB, Reid G. Randomized open-label pilot study of the influence of probiotics and the gut microbiome on toxic metal levels in Tanzanian pregnant women and school children. MBio. 2014 Oct 7;5(5):e01580-14. doi: 10.1128/mBio.01580-14.

32. Fariduddin AKM, Misbahuddin M, Manun MIR, Nahar N. Alcohol extract and residue of spirulina in the prevention of accumulation of arsenic in rats. Bang J Physiol Pharmacol 2001; 17:15-7.
33. Tachino N, Guo D, Dashwood WM, Yamane S, Larsen R, Dashwood R. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res. 1994;308(2):191-203.
34. Dashwood R, Yamane S, Larsen R. Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. Environ Mol Mutagen. 1996;27(3):211-218
35. Breinholt V, Schimerlik M, Dashwood R, Bailey G. Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen. Chem Res Toxicol. 1995;8(4):506-514.
36. Morita K, Ogata M, Hasegawa T. Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats. Environ Health Perspect. 2001 Mar;109(3):289-94.
37. Misbahuddin M, Islam AZ, Khandker S, et al. Efficacy of spirulina extract plus zinc in patients of chronic arsenic poisoning: a randomized placebo-controlled study. Clin Toxicol (Phila). 2006;44(2):135-41.
38. Genuis SJ, Curtis L, Birkholz D. Gastrointestinal Elimination of Perfluorinated Compounds Using Cholestyramine and Chlorella pyrenoidosa. ISRN Toxicol. 2013 Sep 9;2013:657849.
39. Egner PA, Muñoz A, Kensler TW. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutat Res. 2003 Feb-Mar;523-524:209-16.
40. Nakano S, Noguchi T, Takekoshi H, Suzuki G, Nakano M. Maternal-fetal distribution and transfer of dioxins in pregnant women in Japan, and attempts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements. Chemosphere. 2005 Dec;61(9):1244-55.

41.         Hodges RE, Minich DM. Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application. J Nutr Metab. 2015;2015:760689.42.         Kikuchi M, Ushida Y, Shiozawa H, et al. Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects. World J Gastroenterol. 2015 Nov 21;21(43):12457-67.43.         Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu Z. Curcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear  factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficacies. Exp Clin Endocrinol Diabetes. 2015 Jun;123(6):360-7.44.         González-Guardia L, Yubero-Serrano EM, Delgado-Lista J, et al. Effects of the Mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. J Gerontol A Biol  Sci Med Sci. 2015 Jan;70(1):78-84.

45. Brown BI. Nutritional Detoxification (article in preparation). 2017. Unpublished.

MITOCHONDRIA and IMMUNITY
Nicole Paulin, Yvonne Döring, Sander Kooijman, Xavier Blanchet, Joana R. Viola, Renske de Jong, Manuela Mandl, Jeffrey Hendrikse, Maximilian Schiener, Philipp von Hundelshausen, Anja Vogt, Christian Weber, Khalil Bdeir, Susanna M. Hofmann, Patrick C.N. Rensen, Maik Drechsler, Oliver Soehnlein. Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance. EBioMedicine, 2017; DOI: 10.1016/j.ebiom.2017.01.006

Maret G Traber, Eunice Mah, Scott W Leonard, Gerd Bobe, Richard S Bruno. Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial. The American Journal of Clinical Nutrition, 2017; ajcn138495 DOI: 10.3945/ajcn.116.138495.

Martineau AR et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.i6583

Naama Geva-Zatorsky, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, Liang Yang, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell, 2017; DOI: 10.1016/j.cell.2017.01.022

LYME and JOINTS
Monica Viladomiu, Charles Kivolowitz, Ahmed Abdulhamid, Belgin Dogan, Daniel Victorio, Jim G. Castellanos, Viola Woo, Fei Teng, Nhan L. Tran, Andrew Sczesnak, Christina Chai, Myunghoo Kim, Gretchen E. Diehl, Nadim J. Ajami, Joseph F. Petrosino, Xi K. Zhou, Sergio Schwartzman, Lisa A. Mandl, Meira Abramowitz, Vinita Jacob, Brian Bosworth, Adam Steinlauf, Ellen J. Scherl, Hsin-Jung Joyce Wu, Kenneth W. Simpson, Randy S. Longman. IgA-coated E. coli enriched in Crohn’s disease spondyloarthritis promote T H 17-dependent inflammation. Science Translational Medicine, 2017; 9 (376): eaaf9655 DOI: 10.1126/scitranslmed.aaf9655

RESEARCH
J. Firth, B. Stubbs, J. Sarris, S. Rosenbaum, S. Teasdale, M. Berk, A. R. Yung. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychological Medicine, 2017; 1 DOI: 10.1017/S0033291717000022.

Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J. Mack, Esra Guen, Stefano Di Biase, Pinchas Cohen, Todd E. Morgan, Tanya Dorff, Kurt Hong, Andreas Michalsen, Alessandro Laviano, Valter D. Longo. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine, 2017; 9 (377): eaai8700 DOI: 10.1126/scitranslmed.aai8700.

Julia H. Kreznar, Mark P. Keller, Lindsay L. Traeger, Mary E. Rabaglia, Kathryn L. Schueler, Donald S. Stapleton, Wen Zhao, Eugenio I. Vivas, Brian S. Yandell, Aimee Teo Broman, Bruno Hagenbuch, Alan D. Attie, Federico E. Rey. Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes. Cell Reports, 2017; 18 (7): 1739 DOI: 10.1016/j.celrep.2017.01.062.

Robert S. Thompson, Rachel Roller, Agnieszka Mika, Benjamin N. Greenwood, Rob Knight, Maciej Chichlowski, Brian M. Berg, Monika Fleshner. Dietary Prebiotics and Bioactive Milk Fractions Improve NREM Sleep, Enhance REM Sleep Rebound and Attenuate the Stress-Induced Decrease in Diurnal Temperature and Gut Microbial Alpha Diversity. Frontiers in Behavioral Neuroscience, 2017; 10 DOI: 10.3389/fnbeh.2016.00240.

Nina Kim, Thomas H. Thatcher, Patricia J. Sime, Richard P. Phipps. Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients. JCI Insight, 2017; 2 (3) DOI: 10.1172/jci.insight.88588

Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N O’Leary, Arvind Ramanathan, Roy R Gerona, David W Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L Stoller, Pankaj Kapahi. α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nature Medicine, 2017; DOI: 10.1038/nm.4280

Zhongyuan Guo, Nicole J. Martucci, Fabiola Moreno-Olivas, Elad Tako, Gretchen J. Mahler. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine. NanoImpact, 2017; 5: 70 DOI: 10.1016/j.impact.2017.01.002.

Food-grade TiO₂ impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

Sarah Bettini et al. Scientific Reports 7, Article number: 40373 (2017). doi:10.1038/srep40373.

Pete A. Williams, Jeffrey M. Harder, Nicole E. Foxworth, Kelly E. Cochran, Vivek M. Philip, Vittorio Porciatti, Oliver Smithies, Simon W. M. John. Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science, 2017; 355 (6326): 756 DOI: 10.1126/science.aal0092.

NEW RELEASES
An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention

Justin D. Roberts et al. Nutrients 2016, 8(11), 733; doi:10.3390/nu8110733.

IHCAN Feb 2017 references

NEWS

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis.

Ciccia F, Guggino G, Rizzo A, Alessandro R, Luchetti MM, Milling S, Saieva L, Cypers H, Stampone T, Di Benedetto P, Gabrielli A, Fasano A, Elewaut D, Triolo G.

Ann Rheum Dis. 2017 Jan 9. pii: annrheumdis-2016-210000. doi: 10.1136/annrheumdis-2016-210000. [Epub ahead of print]

Ahmed Tawakol, Amorina Ishai, Richard AP Takx, Amparo L Figueroa, Abdelrahman Ali, Yannick Kaiser, Quynh A Truong, Chloe JE Solomon, Claudia Calcagno, Venkatesh Mani, Cheuk Y Tang, Willem JM Mulder, James W Murrough, Udo Hoffmann, Matthias Nahrendorf, Lisa M Shin, Zahi A Fayad, Roger K Pitman. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. The Lancet, 2017; DOI: 10.1016/S0140-6736(16)31714-7

J Calvin Coffey, D Peter O’Leary. The mesentery: structure, function, and role in disease. The Lancet Gastroenterology & Hepatology, 2016; 1 (3): 238 DOI: 10.1016/S2468-1253(16)30026-7

Heather F. Smith, William Parker, Sanet H. Kotzé, Michel Laurin. Morphological evolution of the mammalian cecum and cecal appendix. Comptes Rendus Palevol, 2017; 16 (1): 39 DOI: 10.1016/j.crpv.2016.06.001

LYME – JONATHAN OPRCHARD
Eur Spine J. 2013 Apr;22(4):697-707. doi: 10.1007/s00586-013-2675-y. Epub 2013 Feb 13. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.

Albert HB1, Sorensen JS, Christensen BS, Manniche C.

Br J Sports Med. 2008 Dec;42(12):969-73. doi: 10.1136/bjsm.2008.050369. Epub 2008 Aug 21. Antibiotic treatment in patients with low-back pain associated with Modic changes Type 1 (bone oedema): a pilot study.

Albert HB1, Manniche C, Sorensen JS, Deleuran BW.

Eur J Microbiol Immunol (Bp). 2015 Dec; 5(4): 268–280.

Published online 2015 Nov 12. doi:  10.1556/1886.2015.00031

Effectiveness of Stevia Rebaudiana Whole Leaf Extract Against the Various Morphological Forms of Borrelia Burgdorferi in Vitro

1. A. S. Theophilus, M. J. Victoria, K. M. Socarras, K. R. Filush, K. Gupta, D. F. Luecke, and E. Sapi

OSTEOARTHRITIS – BEN BROWN

1. Glyn-Jones S, et al Osteoarthritis. 2015 Mar 3. pii: S0140-6736(14)60802-3.
2. Patrono C, Baigent C. Nonsteroidal anti-inflammatory drugs and the heart. Circulation. 2014 Feb 25;129(8):907-16.
3. Green JA, Hirst-Jones KL, Davidson RK, et al. The potential for dietary factors to prevent or treat osteoarthritis. Proc Nutr Soc. 2014 May;73(2):278-88.
4. Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Maggi S. Adherence to the Mediterranean diet is associated with better quality of life: data from the Osteoarthritis Initiative. Am J Clin Nutr. 2016 Nov;104(5):1403-1409.
5. Clinton CM, et al. Whole-foods, plant-based diet alleviates the symptoms of osteoarthritis. Arthritis. 2015;2015:708152.
6. Gudbergsen H, et al. Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography. Osteoarthritis Cartilage. 2012 Jun;20(6):495-502.
7. Riecke BF, et al. Comparing two low-energy diets for the treatment of knee osteoarthritis symptoms in obese patients: a pragmatic randomized clinical trial. Osteoarthritis Cartilage. 2010 Jun;18(6):746-54.
8. DeChristopher LR, Uribarri J, Tucker KL. Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years. Nutr Diabetes. 2016 Mar 7;6:e199.
9. Ghoochani N, Karandish M, Mowla K, Haghighizadeh MH, Jalali MT. The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis. J Sci Food Agric. 2016 Oct;96(13):4377-81.
10. Schumacher HR, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP. Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthritis Cartilage. 2013 Aug;21(8):1035-41.
11. Hashempur MH, Sadrneshin S, Mosavat SH, Ashraf A. Green tea (Camellia sinensis) for patients with knee osteoarthritis: A randomized open-label active-controlled clinical trial. Clin Nutr. 2016 Dec 18.
12. Rovati LC, Girolami F, Persiani S. Crystalline glucosamine sulphate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties. Ther Adv Musculoskelet Dis. 2012 Jun;4(3):167-80.
13. Reginster JY, et al. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012 Oct;32(10):2959-67.
14. Salazar J, et al. Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism. Arthritis. 2014;2014:432463
15. Biggee BA, Blinn CM, McAlindon TE, et al. Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis. 2006 Feb;65(2):222-6.
16. Coulson S, Butt H, Vecchio P, et al. Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles. 2013 Feb;21(1):79-90.
17. Henrotin Y, Marty M, Mobasheri A. What is the current status of chondroitin sulphate and glucosamine for the treatment of knee osteoarthritis? Maturitas. 2014 Jul;78(3):184-7.
18. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614.
19. Zeng C, Wei J, Li H, Wang YL, Xie DX, Yang T, Gao SG, Li YS, Luo W, Lei GH. Effectiveness and safety of Glucosamine, chondroitin, the two in combination, or celecoxib in the treatment of osteoarthritis of the knee. Sci Rep. 2015 Nov 18;5:16827.
20. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulphate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006 Feb 23;354(8):795-808.
21. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. 2004;24(6):353-63.
22. Debbi EM, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50.
23. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical Osteoarthritis Cartilage. 2006 Mar;14(3):286-94.
24. Bagchi D, et al. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101-10.
25. Crowley DC, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21
26. Abdel-Tawab M, et al. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. Clin Pharmacokinet. 2011 Jun;50(6):349-69. Doi
27. Cameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2014 May 22;5:CD002947.
28. Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-22.
29. Sengupta K, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin Against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010 Nov 1;7(6):366-77.
30. Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013 Dec;2(1):56.
31. Perkins K, Sahy W, Beckett RD. Efficacy of Curcuma for Treatment of Osteoarthritis. J Evid Based Complementary Altern Med. 2017 Jan;22(1):156-165.
32. Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9.
33. Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010 Dec;15(4):337-44.
34. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8.

MEDICAL NLP

1. Pinker S (New Ed 1995) The Language Instinct: The New Science of Language and Mind. London: Penguin Books Ltd

² House JS, Landis KR, Umberson D (1988) Social relations and health.  Science  241:  540–5; Hafen Q, Karren KJ, Frandsen KJ, Smith NL (1996)  Mind/Body Health: The Effects of Attitudes, Emotions and Relationships , Boston: Allyn & Bacon; The GUSTO Investigators (1993) An international randomized trial comparing four thrombolytic studies for acute myocardial infarction.  New England Journal of Medicine 329: 673–82.

³ Witthöft M, Rubin GJ (2013), Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) Journal of Psychosomatic Research

⁴ Osmo A. Wiio (1978). Wiion lait – ja vähän muidenkin (Wiio’s laws – and some others). Weilin+Göös.

⁵ Sigmund Freud  The Standard Edition of the Complete Psychological Works of Sigmund Freud, translated and edited by James Strachey.  The Institute of Psycho-Analysis and The Hogarth Press

⁶ Freud S (Paperback ed. 1991) Introductory Lectures (1916-17). London:Penguin Books Ltd

⁷ Rosencranz MA et al (2005) Neural circuitry underlying the interaction between emotion and asthma symptom exacerbation. PNAS 102 (37): 13319–24.

⁸ Langer E, Dillon M, Kurtz R, and Katz M (1998) Believing is Seeing, Harvard University, Department of Psychology.

⁹ Coversation with author

¹⁰ Olde Hartman TC, Lucassen PL, van de Lisdonk EH et al (2004) Chronic functional somatic symptoms: a single syndrome? British Journal of General Practice 54: 922–7.
¹¹ See Dr Bandler’s introduction to the 1^st edition of Magic in Practice

BLOATING – PATRICK HOLFORD

1. Holford & Associates Ltd. 100% Digestive Health Survey, awaiting publication in February.
2. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7; see also Zuo X.L., et al. Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia. Clin Exp Allergy. 2007 Jun; 37(6):823-30.
3. Finn R., et al. Immunological hypersensitivity to environmental antigens in the irritable bowel syndrome. Br J Clin Pract. 1987 Dec; 41(12):1041-3.
4. Zar, S., et al. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol.. 2005 Jul; 100(7):1550–7.
5. Atkinson, W., et al. Food elimination based on IgG antibodies in irritable bowel syndrome: A randomised controlled trial. Gut. 2004 Oct; 53(10):1459–64
6. van Gils, T., et al. Prevalence and characterization of self-reported gluten

sensitivity in the Netherlands. Nutrients. 2016 Nov; 8(11):714.

7. Zanwar, V.G., et al. Symptomatic improvement with gluten restriction in irritable bowel syndrome: a prospective, randomized, double blinded placebo controlled

trial. Intestinal Research. 2016 Oct; 14(4):343–350.

8. Sofi, F., et al. Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention trial. Br J Nutr. 2014 Jun; 111(1):1992–9.
9. Maagaard L., et al. Follow- up of patients with functional bowel

symptoms treated with a low FODMAP diet. World J Gastroenterol. 2016

Apr; 22(15):4009–19.

10. Eswaran, S.L., et al. A randomised controlled trial comparing the low FODMAP diet vs. modified NICE guidelines in US adults with IBS-D. Am J Gastroenterol. 2016 Dec; 111(12):1824-1832.
11. Iranio, G. Digestive enzyme supplementation in gastrointestinal diseases. Curr Drug Metab. 2016 Feb; 17(2):187–193.
12. Moayyedi, P., et al. The efficacy of probiotics in the treatment of

irritable bowel syndrome: A systematic review. Gut. 2010 Mar; 59(3):325–32.

13. Silk, D.B., et al. Clinical trial: The effects of a transgalactooligosaccharide

prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacology and Therapeutics. 2009 Mar; 29(5):508–18.

14. Jalanka- Tuovinen, J., et al. Intestinal microbiota in healthy adults:

Temporal analysis reveals individual and common core and relation to intestinal symptoms. PLoS One, 2011 Jul; 6(7):e23035.

15. 1 Baştür, A., et al. Efficacy of synbiotic, probiotic, and prebiotic treatments for

irritable bowel syndrome in children: A randomized controlled

trial. Turk J Gastroenterol. 2016 Sep; 27(5):439-443.

LEARNING ZONE – LYME

1. PHE/RIPL website: https://www.gov.uk/government/collections/rare-and-imported-pathogens-laboratory-ripl
   2. Stevenson B. Variable VlsE Is Critical for Host Reinfection by the Lyme Disease Spirochete. PLoS One. 2013, 8(4)
   3. Meriläinen L et al. Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms. Microbiology. 2015 Mar;161(Pt 3):516-27.
   4. Sapi E et al. Characterization of Biofilm Formation by Borrelia burgdorferi In Vitro. PLoS One. 2013 7(10)
   5. Cook MJ and Puri BP. Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy. Int J Gen Med. 2016, Nov 18;9:427-440
   6. Stricker RB et al. Lyme disease: the promise of Big Data, companion diagnostics and precision medicine. Infect Drug Resist. 2016;9:215-219
   7. Lehman PV et al. Unique Strengths of ELISPOT for T Cell Diagnostics. In: Kalyuzhny AE. Handbook of ELISPOT: Methods and Protocols, Methods in Molecular Biology, Vol. 792. 2nd Ed: Springer; 2012: 3-23.
   8. Stricker RB and Winger EE. Decreased CD57 Lymphocyte Subset in Patients with Chronic Lyme Disease. Immunology Letters, 2001;76, 43-48.

LEARNING ZONE – the Sensitivity Gene

* The January 2015 Duke University study, “Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial,” was published in the Journal of Policy Analysis and Management.
*Benedicte Meyer et al, Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype. PLOS One,  2015, https://dx.doi.org/10.1371/journal.pone.0140883

* Felitti VJ, Anda RF et al. Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med May 1998, 14, 4,: 245–58.

* For The Sensitivity Hypothesis, Dandelion and Orchid Children, see research by Bruce Ellis  University of Arizona, and W Thomas Boyce  University of British Columbia, for example “Biological sensitivity to context: I. An evolutionary–developmental theory of the origins and functions of stress reactivity” in Development and Psychopathology

17, 2005, 271–301. DOI: 10.1017/S095457940505014.

* Childhood Disrupted: How Your Biography Becomes Your Biology and How You Can Heal, by Donna Jackson Nakazawa: https://donnajacksonnakazawa.com/childhood-disrupted/.

* GSC – Genetically Sensitive Client- Chrysalis Effect Specialist Practitioner Training Elaine Wilkins: https://www.thechrysaliseffectpractitioners.com/.

RESEARCH

Isabel Garcia-Perez, Joram M Posma, Rachel Gibson, Edward S Chambers, Tue H Hansen, Henrik Vestergaard, Torben Hansen, Manfred Beckmann, Oluf Pedersen, Paul Elliott, Jeremiah Stamler, Jeremy K Nicholson, John Draper, John C Mathers, Elaine Holmes, Gary Frost. Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial. The Lancet Diabetes & Endocrinology, 2017; DOI: 10.1016/S2213-8587(16)30419-3

A Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies of Eicosapentaenoic and Docosahexaenoic Long-Chain Omega-3 Fatty Acids and Coronary Heart Disease Risk. Dominik D. Alexander et al. Open Access . DOI: https://dx.doi.org/10.1016/j.mayocp.2016.10.018

Mayo Clinic Proceedings, January 2017, Volume 92, Issue 1, Pages 15–29.

NEWS
Arch Intern Med. 1999 Sep 27;159(17):1981-7.). Homeopathy re-revisited: is homeopathy compatible with biomedical observations? Eskinazi D.

Saha, SK. et al. Ultra–highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro.  J. Integr. Med. 13, 400–411 (2015).

Randomised placebo-controlled trials of individualised homeopathic treatment: systematic review and meta-analysis. Robert T Mathie et al. Systematic Rev, 2014, 3:142. DOI: 10.1186/2046-4053-3-142.

Cell, Ocampo et al.: “In vivo amelioration of age-associated hallmarks by partial reprogramming.” DOI: 10.1016/j.cell.2016.11.052 , www.cell.com/cell/fulltext/S0092-8674(16)31664-6

NEW RELEASES

Diabetes Res Clin Pract. 2009 Feb;83(2):e40-2. doi: 10.1016/j.diabres.2008.11.014. Epub 2008 Dec 23. Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus. Chearskul S1, Kriengsinyos W, Kooptiwut S, Sangurai S, Onreabroi S, Churintaraphan M, Semprasert N, Nitiyanant W.

BEN BROWN

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Additional story:
Antonio Gonzalez, Embriette Hyde, Naseer Sangwan, Jack A. Gilbert, Erik Viirre, Rob Knight. Migraines Are Correlated with Higher Levels of Nitrate-, Nitrite-, and Nitric Oxide-Reducing Oral Microbes in the American Gut Project Cohort. mSystems, October 2016 DOI: 10.1128/mSystems.00105-16
NUTRIGENETICS

Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V. J Nutr Biochem. 2002 Aug;13(8):444.

Influence of apple polyphenols on inflammatory gene expression. Jung M, Triebel S, Anke T, Richling E, Erkel G. Mol Nutr Food Res. 2009 Oct;53(10):1263-80. doi: 10.1002/mnfr.200800575.

Christopher T. Ford, Siân Richardson, Francis McArdle, Silvina B. Lotito, Alan Crozier, Anne McArdle, Malcolm J. Jackson. Identification of (poly)phenol treatments that modulate the release of pro-inflammatory cytokines by human lymphocytes. British Journal of Nutrition, 2016; 115 (10): 1699 DOI: 10.1017/S0007114516000805

10. Zamora-Ros, M. Rabassa, A. Cherubini, M. Urpi-Sarda, S. Bandinelli, L. Ferrucci, C. Andres-Lacueva. High Concentrations of a Urinary Biomarker of Polyphenol Intake Are Associated with Decreased Mortality in Older Adults. Journal of Nutrition, 2013; 143 (9): 1445 DOI: 10.3945/jn.113.177121

Harri Hemil. Vitamin E and the risk of pneumonia: using the I²-statistic to quantify heterogeneity within a controlled trial. British Journal of Nutrition, 2016; 1 DOI: 10.1017/S0007114516003408.

Guide and Position of the International Society of Nutrigenetics/Nutrigenomics on Personalised Nutrition: Part 1 – Fields of Precision Nutrition

J Nutrigenet Nutrigenomics 2016;9:12-27, (DOI:10.1159/000445350)

Fulltext PDF (674 Kb) Free Access at www.karger.com/Article/FullText/445350

GUT

From Sample to Multi-Omics Conclusions in under 48 Hours. Robert A. Quinn, Jose A. Navas-Molina, Embriette R. Hyde, Se Jin Song, Yoshiki Vázquez-Baeza, Greg Humphrey, James Gaffney, Jeremiah J. Minich, Alexey V. Melnik, Jakob Herschend, Jeff DeReus, Austin Durant, Rachel J. Dutton, Mahdieh Khosroheidari, Clifford Green, Ricardo da Silva, Pieter C. Dorrestein, Rob Knight

Jack A. Gilbert, Editor. mSystems, 2016: DOI: 10.1128/mSystems.00038-16.

Timothy R. Sampson et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.018.

Christoph A. Thaiss et al. Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations. Cell, December 2016 DOI: 10.1016/j.cell.2016.11.003

Diet-Microbiome Interactions in Health Are Controlled by Intestinal Nitrogen Source Constraints. Andrew J. Holmes et al. Cell Metabolism. In Press. available online 23 November 2016.

RESEARCH
Francesco Foroni, Giulio Pergola, Raffaella Ida Rumiati. Food colour is in the eye of the beholder: the role of human trichromatic vision in food evaluation. Scientific Reports, 2016; 6: 37034 DOI: 10.1038/srep37034

Dagfinn Aune, NaNa Keum, Edward Giovannucci, Lars T. Fadnes, Paolo Boffetta, Darren C. Greenwood, Serena Tonstad, Lars J. Vatten, Elio Riboli, Teresa Norat. Nut consumption and risk of cardiovascular disease, total cancer, all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective studies. BMC Medicine, 2016; 14 (1) DOI: 10.1186/s12916-016-0730-3

10. Zelano, H. Jiang, G. Zhou, N. Arora, S. Schuele, J. Rosenow, J. A. Gottfried. Nasal Respiration Entrains Human Limbic Oscillations and Modulates Cognitive Function. Journal of Neuroscience, 2016; 36 (49): 12448 DOI: 10.1523/JNEUROSCI.2586-16.2016

* Video: https://www.youtube.com/watch?v=1KNn0NYjMWg.

Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, Sarah Nechuta, Eric Leas, Bette J. Caan, John Pierce, Xiao-Ou Shu, Ying Zheng, Wendy Y. Chen. Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project. Cancer, 2016; DOI: 10.1002/cncr.30440.

10. Gunness, J. Michiels, L. Vanhaecke, S. De Smet, O. Kravchuk, A. Van de Meene, M. J. Gidley. Reduction in circulating bile acid and restricted diffusion across the intestinal epithelium are associated with a decrease in blood cholesterol in the presence of oat  -glucan. The FASEB Journal, 2016; 30 (12): 4227 DOI: 10.1096/fj.201600465R.

Inmaculada Moreno, Francisco M. Codoñer, Felipe Vilella, Diana Valbuena, Juan F. Martinez-Blanch, Jorge Jimenez-Almazán, Roberto Alonso, Pilar Alamá, Jose Remohí, Antonio Pellicer, Daniel Ramon, Carlos Simon. Evidence that the endometrial microbiota has an effect on implantation success or failure. American Journal of Obstetrics and Gynecology, 2016; 215 (6): 684 DOI: 10.1016/j.ajog.2016.09.075

Haiqiu Huang, Xiaojing Jiang, Zhenlei Xiao, Lu Yu, Quynhchi Pham, Jianghao Sun, Pei Chen, Wallace Yokoyama, Liangli Lucy Yu, Yaguang Sunny Luo, Thomas T. Y. Wang. Red Cabbage Microgreens Lower Circulating Low-Density Lipoprotein (LDL), Liver Cholesterol, and Inflammatory Cytokines in Mice Fed a High-Fat Diet. Journal of Agricultural and Food Chemistry, 2016; 64 (48): 9161 DOI: 10.1021/acs.jafc.6b03805

NEWS

Giannis Koukkidis, Richard Haigh, Natalie Allcock, Suzanne Jordan, and Primrose Freestone. Salad leaf juices enhance Salmonella growth, fresh produce colonisation and virulence. Applied and Environmental Microbiology, November 2016 DOI: 10.1128/AEM.02416-16
Cheng-Shiuan Lee, Molly E. Lutcavage, Emily Chandler, Daniel J. Madigan, Robert M. Cerrato, Nicholas S. Fisher. Declining Mercury Concentrations in Bluefin Tuna Reflect Reduced Emissions to the North Atlantic Ocean. Environmental Science & Technology, 2016; DOI: 10.1021/acs.est.6b04328

Lei Yin, Kevin Yu, Simon Lin, Xiao Song, Xiaozhong Yu. Associations of blood mercury, inorganic mercury, methyl mercury and bisphenol A with dental surface restorations in the U.S. population, NHANES 2003–2004 and 2010–2012. Ecotoxicology and Environmental Safety, 2016; 134: 213 DOI: 10.1016/j.ecoenv.2016.09.001

Dr Mark Hyman on mercury:
https://drhyman.com/blog/2010/05/20/mercury-get-this-poison-out-of-your-body.

NEWS EXTRA

Elmira Akbari, Zatollah Asemi, Reza Daneshvar Kakhaki, Fereshteh Bahmani, Ebrahim Kouchaki, Omid Reza Tamtaji, Gholam Ali Hamidi, Mahmoud Salami. Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer’s Disease: A Randomized, Double-Blind and Controlled Trial. Frontiers in Aging Neuroscience, 2016; 8 DOI: 10.3389/fnagi.2016.00256

BEN BROWN Migraine

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2. Natoli JL, Manack A, Dean B, Butler Q, Turket CC, Stovner L, et al. Global prevalence of chronic migraine: a systematic review. Cephalalgia. 2010;30:599–609.

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EXTRAS

E. F. G. Naninck, J. E. Oosterink, K.-Y. Yam, L. P. de Vries, H. Schierbeek, J. B. van Goudoever, R.-N. Verkaik-Schakel, J. A. Plantinga, T. Plosch, P. J. Lucassen, A. Korosi. Early micronutrient supplementation protects against early stress-induced cognitive impairments. The FASEB Journal, 2016; DOI: 10.1096/fj.201600834R

Sarkar et al. Psychobiotics and the Manipulation of Bacteria-Brain Signals. Trends in Neurosciences, October 2016 DOI: 10.1016/j.tins.2016.09.002

RESEARCH

PLoS One. 2016 Oct 31;11(10):e0165378. doi: 10.1371/journal.pone.0165378. eCollection 2016. Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance. Lin PJ¹, Borer KT¹.

Giles Major et al. Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-related Symptoms in Individuals with Irritable Bowel Syndrome, Gastroenterology (2016). DOI: 10.1053/j.gastro.2016.09.062

10. Pegorie, D.W. Denning, W. Welfare. Estimating the burden of invasive and serious fungal disease in the United Kingdom. Journal of Infection, 2016; DOI: 10.1016/j.jinf.2016.10.005

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